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Media Farmasi Indonesia
Published by Sekolah Tinggi Ilmu Farmasi Yayasan Pharmasi Semarang
ISSN : 19788495     EISSN : 26551462     DOI : https://doi.org/10.53359/mfi.v17i1
Core Subject : Health, Science, Education,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Other
Media Farmasi Indonesia publishes original article in the all scopes of Pharmaceutical Science such as Pharmaceutics, Biopharmaceutics, Drug Delivery System, Chemical Pharmacy, Pharmaceutical Technology, Pharmaceutical Microbiology and Biotechnology, Pharmacology and Toxicology, Pharmacokinetics, Pharmaceutical Chemistry, Pharmaceutical Biology, Community and Clinical Pharmacy, Management Pharmacy, Alternative Medicines.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 197 Documents
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ANALISIS HKSA SENYAWA TURUNAN EURIKUMANON SEBAGAI ANTIMALARIA MENGGUNAKAN PENDEKATAN REGRESI LINIER BERGANDA Hanifah Yusuf; Mustofa; Mahardika Agus Wijayanti; Ratna Asmah Susidarti; Andrian Saputra; Iqmal Tahir
Media Farmasi Indonesia Vol. 8 No. 1 (2013): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (431.819 KB)

Abstract

Quantitative Structure Activity Relationship (HKSA) study of eurycomanone derivatives as antimalarial compound was done using multiple linear regression approaches. HKSA equation was obtained from theoretical descriptors data which involved atomic net charges (q), partition coefficient (log P), molecular volume (VM), molecular surface area (LP), molecular weight (BM), and HOMO-LUMO energy differences (EHOMO-ELUMO) versus minimum concentration to inhibit 50% of parasite growth Plasmodium falciparum (log IC50) growth. Descriptors data were obtained by applying AM1 semiempirical quantum mechanics calculation using Hyperchem 7.5 software, while the regression data processes were runned using SPSS 17.0 program. Based on multiple linear regression approaches, there is a selected quantitative relationship between log IC50 to the descriptors that was shown by HKSA equation below: Log IC50 = – 3048.930 + 5137.957qC2 – 13799.126qC5 – 1537.764qC12 + 556.313qC16 – 817.654qO29 + 4.654log P – 0.146VM + 0.270BM with n =10, r = 0.982, SE = 1.262, Fcalc/Ftable = 17.805, and PRESS = 1.593
DETERMINASI TOTAL FLAVONOID DAN TOTAL FENOLIK RIMPANG JERINGAU (Acorus calamus L.) DENGAN PERBEDAAN KONSENTRASI PELARUT Fuad Masduqi, Ahmad; Radix Rahardhian, Muhammad Ryan
Media Farmasi Indonesia Vol. 16 No. 1 (2021): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (480.419 KB) | DOI: 10.53359/mfi.v16i1.169

Abstract

Rimpang jeringau merupakan salah satu kenaekaragaman hayati di Indonesia yang mengandung senyawa fenolik golongan flavanoid yang memiliki banyak khasiat untuk kesehatan. Rimpang. Penelitian ini bertujuan untuk mengetahui skrining fitokimia, kromatografi lapis tipis (KLT), determinasi total phenolic content (TPC) dan total flavanoid content (TFC) pada ekstrak etanol rimpang jeringau dengan metode perkolasi. Ekstrak rimpang jeringau mengandung senyawa alkaloid, tanin, flavanoid, saponin dan terpenoid pada skrining fitokimia dan KLT. Nilai TPC pada konsentrasi pelarut 50%, 70% dan 96% berturut- turut adalah 12,115±0,05 mg/g Gallat Acid Equivalent (GAE); 14,17±0,08 mg/g Gallat Acid Equivalent (GAE); 16,699±0,12 mg/g Gallat Acid Equivalent (GAE). Nilai TFC pada konsentrasi pelarut 50%, 70% dan 96% berturut- turut adalah 4,917±0,01 mg/g Rutin Equivalent (RE); 7,20±0,01 mg/g Rutin Equivalent (RE); 6,42±0,01 mg/g Rutin Equivalent (RE). Hasil penelitian dapat disimpulkan bahwa ekstrak rimpang jeringau memiliki potensi sebagai sumber fenolik dan flavonoid dengan nilai TPC tertinggi pada ekstrak konsentrasi pelarut 96% dan nilai TFC tertinggi pada ekstrak konsentrasi pelarut 70%.
OPTIMASI EMULGEL MINYAK ATSIRI ADAS (Foeniculum vulgare Mill.) SEBAGAI ANTI JERAWAT A, Nurrahman; Pamudji W , Gunawan; Diyah Ikasari, Endang
Media Farmasi Indonesia Vol. 16 No. 1 (2021): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (499.539 KB) | DOI: 10.53359/mfi.v16i1.170

