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Ismiarni Komala
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Program Studi Farmasi, Fakultas Ilmu Kesehatan UIN Syarif Hidayatullah Jakarta Jl. Kertamukti No. 5, Pisangan, Ciputat 15412 Tangerang Selatan, Banten, Indonesia Telp: (62-21)74716718 Fax: (62-21) 7404985
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Pharmaceutical And Biomedical Sciences Journal (PBSJ)
Published by Universitas Islam Negeri Syarif Hidayatullah Jakarta
ISSN : 27152979     EISSN : 27156702     DOI : https://doi.org/10.15408/pbsj
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health
Pharmaceutical and Biomedical Sciences Journal is an official peer-reviewed, open access journal that is managed by the Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia. This journal publishes original research articles, review articles, as well as short communications covering all aspects of Pharmacy, Pharmaceutical dan Biomedical Sciences in both Bahasa Indonesia and English. The journal includes various fields of Pharmacy, pharmaceutical and biomedical sciences such as: Pharmacology and Toxicology, Pharmacokinetics, Community and Clinical Pharmacy, Pharmaceutical Chemistry, Pharmaceutical Biology, Pharmaceutics,Pharmaceutical Technology, Biopharmaceutics, Pharmaceutical Microbiology and Biotechnology, Alternative medicines, Biochemistry& Biomedic.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 8 Documents
 1 
Search results for , issue "Vol. 5 No. 2 (2023)" : 8 Documents clear
Hubungan Karakteristik Sosiodemografi dengan Hasil Terapi Tuberkulosis Paru di RSUD Banyumas Shavira, Rurynta Ferly; Restinia, Mita; Nurmeilis, Nurmeilis; Maula, Charisma Soffa
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 5 No. 2 (2023)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i2.29973

Abstract

Pulmonary tuberculosis (TB) is one of the infectious diseases caused by Mycobacterium tuberculosis and is one of the highest causes of morbidity and mortality rates with a low level of treatment outcome. Indonesia is the second country in the world with the largest tuberculosis burden. This study aims to determine the relationship of sociodemographic characteristics with the results of pulmonary tuberculosis therapy at Banyumas Regional Public Hospital for the period 2019-2021. This study used a case-control method. The inclusion criteria in this study were new pulmonary tuberculosis patients at the Banyumas Regional Public Hospital and patients aged ≥18 years, both male and female.  Multi-drug resistance (MDR) TB patients and patients with incomplete medical record data were excluded. There were 166 patients enrolled in this study. Data analysis was performed by univariate analysis and bivariate analysis by chi-square test. The results showed that the sociodemographic characteristics were dominated by male patients (57,2%), patients aged <65 years (66,3%), patients weighing <55 kg (53%), not graduating from college (94%), currently working (64,5%), married (68,7%), have health insurance (94%), and close distance (<10 km) to the hospital (53%). The conclusion is that gender ((P=0,028; OR 2,112; 95%Cl(1,129 – 3,951)), age (P=0,014; OR 2,413; 95% Cl (1,242 – 4,689)), body weight (P=0,000; OR 3,306; 95%Cl (1,748 – 6,252)), and distance from the patient's house to the hospital (P=0,020; OR 2,190; 95% CI (1,176 – 4,077)) have a significant relationship with the outcome of pulmonary TB therapy at Banyumas Regional Public Hospital.
Penetapan Kadar Fenol Total dengan Spektrofotometer UV-Vis dan Uji Sitotoksisitas Ekstrak Air Daun Lidah Mertua (Sansevieria masoniana C.) Terhadap Sel Kanker Paru A-549 Febriyanti, Lilis; Haerussana, Ayu Nala El Muna
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 5 No. 2 (2023)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i2.30080

Abstract

Cancer is the second most common cause of mortality globally, following cardiovascular disease, according to the World Health Organization (WHO). Leading the list of fatal cancers annually are lung, breast, stomach, liver, and colorectal cancers. Hence, the discovery and development of effective agents to treat various types of cancer is urgently needed. Mother-in-law tongue (Sansevieria masoniana Chahin) leaves contain flavonoids and saponins. However, information regarding the total phenolic content of the aqueous extract of the S. masoniana Chahin leaves is currently unavailable. Hence, this research aims to determine the total phenol content using a UV-Vis spectrophotometer and assess the invitro anticancer activity of the water extract of S. masoniana Chahin through the MTT Assay. From the results of measuring the total phenolic content, the water extract of the leaves contained a phenol content of 3.3061 mgGAE/g. Meanwhile, the results of the cytotoxicity assay on lung cancer cells A-549 showed that the IC50 value of the aqueous extract of S. masoniana Chahin leaves was above 100 ppm, indicating that the extract has less potential as an anti-lung cancer agent.
Efek Antinyeri Ekstrak Etanol Buah Belimbing Wuluh (Averrhoa bilimbi L) pada Mencit yang Diinduksi Asam Asetat Kemila, Mira; Suprasetya, Edy; Laga, ,Arifson Umbu
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 5 No. 2 (2023)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i2.31287

