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Pharmaceutical Sciences and Research (PSR)
Published by Universitas Indonesia
ISSN : 24072354     EISSN : 24770612     DOI : https://doi.org/10.7454/psr
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Aims Pharmaceutical Sciences and Research (PSR), an international, peer-reviewed, open access, and official journal from Faculty of Pharmacy, Universitas Indonesia, aims to disseminate research results and findings in Pharmaceutical Sciences and Practices. Major area of interest is natural products in drug discovery and development. We also consider other areas related to pharmaceutical sciences and practices. PSR publishes content in English language to promote the sharing of knowledge to international scholars. PSR publish 5 types of articles: 1. Original article 2. Case report 3. Case series 4. Review article 5. Mini review article Scope Researches in Pharmaceutical Sciences and Practices which are covered by PSR are within these subject areas: - Pharmacognosy and Phytochemistry - Pharmaceutical Chemistry - Pharmaceutical Technology - Pharmaceutical Biotechnology - Clinical Pharmacy - Pharmacology-Toxicology - Social and Administrative Pharmacy, including Pharmacoeconomy
Arjuna Subject : -
Articles 13 Documents
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Search results for , issue "Vol. 6, No. 3" : 13 Documents clear
Vaksin Kanker Radji, Maksum
Majalah Ilmu Kefarmasian Vol. 6, No. 3
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Abstract

Cancer vaccines are medicines that work by stimulating or restoring the immune system’s ability to fight cancers and disease. There are two types of cancer vaccines, prophylactic cancer vaccines, which are intended to prevent cancer from developing in healthy people, and treatment cancer vaccines, which are intended to treat already existing cancers by strengthening the body’s natural defenses against cancer. This article discusses about cancer vaccines including the role of microbes that are respon-sible of human tumor, the mode of action of cancer vaccines and the efficacy of human papillomavirus (HPV) vaccines in preventing various benign and malignant condi-tions, including cervical cancers caused by HPV.
Amobilisasi Sel Lactobacillus Acidophilus FNCC116 Untuk Demineralisasi Limbah Kulit Udang Dalam Pengolahan Kitin Betha, Ofa Suzanti; Setyahadi, Siswa; Suryadi, Herman
Majalah Ilmu Kefarmasian Vol. 6, No. 3
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Chitin, a homopolimer, is the most abundant renewable natural resources after cellulose. Chitin and its derivatives hold many applications in agriculture, textile, pharmacy and medic. Chitin that extracted from waste shrimp shells by biological fermentation has better quality than chemical procees. Demineralization of chitin by biological procees use lactic acid as product of fermentation. Deproteinization of chitin use proteolytic activity of enzyme that produce by bacteria in fermentation. Lacto-bacillus acidophilus FNCC116 has been immobilized by entrapment methods and 2% sodium alginate in 0,2 M CaCl2 as the matric . The ability of immobilized Lacto-bacillus acidophilus FNCC116 cell in fermentation was tested. The fermentation that was carried out in medium which consist of 6% glukosa, 1,5% yeast extract, 0,003% MnSO4 0,003% FeSO4.7H2O, 0,02% MgSO4.7H2O and has been producted 2,24% lactic acid. Demineralization of waste shrimp shell with 30% immobilized Lactobacillus acidophilus FNCC116 cell has successfully decreased ash content tol 1,18% and produced lactic acid maximum 2.24%. Immobilization of Lactobacillus acidophilus FNCC116 cell promised an efficient method in bioproceesing of chitin recovery.
