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Jurnal Buana Farma
Published by Universitas Buana Perjuangan Karawang
ISSN : -     EISSN : 27972100     DOI : 10.36805
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology
The major focus of Jurnal Buana Farma is to publish articles in the area of Experimental Pharmacology, Clinical Pharmacy, Pharmaceutical Technology, Pharmacoeconomy, Pharmacognosy, Pharmaceutical chemistry.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 204 Documents
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STUDI IN VITRO ANTIKOLESTEROL DAN FLAVONOID TOTAL DARI EKSTRAK BAWANG PUTIH TUNGGAL (Allium sativum L) Nafiah, Azidatun; Raharjo, Danang; Ardiyantoro, Bagas
Jurnal Buana Farma Vol. 5 No. 3 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i3.1504

Abstract

Hypercholesterolemia is one of the main factors that increase the risk of heart and blood vessel disease, which can cause atherosclerosis and disorders in fat metabolism. Single garlic is known to contain bioactive compounds such as flavonoids that play a role in reducing cholesterol. This study aims to assess the total flavonoids and anticholesterol activity in vitro of ethanol extract of single garlic (Allium sativum L.). The extraction process was carried out using the maceration method with 96% ethanol as the solvent. Total flavonoids were measured using UV-Vis spectrophotometry with quercetin as the standard, while anticholesterol activity was tested using the Lieberman-Burchard method in vitro. The findings of this study indicate that the sample extract contains secondary metabolites such as flavonoids, alkaloids, saponins, and tannins. Single garlic shows effective flavonoid content in lowering lipid levels. The anticholesterol test shows that this extract can reduce cholesterol levels with a significant IC₅₀ value. The conclusion of this study is that single garlic has the potential as an alternative way to lower cholesterol.
EVALUASI WAKTU TUNGGU PELAYANAN RESEP DI RUMAH SAKIT X fiman, imran; Marwan, Aulia
Jurnal Buana Farma Vol. 5 No. 3 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i3.1508

Abstract

Prescription service waiting time is one indicator of the quality of pharmaceutical services in hospitals, where excessive wait times can impact patient satisfaction with the service. Based on Regulation of the Minister of Health of the Republic of Indonesia Number 129/Menkes/SK/II/2008, the maximum standard wait time for non-compounded prescriptions is ≤ 30 minutes and for compounded prescriptions is ≤ 60 minutes. This study aims to evaluate the waiting time for prescription services in the Outpatient Pharmacy Unit of X Hospital. This study used a descriptive analytical method with a non-experimental quantitative approach. Data were collected prospectively through direct observation of prescription services using a purposive sampling technique and analyzed using Microsoft Excel. The results showed that the average wait time for non-compounded prescriptions was 51 minutes and for compounded prescriptions 82.2 minutes. Both categories fall short of the Ministry of Health's prescription service waiting time standards, which are ≤ 60 minutes for compounded and ≤ 30 minutes for non-compounded. Factors influencing waiting times for services include medication availability, the number and completeness of prescriptions, and the adequacy and skills of the pharmacy staff. Therefore, waiting times for prescription services at X Hospital do not meet minimum service standards, necessitating improvements in the efficiency of the pharmaceutical service system.
EVALUASI RASIONALITAS PENGGUNAAN ANTIBIOTIK PASIEN PNEUMONIA DI RS TIPE B KOTA BOGOR Septiani, Wulan; Rosiana, Rosiana; Dewi, Masita Sari; Marselina, Marselina
Jurnal Buana Farma Vol. 5 No. 3 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i3.1509

