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Jurnal Farmasi Sains dan Praktis
Published by Universitas Muhammadiyah Magelang
ISSN : 25499068     EISSN : 25794558     DOI : -
Core Subject : Health, Science,
Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Farmasi Sains dan Praktis aims to serve the updated scientific knowledge for international researchers in pharmaceutical sciences. Jurnal Farmasi Sains dan Praktis (JFSP) publishes review article, original article, as well as short communication in the all scopes of Pharmaceutical Science such as Pharmaceutics, Biopharmaceutics, Drug Delivery System, Physical Pharmacy, Pharmaceutical Technology, Pharmaceutical Microbiology and Biotechnology, Pharmacology and Toxicology, Pharmacokinetics, Pharmaceutical Chemistry, Pharmaceutical Biology, Community and Clinical Pharmacy, Pharmaceutical Marketing, Alternative Medicines, Pharmaceutical Management, Pharmacoeconomic, Pharmacoepidemiology, Social Pharmacy, Pharmacy Policies.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 259 Documents
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ANTI-AGING PEEL-OFF MASK OF DRAGON FRUIT PEEL EXTRACT (HYLOCEREUS POLYRHIZUS) Wahdaningsih, Sri; Rizkifani, Shoma; Utari, Eka Kartika
Jurnal Farmasi Sains dan Praktis Vol 9 No 3 (September-December 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i3.8837

Abstract

Antioxidants can be used to protect the skin from damage caused by oxidation to prevent premature aging. The more increasing consumption level of red dragon fruit (Hylocereus polyrhizus) affects the amount of unused remaining fruit peels. In fact, the peel of red dragon fruit is considerably potential for natural antioxidant. Pitaya or dragon fruit is reported to contain betacyanin color pigment, with antioxidant activity. The use of cosmetics containing antioxidant compounds can prevent premature aging due to free radicals. One of the interesting forms of cosmetic preparations for skin care is the peel-off gel mask. The base that can be used as a film former for peel-off gel facial masks is polyvinyl alcohol (PVA). This study aims to determine the effectiveness of red dragon fruit peel extract peel-off masks as anti-aging. Anti-aging effectiveness testing was carried out on 10 volunteers and divided into two groups, namely the blank group (F0) and the extract group (FIII) for four weeks, and anti-aging activity was measured using a skin analyzer). Based on the results and discussions in this study, it can be concluded that the application of a peel-off mask of red dragon fruit peel extract (Hylocereus polyrhizus) is effective for repairing the skin and providing an anti-aging effect.
SAGO STARCH AND SODIUM ALGINATE AS NATURAL CROSSLINKING FOR CAPSULE ALTERNATIVES Harimurti, Sabtanti; Mulyanti, Amelia Nur'afni; Kusnindyasita, Anisa; Widada, Hari; Febriansah, Rifki; Suwanda, Totok; Muhtadi, Muhtadi
Jurnal Farmasi Sains dan Praktis Vol 9 No 3 (September-December 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i3.8856

Abstract

Capsule shells are generally made from gelatin. The gelatin that is spread in the world is commonly derived from pigs. This animal is forbidden to be consumed by Muslims. This issue is due to the halal aspect. Sago starch and sodium alginate are halal materials that are capable of gelatinizing. This property made it able to be molded as a capsule. This research aims to determine the formula of sago and sodium alginate as a capsule and the evaluation. Three formulas were made with the ratio of sago and sodium alginate 100%: 0% (formula 1), 50%: 50% (formula 2), and 0%: 100% (formula 3). The capsule was manually molded using a food-grade stainless steel capsule mold. The size of the capsule, weight uniformity, swelling, and disintegration time were determined for a physical evaluation. SLD was used to determine the best formula, and the validation was done using One-sample T-test. The evaluations of the capsule shell were found ranged as follows: the size specifications were 21-22 mm, the body diameter was 6.1-7.2 mm, the cap diameter was 13.6-13.8 mm, weight uniformity was 0.10-0.26 gram, the swelling test was 433-1583%, and the disintegration time was 10.20-14.43 minutes. The best formula based on the SLD of the experiment was formula 3, which are two parameters that met the requirements, i.e., swelling and disintegration time. The sago and sodium alginate were crosslinked, and the capsule was made. However, the performance dislike of gelatin capsules. Continued research shall be done to find the optimum formula and its characteristics for alternative material on halal capsules.
APPLICATION OF LAKES SYSTEM IN PREPARATION OF HAIR DYES POMADE CREAM OF FREEZE-DRIED RED DRAGON (Hylocereus polyrhizus) FRUIT PEEL JUICE AND ACUTE DERMAL IRRITATION Prihantini, Malinda; Ikhsan, Muhammad; Karim, Hasan Abdul; Rianis, Sindi Fadillah; Sobari, Sobari; Rheza, Faykar
Jurnal Farmasi Sains dan Praktis Vol 10 No 1 (January-April 2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v10i1.8889