Aplikasi Ko-Kemoterapi Fraksi Etil Asetat Ekstrak Etanolik Daun Sambung Nyawa (Gynura procumbens (Lour.) Merr.) Pada Sel Kanker Payudara MCF-7 Jenie, Riris Istighfari; Meiyanto, Edy
Majalah Ilmu Kefarmasian Vol. 6, No. 3
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Combination chemotherapy has been an interesting attention in recent years to cure cancer e.g. non-toxic or less toxic phytochemicals are being combined with chemo-therapeutic agents to sensitize cancer cell and to enhance the efficacy of chemothera-peutic agents as well as to reduce its toxicity to normal tissues. The aim of this research is to examine whether ethyl acetate fraction of Gynura procumbens ethanolic extract (SEF) synergizes the therapeutic potential of doxorubicin (Dox) on breast cancer cell line MCF-7. MTT assay were used to measure the growth inhibitory effect of the combination therapy on MCF-7 cells. SEF (5-250 µg/ml) treatment of cell resulted in 15-76% growth inhibition in a dose dependent manner (IC50 85 µg/ml), while Dox (10-100 nM) treatment did not show any inhibitory effect. The combina-tions of SEF (5-40µg/ml) with Dox (10-75 nM) seemed to not have any synergistic efficacy towards cell growth inhibition. Nevertheless, this result need further observa-tion regarding the IC50 of Dox on MCF-7 has not been determined yet. The cell characterization may influence the result. Doxorubicin could induce Akt survival apoptosis pathway in MCF-7 resulting resistancy of the cell towards doxorubicin.
Studi Penggunaan Antibiotika Pada Penderita Rawat Inap Pneumonia (Penelitian Di Sub Departemen Anak Rumkital Dr. Ramelan Surabaya) Suharjono, Suharjono; T, Yuniati; Sumarno, Sumarno; SJ, Semedi
Majalah Ilmu Kefarmasian Vol. 6, No. 3
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Pneumonia is an infectious disease that was caused inflammation of acute parenchy-mal compression of the lungs and bacterial exudate from lung tissue on the main from Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, Klebsiella pneumonia, Mycobacterium tuberculosis. Selection of appropriate antibiotic therapy and rational will determine the treatment to avoid the occurrence of bacterial resistance. In addition it is also possible the use of other drugs that can increase the chances of Drug Related Problems (DRP). Pattern of antibiotic use in Rumkital Dr. Ramelan Surabaya has never been done. Studying the pattern use of antibiotics in hospitalized patients with pneumonia in the Sub Department of Pedi-atric Rumkital Dr. Ramelan and related the dose, other therapies, as well as identify the DRP. This research is a method descriptive survey research in the form of a retrospective and descriptive study. Materials research is the Medical Records pa-tients hospitalized with the final diagnosis of pneumonia, starting January 1, 2004 until April 30, 2006 that meet inclusion criteria. Of the study population who account for 50 found 41 patients who fulfilled the inclusion criteria. Antibiotics single most widely accepted patients without comorbidities were ampicillin iv 26.92% (14 patients) and iv sefotaksim 21.15% (11 patients), while the antibiotic combina-tion widely accepted patients is ampicillin iv / po + kloksasilin iv / po 13.46% (7 patients) and kloksasilin iv + ceftriaxone iv 5.77% (3 patients) and the rest other antibiotic combinations. DRP study found 56.9% patients received appropriate anti-biotic dose literature and 43.1% patients receiving doses underdose. Use of antibiotics above is already in ccordance with reference and other therapies. Single antibiotic or combination of 2 antibiotics penicillin and cephalosporin classes often used to treat pneumonia.