Abstract

Pneumonia remains one of the leading causes of morbidity and mortality worldwide. Inappropriate use of antibiotics can increase the risk of bacterial resistance. Rationality evaluation is essential to ensure appropriate selection, dosage, and duration of therapy. This study aimed to describe the characteristics of pneumonia patients, antibiotic prescribing patterns, and their rational use in the inpatient ward of Type B Hospital in Bogor City in 2024. A retrospective descriptive design was employed using medical records of 83 pneumonia patients from January to December 2024. Data were analyzed descriptively, and rationality was assessed using the Gyssens method based on the Ministry of Health Regulation No. 28 of 2021. The results showed that most patients were aged ≥60 years (41.0%) and male (51.8%). The most commonly used antibiotics were ceftriaxone (57.9%) and levofloxacin (20.0%). Category 0 (appropriate) accounted for 55.6%, while 44.4% were inappropriate, mainly IVa (23.3%) and IIIb (10.0%). Conclusion: Improving rationality requires regular evaluation, clinical pathways, and antimicrobial stewardship programs.
HUBUNGAN TINGKAT KEPATUHAN TERAPI ANTIHIPERTENSI DENGAN RISIKO KARDIOVASKULAR DI PUSKESMAS CIKARANG Anggita, Rahmi; Marselina; Adwisastra, Nuzul Gyanata; Dewi, Masita Sari
Jurnal Buana Farma Vol. 5 No. 3 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i3.1511

Abstract

Hypertension is a major risk factor for cardiovascular disease. However, evidence regarding the association between adherence to antihypertensive therapy and cardiovascular risk remains inconsistent, particularly in primary care settings. This study was conducted at Cikarang Community Health Center, where hypertension is among the top ten most prevalent diseases. The objective was to determine the relationship between adherence to antihypertensive therapy and cardiovascular risk. A cross-sectional analytical study was conducted on 85 purposively selected hypertensive patients. Adherence was assessed using MARS-5 and Medication Possession Ratio (MPR), while cardiovascular risk was calculated with the ASCVD score. Data were analyzed using Chi-Square, linearity test, and Odds Ratio. Results showed that most patients were adherent (MARS-5 = 91.8%; MPR = 76.5%) and had low cardiovascular risk (64.7%). There was a significant association between adherence and cardiovascular risk (MARS-5 p=0.041; MPR p=0.049). Adherent patients were more likely to have lower cardiovascular risk. In conclusion, higher adherence is associated with lower cardiovascular risk. Continuous education and routine monitoring are essential to maintain adherence and prevent complications.
POTENSI ANTIJAMUR MINYAK ATSIRI DAGING BUAH PALA (Myristica fragrans Houtt) ASAL PULAU SANGIHE PADA Malassezia furfur Nahor, Evelina Maria; Rindengan, Elvie Rifke; Maramis, Rilyn Novita; Rintjap, Djois Sugiaty; Soenjono, Steven Jacob; Kalonio, Donald Emilio
Jurnal Buana Farma Vol. 5 No. 3 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i3.1513

Abstract

Pityriasis versicolor or tinea versicolor is a skin disease caused by the fungus Malassezia furfur. Nutmeg fruit pulp essential oil contains myristicin compounds that have potential as antimicrobials. The purpose of this study was to determine the antifungal activity of nutmeg fruit pulp essential oil (Myristica fragrans Houtt) from Sangihe Island against Malassezia furfur fungus using the Agar Diffusion and Vapor Phase Test methods. The samples used were nutmeg fruit taken directly from the garden, isolated nutmeg fruit pulp essential oil using the water vapor distillation method. The antifungal activity test for Malassezia furfur used the Agar Diffusion method, using nutmeg oil with concentrations of 20%, 40%, 60%, 80% and 100%, while the antifungal test with the Vapor Phase Test method used nutmeg oil with volumes of 0 μL, 10 μL, 20 μL, 40 μL, 80 μL and 100 μL. Observations were made by measuring the diameter of the clear zone after 24 hours of incubation. The results showed that essential oils of nutmeg fruit flesh at concentrations of 20%, 40%, 60%, 80% and 100% using the Agar Diffusion method were able to inhibit the growth of Malassesia furfur fungus, while with the Vapor Phase Test method the antifungal activity of essential oils of nutmeg fruit flesh was at test volumes of 40 μL, 80 μL and 100 μL.
ANALISIS FAKTOR RESIKO PENYEBAB PELAYANAN ANTIBIOTIK TANPA RESEP DOKTER DI APOTEK: A REVIEW Tupak, Helma Malini Marol; Vikasari, Suci Nar
Jurnal Buana Farma Vol. 5 No. 3 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i3.1514