Abstract

Pain is an unpleasant combination of sensory and emotional experience linked to the potential or actual of tissue damage. Typically, pain arises from stimulation of peripheral receptors, which send impulses through pain pathways to the brain. Starfruit is a medicinal plant that is used empirically as an analgesic. This study aims to determine the analgesic effect of starfruit extract on the stretch index and pain protection ratio against acetic acid-induced mice. This study used 25 mice divided into three test groups: one control group (Na-CMC) and one comparison group (Mefenamic acid). The results showed that starfruit can reduce the pain stretch index and have a pain protection ratio compared to the control group. A dose of 250 mg/kg has an analgesic protection ratio of 75.75%, and a dose of 500 mg/kg has a protection ratio of 85.14%. Thus, based on the results of this study, it can be seen that starfruit has the ability to act as an anti-pain.
Combination of Beetroot Juice, Honey and Green Apple on Hemoglobin Levels in Anemia Pregnant Women at Payung Sekaki Health Center, Pekanbaru Sari, Septi Indah Permata; Susilawati, Elly; Devi, Shinta; Pamudi, Berwi Fazri
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 5 No. 2 (2023)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i2.31539

Abstract

Anemia is a medical condition characterized by lower-than-normal hemoglobin (Hb) levels. In pregnant women, anemia can lead to prolonged delivery times, increased bleeding, and shock during contractions. The adverse effects of anemia on the fetus include premature birth, low birth weight (LBW), potential disabilities, and infant mortality. The recommended solution to overcoming anemia in pregnant women is to consume a combination of beetroot juice and green apples juice. Beets contain essential components that can elevate Hb levels, whereas green apples provide minerals and vitamin C, enhancing iron absorption (Fe). This study aimed to investigate the effect of a combination of beetroot juice and green apple juice on Hb levels in pregnant women with anemia. The study population was comprised of 200 normal pregnant women, with a sample size of 15 in trimester III (TM III) with anemia, selected through purposive sampling. The intervention involved administering the juice daily for seven days. Data were collected using observation sheets and easy-to-touch devices. The research design was pre-experimental, utilizing a one-group pre-test–post-test design. This study was conducted within the working area of the Payung Sekaki Public Health Center (PHC) from January to April 2022. Dependent T-test analysis was used for data evaluation. The average Hb level of TM III pregnant women before juice consumption was 9.7 g/dL, which increased to 10.6 g/dL after the intervention. The dependent t-test results, with a 95% confidence level (Cl), indicated a p-value of 0.000, signifying a significant impact of fruit juice on the Hb levels of TM III pregnant women experiencing anemia. These findings suggest that clinical midwives should educate pregnant women about the importance of Fe tablets and the positive influence of fruit juice on Hb levels.
The Impact of EG and DEG Cases on Sales of Over-The-Counter Syrup Mendra, Ni Nyoman Yudianti; Antari, Ni Putu Udayana; Siada, Nyoman Budiartha; Marwati, I Gusti Ayu
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 5 No. 2 (2023)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i2.32013

Abstract

The Indonesian Food and Drug Authority (BPOM) investigated and listed safe and unsafe syrup products in response to the contamination of Ethylene Glycol (EG) and Diethylene Glycol (DEG), causing Acute Kidney Injury in pediatric patients. Unsafe products were recalled and removed from distribution, leading to uncertainty and panic among the public and significantly impacting over-the-counter syrup sales in several pharmacies. This retrospective observational study assessed the impact of EG and DEG contamination on the sales of over-the-counter syrup in Pharmacy X in South Denpasar. Data from three months before (August to October 18th, 2022) and three months following the official instruction was published (October 19th, 2022 to December 2022) were analyzed using Wilcoxon test. The findings reveal a staggering decline in the sales of over-the-counter syrup by 35,03% (p-value of 0.03). Moreover, there was a notable increase of prescriptions in powder forms. The contamination cases caused panic, resulting in changes in behavior and consumption patterns. Despite the availability of safety information on an official website, public hesitance toward syrup products persists, indicating the need to implement a more effective strategy to address misinformation and restore public trust. Each individual must be responsible for educating the public during crises to prevent the spread of misinformation, ultimately restoring trust and normal consumer behavior. Furthermore, efficient stock management should be implemented to anticipate potential health crises in the future proactively.
Penggunaan Obat Herbal pada Responden COVID-19 yang Menjalani Isolasi Mandiri Restinia, Mita; Aldrat, Hendri; Pangestuti, Alia Dening; Musir, Ahmad
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 5 No. 2 (2023)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i2.32294