Abstract

Acne is a common skin problem. One factor that causes acne is the bacterium Propionibacterium acnes by infecting the skin, causing inflammation. Fennel essential oil (Foeniculum vulgare Mill.) Has potential as an antibacterial. This study aims to determine the combination effect of HPMC, propylene glycol and tween 80 which is formulated to be the optimum preparation of fennel essential oil emulgel with good stability as an anti-acne. Oleum Foeniculi are identified by GC-MS to determine the content of chemical compounds and are tested in vitro against Propionibacterium acnes to find out the minimum inhibitory concentration (MIC). Formula optimization is carried out using the factorial design method. The results showed that Foeniculum oil has content of Benzene, 1-methoxy-4- (2-propenyl) (83.64%), 1-Limonene (3.75%) and Fechone (3.58%) which have potential antibacterial properties against Propionibacterium acnes. Foeniculum oil with a concentration of 6% shows a MIC value of 1.7 cm. The concentration of fennel essential oil is formulated into an optimum emulgel preparation with a combination of 4% : 10% : 10.99%. of HPMC, propylene glycol, and tween 80
PENGARUH CARA PENGERINGAN SIMPLISIA TERHADAP KADAR FENOLIK DAN AKTIVITAS TABIR SURYA EKSTRAK ETANOL 70% DAUN CINCAU HIJAU (Cyclea barbata Miers.) Rusmawati, Lisa; Rahmawan Sjahid, Landyyun; Fatmawati, Sofia
Media Farmasi Indonesia Vol. 16 No. 1 (2021): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (563.672 KB) | DOI: 10.53359/mfi.v16i1.171

Abstract

Extract cincau leaves green according to previous studies have the value of the antioxidant IC50 49,45±0,64 µg/mL. According to researchers the phenol formerly produced through a method of drying oven with higher than the drying with sunlight and dried use wind. The research aims to understand the influence of means drying simplisia against phenolic levels total and the activity of a natural sunscreen on extract ethanol 70 % cincau leaves green (Cyclea barbata Miers). Drying simplisia in research is divided into three which is drying with the dry wind, the sun, and an oven. Green leaves cincau simplisia extracted by using the method maceration. Testing the phenolic committed using the folin ciocalteu method. The determination is based on the SPF value Mansur. The results of the value of phenolic or on the program have managed to extract by the difference means drying simplisia dry wind, the rays of the sun and an oven respectively namely 32,7089; 46,2500 and 59,5500 mgGAE / g. The SPF value obtained from each extract with different methods of drying simplisia showed significant differences in various concentration test.
EFEK PEMBERIAN SEDUHAN SERBUK HERBA SELEDRI (Apium graviolens L.) TERHADAP KADAR ASAM URAT SERUM DARAH AYAM LEGHORN JANTAN HIPERURIKEMIA Kristiyani, Ani
Media Farmasi Indonesia Vol. 16 No. 1 (2021): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (328.061 KB) | DOI: 10.53359/mfi.v16i1.172

Abstract

Apium graviolens L. is a medicinal plant that is useful for treating gout. Flavonoids are components of chemical compounds found in celery because they can work as antioxidants and inhibit the action of the xanthine oxidase enzyme to form uric acid. This study aims to determine the effect of giving celery herb powder on the blood serum uric acid levels of hyperuricemia male leghorn chickens. This study used twenty-five male leghorn chickens which were randomly divided into 5 groups. All groups were made hyperuricemia by being given 100% chicken liver juice 5 mL/l kg BW once a day orally during treatment. Group 1 was given 0.5% CMC suspension solution as a negative control group. Group 2 was treated with allopurinol 14 mg/1.5 kg BW in CMC 0.5% as a positive control. Groups 3, 4, 5 received infusion of celery herb powder in the order of doses (0.6 g/1.5 kg BW), (1.2 g/1.5 kg BW), (1.8 g/1.5 kg BW). Examination of uric acid levels was carried out on days 0, 4, 8, 12. The results showed that steeping celery could reduce uric acid levels in proportion to the dose. The greater the dose given, the greater the decrease in uric acid levels. The dose of celery herb group 3 (1.8 g/1.5 kg BW) was the most effective doses because it had the same value as the positive control.
UJI KANDUNGAN PROTEIN FORMULASI KERANG/KOTENG (Pilsbryoconcha exilis) MENJADI MP-ASI DI DESA LAMASI PANTAI Hamdan, Dian Furqani; Mardiana
Media Farmasi Indonesia Vol. 16 No. 1 (2021): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (331.459 KB) | DOI: 10.53359/mfi.v16i1.173