Abstract

Dyes used in market products are mostly synthetic, which can irritate the skin and in the long term increase the risk of skin cancer. The peel of dragon fruit contains the red-violet pigment Betacyanin, which is potential as hair dyes but extremely sensitive to light and oxygen. The lakes system is the option to overcome the problem and increase the stability of pigments. The objective of this study was to learn about the use of the lakes system in the preparation of hair dyes pomade cream of freeze-dried red dragon fruit peel juice and its irritation aspect on skin. The lakes system was made with a 50% red dragon fruit peel juice, mixed with 5% alucol, then dried with 45% aerosil. Pomade cream was prepared by mixing oil phase and water phase at a temperature of ±60 °C with continuous mixing in 600 rpm for 10 minutes. Formula III is the bases without freeze-dried red dragon fruit peel juice. The non-lakes system of freeze-dried red dragon fruit peel juice was added to the bases for the FII, while the lakes system was added for the FI. Hair dyes pomade cream of red dragon fruit peel juice prepared in the lakes system has superior properties to the formula prepared without the lakes system. It demonstrated better homogeneity and softer texture, in addition acceptable skin pH range. The lakes system is suitable for the preparation of natural hair dye cream and does not irritate the skin.
OPTIMIZATION OF DICLOFENAC POTASSIUM TRANSDERMAL PATCH FORMULA USING A COMBINATION OF POLYVYNIL PYRROLIDONE K 30, ETHYL CELLULOSE AND MENTHOL WITH SIMPLEX LATTICE DESIGN METHOD Gunawan, Sahrul; Supriyadi, Supriyadi; Kuncahyo, Ilham
Jurnal Farmasi Sains dan Praktis Vol 10 No 1 (January-April 2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v10i1.8956

Abstract

Diclofenac potassium is one of the NSAID drugs which can cause gastrointestinal irritation and damage to the small intestinal mucosa including erosion and ulceration. The purpose of this study was to determine the effect of the combination of PVP K 30, ethyl cellulose and menthol on organoleptic, thickness, weight uniformity, moisture and folding resistance of diclofenac potassium transdermal patch.This research is an experimental study that includes an experiment to optimize the formulation of a transdermal patch preparation with the active ingredient potassium diclofenac and a combination of PVP K 30, ethyl cellulose and menthol. The optimization method uses the simplex lattice design method. There are 13 formula designs consisting of a combination of PVP K 30, ethyl cellulose and menthol. Each formula was tested for organoleptic, thickness, weight uniformity, moisture and folding resistance. Then the optimum formula was determined and analyzed using the simplex lattice design method. The combination of PVP K 30, ethyl cellulose and menthol with a simplex lattice design has an effect on the transdermal patch of diclofenac potassium which increases the consistency of the patch surface, reduces the thickness directly proportional to the weight of the patch and increases folding resistance. The proportion of PVP K 30, ethyl cellulose and menthol that can produce the optimum formula for diclofenac potassium transdermal patches with the simplex lattice design on the critical parameters of thickness, moisture, folding resistance and penetration tests, namely PVP K 30 of 14.87%, ethyl cellulose of 10.00% and 5.13% menthol.
OVERVIEW OF FACTORS INFLUENCING DRUG MANAGEMENT AT PRIMARY HEALTH CENTERS IN INDONESIA: A SYSTEMATIC REVIEW Khasanah, Uswatun; Yasin, Nanang Munif; Satibi, Satibi
Jurnal Farmasi Sains dan Praktis Vol 9 No 3 (September-December 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i3.9125

Abstract

Drug management is part of pharmaceutical service activities, which includes interrelated stages: selection, planning, requesting, receiving, storage, distribution, controlling, recording, reporting, monitoring and evaluation, which play an essential role in ensuring the availability of drugs at PHCs. The systematic review aims to identify indicators of drug management at PHCs in Indonesia and analyze factors that influenced it. This systematic review used the PRISMA methods. Google Scholar is an electronic database to identify related studies. This study is limited publications from 2013 to 2023. The quality of the articles was assessed using JBI Critical Appraisal. The electronics database search earned 570 articles, while only nine articles met the criteria for analysis. Several indicators are different from the standards used due to several factors. Based on the result, factors influencing drug management at PHCs include human resources, financing, information management, facilities, and technology. For most of them, human resources are a determining factor that significantly influences the quality of pharmaceutical services at PHC’s in Indonesia. The implementation of pharmaceutical services at the PHCs must be carried out by at least one pharmacist, the person in charge, who can be assisted by pharmaceutical technical staff as needed. Resources humans influence indicators of planning accuracy; suitability of requests; storage; distribution; control; recording, reporting, and archiving. This study's results are to make improvement strategies, including interventions to improve the quality of pharmaceutical services that impact community satisfaction and stakeholders.
IN SILICO STUDIES FOR ANTI-BREAST CANCER ACMELLA OLERACEA (L.) FLOWERS Amrilah, Muhammad Shofi; Hilman, Rifqi
Jurnal Farmasi Sains dan Praktis Vol 10 No 1 (January-April 2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v10i1.9145