Validasi Metode Analisis Rebamipid Dalam Plasma In Vitro Secara Kromatografi Cair Kinerja Tinggi-Ultraviolet Harahap, Yahdiana; Alia, Nu
Majalah Ilmu Kefarmasian Vol. 6, No. 3
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Rebamipide is antiulcer agent and it is one of the drug that have to be evaluated with bioequivalency test according to Food and Drug Administration (FDA). The objec-tive of this research is to find out the optimum condition of rebamipide in human plasma in vitro analysis by High Performance Liquid Chromatography (HPLC) with ultraviolet detector, and then the method was validated. The chromatography was carried out by isocratic technique on a reversed-phase Kromasil® C18 (5 µm, Akzo Nobel), column length was 250 x 4.6 mm, with mobile phase consisted of acetonitrile - phosphate buffer pH 3.0 (40:60) at flow rate of 1.0 ml/min, and detection was performed at wavelength of 230 nm. The sample preparation technique was liquid-liquid extraction by phosphoric acid and ethyl acetate. Carbamazepine was used as the internal standard. The method was valid according to FDA in Bioanalitycal Method Validation, with coefficient correlation of 0.9993 and linear in the range concentra-tion of 0.04 – 1.2 µg/ml, the lower limit of quantitation was 42.0 ng/ml, precision less than 6% and recovery percentage was 90.32 to 113.45%. Rebamipide in plasma was stable for 14 days storage in -200C.
Identification and Evaluation of Antibacterial Compounds from the Vibrio sp. associated with the Ascidian Pycnoclavella diminuta Dermawan, Abdurraafi’ Maududi; Julianti, Elin; Putra, Masteria Yunovilsa
Pharmaceutical Sciences and Research Vol. 6, No. 3
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Abstract

This study aims to obtain secondary metabolites that have antibacterial activity from bacteria endophytic of ascidian Pycnoclavella diminuta collected from the coast of Bitung, North Sulawesi, Indonesia. The research was started with screening antibacterial activity of six bacteria isolated from P. diminuta. The active bacteria were selected for identification using standard biological molecular method and further fermentation to produce secondary metabolites. The isolation of secondary metabolites was conducted by various chromatography method and then selected fraction was based on the antibacterial activity from bioautography results. The result showed that the active isolate by coding M2.Tnk.Bt 5.10-3.2 was identified as Vibrio sp. The potential active fraction was further sub-fractionated by HPLC semi-preparative and each of these sub-fractions was tested against Staphylococcus aureus, Bacillus cereus, Enterococcus faecalis, Eschericia coli, and Vibrio cholerae. The test results showed that all 17 sub-fractions were active against Gram-positive bacteria S. aureus and B. cereus, and only one sub-fraction (SFr 2) showed antibacterial activity against E. faecalis. Whereas in Gram-negative bacteria, 2 sub-fractions (SFr 12 and SFr 13) showed antibacterial activity against E. coli and 12 sub-fractions active against V. cholerae. GC-MS analysis of the SFr 2 sub-fraction showed the presence of fifteen phytochemical constituents with a major compound Pyrrolo [1,2-a] pyrazine-1,4-dione, hexahydro-3- (2 methylpropyl).
Characterization of Secondary Metabolites Profile of Flavonoid from Salam Leaves (Eugenia polyantha) Using TLC and UVSpectrophotometry Syarifah, Anisa Lailatusy; Retnowati, Rurini; Soebiantoro,
Pharmaceutical Sciences and Research Vol. 6, No. 3
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The flavonoids derived from Eugenia polyantha leaves were characterized by rapid and low cost approach. The aim of this research is to characterize secondary metabolite profile of flavonoids in the n-butanol fraction of E. polyantha using thin layer chromatography and ultraviolet-visible spectrophotometry. The n-butanol fraction was separated by using silica gel 60 GF254 as the stationary phase; chloroform: ethanol: glacial acetic acid (9.4: 0.5: 0.1) as the mobile phase; and visualized by using UV light 366 nm. Five isolates were obtained from the separation, but there were only three isolates (Rf 0.26; 0.44; 0.77) respectively identified as flavonoid compounds. The characterization of the isolates by UV-Vis spectrophotometry showing that the ranges of λmax were 250-280 nm (band II) and 310-360 nm (band I), which indicate the existence of flavone compounds. Further characterization of the three isolate using the AlCl3 5%/HCl 6 M solution showed that the λmax shifted from band I to the higher wavelength (bathochromic). The λmax shift indicated the existences of ketone at C-4, hydroxyl group at C-5, and orthodihydroxyl at ring B. According to the maximum wavelength, the result of the characterization showed that the flavonoid compounds of the n-butanol were 5,3’,4’-trihydroxyflavone3-C-glycoside or 5,4’,5’-trihydroxyflavone-3-C-glycoside; 5,6,3’,4’-tetrahydroxyflavone or 5,6,4’,5’-tetrahydroxyflavone; and 5,3’,4’-trihydroxyflavone or 5,4’,5’-trihydroxyflavone.