Abstract

Based on RISKESDAS data on the amount of stunting in children under five in Indonesia, this study conducted a test of the nutritional content of protein in local foodstuffs of the coastal Lamasi village community, namely Koteng mussels (Pilsbryoconcha exilis). This is to support the government of South Sulawesi to reduce the prevalence rate of stunting (very short and short) who experience malnutrition and malnutrition. This study only focuses on testing the protein content as the main substance and nutrition for the growth and development of toddlers, while the method used in this study is the shellfish formulation which is done manually where the raw material is boiled and dried then smashed into powder and then tested for protein content using the Kjeldahl method in the Sucofindo laboratory weighing 500 grams. The results of the protein content test of the formulation of Koteng shellfish (P.exilis) resulted in a protein content of 56.66%. As for the preparation of MP-ASI recipes with a collection of river clams worth 70 g, 4 g skim milk, 6 g rice flour, and 2 g vegetable oil, each containing protein worth 7,9% successively 6,5%; 9,6%; 2%
PENURUNAN SKALA NYERI PENGGUNAAN KETOROLAK INJEKSI PADA PASIEN OPERASI SESAR DI RUMAH SAKIT ROEMANI MUHAMMADIYAH SEMARANG Octasari, Paulina Maya; Inawati, Menik
Media Farmasi Indonesia Vol. 16 No. 2 (2021): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (341.799 KB) | DOI: 10.53359/mfi.v16i2.179

Abstract

Pain management after cesarean section must be done properly to prevent the emergence of chronic pain in patients. Ketorolac is the first choice as an analgesic to treat that pain. The appropriate dosage and time of analgesic treatment have impact to pain scale decreasing and another analgesic adding. The purpose of this study was to determine the magnitude of the reduction in the pain scale of using ketorolac injection in cesarean section patients at Roemani Muhammadiyah Semarang Hospital. This research is a descriptive observational study. The research design is cross-sectional study by using retrospective data. The data were taken through the medical records of patients with cesarean section at Roemani Muhammadiyah Hospital Semarang for the period July - December 2019. The sample of this study was elective caesarean section patients who received ketorolac injection therapy in that period. The age range of patients taken was 18- 45 years. The reduction in pain scale was measured by the Numeric Rating Scale (NRS) method. The results showed that the sample data obtained and those who met the inclusion criteria were 88 patients. Before the administration of ketorolac injection, the number of patients with moderate pain was in the greatest number, namely 53.41% and after the administration of ketorolac injection, the number of patients with mild pain was the greatest, namely 63.64%. Patients who experienced a decrease in the pain scale of 39.78%, the stability of the pain scale of 47.72%, and an increase in the pain scale of 12.50%. The average reduction in the pain scale of cesarean patients who received ketorolac injection at the Roemani Muhammadiyah Semarang Hospital was 1.09. Keywords: Cesarean section, Pain, Pain scale, Ketorolac, Roemani Muhammadiyah Hospital Semarang.
PERBANDINGAN KANDUNGAN FENOLIK TOTAL, FLAVONOIDTOTAL DAN AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOLDAUN JAMBU BOL (Syzigium malaccense L.) DAN DAUN JAMBU AIR KANCING (Syzigium aqueum) Zahrani Primadiastri, Ilavi; Dwi Wulansari, Endang; Suharsanti, Ririn
Media Farmasi Indonesia Vol. 16 No. 2 (2021): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (542.028 KB) | DOI: 10.53359/mfi.v16i2.180

