cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Elmiawati Latifah
Contact Email
elmiawatilatifah@ummgl.ac.id
Phone
+6281392212213
Journal Mail Official
journal.psp@ummgl.ac.id
Editorial Address
Universitas Muhammadiyah Magelang, Jl. Mayjen Bambang Soegeng, Glagak, Sumberrejo, Kec. Mertoyudan, Magelang, Jawa Tengah 56172, Indonesia
Location
Kab. magelang,
Jawa tengah
INDONESIA
Jurnal Farmasi Sains dan Praktis
Published by Universitas Muhammadiyah Magelang
ISSN : 25499068     EISSN : 25794558     DOI : -
Core Subject : Health, Science,
Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Farmasi Sains dan Praktis aims to serve the updated scientific knowledge for international researchers in pharmaceutical sciences. Jurnal Farmasi Sains dan Praktis (JFSP) publishes review article, original article, as well as short communication in the all scopes of Pharmaceutical Science such as Pharmaceutics, Biopharmaceutics, Drug Delivery System, Physical Pharmacy, Pharmaceutical Technology, Pharmaceutical Microbiology and Biotechnology, Pharmacology and Toxicology, Pharmacokinetics, Pharmaceutical Chemistry, Pharmaceutical Biology, Community and Clinical Pharmacy, Pharmaceutical Marketing, Alternative Medicines, Pharmaceutical Management, Pharmacoeconomic, Pharmacoepidemiology, Social Pharmacy, Pharmacy Policies.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 259 Documents
 21   22   23   24   25 
MIGRATION INHIBITION ACTIVITY BY METHANOL EXTRACT Hibiscus tiliaceus Linn. ON 4T1 BREAST CANCER Alviani, Dwi Lutvi; Safitri, Erika Indah; Hidayati, Devi Nisa
Jurnal Farmasi Sains dan Praktis Vol 10 No 2 (May-August 2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v10i2.9393

Abstract

The prevalence of breast cancer cases in Indonesia is increasing along with the ability of cancer cells to migrate or move from the primary tumor mass and form new colonies elsewhere. The migration of cancer cells has encouraged the develop anticancer drugs from natural ingredients. Waru leaves have been shown to have cytotoxic activity. This study aims to determine the inhibition activity of migration of breast cancer cells 4T1 from methanol extract of waru leaves. Waru leaves methanol extract was obtained using the maceration method. Cytotoxic test of methanol extract of waru leaves (MEWL) was the migration test used in the scratch wound healing method at concentrations 162.5, 325, and 650 μg/mL at 0, 18, 24, and 42 hours after treatment. Analysis of IC50 using linear regression, while large areas were analyzed using Image-J software. The percentage of data closure was analyzed statistically with the Anova Repeated Measure test. All concentrations of Methanol Extract of Waru Leaves had significant inhibition of cell migration (p<0,05) compared to control at each observation time at 0, 18, 24, and 42 hours after treatment. So, MEWL is able to inhibit migration in 4T1 cells
EFFECTIVENESS OF MAGNESIUM CITRATE ADJUNCTIVE THERAPY ON CRAMPING PAIN INTENSITY IN NOCTURNAL LEG CRAMPS PATIENTS AT BETHESDA HOSPITAL YOGYAKARTA Digdoyo, Ananda; Pinzon, Rizaldy Taslim; Pramudita, Esdras Ardi
Jurnal Farmasi Sains dan Praktis Vol 10 No 1 (January-April 2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v10i1.9534