Abstract

The dispensing of antibiotics without a doctor’s prescription in pharmacies remains a common practice and contributes significantly to the rise of antibiotic resistance, which poses a major threat to public health. This phenomenon is driven by interrelated risk factors, including easy access, limited public knowledge, socioeconomic influences, and weak regulatory enforcement. This study aims to identify the risk factors underlying the dispensing of antibiotics without prescriptions in pharmacies. A literature review was conducted by collecting and analyzing Indonesian and English journal articles published between 2015 and 2025. Data were retrieved from Google Scholar and PubMed using keywords related to the sale and purchase of antibiotics without a doctor’s prescription. The findings were analyzed narratively and grouped into three perspectives: business actors, patients or consumers, and regulators. From the perspective of business actors, the risk factors include pharmacy staff attitudes that facilitate non-prescription antibiotic sales, financial motivations, consumer pressure and demand, and insufficient professional knowledge. From the perspective of patients, risk factors involve the ease of obtaining antibiotics without a prescription, economic, social, and cultural influences, lack of awareness and understanding, and prior personal experiences of antibiotic use. From the perspective of regulators, weak supervision and poor law enforcement remain key drivers of this practice. In conclusion, comprehensive efforts are required to address this issue. These include strengthening regulations, improving public education, and enhancing the training of pharmacy personnel. Such interventions are critical to preventing antibiotic misuse and mitigating the long-term consequences of antibiotic resistance on public health.
FORMULASI HAIR TONIC KOMBINASI EKSTRAK BUNGA SEPATU (Hibiscus rossa sinensis L.) DAN DAUN SELEDRI (Apium graveolens L.) SEBAGAI PERANGSANG PERTUMBUHAN RAMBUT PADA KELINCI (New Zealand White) Qurrota'Ain, Rusyda; Wicahyo, Septian Maulid; Fitriawati, Anna
Jurnal Buana Farma Vol. 5 No. 3 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i3.1515

Abstract

Hair plays an essential role not only as protection for the scalp but also as an aesthetic element that influences appearance. One way to maintain hair health is through the use of hair tonic, a liquid cosmetic preparation formulated to care for and stimulate hair growth. This study aimed to formulate and evaluate the effectiveness of a hair tonic combining hibiscus (Hibiscus rosa-sinensis L.) and celery (Apium graveolens L.) extracts, both of which are traditionally recognized for their bioactive compounds that promote hair growth. The extracts were obtained by maceration using 96% ethanol and formulated into three concentration variations: F1 (2.5%:7.5%), F2 (5%:5%), and F3 (7.5%:2.5%). The experiment was conducted using male New Zealand White rabbits, with hair growth observed for 28 days, while physical quality parameters such as organoleptic properties, homogeneity, pH, and viscosity were also evaluated. The results showed that all formulas met the physical quality requirements of hair tonic, but differences in effectiveness were observed between formulas. Formula II (5%:5%) produced the most optimal effect, with an average hair length of 16.86 mm, outperforming Formula I (15.39 mm) and Formula III (13.39 mm), and approaching the positive control (17.89 mm). These findings highlight that the balanced combination of hibiscus and celery extracts provides a synergistic effect on hair growth. In conclusion, the formulated hair tonic not only demonstrated stability and compliance with physical standards but also offers novelty as a natural alternative that may be safer than synthetic minoxidil-based products.
ANALISIS EFEKTIVITAS BIAYA PENGOBATAN ASPILET DAN CLOPIDOGREL PADA PASIEN KELAINAN JANTUNG ISKEMIK Rosa; Arantika, Jane; Fajri, Mathlail
Jurnal Buana Farma Vol. 5 No. 3 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i3.1516

