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Media Farmasi Indonesia
Published by Sekolah Tinggi Ilmu Farmasi Yayasan Pharmasi Semarang
ISSN : 19788495     EISSN : 26551462     DOI : https://doi.org/10.53359/mfi.v17i1
Core Subject : Health, Science, Education,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Other
Media Farmasi Indonesia publishes original article in the all scopes of Pharmaceutical Science such as Pharmaceutics, Biopharmaceutics, Drug Delivery System, Chemical Pharmacy, Pharmaceutical Technology, Pharmaceutical Microbiology and Biotechnology, Pharmacology and Toxicology, Pharmacokinetics, Pharmaceutical Chemistry, Pharmaceutical Biology, Community and Clinical Pharmacy, Management Pharmacy, Alternative Medicines.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 197 Documents
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PERBANDINGAN AKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL DAUN SIDAGURI (Sida rhombifolia L.) DALAM SEDIAAN SELFNANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS)DANSUSPENSI PADA TIKUS PUTIH JANTAN Hapsari, Retty Diah; Bagiana, I Kadek; Herlyanti, Kyky
Media Farmasi Indonesia Vol. 11 No. 1 (2016): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

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Abstract

SARISidaguri (Sida rhombifolia L.) merupakan tanaman herbal yang telahterbukti memiliki aktivitas antiinflamasi. Penggunaan ekstrak sidaguri padasediaan oral masih terbatas karena kelarutan ekstrak yang rendah dalam airsehingga berakibat pada bioavailabilitas oral yang kurang maksimal,salah satumetode yang dapat membantu kelarutan ekstrak etanol daun sidaguri (EEDS)adalah metode Self-Nanoemulsifying Drug Relivery System (SNEDDS). Penelitianini bertujuan untuk membandingkan aktivitas antiinflamasi ekstrak etanol daunsidaguri (EEDS) dalam sediaan SNEDDS dan suspensi dilihat dari persentasedaya antiinflamasi (DAI) dan effective dose50 (ED50) antiinflamasi masing-masingsediaan.Metode uji antiinflamasi yang digunakan adalah pembentukan udembuatan dengan induksi karagenin 1% 0,1 ml secara subplantar. Variasi dosiseksrak etanol daun sidaguri dalam SNEDDS maupun suspensi yaitu 75, 150, 300mg/kg BB tikus.Hasil uji statistika nilai AUC lanjutan menunjukkan terdapatperbedaan signifikan (p<0,05) kelompok SNEDDS tanpa ekstrak dengankelompok pemberian ekstrak etanol daun sidaguri dalam sediaan SNEDDSmaupun suspensi. Berdasarkan hasil statistika tersebut membuktikan bahwaekstrak etanol daun sidaguri dalam sediaan SNEDDS maupun suspensi memilikiaktivitas antiinflamasi.Hasil uji statistika persentase DAI menunjukkan terdapatperbedaan antar sediaan SNEDDS dan suspensi EEDS pada dosis 150 dan300mg/kgBB tikus.Perbedaan aktivitas antiinflamasi antar sediaan ditunjukkandari nilai ED50antiinflamasi SNEDDS EEDS sebesar 209, 35 mg/Kg BB dansuspensi EEDS sebesar 348,07 mg/Kg BB tikus.
OPTIMASI STARCH 1500® DAN CROSPOVIDONE PADA FORMULASIORALLY DISINTEGRATING TABLET (ODT) ANTASIDA Ananthi, Dea Gita; Sulaiman, T.N. Saifullah; Lewi, Ishak
Media Farmasi Indonesia Vol. 11 No. 1 (2016): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

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Abstract

SARIGastritis atau secara umum dikenal dengan istilah sakit “maag” ialahperadangan pada dinding lambung terutama pada selaput lendir lambung.Penyakitgastritis umumya diatasi dengan penggunaan antasida yang merupakan kombinasiantara Aluminium Hidroksida dan Magnesium Hidroksida.Orally DisintegratingTablet diketahui dapat hancur atau melarut dalam mulut tanpa memerlukanair.Antasida diformulasikan dalam bentuk sediaan Orally Disintegrating Tabletdiharapkan mampu memberikan onset yang cepat dengan penggunaan yang lebihpraktis.Diperlukan eksipien berupa superdisintegrant untuk dapat meningkatkanwaktu hancurnya.Penelitian ini bertujuan untuk mengetahui pengaruh dari Starch1500® dan Crospovidone sebagai superdisintegrant serta interaksi keduanya danmenentukan formula optimum pada karakteristik fisik Orally DisintegratingTablet (ODT) Antasida.Optimasi Starch 1500® dan Crospovidone dilakukandengan metode factorial design.Konsentrasi Starch 1500® yang digunakan adalah5% dan 10%, sedangkan Crospovidone 2% dan 5%.Orally Disintegrating Tablet(ODT) Antasida dibuat dengan metode kempa langsung dan formula optimumdiperoleh dari respons daya alir, kandungan lembab, kekerasan, kerapuhan, waktuhancur serta wetting time. Formula optimum yang didapat adalah komposisiStarch 1500® sebesar 6,467% danCrospovidone sebesar 2,000%.
EVALUASI KUALITAS PELAYANAN KEFARMASIAN PUSKESMAS DI KABUPATEN WONOSOBO PERIODE JULI – DESEMBER 2014 Saputro, Rizal Dwi; N. S. Hadirahardja, Maria Caecilia; Kusmini, Kusmini
Media Farmasi Indonesia Vol. 11 No. 1 (2016): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