Abstract

Nocturnal Leg Cramps (NLC) are involuntary lower limb contractions that are painful and occur during long rest periods. Magnesium is thought to have potential in the treatment of NLC as one of the precipitating factors of NLC is low levels of certain minerals, such as magnesium deficiency. This study aimed to assess the effectiveness of magnesium adjunctive therapy in reducing cramping pain intensity in patients with NLC. This study was a randomized clinical trial, open-label, controlled group that was followed up for 2 weeks. 30 subjects who have been diagnosed with the NLC short-form adaptation of ICSD 2005 were divided into 2 groups; (1) the intervention group who was given standard NLC therapy (calcium and gabapentin) with additional therapy of magnesium citrate 100 mg (Hi-Mg100) one tablet a day, (2) the control group who was only given standard NLC therapy. NLC cramping pain was measured using the Numeric Rating Scale (NRS) before the administration of therapy (baseline) and at week 2 after therapy. The results obtained were the addition of magnesium to standard therapy provided a significant reduction in cramping pain intensity between before and after treatment based on the Wilcoxon signed rank test (p=0.000). However, there was no statistically significant difference effect between the two therapy groups based on the Mann-Whitney test (p=0.073). In conclusion, magnesium adjunctive therapy was not significantly more effective in reducing cramping pain than standard drug therapy in patients with NLC.
POTENTIAL KETAPANG (Terminalia cattapa) LEAF EXTRACT AS A DOXORUBICIN CO-CHEMOTHERAPY AGENT ON BREAST (T47D) AND CERVIX (HeLa) CANCER CELL LINES Sundhani, Elza; Solehah, Senja Nur; Septiadi, Binaripan; Nurulita, Nunuk Aries
Jurnal Farmasi Sains dan Praktis Vol 10 No 1 (January-April 2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v10i1.9845

Abstract

Doxorubicin (DOX) is chemotherapy for breast and cervical cancer with serious side effects. Ketapang (Terminalia cattapa) is a potential plant as a co-chemotherapy agent. The purpose of this research was to examine the sensitivity of DOX as a cytotoxicity drug in combination with ethanolic extracts of ketapang leaves (EKL) against T47D and HeLa cancer cells. Cytotoxicity was determined using the MTT assay, with DOX concentration series (0.625-40 nM for T47D and 0.5-6 M for HeLa) and EKL (50-1000 mg/mL) used in combination with the study. DOX and EKL combination assays utilizing their respective IC50 values were performed in T47D cells and HeLa cells, and the results were used to calculate the Combination Index (CI). Furthermore, the doubling time method was used to investigate the combination of DOX and EKL proliferation inhibition on both cell lines. DOX and EKL had IC50 values of 158 nM and 30 mg/mL for T47D, respectively, and 3.4 M and 640 mg/mL for HeLa cell growth. While DOX and EKL have a synergistic effect on T47D cells, their combined effect on HeLa cells is cytotoxic and dose-dependent. EKL increases the inhibitory effect of DOX on the proliferation of T47D and HeLa cancer cells. In T47D cells, the combination of DOX and EKL has a higher potential for cytotoxic and antiproliferative activity than in HeLa cells
REVIEW: QUALITY OF LIFE OF TYPE 2 DIABETES MELLITUS PATIENT WITH APPLICATION OF LIFESTYLE Yunita, Alfiranty; Aretzy, Alfia
Jurnal Farmasi Sains dan Praktis Vol 10 No 1 (January-April 2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v10i1.10112

Abstract

Diabetes is a chronic disease that has increased growing from year to year in the number of sufferers from year to year. It is associated with changes in lifestyle in modern times that can affect the quality of life of the patients. The quality of life itself refers to the value assigned during a lifetime that changes with decreased functional, perceptual, and social value and can be affected by disease and treatment. The assessment of the quality of life, especially for patients with type 2 diabetes mellitus, aims to restore not only physical function in terms of mobility but also perceptions of health. This research aims to determine the role of lifestyle in improving the quality of life of type 2 diabetes mellitus patients. The non-experimental study is based on a review of various articles on the quality of life of people with type 2 diabetes mellitus published in various national journals from 2016 to 2022. The results of this study showed that exercising, consuming a balanced, nutritious diet, and monthly health check-ups greatly contribute to the improvement of the quality of life. The quality of life can also be measured using the EQ-5D-5L instrument which cover five domains mobility (the ability to move or walk), self-care, usual activities, pain or discomfort, and anxiety or depression and five domain levels. This article concludes that a good lifestyle can improve the quality of life of type 2 diabetes mellitus patients
SUN PROTECTION FACTOR (SPF) VALUE AND PHYSICAL PROPERTIES OF PURIFIED GAMBIER GEL PREPARATION Faizin, Muhammad Asrofi; Purwanto, Purwanto
Jurnal Farmasi Sains dan Praktis Vol 10 No 1 (January-April 2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v10i1.10208

