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Conrad Liab Hendricson Folamauk
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Cendana Medical Journal
Published by Universitas Nusa Cendana
ISSN : 23023007     EISSN : 27466809     DOI : https://doi.org/10.35508/cmj
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
Cendana Medical Journal (CMJ) menerima naskah dari sarjana, mahasiswa pascasarjana, residen, doktor program internship, staf fakultas kedokteran, staf rumah sakit dan pihak-pihak yang tertarik untuk menulis karya ilmiah. Artikel ilmiah yang diposting di CMJ meliputi: editorial, artikel penelitian, EBCR (Evidence Based Case Report), laporan kasus, dan ulasan. Untuk artikel penelitian sebaiknya penelitian kedokteran dasar atau biomedis.
Arjuna Subject : Kedokteran - Review dan Referensi, Kedokteran
Articles 5 Documents
 1 
Search results for , issue "Vol 12 No 2 (2024): Cendana Medical Journal" : 5 Documents clear
Effect of Garlic (Allium sativum) Extract Administration on the Histopathological Features of Mammary Glands in Female Sprague-Dawley Rats Induced with 7,12-Dimethylbenz(a)anthracene (DMBA) Dewanti, Intan Putri; Br Damanik, Efrisca Meliyuta; Amat, Anita Lidesna Shinta; Sasputra, I Nyoman
Cendana Medical Journal Vol 12 No 2 (2024): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cmj.v12i2.10948

Abstract

Latar Belakang: Kanker adalah penyebab utama kedua kematian secara global, terhitung sekitar 9,6 juta kematian, atau satu dari enam kematian pada tahun 2018. Angka insidensi kanker payudara sebanyak 11.6% dan angka kematian 6,6% pada tahun 2018. Tanaman obat diduga memiliki potensi sebagai antikanker dengan efek samping minimal jika digunakan dengan dosis dan waktu penggunaan yang tepat serta cara penggunaan yang tepat. Tujuan Penelitian : Untuk mengetahui pengaruh pemberian ektrak bawang putih terhadap gambaran histopatologi payudara tikus Sprague-Dawley betina yang diinduksi DMBA. Metodologi : Penelitian ini menggunakan metode eksperimental post test only control group design dengan 6 kelompok perlakuan. Sampel sebanyak 30 tikus setiap kelompok berisi 5 ekor tikus. Data dianalis dengan menggunakan uji normalitas Shapiro-wilk dan uji non-parametrik Kruskal Wallis. Hasil : Hasil penelitian didapatkan tidak terdapat pengaruh pada pemberian ekstrak bawang putih terhadap gambaran histopatologi payudara tikus Sprague-Dawley betina yang diinduksi DMBA. Kelompok 1 epithel duktus normal. Kelompok 2 perubahan epithel duktus hiperplasia dengan atipia. Kelompok 3, kelompok 4, kelompok 5, kelompok 6 perubahan epithel duktus severe hiperplasia. Hasil uji statistik Kruskall-Wallis didapatkan perbedaaan yang tidak signifikan (p>0,05). Hasil uji post hoc Mann-Whitney pada kelompok 1 dan 2 didapatkan perbedaaan yang signifikan (p<0,05). Kesimpulan : Pemberian ekstrak bawang putih (Allium sativum) tidak dapat memberikan perubahan terhadap gambaran histopatologi payudara tikus Sprague-Dawley betina yang diinduksi 7,12 Dimetilbenz(a)antrasen (DMBA).
Potential of Moringa oleifera Leaf Extract as an Active Ingredient for Natural Hand Sanitizer Thaal, Mario Bernardo; Pakan, Prisca Deviani; Woda, Rahel Rara
Cendana Medical Journal Vol 12 No 2 (2024): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cmj.v12i2.13032

Abstract

Background: COVID-19 infection has become a pandemic due to the continuously increasing number of confirmed cases worldwide, making it necessary to establish effective control and prevention measures against the spread of COVID-19. Antiseptic hand sanitizers can help prevent the transmission of infectious diseases. However, conventional hand sanitizers, which contain alcohol and synthetic chemicals, are relatively expensive and often cause skin health issues. Therefore, it is important to explore natural antiseptic alternatives as active ingredients for hand sanitizers that are more affordable, safe, effective, and accessible to all segments of society. One such medicinal plant is Moringa (Moringa oleifera), which has long been cultivated and used for traditional medicine. Objective: This study aimed to determine the potential of Moringa leaf (Moringa oleifera) extract as an active ingredient in natural hand sanitizer formulations. Methods: This study used a true experimental design with a posttest-only control group design. The treatment groups consisted of a positive control (alcohol-based hand sanitizer), a negative control (sterile aquadest), and Moringa leaf extract at concentrations of 100%, 75%, 50%, 25%, 10%, 5%, and 1%, with each group tested in triplicate against Staphylococcus aureus and Escherichia coli. Data were analyzed using One-Way ANOVA at a 95% confidence level. Results: The antibacterial activity test results showed that Moringa leaf extract has antibacterial potential against the growth of Staphylococcus aureus and Escherichia coli. The One-Way ANOVA analysis indicated a p-value of 0.000, which is lower than α = 0.05, meaning there was a significant difference in the mean diameter of the inhibition zones between the treatment groups. Conclusion: Moringa leaf (Moringa oleifera) extract has potential as an active ingredient for natural hand sanitizer formulations. Keywords : Moringa oleifera in NTT, Hand sanitizer, Antibacterial.
Correlation of Age, Administration Method, and Amlodipine Dosage with the Risk of Side Effects in Hypertensive Patients Tarapanjang, Tiara Rambu Renesia; Riwu, Magdarita; Lada, Christina Olly; Tallo Manafe, Derri Riskiyanti
Cendana Medical Journal Vol 12 No 2 (2024): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cmj.v12i2.15537

