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Hang Tuah Medical Journal
Published by Universitas Hang Tuah
ISSN : 16931238     EISSN : 25984861     DOI : https://doi.org/10.30649/htmj.v19i2
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health
Hang Tuah Medical Journal: is published by Faculty of medicine, Universitas Hang Tuah with p-ISSN: 1693-1238 e-ISSN: 2598-4861. Its disciplinary focus is medical science and speciality in bio marine science. Hang Tuah Medical Journal is published in English and Indonesia for May and November. Each 90-100 page edition contains between nine and eleven scientific articles on research, case reports and study literature. Contributors of Hang Tuah Medical Journal included: medical researchers, dental practitioners, lecturers, and students drawn from Indonesia and a wide range of other countries. Hang Tuah Medical Journal as the open-access journal has been indexed by SINTA-Science and Technology Index, Garuda, Google scholar Hang Tuah Medical journal has been certificated as a Scientific Journal by Sinta (Science and Technology Index) S5 . valid until Volume 17 No.1, 2017.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 161 Documents
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Pengaruh Alginat dari Alga Coklat (Sargassum sp) terhadap Penyembuhan Luka Diabetes Melitus pada Tikus yang Diinduksi Streptozotocin TAUFAN ANTARISKA; NITA PRANITASARI; JUDYA SUKMANA; IRMA ANDRIANI PASARIBU
HANG TUAH MEDICAL JOURNAL Vol 19 No 2 (2022): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v19i2.212

Abstract

Diabetes mellitus is a degenerative disease which its prevalence increases over time, this disease is often overlooked, thereby increasing complications. Uncontrolled long-term hyperglycemia will cause sensory nerve and blood vessel function disorders. Disruption of the non-healing chronic wound reparation process due to this condition will result in excessive ROS level accompanied by secondary infection, increasing the risk of amputation and death. On the other hand, alginate produced by the cell walls of brown algae (Sargassum sp) is believed to be able to increase the formation of new blood vessels, balance excessive ROS level, and prevent infection at the wound site. This study was conducted to examine the effect of topical alginate on wound healing in diabetic rats. The population in this study includes articles that discuss wounds healing process in diabetic rats induced by streptozotocin (STZ) given alginate therapy. The research sample was obtained from data that had been affixed in 15 international research articles indexed by Scimago from 2016 to 2021. The method used in this study was a literature review. This research took place from May to December 2021.The results of the 15 articles reviewed revealed that alginate could improve wound healing in STZ-induced diabetic rats, this was indicated by decrease in duration of wound closure and inflammation, increase proliferation of epithelial cells and collagen density, and prevent the occurrence of secondary infection at the wound site. Based on these findings, it was concluded that topical administration of alginate had a good effect on the wound healing process of STZ-induced diabetic rats. Keywords: Alginate; diabetic mice; streptozotocin; wound healing
Pengaruh Ekstrak Minyak Ikan Patin Terhadap Kadar Kolesterol Hdl Rattus Norvegicus yang Diinduksi Aloksan TEO AL_ABDUL; FITRI HANDAJANI; TRI MARTINI SUMARNO
HANG TUAH MEDICAL JOURNAL Vol 19 No 2 (2022): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v19i2.222

Abstract

Diabetes mellitus is a chronic condition due to insufficient amount of insulin produced by the pancreas. This condition can cause dyslipidemia. This study aimed to observe the effect of catfish (Pangasius sp) fish oil extract on HDL cholesterol level in male white rat (Rattus norvegicus) with alloxan-induced diabetes model. Alloxan was used to create diabetic conditions in the rats and the administration of catfish oil extract which contain omega-3 was expected to increase HDL cholesterol level. This is an experimental laboratory study carried out in the Biochemistry Laboratory Hang Tuah Medical Faculty from the beginning of May 2021 to the end of December 2021. Twenty seven male white rats selected based on the simple random sampling method divided into 3 groups: the negative control group with standard feeding and PDAM drinking water, the positive control group induced by alloxan 150 mg/kgBW, and the treatment group induced by alloxan 150 mg/kgBW and 3 days later given catfish (Pangasius sp) fish oil extract 73 mg/kgBW for 14 days. At the end of the study HDL cholesterol levels were measured in all sample. Data analysis showed lower HDL cholesterol levels in the positive control group (mean=20.78 mg/dl) than in the negative control group (mean=31.00 mg/dl) significantly (p = 0.004) and higher HDL cholesterol levels in the treatment group (mean=27.00 mg/dl) than in the positive control group (mean=20.78 mg/dl) athough the increase was not significant (p = 0.91). Conclusion of this study: the administration of catfish fish oil extract (Pangasius sp) dose of 73 mg/kgBW in alloxan induced male white rats (Rattus norvegicus) wistar strain increase HDL cholesterol levels although not significantly. Keywords : Pangasius sp, HDL Cholesterol level, Rattus norvegicus, Alloxan.
Hubungan Pemberian Terapi Oksigen Hiperbarik Terhadap Aktifitas Osteoblastik Dan Osteoklastik Pada Tikus Model Fraktur CALVIN JUSO HANDONO; TOTOT MUDJIONO; ANNISA ULLYA RASYIDA
HANG TUAH MEDICAL JOURNAL Vol 19 No 2 (2022): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v19i2.267