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Abstract

SARIPelayanan kefarmasian di Puskesmas merupakan salah satu pelaksanaanupaya kesehatan perorangan. Penelitian ini bertujuan untuk mengevaluasi kualitaspelayanan kefarmasian Puskesmas di Kabupaten Wonosobo dengan parameterpenilaian pelayanan kefarmasian dan penggunaan obat rasional (POR).Penelitian yang dilakukan adalah penelitian deskriptif. Obyek penelitianadalah Puskesmas di Kabupaten Wonosobo yang memiliki tenaga farmasi( Apoteker atau Tenaga Teknis Kefarmasian). Sampel penelitian adalah pelayanankefarmasian, resep dan pasien poliklinik umum pada periode Juli – Desember2014. Teknik sampling menggunakan metode purposive sampling dengan totalsampel yang didapatkan adalah 360 sampel.Hasil penelitian menunjukkan pelayanan kefarmasian di puskesmas6,67 % masuk kriteria KURANG dan 93,33 % masuk kriteria SEDANG denganindeks kepuasan pasien adalah PUAS sebesar 28 %, CUKUP PUAS sebesar 68 %dan KURANG PUAS sebesar 4 %. Tingkat rasionalitas menurut indikatorperesepan menunjukkan persentase penggunaan antibiotik pada kasus ISPA NonPneumonia sebesar 6,25 % dan Diare Non Spesifik sebesar 30,60 %, persentasepenggunaan injeksi pada kasus Myalgia sebesar 1,99 %, rata - rata jumlah obatyang diresepkan tiap pasien sebesar 3,51 item. Persentase penggunaan obatrasional (POR) total sebesar 46,87 % lebih kecil dari target Kemenkes RIsebesar 70 %.Dari penelitian ini dapat disimpulkan bahwa kualitas pelayanankefarmasian puskesmas di Kabupaten Wonosobo pada periode Juli – Desember2014 belum optimal sehingga disarankan puskesmas menambahkan tenagaApoteker, membuat Formularium Puskesmas dan upaya promotif dan edukatifkepada penulis resep dan pasien.
UJI AKTIVITAS EKSTRAK ETANOL DAN ISOLAT FLAVONOID KULIT KACANG TANAH (Arachis hypogaea L.) TERHADAP PENURUNAN KADAR ASAM URAT SECARA IN VITRO Dinurrosifa, Rahmawati Salsa; Mutiara, Erlita Verdia; Nafi’ah, Rohmatun
Media Farmasi Indonesia Vol. 11 No. 1 (2016): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

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Abstract

SARIHiperurisemia adalah suatu keadaan tingginya kadar asam urat yangdisebabkan terjadinya penumpukan asam urat secara berlebihan. Penurunan asamurat dapat digunakan obat alam dan obat sintetik. Obat alam yang digunakan salahsatunya kulit kacang tanah (Arachis hypogaea L.) yang banyak mengandungflavonoid dan mineral yang mampu menurunkan kadar asam urat. Penelitian inibertujuan untuk mengetahui perbedaanaktivitas pemberian ekstrak dan isolatflavonoid kulit kacang tanah (Arachis hypogaea L.) terhadap penurunan kadarasam urat secara in vitro, mengetahui persentase penurunan kadar asam uratsetelah penambahan ekstrak etanol dan isolat flavonoid kulit kacang tanah, sertamengetahuistruktur senyawa flavonoid dalam isolat kulit kacang tanah (Arachishypogaea L.). Metode ekstraksi yang digunakan dalam penelitian ini adalahmetode remaserasi. Isolasi senyawa flavonoid dilakukan dengan menggunakanmetode kromatografi kolom vakum, fase geraknya menggunakan n-heksan : etilasetat, dan fase diamnya menggunakan silika gel GF 60. Untuk uji penurunankadar asam urat, ekstrak dan isolat kulit kacang tanah dibuat deret konsentrasi100, 200, 300, 400, dan 500 ppm. Hasil uji anava satu jalan ekstrak menunjukkanbahwa ada perbedaan ekstrak etanol dan isolat flavonoid kulit kacang tanah dalammenurunkan kadar asam urat. Hasil persentase penurunan kadar asam urat setelahpenambahan ekstrak kulit kacang tanah berturut-turut sebesar 49,88; 54,13; 57,09;59,22 dan 61,06%, sedangkan setelah penambahan isolat flavonoid berturut-turutyaitu 40,26; 43,74; 47,94; 50,22; dan 52,92%. Struktur flavonoid dari kulit kacangtanah yang dapat menurunkan kadar asam urat secara in vitro yaitu senyawaturunan flavon dengan rumus 7,3’,4’-trihidroksi flavon.
PENGARUH PROSES PENCAMPURAN TERHADAP SIFAT FISIK SEDIAAN VIRGIN COCONUT OIL(VCO) COLD CREAM Octavianus Rico Aditya Putra; Agatha Budi Susiana Lestari
Media Farmasi Indonesia Vol. 8 No. 1 (2013): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