Abstract

Ischemic Heart Disease (IHD) is a leading cause of mortality in Indonesia and imposes a considerable financial burden on the national health insurance system (BPJS). Antiplatelet agents such as Aspilet and Clopidogrel are widely prescribed, yet their comparative effectiveness and cost-efficiency remain essential to evaluate. This study employed a Cost-Effectiveness Analysis (CEA) with a retrospective design using inpatient medical records at RSUD Pemangkat. A total of 66 patients were selected by purposive sampling. Clinical outcomes included reductions in blood pressure, heart rate, and total treatment costs. Cost analysis applied the formulas for ACER (Average Cost-Effectiveness Ratio) and ICER (Incremental Cost-Effectiveness Ratio). Results showed that Aspilet achieved greater reductions in systolic (25.24 mmHg) and diastolic blood pressure (24.28 mmHg) compared to Clopidogrel (25.24 mmHg; 13.17 mmHg). Conversely, Clopidogrel provided superior heart rate reduction (12.04 bpm) compared to Aspilet (10.52 bpm). Treatment costs were lower for Aspilet (Rp 64,045) than Clopidogrel (Rp 68,580). ACER indicated Aspilet was more cost-effective for blood pressure outcomes (Rp 2,021/mmHg vs Rp 5,207/mmHg), whereas Clopidogrel was more efficient for heart rate (ICER Rp 432.49). In conclusion, therapy selection may be tailored to the patient’s dominant clinical parameter: Aspilet is more cost-effective for blood pressure control, while Clopidogrel is preferable for heart rate management. Clinically, CEA findings can guide hospital decision-makers and BPJS in optimizing antiplatelet therapy choices.
MANDUPI (Etlingera rubroloba A.D Poulsen): TINJAUAN KANDUNGAN METABOLIT DAN AKTIVITAS FARMAKOLOGINYA Tahoangako, Sarmadhan Saputra
Jurnal Buana Farma Vol. 5 No. 3 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i3.1517

Abstract

Etlingera rubroloba A.D Poulsen, a member of the Zingiberaceae family. Etlingera rubroloba A.D Poulsen is a locally known plant such as Mandupi (Muna), Kasimpo (Makassar), Pane (Bugis) and Wualae (Tolaki). This plant has been widely used empirically as a remedy for muscle pain and gout, particularly among the people of Sulawesi. Mandupi (Etlingera rubroloba A.D Poulsen) contains secondary metabolite compounds in the form of alkaloids, flavonoids, saponins, terpenoids, and tannins. This aim of this study is to identify the pharmacological activities of the chemical compounds present in Mandupi through a literature review of various related journals. The results of various studies indicate that Mandupi has pharmacological activities such as antibacterial, antihyperuricemia, antioxidant, anti-inflammatory and immunomodulator.
PENGARUH KONSENTRASI ETANOL TERHADAP TOTAL FENOLIK DAN FLAVONOID SERTA AKTIVITAS ANTIOKSIDAN DARI DAUN KUNYIT (Curcuma longa L.) DENGAN METODE ABTS Nurcahyani, Dona Agustin; Raharjo, Danang; Apriliawan, Hidayah
Jurnal Buana Farma Vol. 5 No. 3 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i3.1520

Abstract

Turmeric's leaves possess the greatest antioxidant potential. Therefore, further utilization of flavonoid and phenolic compounds is necessary as antioxidants and to enhance their bioactivity as a medicine. This study aimed to determine the effect of ethanol concentration on total phenolic content using the Folin-Ciocalteau analysis method while total flavonoid content using the AlCl₃ analysis method and antioxidant activity of turmeric leaves using the ABTS method, The research design used was experimental research. The results obtained were ethanol concentrations of 50%, 70% and 96%, The results showed that 70% ethanol extract had the highest phenolic content with an average of (63.77 ± 0.40 mg GAE / g), and 70% ethanol extract had the highest flavonoid content with an average of (22.88 ± 0.5 mg QE / g). However, the strongest antioxidant activity was shown by 96% ethanol extract with an IC₅₀ value of (46.36 ± 1.15 ppm (<50 ppm). Thus, turmeric leaf extract with 96% ethanol solvent had the strongest antioxidant activity, while 70% ethanol produced the highest phenolic and flavonoid levels.

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