Abstract

Background : Fracture is a condition where the bone is cut off due to significant pressure which can be in the form of bending, twisting, or pulling due to trauma, work accidents, traffic accidents, as well as degeneration and pathological processes. Fractures can result in loss of productivity and individual disability. One of the adjuvant therapies to accelerate the bone healing process in patients with fractures is hyperbaric oxygen (HBO) therapy. Objective: The purpose of this study was to determine the effect of Hyperbaric Oxygen therapy on the amount of osteoblasts and osteoclasts formed in ratsmodeled with diaphyseal femur fractures. Methods: This research is an experimental study using a post test only control group design. The object of this study is a rat fracture model with TOHB therapy as the independent variable and a fracture model without HBO therapy as a control variable. Results: The results of this study showed positive results on the effect of HBO therapy on the formation of osteoblastic and osteoclastic cells. Conclusion: There was a significant difference in the number of osteoblast and osteoclast in fracture model mice treated with HBO compared to those not treated with HBO. Keywords: HBO therapy, Fracture, Callus, Osteoblast, Osteoclast, Wistar Rat
Pengaruh Pengetahuan Hygiene Saat Menstruasi Terhadap Kejadian Fluor Albus pada Siswi Kelas 8 dan 9 di SMPN 1 Sidoarjo FAIZAH ALDA SARASWATI; ANNISA ULLYA RASYIDA; EFYLUK GARIANTO
HANG TUAH MEDICAL JOURNAL Vol 19 No 2 (2022): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v19i2.318

Abstract

Personal hygiene was very important, especially for young women who were menstruating. Poor hygiene could cause symptoms or diseases, especially those that could attack the female reproductive organs. One of the symptoms due to not maintaining personal hygiene during menstruation was vaginal discharge. However, every woman had experienced vaginal discharge or fluorine albus. Fluor albus was divided into 2, namely physiological or normal vaginal discharge and pathological or abnormal vaginal discharge. The purpose of this study was to analyze the effect between hygiene knowledge during menstruation and fluor albus incidence on 8th and 9th grade students 1 Sidoarjo. This study used an observational analytic design by means of cross sectional data collection. The number of research subjects was 78 students with the sampling technique using consecutive sampling. Data collection was conducted by distributing questionnaires online via Google form (gform) site aimed at the research sample. The results showed that the majority of respondents in this study had sufficient knowledge of hygiene during menstruation as many as 47 respondents with a percentage of 60% and as many as 43 respondents with a percentage of 55% experienced pathological or abnormal fluor albus. Furthermore, a statistical test was conducted using Chi-square showing that the influence between variables had a significant value of 0.604 (p >α). The conclusion of this study showed there is no effect, between hygiene knowledge during menstruation and fluor albus incidence on 8th and 9th grade students at SMPN 1 Sidoarjo.
Korelasi Pengetahuan Gizi Ibu dengan Kejadian Stunting Balita di Puskesmas Sawan 1 Bali ERNY ERNY; RIKA INDAH; AYLY SOEKANTO
HANG TUAH MEDICAL JOURNAL Vol 19 No 2 (2022): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v19i2.320