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Abstract

Abstract The aim of the research was to investigate the significant effect among mixing time, mixing rate, and their interaction on the Virgin Coconut Oil (VCO) Cold Cream’s. In this research, the physical as properties of cold cream studied were viscosity, spreadability and viscosity shift. The result showed that mixing time, mixing rate and their interaction did not significantly affect the viscosity, spreadability, and viscosity shift responses.
HUBUNGAN ANTARA KESEIMBANGAN TUBUH DAN KOGNISI TERHADAP RISIKO JATUH LANJUT USIA DI PANTI WREDA PUCANG GADING ROSDIANA, Ika; Cahyani LESTARI, Aghnia
Media Farmasi Indonesia Vol. 15 No. 2 (2020): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (454.692 KB) | DOI: 10.53359/mfi.v15i2.159

Abstract

The aging process is marked by the degeneration of organ systems and tissues, physiological changes occur that cause the elderly to experience impaired mobilization due to reduced muscle strength. Another thing is the emergence of cognitive dysfunction can be experienced by patients who progress to dementia, both of which can increase the risk of the elderly experiencing impaired balance and risk of falling. This study aims to find a correlation between body balance and cognition with the risk of falling in the elderly carried out at the Pucang Gading Nursing Home in Pedurungan District, Semarang. In this type of observational analytic study with a cross-sectional design, the independent variable is balance and cognition while the dependent variable is the risk of falling. The results showed the highest body balance level in the medium category was 66.0%, the high was 21.3% and the low was 12.8%. For the category of cognitive function in the elderly, it is found that definite respondents are 8.5%, probable 25.5%, and normal 66.0% respondents. The risk of falling in the elderly is low at 63.8%, while the risk of falling at a moderate level of 19.1% and high at 17.0%. . Spearman correlation test results between balance and risk of falling p = 0.000 (p <0.05) with a value of r = -0.497 while the spearmen correlation test between cognition and risk of falling obtained p = 0.224 (p <0.05). In conclusion, there is a relationship between balance and risk of falling with a value of p = 0,000 with a value of r = -0.49 and there is no relationship between cognition with a risk of falling p = 0.224.
Gambaran Kasus Entropion Involusional di Sultan Agung Eye Center (SEC) Rumah Sakit Islam Sultan Agung Semarang Tahun 2008-2018 INDRAJATI, Christina; WIDIYANTO, Bagas
Media Farmasi Indonesia Vol. 15 No. 2 (2020): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (322.521 KB) | DOI: 10.53359/mfi.v15i2.160

Abstract

Involutional entropion is an eye disorder that often occurs because of the aging process. The most severe complication of this case is the permanent decrease in vision caused by corneal damage due to friction of the eyelid. This study aims to provide an overview of involutional entropion at the SEC Sultan Agung Islamic Hospital Semarang. The research method used was descriptive observational. Research subjects were 69 patients diagnosed with involutional entropion from January 2008 until January 2018. 69 research subjects were used, divided into several characteristics. Gender, 36.2% males, and 63.8% female. Age group, <60 years 31.9% and> 60 years 68.1%. The location of the eyelids, the upper eyelid 40.6%, and the lower eyelid 59.4%. Operating techniques, ALR (Anterior Lamelar Reposition) 40.6%, Everting Suture technique 29.0%, Weis technique 30.4%. Results of surgery recovered 86.2% and recurring 13.8%.
PENGGUNAAN ANTIHIPERTENSI PADA PASIEN STROKE NON HEMORAGIK DI INSTALASI FARMASI RAWAT JALAN RUMAH SAKIT X SEMARANG Maya OCTASARI, Paulina; Veny OKTAVIANI, Anastasia
Media Farmasi Indonesia Vol. 15 No. 2 (2020): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (448.286 KB) | DOI: 10.53359/mfi.v15i2.161