Pengujian Mutu Sediaan Kapsul Minyak Hati Ikan Cucut Botol Dalam Beberapa Produk yang Beredar di Pasaran Wijaya, Triyadi Hendra; Kartawinata, Tutus Gusdinar; Nugrahani, Ilma
Pharmaceutical Sciences and Research Vol. 6, No. 3
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National standard agency of Indonesia has set the quality standard of shark liver oil through the Indonesian national standard which consists of sensory test, moisture content, free fatty acid as well as squalene concentration. The purpose of this study is to evaluate quality of shark liver oil capsule on market. As many as 6 samples were tested for the quality in accordance to SNI through organoleptic test (< 7), moisture content (max 0.3%), free fatty acid content (max 1.5%) and squalene concentration (min 70%). The results showed that the level of squalene in all samples do not meet the standard requirement, however all samples meet the free fatty acid content requirements. One sample does not fit the standard criteria in the term of organoleptic test and moisture content.
Evaluation of Category I of Anti-tuberculosis Therapy in Intensive Phase Pulmonary TB by Conversion of Acid-Fast Bacilli Sputum Putra, Oki Nugraha; Damayanti, Amitasari; Nurrahman, Nani Wijayanti Dyah; Devi, Tsania; Aluf, Wildatul
Pharmaceutical Sciences and Research Vol. 6, No. 3
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Acid fast bacilli (AFB) sputum microscopy is used to diagnose tuberculosis (TB) and to evaluate the effectiveness of anti-tuberculosis drugs in TB eradication program. The AFB sputum microscopy should be performed before treatment, two months after intensive phase and four months after advance phase treatment. The aim of this study was to evaluate the sputum conversion rate of AFB in pulmonary TB patients who received category I of antituberculosis (anti-TB) drugs. Evaluation of sputum conversion was perfomed before initation of anti TB drugs and at the end of the intensive phase. This cohort prospective study was done from February to May, 2018. Nine pulmonary TB patients fulfilled the criteria during the study. This AFB sputum microscopy was evaluated by using Ziehl Neelsen and read by means of International Union Against Tuberculosis and Lung Disease (IUATLD) scale. Nine sputum smear positive were followed for two months. After two months (end of the intensive phase), the smear conversion rate was 100%. All patients received standard dose of anti-TB drugs in fix dose combination (FDC). It can be concluded that the sputum conversion of AFP in pulmonary TB patients who received category I of anti-TB was success at the second month of intensive phase.
Model Hewan Coba pada Penelitian Diabetes Husna, Fauzul; Suyatna, Franciscus D; Arozal, Wawaimuli; Purwaningsih, Erni H
Pharmaceutical Sciences and Research Vol. 6, No. 3
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The animal model has been widely used and contributed vastly to the scientific research over the years. While it can be used as an alternate subject in a study, the selection of the animal is crucial to assess and investigate the influence of the environment and genes on the pathogenesis of a disease. Many factors contribute to the choosing of the animal. They can be ranged from the similarities with the modelled object, easily looked after with less expensive cost, good reproductive performance, ability to produce blood and tissue samples, well-known genetic composition, and the status of the disease can be explained. Research has been taking place to investigate and find the best approach to prevent and deal with diabetes mellitus (DM) and insulin resistance and its complications. It starts with an initial in vitro method and finished with a clinical trial. Similarly, a series of in vivo studies using the animal model has been done aiming at figuring out its conditions or diseases that are identical to that of humans. This article discusses a variety of animal models frequently used in DM research.

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