Abstract

The study of the efficacy of Acmella oleracea (L.) flowers on breast cancer is still in its early stages. The molecular interaction mechanisms underlying Acmella oleracea's anti-breast cancer activity will be elucidated using in-silico analysis. For this study, seventeen bioactive compounds were used: spilanthol, alpha- and beta-amyrin ester, stigmasterol, beta-sitosterol, alpha-1-sitosterol, 3-acetylaleuritic acid, scopoletin, vanillic acid, trans-ferulic, (72,9E)-2-oxo-undeca-7,9-dienyl 3-methylbut-2-enoate, beta-caryophyllene, beta-pinene, myrcene, caryophyllene oxide, and limone Canonical smiles were obtained from PubChem and inserted into the PASS server to determine biological activity. Several compounds were docked with protein targets, such as ESR1, MAP2K2, and PGR. We used Pyrx 0.8 software for anchoring molecular interaction and Discovery Studio software to visualize the complex binding. In terms of Antineoplastic, apoptosis agonist, caspase-3, caspase-8 stimulant, ovulation inhibitor, steroid synthesis inhibitor, and TP53 expression enhancer, all the compounds tested positive for anticancer activity. According to Swiss ADME and protox analysis, Acmella oleracea flowers have the potential to modulate apoptosis and cell growth. More research is required to confirm the role of Acmella oleracea bioactive compounds in developing target cancers. The study reveals that Acmella oleracea has numerous bioactive chemicals advantageous for cancer therapy by inducing apoptosis through interaction with ESR1, MAPK2, and PGR protein.
A SYSTEMATIC REVIEW: MECHANISM OF ACTION ORAL AND TOPICAL RETINOL (Retinyl palmitate) AS A THERAPY OF ACNE SKIN IN BEAUTY PRODUCTS Yanuar, Rizqi Fitria; Indrayudha, Peni
Jurnal Farmasi Sains dan Praktis Vol 9 No 3 (September-December 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i3.9185

Abstract

Acne is one of the dermatological diseases that often appears in adolescence to adulthood. Retinol (retinyl palmitate) is a first-generation vitamin A derivative used for acne therapy by reducing sebum production which can cause acne bacteria to grow. This study aims to determine the effectiveness and safety of oral and topical retinol preparations. The method used in the study is systematic review using the PubMed search engine and google scholar according to keywords using the PICO method. Articles that can be downloaded with a period of 2013-2023 for the next article are downloaded in selection according to the criteria, namely inclusion and exclusion. The results of the selection of inclusion criteria there are 12 journals to discuss the effectiveness and safety related to topical preparations and peroral retinol as anti-products acne. The mechanism of action of topical retinol is to reduce the production of micro-comedones caused by the bacteria Propionibacterium acnes (P. acne) for oral retinol has the mechanism of action works by inhibiting the production of sebum by androgen hormones in the 3-alpha-hydroxysteroid oxidation pathway using the enzyme retinol dehydrogenase to retinaldehyde to be able to dissolve and be delivered at the destination. Oral or topical retinol preparations provide different side effects. Topical retinol has a lower rate of side effects compared to oral retinol. The level of safety and effectiveness of topical retinol preparations is better than oral retinol.
FORMULATION AND ANTIOXIDANT ACTIVITY TEST OF FACE TONER EXTRACT PREPARATION FROM 70% ETHANOL OF CUCUMBER FRUIT (Cucumis sativus L.) Safitri, Meta; Sauri, Sufyan; Kuncoro, Banu; Aprilliani, Arini
Jurnal Farmasi Sains dan Praktis Vol 10 No 2 (May-August 2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v10i2.9205