Abstract

Non-hemorrhagic stroke is a functional disorder of the brain’s neurologic deficits caused by vasocontraction due to blockage in the arterial vessel leading to the brain. There were 79% of non-hemorrhagic stroke patients are caused by hypertension. Antihypertensive therapy for the patients given as secondary therapy to prevent recurrent stroke, decreased brain edema risk, hemorrhagic risk, and prevent further vascular damage. Therefore this research aimed to evaluate antihypertensive usage in non-hemorrhagic stroke patients in the Hospital. The research is an observational descriptive with cross-sectional design and retrospective data. Data retrieval through the medical record of outpatients with ages 36-65 years were diagnosed with non-hemorrhagic stroke with or without comorbidities and National Health Insurance patients period of October - December in 2019. Data were classified based on age, gender, and antihypertensive agent, and were analyzed by calculating the percentage of patients who have decrease, stability, and increased blood pressure. 92 patients who were included in the inclusion criteria. The result showed that more male patients (68,48%), mostly age category 55-65 years (70,65%) with hypertensive (51,09%). Antihypertensive usage in non-hemorrhagic stroke is mostly used CCB group (70,65%). The percentage of patients who suffered a decrease in systolic blood pressure as much as 53 patients (57,6%), meanwhile the decrease in diastolic blood pressure as much as 63 patients (68,46%). There were 69 patients (75%) has blood pressure target therapy.
PENGARUH PERBEDAAN BAGIAN TANAMAN TERHADAP KADAR TOTAL FENOLIK DAN KADAR TOTAL FLAVONOID EKSTRAK TALAS (Colocasia esculenta L) Laksmi RAMAYANI, Septiana; Putri SANDIYANI, Riska; Oktaviani DINASTYANTIKA, Vavi
Media Farmasi Indonesia Vol. 15 No. 2 (2020): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (455.38 KB) | DOI: 10.53359/mfi.v15i2.162

Abstract

The Taro plants (Colocasia esculenta L) consist of leaves, stalk, and tubers that have pharmacological activity. There are the healing of wounds and antioxidant activity because of the containing of phenolic and flavonoid compounds. Activity pharmacology of various plant parts taro influenced by the active substance contained in each part of a plant that produces differences of activity pharmacology. The purpose of the research is to know the influence of parts of an organ plant on the total phenolic and the total flavonoid plant extracts taro. The extraction method used Microwave-Assisted Extraction (MAE) with 96% ethanol. An extract obtained determined the total phenolic with the methods Folin-ciocalteau using gallic acid as standard while levels flavonoid determined by the addition of reagent AlCl3 using Quercetin as a standard. Total phenolic content and total flavonoid content measured the use of the spectrophotometer UV-Vis. This research result indicates that the differences part of a plant significantly affected the total phenolic and flavonoid plant extracts taro. The highest levels of total phenolic and flavonoid there are on the leaves of taro plants
UJI KANDUNGAN FENOLIK TOTAL DAN AKTIVITAS ANTIBAKTERI EKSTRAK KULIT BUAH ASAM PAYA (Eleiodoxa conferta (Griff.) Burret) TERHADAP Staphylococcus aureus. Elisabeth SITORUS, Febrina Claudia; Dwi WULANSARI, Endang; SULISTYARINI, Indah
Media Farmasi Indonesia Vol. 15 No. 2 (2020): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (467.003 KB) | DOI: 10.53359/mfi.v15i2.163

Abstract

Asam paya (Eleiodoxa conferta (Griff.) Burret) contains phenolic compounds which can function as antibacterial agents against Staphylococcus aureus. Extraction using soxhlet with multilevel polarity, namely n-hexane and ethanol. The antibacterial activity test by TLC contact-bioautography showed that the phenolic compounds in the ethanol extract had antibacterial activity, and the diffusion test results showed that the ethanol extract had a larger inhibition zone diameter than the n-hexane extract. The total phenolic compound of extract was determined using the Folin-Ciocalteu reagent. The total phenolic compounds of Eleiodoxa conferta (Griff.) Burret. ethanolic extract is 7,326± 0,0989 mg GAE/gram sample. The ethanol extract was fractionated using a separating funnel, followed by purification with preparative TLC. The phenolic isolates obtained were tested for purity by three eluent TLC. The results of antibacterial activity diffution test and TLC contact-bioautography test showed that phenolic isolates had antibacterial activity against Staphylococcus aureus.

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