Abstract

COVID-19 is an infectious disease caused by spreading the coronavirus worldwide. In Indonesia, COVID-19 patients with mild symptoms can undergo independent isolation at home. The public widely uses herbal medicines in the treatment of COVID-19. A non-experimental cross-sectional study was performed to identify the profile of the use of herbal medicines by COVID-19 respondents during independent isolation in South Tangerang. The sampling technique conducted purposive sampling on 96 respondents who met the inclusion criteria. The instrument used is a questionnaire with close-formatted and open-ended questions. Questionnaires were distributed online from March to May 2022. The most used herbal medicines were honey (85.4%), ginger (52.1%), propolis (35.4%), turmeric (32.3%) and garlic (26%). The reason respondents used herbs because they were made from natural ingredients (84.4%), the method of use was boiled or brewed (58.3%), information on the use of herbal medicines was obtained from the family (63.5%), the source of obtaining herbal medicines was sent by relatives/family/friends (69.8%), the duration of using herbal medicines is 1-7 days (39.6%), the time to use herbal medicines was generally in the morning (49%), and the cost of herbal medicines is IDR 100,000 - 500,000 (44.8%). Through this research, it can be concluded that South Tangerang City's people still use herbal medicines as an alternative treatment while infected with COVID-19. Therefore, further education on the safety and maximum use of herbal medicines is required.
Penambatan Molekul Senyawa Swietemacrophyllanin dari Kulit Batang Mahoni (Swietenia macrophylla King,) sebagai Inhibitor Enzim Alfa Glukosidase Khaerunnisa, Arini; Djamil, Ratna; Sulastri, Lilik; Rudiana, Tarso; Simanjuntak, Partomuan
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 5 No. 2 (2023)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i2.32926

Abstract

Mahogany (Swietenia macrophylla King.) is one of the plants used as an antidiabetic agent. 96% ethanol extract of S. macrophylla stem bark can inhibit the α-glucosidase enzyme. Methanol and aqueous extracts of S. macrophylla stem bark can reduce rat blood glucose levels induced by streptozotocin. Molecular docking is one of the most widely used structural-based drug design strategies due to its wide application in the analysis of binding energy and molecular interactions between drug compounds and receptors. This study aims to identify the compounds in the stem bark of S. macrophylla and analyze the molecular anchoring of the compounds produced by the aid. The research was carried out by means of the water fraction of the stem bark of S. macrophylla and was purified by column chromatography. Fraction 2 was identified by LCMS-MS. Molecular docking using AutoDock 4.2.6. The results of Fraction 2 showed the presence of catechins, evodionol, swietemacrophyllanin, swietenitin K and β-sitosterol. The results of an in-silico study showed that swietemacrophyllanin provided a better affinity than acarbose with a binding energy value of -8.57 kcal/mol and an inhibition constant of 0.52 µM. Forms hydrogen bonds with catalytic residues (Glu277 and Asp352) from the active site of the α-glucosidase enzyme. Swietemacrophyllanin has potential as an antidiabetic agent
In Silico Assessment of Chemical Constituents of Zingiber officinale Rosc. For Anti-diabetic Activity: Molecular Docking with α-Glucosidase Receptor Normi, Normi; Supandi, Supandi; Komala, Ismiarni
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 5 No. 2 (2023)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i2.36161

Abstract

Diabetes Mellitus (DM) is a disease in which blood sugar (glucose) levels are elevated because the body cannot release or utilize insulin adequately. Rhizome of Zingiber officinale Rosc. (ginger) has been reported to possess anti-diabetic properties. This study aimed to provide information on the chemical components of ginger that have potential in silico antidiabetic activity against the α-glucosidase receptor. Twenty chemical components of ginger (quercetin, catechin, humulene, β-sesquiphellandrene, camphene, farnesene, β-sitosterol, stigmasterol, curcumin, 6-gingerol, 8-gingerol, 10-gingerol, 6-shogaol, 8-shogaol, 10-shogaol, 6-paradol, 8-paradol, 10-paradol, methyl-6-gingerol, and methyl-8-gingerol) were used as ligands. An in silico study was conducted using the molecular docking technique with the AutoDock Vina software, which was then displayed using PyMOL and Biovia Discovery Studio. The grid box settings obtained in this study were as follows: center_x = -20.209, center_y = -6.763, center_z = 9.393, size_x = 12, size_y = 10, size_z = 12, and spacing (angstrom) = 1. The results indicated that the native ligand acarbose exhibited a binding energy of -6.9 kcal/mol. In contrast, four test ligands, quercetin (-7.3 kcal/mol), catechin (-7.1 kcal/mol), curcumin (-7.0 kcal/mol), and 6-gingerol (-7.0 kcal/mol) - demonstrated lower binding energies than acarbose, suggesting more stable conformations and more potent pharmacological effects. Lipinski analysis revealed that these four test ligands met all five Lipinski rule criteria. The study calculated the Root Mean Square Deviation (RMSD) value for the Docking of acarbose with the α-glucosidase macromolecule, resulting in a value of 0.384 Å. Interaction analysis conducted using Biovia Discovery Studio software revealed various interaction types, including hydrogen bonding, hydrophobic, electrostatic, and unfavorable interactions. In conclusion, this study provides valuable insights into potential therapeutic compounds derived from ginger and offers a foundation for further research and development in pharmaceutical and medicinal chemistry.

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