Abstract

Abstract Background: Stunting is a chronic nutritional disorder caused by many factors and has a long-term impact. Causes are very diverse and must identify to determine treatment. A mother's knowledge about nutrition is one factor that plays an essential role in preventing and overcoming stunting. Method: quantitative analysis with a cross-sectional approach to finding the correlation between mothers' knowledge about nutrition and the incidence of stunting in toddlers at the Sawan 1 Public Health Center, Buleleng Bali. Results: The statistical analysis showed that p-value of 0.007, which means a relationship between a mother's knowledge about nutrition and the incidence of stunting in children under five at the Sawan 1 Public Health Center, Buleleng Regency, Bali Province. Conclusion: Mother's knowledge about nutrition for toddlers is highly correlated with the incidence of stunting in toddlers at the Sawan 1 Public Health Center, Buleleng Bali.
Efek Pemberian Infusa Daun Carica papaya Terhadap Perkembangan Vektor Larva Nyamuk Aedes aegypti VINA LIDYA SETJAPUTRA; STEVEN CHRISTIAN SUSIANTO; RISMA
HANG TUAH MEDICAL JOURNAL Vol 20 No 1 (2022): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v20i1.183

Abstract

Background: Vector eradication is the most effective strategy to prevent Dengue Hemorrhagic Fever, particularly larvae elimination by larvicide. The papaya leaf (Carica papaya) contains several chemicals used as a larvicidal agent. This study aimed to determine the larvicidal activity of papaya leaf (Carica papaya) infusion against third instar Aedes aegypti larvae as dengue hemorrhagic fever prevention. Method: This was an experimental laboratory study with a post-test-only control group design. We used the third instar of Aedes aegypti mosquito larvae, divided into seven treatment groups, one positive control group, and one negative control group, containing 25 larvae each. The treatment groups were given papaya leaf infusion with concentration of 4%, 4,5%, 5%, 5,5%, 6%, 6,5%, 7%, respectively. The negative control group did not receive any treatment, and the positive control group received Temephos with 1 ppm dose. Larvae mortality was recorded after 24 hours, and we replicated the experiment 3 times. The mortality data were analyzed using a one-way ANOVA test for normally distributed and Kruskal Wallis for not normally distributed. Results: There were no significant differences between treatment groups and negative control group, except in concentration of 6,5% (p=0,034) and 7% (p=0,037) group, and significant differences between all treatment groups compared to the positive control group (p<0,05). Conclusion: Papaya leaf infusion as Aedes aegypti larvicide in concentrations of 6,5% and 7% showed a significant effect on larvae mortality after 24-hour. However, compared to Temephos, it was a less larvicidal effect.
Hubungan Status Gizi Pasien Penyakit Hirschsprung dengan Infeksi Luka Operasi di RSPAL dr. Ramelan Surabaya Periode Waktu 2016-2020 PUTU SITHA AISHWARYA SARASWATI GIUR Giur; SAPTA PRIHARTONO RACHMAN; DIAH PURWANINGSARI; PRAWESTY DIAH UTAMI
HANG TUAH MEDICAL JOURNAL Vol 20 No 1 (2022): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v20i1.279

Abstract

Background: Hirschsprung's disease is a congenital intestinal motility disorder that causes functional intestinal obstruction due to the absence of enteric ganglion cells in the distal intestine. The management of each case of Hirschsprung's disease is surgery, where surgery on the digestive tract increases the occurrence of surgical site infections. Disturbances in the gut cause decreased resistance to infection, delayed cognitive development, and problems with nutritional status. Methods: This study was a descriptive and analytical observational study, where the primary data were taken from the registration data of Hirschprung's disease patients at RSPAL dr. Ramelan Surabaya in 2016-2020. The nutritional status of the patient was determined by plotting the weight per age curve according to WHO for children aged 0-5 years. Results: Observations of 38 patients who met the study requirements, obtained 4 patients who had poor nutritional status and 1 patient who had excess nutritional status, none of which experienced complications in the form of surgical wound infections. In 10 patients with poor nutritional status, 2 experienced complications in the form of surgical wound infection and 23 patients with good nutritional status, 1 experienced complications in the form of surgical wound infection. The results of the contingency coefficient correlation test showed P-value = 0.408 (p>α). Conclusion: There was no relationship between the nutritional status of Hirschprung's disease patients with surgical wound infections at RSPAL dr. Ramelan Surabaya Keywords: Hirschsprung's disease, nutritional status of children, surgical site infection.
Analisis Beberapa Jenis Vaksin Covid-19 yang akan Dipakai di Indonesia MASFUFATUN; NI PUTU MANIK SURYANINGSIH; I MADE DWIKY KARINA JAYA; ALMAIDAH SAFITRI; TEOFILUS DANI PRASETYOADI; JAMES HADIPUTRA SUNARPO
HANG TUAH MEDICAL JOURNAL Vol 20 No 1 (2022): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v20i1.325