Abstract

Hypertension, known as the "silent killer," poses a global threat with potentially fatal consequences. Lifelong treatment, often involving Amlodipine, requires careful management of age, dosage, and administration to mitigate side effects and enhance patients' quality of life. This study at RSUD Prof. Dr. W. Z. Johannes Kupang aimed to explore the correlation between age, Amlodipine dosage, and side effect risks. Utilizing an observational analytic method with a cross-sectional approach, data from 84 patients, aged 15-70, were collected between May and October 2023. Predominant side effects included edema (38.10%), dizziness (28.57%), fatigue (17.85%), and nausea (15.48%). Findings indicated age (p=0.013) and Amlodipine dosage (p=0.002) correlated with side effect risks. However, administration method analysis was hindered by consistent post-meal consumption in all participants. In conclusion, this research underscores the relevance of age and Amlodipine dosage in side effect risks for hypertensive patients. Practical implications include refined medication management strategies to improve overall patient well-being.
Molecular Docking Analysis of Anti-dengue Activity of Moringa oleifera Leaves Bioactive Compounds Riwu, Audrey Gracelia; Jannah, Insani Fitrahulil; Riwu, Katty Hendriana Priscilia; Kale, Maria Laurenci Fanny Permata; Loe, Fhady Risckhy; Asa, Halena Meldy
Cendana Medical Journal Vol 12 No 2 (2024): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cmj.v12i2.23665

Abstract

Background: Dengue infection is an endemic disease in various tropical regions, including Indonesia, with increasing incidence and mortality rates, and currently, no specific therapy is available. One of the potential targets for therapeutic development is the dengue virus (DENV) envelope (E) protein, which plays a crucial role in viral replication in the host. Objective: This study aimed to explore the potential of bioactive compounds from Moringa oleifera leaves as inhibitors of the E protein through an in silico approach using molecular docking methods. Methods: A total of 17 bioactive compounds from Moringa oleifera leaf extract, based on previous studies, were obtained from the PubChem database, while the target protein structure was retrieved from the Protein Data Bank (RCSB). The drug-likeness properties of the compounds were evaluated using the SwissADME web tool. Molecular docking analysis was performed using PyRx Autodock, followed by 3D visualisation and ligand–protein interaction analysis using PyMOL and Discovery Studio 2.0. Apigenin, chrysin, kaempferol, and quercetin exhibited more negative binding affinity values than the control compound Celgosivir (-6.2 kcal/mol), with respective values of -7.4, -7.3, -7.4, and -7.3 Results: kcal/mol. These compounds also shared key amino acid residues with the control at the active site of the envelope protein. Moreover, all four compounds fulfilled the five drug-likeness criteria, indicating good oral bioavailability. Conclusion: Moringa oleifera leaves show potential as candidate anti-dengue agents through inhibition of the DENV envelope protein. Keywords: Moringa oleifera, molecular docking, dengue, antiviral, envelope protein
Depression Levels Among Nursing Students: A Descriptive Study Tunggal, Deif; syahrir, Syahrir; Asa, Halena Meldy; Jannah, Insani Fitrahulil; Riwu, Audrey Gracelia
Cendana Medical Journal Vol 12 No 2 (2024): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cmj.v12i2.23698

Abstract

Background : Depression is one of the most common mental health disorders and a serious global concern, particularly among university students. Nursing students are highly vulnerable to depression due to academic pressure, professional expectations, and the challenges of clinical and social environments. Objective : This study aimed to assess the level of depression among nursing students at Nusantara Institute of Health Sciences as a foundation for developing targeted mental health interventions. Methods : This research employed a descriptive quantitative design with 55 participants selected using purposive sampling. The instrument used was the Indonesian-validated version of the Patient Health Questionnaire-9 (PHQ-9). Data were analyzed using SPSS version 20.0. The results showed that the majority of respondents were over 20 years old (52.7%), female (67.3%), lived in boarding houses (67.3%), and were self-motivated to pursue nursing education (76.4%). Based on PHQ-9 scoring, 49.1% of the participants experienced mild depression, 9.1% moderate depression, 3.6% moderately severe depression, and 38.2% had no signs of depression. Conclusion: These findings indicate that although most respondents had intrinsic motivation and independent living conditions, mild depressive symptoms remained prevalent. Therefore, early detection and preventive mental health interventions are essential to support academic success and future professionalism among nursing students. Keywords: Depression, Nursing Students, PHQ-9, Mental Health, Early Detection.

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