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Jurnal Buana Farma
Published by Universitas Buana Perjuangan Karawang
ISSN : -     EISSN : 27972100     DOI : 10.36805
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology
The major focus of Jurnal Buana Farma is to publish articles in the area of Experimental Pharmacology, Clinical Pharmacy, Pharmaceutical Technology, Pharmacoeconomy, Pharmacognosy, Pharmaceutical chemistry.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 204 Documents
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EVALUASI PENGGUNAAN OBAT PADA PASIEN GAGAL GINJAL KRONIK YANG MENJALANI HEMODIALISIS : NARATIVE LITERATURE RIVIEW Irawan, Wira; Sukandar, Elin Yulinah
Jurnal Buana Farma Vol. 5 No. 1 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i1.1327

Abstract

Chronic kidney failure is a condition characterised by a gradual deterioration of renal function over months to years, resulting in the replacement of normal cells by fibrous tissue, impairing the kidneys' ability to effectively filter waste products from the bloodstream. This review article is to examine medications that demonstrate effective therapeutic outcomes in accordance with treatment guidelines for patients with chronic renal failure, based on the criteria of appropriate patient, appropriate drug, appropriate indication, and appropriate dosage. The employed methodology is a narrative literature review, encompassing an examination of 14 papers published between 2015 and 2025. Literature searches were performed using the Google Scholar, PubMed, and Science Direct databases. The search employs the terms "Chronic Kidney Failure" and "Hemodialysis". The journal review indicates that pharmacological interventions in hospitalised chronic kidney failure patients aim to optimise renal filtration rates, avert the exacerbation of chronic kidney failure, and ameliorate physiological disturbances resulting from renal impairment. The hospital treatment adheres to the precision of diagnosis, indications, pharmacological selection, dosage, administration method, awareness of adverse effects, and evaluation of the patient's state in accordance with established therapeutic recommendations.
POTENSI FAMILI MYRTACEAE SEBAGAI ANTIHIPERURISEMIA : REVIEW Jamilah, Putri Ayu Nurul; Riyanti, Soraya
Jurnal Buana Farma Vol. 5 No. 1 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i1.1330

Abstract

Hyperuricemia is a condition of uric acid levels that have increased beyond normal limits in the blood. The prevalence of gout in Indonesia has increased by 11.9% and generally the highest prevalence is at the age of ≥ 75 years at 54.8%. Based on information, gout sufferers in women are higher (8.46%) compared to men (6.13%). The utilization of medicinal plants has been widely practiced by the community in dealing with the problem of gout. This article discusses several plants of the Myrtaceae family that are widely used by the community as traditional medicine in dealing with uric acid problems or as antihyperuricemia. The literature search method was carried out online to get articles from national and international journals. The results of the literature search obtained several plants of the Myrtaceae family, namely Salam (Syzygium polyanthum Wight.), guava (Psidium guajava L.), jamblang (Syzygium cumini L.), cloves (Syzygium cumini L.), and clove (Syzygium cumini L.). ), cloves (Syzygium aromaticum), Kupa (Syzygium polycephalum), guava rose (Syzygium jambos L.), and red shoots (Syzygium myrtifolium Walp.) that have antihyperuricemia activity through In vivo and In vitro testing. This review article can provide information about the potential of the Myrtaceae family that has activity as antihyperuricemia.
POTENSI AKTIVITAS ANTIINFLAMASI DAN ANTIKANKER DARI EKSTRAK DAN FRAKSI DAUN ALPUKAT DAN DAUN PEPAYA: NARRATIVE REVIEW Rahayu, Ihsanti Dwi; Aliya, Fariha Ais; Al Hanif, Jazaul Fariha
Jurnal Buana Farma Vol. 5 No. 1 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i1.1331

Abstract

Avocado leaves and papaya leaves have been empirically widely used by Indonesian people as traditional medicine with various benefits. The discovery and development of new drugs that lead to the use of medicinal plants have triggered the need for accurate and reliable information, especially related to avocado leaves and papaya leaves in the treatment of cancer and inflammation. The purpose of writing this article is to determine the potential of avocado leaves and papaya leaves, both in the form of extracts and fractions, for anti-inflammatory and anticancer activities collected in narrative review articles. The search for articles as reference materials for writing was carried out by combining keywords and boolean operators (AND, OR) typed on article database sites such as Google Scholar, PubMed, and Researchgate. There are inclusion criteria in the search for articles, namely relevant articles in journals that have been published in 2015 to 2024, articles available in full-text in Indonesian or English, and obtained from experimental study research designs. Based on the results of the journal article selection, 23 journal articles were obtained that met the inclusion criteria for the review process. The results of the review of 23 articles show that avocado leaves and papaya leaves have been scientifically proven to have pharmacological activity as anti-inflammatory and anticancer both in the form of extracts and fractions. The content of secondary metabolite compounds that are suspected to be responsible for the production of anti-inflammatory and anticancer activities in avocado leaves and papaya leaves are flavonoid compounds.
REVIEW ARTIKEL: SISTEM PENGHANTARAN OBAT SNEEDS (Self-Nanoemulsifying Drug Delivery System) DALAM FORMULASI OBAT HERBAL Khoerunnisa, Rita; Pamudji, Jessie Sofia
Jurnal Buana Farma Vol. 5 No. 1 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i1.1334