Abstract

Cucumber (Cucumis sativus L.) is a natural ingredient with potential therapeutic properties for addressing various skin-related problems. The study aims to identify a suitable formulation for a facial toner extract that exhibits favourable physical properties as determined by organoleptic, homogeneity, pH, and hedonic testing. The present study employed an experimental approach to produce a 70% ethanol extract of cucumber fruit through the maceration method, utilising 70% ethanol solvent. Subsequently, the extract derived from the cucumber fruit developed four formulas to prepare face toners. The concentrations of these formulas were designated as F0 (0%), FI (0.5%), F2 (1%), F3 (1.5%), and F4 (utilising brand x toner as a positive control). The physical evaluation test yielded the fulfilment of the physical criteria for the toner, encompassing the organoleptic, homogeneous, pH, and hedonic tests. The IC50 values obtained from the antioxidant activity test conducted on face toner preparations containing cucumber fruit extract at concentrations of 0.5%, 1%, and 1.5% were found to be 128 ppm, 91.017 ppm, and 62.218 ppm, respectively. The SPSS analysis reveals a significant difference in the IC50 value among the various formulas. Specifically, F3 exhibits a smaller IC50 value than the other formulas, indicating a stronger antioxidant activity. It is important to note that a smaller IC50 value indicates a stronger antioxidant activity. The study's findings suggest a positive correlation existing between the extract's concentration and its antioxidant activity, specifically, the extract denoted as F and administered at a concentration of 1.5%.
EFFECT OF CHITOSAN CONCENTRATION ON PHYSICAL CHARACTERISTICS OF EXTRACT ETHANOLIC OF BAY LEAF (Syzygium polyanthum) NANOPARTICLE PREPARED BY CROSS-LINKING METHODS Rahayyu, Annisa Maulidia; Hidayati, Evi Nurul; Masruriwati, Eni
Jurnal Farmasi Sains dan Praktis Vol 10 No 2 (May-August 2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v10i2.9233

Abstract

Chitosan is a natural cationic polysaccharide that could form bonds with negatively charged polyanions like sodium tripolyphosphate (STPP) as a crosslinker. One of the important factors to develop nanoparticles is the concentration of polymer. The increased polymer concentration will increase the viscosity of the solution formed, and the size of the nanoparticles created will increase. However, if the amount of polymer is too small, the particles formed are smaller, and aggregation could be formed. In this study, the ethanolic extract of bay leaf (Syzygium polyanthum) was used as a drug that has a potent anti-dyslipidemia effect by lowering cholesterol and triglyceride levels. Studies on the ethanolic extract of a bay leaf as an anti-dyslipidemia are still limited. The objective of this research was an investigate effect of the chitosan concentration used 0.6 mg/ml (F1); 1mg/ml (F2); and 1.4 mg/ml (F3) on the physical characteristics of ethanolic extract of bay leaf (Syzygium polyanthum) nanoparticles (NSPs) prepared by cross-linking methods. The result of particle size evaluation showed that the particle size was 665.1 nm ± 14.71 (F1); 180.1 nm ± 0.5; and 221.35 nm ± 1.91 (F3), while the polydispersity index F1, F2, and F3 were 0.773 ± 0.152; 0.220 ± 0.016; and 0.212 ± 0.024 respectively. The results of this study found F2 was the most optimal chitosan concentration with particle size under 200 nm, and polydispersity index under 0.5 with positive ζ-potential value. In conclusion, chitosan concentration showed has an effect on the physical characteristics of the nanoparticles.
A STUDY OF DRUG RELATED PROBLEMS IN CHRONIC KIDNEY DISEASE PATIENTS IN HOSPITAL Sholihah, Inayatush; Salindri Pratama, Tiara Dewi; Ikakusumawati, Novita Dhewi; Rahardjoputro, Rolando
Jurnal Farmasi Sains dan Praktis Vol 10 No 2 (May-August 2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v10i2.9348

Abstract

Patients with chronic kidney disease experience decreased kidney function (as an organ of elimination) and receive various drugs, so they are susceptible to Drug Related Problems (DRP). This study aimed to identify the type of potential DRP and analyzed the influence of gender, age, number of drugs, co-morbidities and length of stay on the incidence of DRP in hospitalized chronic kidney disease patients. This study was a cross-sectional study with retrospective data collection. The subjects of the study were chronic kidney disease patients who underwent hospitalization at a hospital in Surakarta at 2016-2021. The incidence of DRP was analyzed descriptively using the PCNE V9.1 algorithm, while the associations between risk factors and the incidence of DRP was analyzed statistically using the Fisher’s Exact Test. Data were obtained from 54 patients whose progress was followed up through medical record. The results showed that 36 patients (66.67%) had DRP while 18 patients (33.33%) did not. In the Problem category there were 22 events while in the Cause category there were 34 events. The results of statistical analysis using the Fisher's Exact Test showed that there were no significant associations between the risk factors (gender, age, number of drugs, number of co-morbidities, length of stay) and the incidence of DRP in hospitalized chronic kidney disease patients.

Page 22 of 26 | Total Record : 259

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