Abstract

Gambier is an export product from Sumatera, Indonesia, that can be purified and utilized in cosmetic preparations. The content of phenolic and flavonoid compounds of purified gambier has a potential skin protection against UV rays. The chemical content of extract is closely related to the polarity of solvent, so this study aims to analyze the effect of ethanol concentration as solvent in gambier purification on phenolic content, flavonoids, and SPF value. The ethanol concentrations for this purpose were 0%, 25%, 50%, 75% and 96%. Total phenolic and flavonoid contents were analyzed by colorimetric method, whereas the SPF value of gel was measured by UV spectrophotometer. The gel preparation was evaluated for its physical properties including organoleptic test, spreadability, adhesiveness, viscosity, pH and stability. Statistical analysis performed with one-way ANOVA at 95% confidence level. As the results, ethanol concentration significantly influenced phenolic, flavonoid content and SPF values. The highest phenolic content was obtained in purification by 50% ethanol with a value of 757.2 ± 13.1 mg GAE/g, while highest flavonoid content was achieved in 96% ethanol at 5.18 ± 0.21 mg QE/g. Ethanol concentration with highest SPF value was 96% at 27.07 ± 0.33. In the gambier gel formulation with 0.2% dose had an SPF value of 6.60 ± 0.58. The gel has good homogeneity, viscosity, and pH for cosmetic preparations but poor spreadability. The stability of the gel formulation changed after accelerated stability testing for 4 weeks
POTENTIAL INHIBITION OF AKT1 AND P53 PROTEIN IN COLON CANCER BY GALLIC ACID DERIVATIVES COMPOUND WITH MOLECULAR DOCKING APPROACH Humaedi, Aji; Kurniawan, Muhammad Rizki; Halimatushadyah, Ernie
Jurnal Farmasi Sains dan Praktis Vol 10 No 2 (May-August 2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v10i2.10390

Abstract

Colon cancer is a degenerative disease that attacks the large intestine through a process of initiation, promotion and progression. Related research reports that overexpression of the AKT1 protein was found to be 60-70% and p53 at 50%. This research analyses the affinity, stability and interaction of gallic acid derivative compounds and reference ligands with the target proteins AKT1 and p53 by molecular docking. The study stages carried out include preparation and optimisation of target proteins and ligand compounds, file creation and simulation processes, and analysis and visualisation of docking results. The docking simulation results show that four gallic acid derivative compounds provide potential inhibitory activity against the AKT1 and p53 proteins based on binding energy values. BG and 2HBG compounds have strong inhibitory power against target proteins, thus enabling the formation of strong interactions and complexity towards the active site of amino acids with a bond distance of <3.0 Å. Thus, gallic acid derivative compounds have potential as inhibitors and are expected to activate other proteins, causing cancer cell apoptosis.
THE EFFECTIVENESS OF CORN SILK EXTRACT AGAINST DENTAL CARIES-CAUSING BACTERIA AND ITS FORMULATION IN MOUTHWASH PREPARATION Qariru, Davin Elian; Kar, Kevin Lensrich; Alfaqih, Muhammad Yusuf; Zahra, Aulia Putri Fatiya; Aulia, Rahma; Purwanto, Purwanto
Jurnal Farmasi Sains dan Praktis Vol 10 No 2 (May-August 2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v10i2.10484