Abstract

SNEDDS is a drug delivery system that aims to increase the solubility and bioavailability of drugs that are poorly soluble in water. Increased bioavailability can improve the kinetic profile of drugs in the body. This article review aims to discuss the advantages of SNEDDS formulation used to make drugs with natural ingredient extracts. The research method applied in this article is a literature review by collecting articles in the form of journals about the formulation of SNEDDS herbal medicine. SNEDDS combines various types of oils, surfactants, and cosurfactants. The selection of SNEDDS formulation composition should be done very carefully. Research and development of SNEDDS has shown the potential of SNEDDS in increasing the solubility and bioavailability of drugs that are poorly soluble in water. Although there are many challenges to be faced in SNEDDS, SNEDDS has great potential to improve the efficiency of drug therapy.
FAKTOR-FAKTOR YANG MEMPENGARUHI KEPATUHAN PASIEN TBC SEHINGGA TERCAPAINYA KEBERHASILAN TERAPI Indriyani, Atika Sri; Sutjiatmo, Afifah B.
Jurnal Buana Farma Vol. 5 No. 1 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i1.1340

Abstract

TB is one of the oldest infectious diseases ever suffered by humans. The infection caused by the Mycrobacterium tuberculosis complex bacteria, known as tuberculosis, usually attacks the lungs, but these bacteria can also infect the bones, brain, or kidneys. One of the obstacles hindering tuberculosis (TB) treatment efforts is adherence. There may have been a decrease in TB cases in recent years due to the increased adherence to TB treatment. Improving tuberculosis (TB) patients' adherence to TB treatment can be achieved through various means, including family communication, healthcare professionals via telemedicine, healthcare professionals with home pharmacy care, and much more. This narrative review method uses primary journal data sources directly collected from the Pubmed and Google Scholar websites. Individuals, families, environments, and medical personnel are factors that influence the success of therapy in TB patients.
PERAN APOTEKER DALAM MENINGKATKAN HASIL PENGOBATAN PASIEN DIABETES TIPE 2: TINJAUAN INTERVENSI DI FASILITAS KESEHATAN INDONESIA Amelia, Riza; Hermanto, Faizal
Jurnal Buana Farma Vol. 5 No. 1 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i1.1342

Abstract

Type 2 diabetes mellitus is one of the chronic diseases with low treatment success rates. This article aims to assess the effectiveness of pharmacist interventions in improving treatment outcomes for patients with type 2 diabetes. The research method used is a narrative review through searching the PubMed and Google Scholar databases. This study reviewed journals from the years 2015 to 2025, resulting in 791 articles. A total of 11 articles met the inclusion criteria. The results of the research indicate that pharmacist interventions can significantly improve treatment outcomes, including increased adherence, improved quality of life for patients with type 2 diabetes, and achievement of stable glucose levels.
AKTIVITAS ANTIINFLAMASI SENYAWA AKTIF DAUN JAWER KOTOK (Plectranthus scutellarioides (L.)R.Br.) MELALUI INHIBISI Siklooksigenase-2 SECARA IN SILICO Maharani, Alya Rizqi; Purwono, Rini Madyastuti; Siswandi, Riki; Nurkarimah, Dona Astari; Farhamzah
Jurnal Buana Farma Vol. 5 No. 1 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i1.1343

Abstract

Inflammation is the body’s response to harmful stimuli, and it plays a crucial role in boosting immunity. However, if inflammation is not managed properly, it can lead to degenerative diseases. This research aims to analyze the potential of Plectranthus scutellarioides (L.) R. Br. leaves as an anti-inflammatory agent. The study employs an in silico molecular docking method, using the active compound from the plant as the test ligand and the COX-2 receptor as the target. The results indicate that the test ligand, Antosianin, shows the best interaction as an inhibitor of the target receptor, as demonstrated by its superior affinity energy value compared to the other test ligands.
REVIEW: POTENSI KAYU MANIS SEBAGAI ANTIDIABETES Utari, Roly Rahmah; Suryani
Jurnal Buana Farma Vol. 5 No. 1 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i1.1346