Abstract

Leaves of malay apple (Syzygium malaccense L.) and water apple (Syzygium aqueum) are plants that contain phenolic and flavonoid compounds which have antioxidant activity. The aim of this study was to determine the differences in total phenolic content, total flavonoids and antioxidant activity of ethanol extract of malay apple leaves and water apple leaves. The extraction method uses maceration with 96% ethanol solvent in a ratio of 1:15. The ethanol extract of malay apple leaves and water apple was tested for total phenolic content using the Folin-Ciocalteu method, total flavonoids using the colorimetric method and antioxidant activity using the DPPH method. Qualitative identification of quercetin compounds was performed by densitometry tlc. In the phenolic and flavonoid content test, the total sample extract was made with a concentration of 5000 ppm. In the antioxidant activity test of the extract samples, a series of concentrations of 80, 100, 120, 140 and 160 ppm were made. The results showed that the total phenolic content in the ethanol extract of malay apple leaves has an average of 12.5149 mgGAE/g and water apple leaves of 14.3207 mgGAE/g. The total flavonoid content in the ethanol extract of malay apple leaves has an average of 9.1613 mgQE/g and water apple leaves of 16.5893 mgQE/g. The ethanol extract of malay apple leaves has antioxidant activity with an average IC50 of 138.3315 ppm and water apple leaves of 117.6745 ppm. In qualitative identification densitometry the Rf value of quercetin is 0,68; ethanol extract of malay apple leaves is 0,68 and water apple leaves is 0,85. The results of the independent statistical T test showed that there were differences in the total phenolic content, total flavonoids and antioxidant activity in the ethanol extract of malay apple leaves and water apple leaves.
ANALISA KEBERADAAN BAKTERI Escherichia coli DAN Pseudomonas aeruginosa PADA AIR MINERAL DI KELURAHAN CEMANI KABUPATEN SUKOHARJO Putri Rahmawati, Nuraini; Siska Wardani, Tatiana; Irma Permatasari, Desy Ayu
Media Farmasi Indonesia Vol. 16 No. 2 (2021): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (631.342 KB) | DOI: 10.53359/mfi.v16i2.183

Abstract

Clean, potable fresh water is becoming scarce in cities, the river which is the source of it is polluted with various wastes ranging from organic waste, household waste, and industrial waste. Drinks water quality could affects public health, especially mineral water. One of the parameters for the quality requirements of mineral water are the evaluate for Escherechia coli and Pseudomonas aeruginosa bacteria. The aim of this study was to identify the contamination of Escherechia coli and Pseudomonas aeruginosa bacteria in mineral water samples, using the MPN (Most Probable Number) method. The research method uses descriptive research. The research samples of mineral water were taken in stalls around the Duta Bangsa University Surakarta campus is as much 3 (three) samples. Collecting data by laboratory observation, data analysis with descriptive analysis. The results of the study were carried out from seven samples of mineral water, all samples showed there was no Escherechia coli and Pseudomonas aeruginosa bacteria by the MPN method. The conclusion of this study is that there are no Escherechia coli and Pseudomonas aeruginosa bacteria in mineral water sold in stalls around the campus of Universitas Duta Bangsa Surakarta.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK, FRAKSI N-HEKSAN, FRAKSI ETIL ASETAT, FRAKSI AIR DAUN PEGAGAN (Centella asiatica (L.) Urb) TERHADAP Escherichia coli ATCC 25922 Monica Sandy; Siska Wardani, Tatiana; Dwi Septiarini, Anita
Media Farmasi Indonesia Vol. 16 No. 2 (2021): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (584.144 KB) | DOI: 10.53359/mfi.v16i2.184

Abstract

Daun pegagan (Centella asiatica (L.) Urb) adalah salah satu tanaman yang dapat digunakan sebagai antibakteri. Daun pegagan memiliki kandungan kimia flavonoid, tanin dan saponin. Tujuan penelitian ini untuk mengetahui aktivitas antibakteri ekstrak etanol, fraksi n-heksan, fraksi etil asetat dan fraksi air dari daun pegagan serta untuk mengetahui Konsentrasi Hambat Minimum (KHM) dan Konsentrasi Bunuh Minimum (KBM) dari fraksi teraktif daun pegagan terhadap pertumbuhan Escherichia coli ATCC 25922. Serbuk daun pegagan dimaserasi menggunakan etanol 96%, kemudian difraksinasi menggunakan pelarut n-heksan, etil asetat dan air. Ekstrak, fraksi n-heksan, fraksi etil asetat dan fraksi air diuji aktivitas antibakteri menggunakan metode difusi dan dilusi. Metode difusi dengan konsentrasi 1%, 5%, 10%, 15%, 20% dan Metode dilusi konsentrasi 50%, 25%, 12,5%, 6,25%, 3,12%, 1,56%, 0,78%, 0,39%, 0,195% dan 0,098% terhadap bakteri Escherichia coli ATCC 25922. Hasil pengujian aktivitas antibakteri dengan metode difusi menunjukkan ekstrak, fraksi n-heksan, fraksi etil asetat dan fraksi air daun pegagan dapat menghambat pertumbuhan bakteri dengan adanya daya hambat. Fraksi etil asetat 20% paling efektif karena memiliki rata-rata daya hambat paling besar yaitu 13,67 mm. Hasil uji metode dilusi menunjukkan nilai KBM fraksi etil asetat yaitu 12,5%. Berdasarkan hasil penelitian dapat disimpulkan bahwa fraksi etil asetat adalah fraksi teraktif. Kata kunci: Centella asiatica (L.) Urb, Antibakteri, Escherichia coli ATCC 25922

Page 13 of 20 | Total Record : 197

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