Abstract

Indonesia is undergoing a dental caries emergency with a prevalence of 51.1% (Riskesdas, 2018). This may cause tooth decay due to dental plaque bacteria such as Streptococcus mutans. Mouthwash can be a solution because it has antibacterial properties and reaches interspaces on the teeth. Unfortunately, the active ingredient of mouthwash, chlorhexidine, can cause cancer-related mutations if used continuously. Therefore, it requires alternatives to natural ingredients, such as corn silk. The research aims to determine the corn silk phytochemical profile and minimum inhibitory concentration (MIC) against Streptococcus mutans. The research started by macerating corn silk simplicia using 70% ethanol. Afterwards, thin layer chromatography (TLC) was conducted to determine its phytochemical profile. Disk-diffusion and broth microdilution methods were conducted using various concentrations of corn silk extract to determine its antibacterial activity and minimum inhibitory concentration (MIC) against Streptococcus mutans. Then, the MIC₅₀ was used as the minimum dose of corn silk extract concentration in mouthwash formulation which qualities controlled by pH and organoleptic tests. The yield of corn silk extracted was 16.17%w/w. The phytochemical profile from TLC showed that flavonoids, tannins, and terpenoids were present. Corn silk extract has antibacterial activities against Streptococcus mutans with MIC₅₀ of 7.2%w/v. Corn silk extract, tween 80, sorbitol, sodium benzoate, sodium metabisulfite, oleum menthae piperitae, and distilled water were used in four mouthwash formulas (F1-F4). The pH of all formulas was 5 and the organoleptic test showed that from 30 panelists, the majority chose F2 as the best in terms of taste, color, and smell.
AUTHENTICATION OF PATCHOULI OIL FROM VARIOUS GROWING REGIONS USING GC-MS METHOD WITH CHEMOMETRIC COMBINATION ON THE PRODUCTS IN THE MARKET Nurani, Laela Hayu; Guntarti, Any; Milanie, Rida Dwi; Gandjar, Ibnu Gholib; Rais, Ichwan Ridwan; Prasasti, Dian; Edityaningrum, Citra Ariani
Jurnal Farmasi Sains dan Praktis Vol 10 No 1 (January-April 2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v10i1.10523

Abstract

Adulteration in patchouli oil trade is an ancient practice, where additional substances like turpentine oil are added to increase volume and odor. Therefore, this research aimed to determine the composition of patchouli oil, considering variations in growing regions and potential adulteration in the products available in the market. The analysis was carried out using the Gas Chromatography-Mass Spectrormetry (GC-MS) method with a Principal Component Analysis (PCA) chemometric combination for authentication. The sample obtained from Bantul, Kulon Progo, and Purworejo was isolated through steam and water distillation. Subsequently, it was tested in accordance with SNI standard 06-2385-2006 and analyzed using GC-MS. The results were compared to the products on the market and processed using multivariate chemometric, namely PCA with Minitab 19 software. GC-MS analysis showed the presence of various compounds contained in the oil, including alcohol, alpha-guaiene, beta-humulene, seychellene, trans-caryophyllene, neoalloocimene, and beta-patchoulene. The combination of GC-MS and PCA chemometrics was able to distinguish patchouli oil from others and the products available on the market. PCA chemometric analysis showed that the patchouli oil from various growing regions had the same chemical components as essential oil. Furthermore, PCA chemometric analysis of market products also showed similar results but varied significantly from turpentine oil. This showed that the patchouli oil product available on the market did not contain turpentine oil.
USE D-OPTIMAL MIXTURE DESIGN IN FORMULATION OF ONCHIDIID SLUG (ONCHIDIUM TYPHAE) INSTANT POWDER AS FUNCTIONAL FOODS Wijianto, Bambang; Tendianus, Tendianus; Pratiwi, Liza
Jurnal Farmasi Sains dan Praktis Vol 10 No 2 (May-August 2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v10i2.11107