Abstract

Cinnamon has long been used in traditional medicine and is gaining increasing attention in modern scientific circles due to its bioactive compounds, such as cinnamaldehyde, polyphenols, and flavonoids, which play a role in antihyperglycemic effects and improving insulin sensitivity. Several clinical trials have shown that cinnamon supplementation (1–6 grams per day for 8–16 weeks) can reduce fasting blood glucose levels by 10–29 mg/dL and HbA1c by 0.4–0.7% in patients with type 2 diabetes.This study aims to evaluate the potential of cinnamon as an antidiabetic agent by reviewing scientific evidence related to its mechanism of action, effectiveness, and safety of long-term consumption. A literature search was conducted through the PubMed and Google Scholar databases using the keywords “Cinnamon” AND “Antidiabetes” for articles published in the period 2003–2023. The included articles included in vitro, in vivo, and clinical trial experimental studies, while review articles and meta-analyses were excluded. A total of 30 articles that met the criteria were analyzed descriptively.The review results suggest that cinnamon works through the mechanism of inhibiting the enzyme α-glucosidase and increasing insulin sensitivity, which contribute to lower blood glucose and HbA1c levels. However, heterogeneity in the type of cinnamon used, variation in dosage, method of consumption, and the lack of long-term studies on its safety are limitations that need to be considered. Therefore, further research is needed, especially large-scale clinical trials with longer duration, to confirm the efficacy and safety of cinnamon in the management of diabetes.
A LITERATURE REVIEW: AKTIVITAS ANTIBAKTERI TANAMAN OBAT TERHADAP BAKTERI PENYEBAB PNEUMONIA Sinabutar, Rahel Margarenta; Nurfitriani, Iis; Maharani, Dinda Eka; Riasari, Hesti
Jurnal Buana Farma Vol. 5 No. 3 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i3.1382

Abstract

Pneumonia is an acute respiratory tract infection caused by various pathogenic bacteria, including Streptococcus pneumoniae, Staphylococcus aureus, and Klebsiella pneumoniae. The increasing prevalence of antibiotic resistance among these pathogens highlights the need for alternative therapeutic strategies derived from natural products. This study aimed to review the antibacterial potential of medicinal plants against pneumonia-causing bacteria and their underlying mechanisms. A systematic literature review was conducted by searching scientific articles in Google Scholar, PubMed, ScienceDirect, and MDPI. Articles were selected based on inclusion criteria covering antibacterial activity, active compounds, and reported mechanisms of action. A total of 30 eligible articles were analyzed descriptively. The medicinal plants reviewed include Etlingera elatior, Cassia alata, Morinda citrifolia, Melaleuca leucadendra, Momordica charantia, Guazuma ulmifolia, Artocarpus altilis, Acacia nilotica, Gynura procumbens, Trigona incisa propolis, and Ficus carica. These plants contain secondary metabolites such as flavonoids, alkaloids, saponins, tannins, and phenols, which exhibit antibacterial activity by disrupting cell membranes, inhibiting protein synthesis, interfering with essential enzymes, and inducing oxidative stress in bacteria. The findings indicate that medicinal plants hold great potential as complementary or alternative therapies for pneumonia caused by antibiotic-resistant bacteria; however, further research, particularly in vivo and clinical studies, is required to confirm their efficacy and safety.
REVIEW ARTIKEL: POTENSI FITOTERAPI DARI TANAMAN HERBAL DALAM PENANGANAN RHEUMATOID ARTHRITIS Nurhayati, Ismaya; Maulani, Sintia Putri; Lathifah, Meira H.; Riasari, Hesti
Jurnal Buana Farma Vol. 5 No. 3 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i3.1387

Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation of the joints, resulting in progressive damage and a decreased quality of life for patients. Conventional therapies such as NSAIDs and DMARDs are indeed effective, but their long-term use carries the risk of serious side effects and high costs. Therefore, safer and more affordable alternative therapies are needed, one of which is through the use of medicinal plants. This study aims to examine the potential of herbal plants as an additional or alternative therapy for rheumatoid arthritis. The method employed is a literature study, involving the search and analysis of 31 scientific journals retrieved from academic databases, including Google Scholar, PubMed, ScienceDirect, and MDPI. The articles analyzed were selected based on certain criteria and contained information about the content of active compounds, pharmacological activity, and the mechanism of action of plants on the RA inflammation process. The results of the study showed that various herbal plants such as Zingiber officinale, Curcuma longa, Boswellia serrata, and Nigella sativa have significant anti-inflammatory and immunomodulatory activities. The active compounds in these plants work by inhibiting the inflammatory pathway and reducing the production of pro-inflammatory cytokines. In conclusion, medicinal plants have great potential to be used as additional therapy in the treatment of rheumatoid arthritis. However, further research is needed, especially clinical trials, to ensure the long-term safety and effectiveness of their use.

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