Abstract

At the end of 2019, there was a pandemic that originated in Wuhan, China. This pandemic is known as the corona virus / COVID-19. COVID-19 itself is caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2). In Indonesia alone, COVID-19 cases have reached 1.17 million and those who died have reached 31,976 people. From this case, experts are racing to find this COVID-19 vaccine. The COVID-19 vaccine itself is expected to control the spread of the virus in the world. This review article aims to discuss the various types of vaccines that will be used in Indonesia in terms of types, methods of action, efficacy, specificity, sensitivity, dosage, and side effects. The results of the review article show that vaccines are one of the most effective and economical methods. Various studies have been carried out by several experts from around the world to develop a vaccine for COVID-19. Each vaccine used has the same goal, namely to control the spread of the COVID-19 virus which is currently still a pandemic around the world. Based on the results of the review article, it can be concluded that all types of vaccines have their respective advantages and disadvantages. Thus, the community will not feel worried and are more confident in determining what kind of vaccine will be taken.
Pediatric Covid-19 Patients Laboratory Characteristics in Dr.Ramelan Central Navy Hospital: A-Year Epidemiology Study RETNO WISANTI; RUSDIAN NIATI NINGSIH
HANG TUAH MEDICAL JOURNAL Vol 20 No 1 (2022): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v20i1.326

Abstract

Covid-19 in children has several different characteristics with the adults, from clinical manifestation to laboratory result. There is also challenges in Covid-19 diagnosis in children with their inability to describe their condition clearly. Laboratory examination used to confirm the diagnosis, but the accuracy still in doubt. We aims to describe the laboratory examination result of pediatric Covid-19 patients. We analyze the medical records of 69 children with suspect Covid-19 who hospitalized in isolation room in a year period, from May 2020 to April 2021. All of the suspect patient were examined by PCR test, rapid antibody test, chest x-ray, and complete blood count. 40 patients were Covid-19 positively-confirmed by the PCR test. Chest x-ray gave better sensitivity and specificity for early screening than rapid antibody test. The complete blood count gave normal results in general, only slight relative lymphocytosis occurred. The neutrophilia and lymphopenia pattern in adults with Covid-19 are different with the children’s result. The increase of NLR, who commonly used as an early screening test in adult Covid-19, cannot be used in children. The lower inflammatory response and physiologically higher lymphocyte cell count in younger age explain these results. In conclusion, the laboratory test should be performed for pediatric Covid-19 cases, but not for confirm the diagnosis.
Faktor-Faktor yang Berhubungan Dengan Kejadian Proteinuria pada Pasien Diabetes Melitus di Puskesmas I dan IV Denpasar Selatan PUTU ARYA SURYANDITHA; NI MADE DHANISWARA PUTRI WIRAWAN; DEWA AYU PUTRI SRI MASYENI
HANG TUAH MEDICAL JOURNAL Vol 20 No 1 (2022): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v20i1.331

Abstract

Diabetes Mellitus (DM) is a major health problem in the world. Various complications can arise due to uncontrolled blood sugar levels. One of the complications of DM involving the kidneys is diabetic nephropathy, which is characterized by the occurrence of proteinuria in DM patients. This study aims to determine the factors associated with the incidence of proteinuria in patients with diabetes mellitus at Puskesmas I and IV Denpasar Selatan. The design in this study is an analytical study with a cross sectional approach using primary data obtained from interviews and urinalysis examinations. The minimum sample size in this study was 106 people who met the inclusion and exclusion criteria. Data were analyzed using Chi Square test with a significance level of 5%. The number of respondents in this study were 106 respondents. The results of this study showed that as many as 33% of all DM patients had proteinuria. There is a significant relationship between the onset of DM and the incidence of proteinuria (p<0.05), so it can be interpreted that the longer the duration of experiencing DM, the incidence of proteinuria will increase, and vice versa. There was no significant relationship between age, gender, BMI, type of DM therapy, and fasting blood glucose levels with the incidence of proteinuria (p>0,05). Patients with diabetes onset more than 10 years tend to have proteinuria. DM patients are advised to do regular proteinuria checks if the onset of DM is more than 5 years.

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