Abstract

Onchidiid slug (Onchidium typhae) is an animal with bioactive compounds with high nutritional value and the potential to be used as a functional food product. The study aimed to optimize the onchidiid slug instant powder formula, analyze its proximate content, and determine its hedonic level. The formula of instant powder was made with a comparison of the composition of maltodextrin and dextrose based on the run in the D-Optimal Mixture Design (DMD) program, namely run 1 (20%:10%), run 2 (10%:20%), run 3 (13.33%: 16.67%), run 4 (16.67%:13.33%), run 5 (15%:15%), run 6 (12.5%:17.5%), run 7 (10%: 20%), run 8 (20%:10%). The powder is tested for water content and dissolution time, and the optimal formula is analyzed using One Sample T-Test in SPSS. The results showed that the composition of maltodextrin and dextrose significantly affected the characteristics of instant powder. The optimal instant powder formula combines 18.690% maltodextrin and 11.310% dextrose with a water content of 4.892% and a soluble time of 118.052 seconds. The results of statistical analysis in verifying the optimal formula show a p-value > 0.05 (not significant). The results of the proximate content test were 8.21% water content, 0.42% ash content, 0.85% crude fiber, 3.54% protein, and 1.54%. They had a preference level in the like and acceptable in terms of color, taste, texture, and scent.
COMPARISON OF FORECASTING DRUG NEEDS USING TIME SERIES METHODS IN HEALTHCARE FACILITIES: A SYSTEMATIC REVIEW Wiedyaningsih, Chairun; Yuniarti, Endang; Ginanti Putri, Ni Putu Vyra
Jurnal Farmasi Sains dan Praktis Vol 10 No 2 (May-August 2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v10i2.11145

Abstract

Drug planning is essential to ensure the fulfillment of the right type, amount, and time criteria. Forecasting can be utilized during the planning stage to predict future drug needs. Perfect forecasting is impossible due to uncertainties in various factors, necessitating selecting the best method. This study aimed to identify the optimal forecasting method for healthcare facilities based on the smallest Mean Absolute Deviation (MAD), Mean Square Error (MSE), and Mean Absolute Percent Error (MAPE) values obtained from forecasting results using time series methods like Single Moving Average (SMA), Weight Moving Average (WMA), (Single Exponential Smoothing) SES, Double Exponential Smoothing (DES), and Triple Exponential Smoothing (TES). This research involved a descriptive observational study with retrospective data and adhered to PRISMA guidelines. PubMed, Google Scholar, and Garuda served as the data sources. Nine articles meeting the eligibility criteria were employed. The findings revealed that the SES, DES, and TES methods produced forecasts with MAPE values below 10%, indicating highly accurate forecasting. The MAPE values for the SMA and WMA methods were less than 50%, which is still acceptable. Therefore, the ES methods, particularly SES, are highly recommended for accurate drug planning. Forecasting accuracy factors include data stability, pattern consistency, and smoothing constants. The SES method emerged as the best forecasting method, generating the smallest MAD, MSE, and MAPE values compared to other methods, falling below 10%, reflecting highly accurate forecasting.

Page 23 of 26 | Total Record : 259

 21   22   23   24   25 

Filter by Year

2015 2025


Reset
Filter By Issues
All Issue Vol 11 No 3 (September-December 2025) Vol 11 No 2 (May-August 2025) Vol 11 No 1 (January-April 2025) Vol 10 No 3 (September-December 2024) Vol 10 No 2 (May-August 2024) Vol 10 No 1 (January-April 2024) Vol 9 No 3 (September-December 2023) Vol 9 No 2 (May-August 2023) Vol 9 No 1 (January-April 2023) Vol 8 No 3 (September-December 2022) Vol 8 No 2 (May-August 2022) Vol 8 No 1 (January-April 2022) Vol 7 No 3 (2021): Supplementary Issue (The 4th National Pharmacy Conference 2021 Universitas Halu O Vol 7 No 2 (2021) Vol 7 No 1 (2021) Vol 6 No 2 (2020) Vol 6 No 1 (2020) Vol 5 No 2 (2019) Vol 5 No 1 (2019) Vol 4 No 2 (2018) Vol 4 No 1 (2018) Vol 3 No 2 (2017) Vol 3 No 1 (2017) Vol 2 No 1 (2016) Vol 1 No 2 (2016) Vol 1 No 1 (2015) More Issue