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Murdani Abdullah
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Divisi Gastroenterologi, Departemen Ilmu Penyakit Dalam, FKUI/RSUPN Dr. Cipto Mangunkusumo, Jl. Diponegoro No. 71 Jakarta 10430 Indonesia
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INDONESIA
The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Published by The Indonesian Society for Digestive Endoscopy
ISSN : 14114801     EISSN : 23028181     DOI : -
Core Subject : Health,
Medicine & Pharmacology
The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy is an academic journal which has been published since 2000 and owned by 3 Societies: The Indonesian Society of Gastroenterology; Indonesian Association for the Study of the Liver; The Indonesian Society for Digestive Endoscopy. The aim of our journal is to advance knowledge in Gastroenterology, Hepatology, and Digestive Endoscopy fields. We welcome authors for original articles, review articles, and case reports in the fields of Gastroenterology, Hepatology, and Digestive Endoscopy.
Arjuna Subject : Kedokteran - Ilmu Pencernaan
Articles 771 Documents
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Non-Cirrhotic Portal Hypertension: An Update of Diagnosis and Management Zulkifly, Steven; Hasan, Irsan
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 2 (2023): VOLUME 24, NUMBER 2, August, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2422023143-153

Abstract

Portal hypertension is not the only caused by liver cirrhosis. Non-cirrhotic portal hypertension (NCPH) is characterized by elevated portal pressure in the absence of cirrhosis and is often underdiagnosed in daily clinical practice. The clinical manifestations of NCPH are similar to liver cirrhosis. The diagnosis of NCPH is still challenging due to the various underlying etiologies and often require either non-invasive or invasive examination. Laboratory examination, abdominal ultrasound, endoscopic procedure, hepatic venous gradient measurement, and liver biopsy have role in diagnosis of NCPH. The principle management of NCPH is to treat portal hypertension and its complications, such as prophylaxis and acute management of variceal bleeding, anticoagulants, surgery, splenectomy, and liver transplantation.
Characteristics of Gastroesophageal Reflux Disease (GERD) Patients at RSUP Dr. M. Djamil Padang Period 2018-2021 Setiawan, Mentari Adinda; Fasrini, Ulya Uti; Amir, Arni; Muchtar, Masrul; Miro, Saptino; Endrinaldi, Endrinaldi
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 3 (2023): VOLUME 24, NUMBER 3, December, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2432023227

Abstract

Background: Gastroesophageal reflux disease (GERD), a common digestive problem, is increasing and affecting the individual’s quality of life. This study aimed to describe the characteristics of GERD patients at Dr. M. Djamil Central General Hospital.Method: This cross-sectional study used data from patients' medical records that involved 111 GERD patients, excluding chronic disease and pregnancy. The analysis used univariate analysis and performed the data in cross-tables.Results: The results indicated that demographically, nearly all of the samples fall within the range of productive age (94.59%), with a higher proportion of the female gender (54.05%), the majority having a middle education level (72.08%), being housewives (27.92%), and residing in Padang City (35.13%). Most of the main symptoms were heartburn (62.16%), followed by vomiting, nausea, and dysphagia (4.50%, 2.70%, and 1.80%). More patients received outpatient treatment with two visits (18.02%). Clinically, based on the BMI, the obese classification was higher (43.25%). The levels of triglycerides and total cholesterol in the blood of GERD patients were more in the normal category (60.60% and 61.80%), while the levels of HDL and LDL in the blood of GERD patients were in the abnormal category, with lower HDL (97.80%), and a higher LDL (72.70%).Conclusion: The majority of GERD patients were in the productive age group, female, middle level of education, housewives, and resided in Padang. Clinical characteristics of GERD patients included most were categorized as obese according to their BMI, main symptom heartburn, and treated as an outpatient. Triglyceride and total cholesterol were primarily normal; blood HDL and LDL were abnormal.
Secondary Prevention of Esophageal Variceal Bleeding Using Transjugular Intrahepatic Portosystemic Shunt Compared to Endoscopic Band Ligation plus Beta-Blocker Yo, Edward Christopher; Nursyirwan, Saskia Aziza
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 3 (2023): VOLUME 24, NUMBER 3, December, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2432023275

Abstract

Aim: This study aims to compare the effectiveness of transjugular intrahepatic portosystemic shunt (TIPS) against combination therapy in the secondary prevention of esophageal variceal bleeding.Method: Literature search was conducted using 4 databases (PubMed, Cochrane, Ovid MEDLINE, and Ovid Embase) and individual hand searching. The selected studies were then critically appraised for their validity, importance, and applicability.Results: A total of 136 results were retrieved, and 2 systematic reviews and meta-analysis of randomized controlled trials (RCTs) were selected. Both studies showed that TIPS significantly decreased incidence of esophageal variceal rebleeding but had no significant effect on reducing overall mortality when compared to combination therapy. Study by Lin et al found that TIPS was significantly better than combination therapy for reducing mortality from variceal rebleeding, but study by Jing et al found no significant difference.Conclusion: TIPS is superior to combination therapy in reducing the incidence of esophageal variceal rebleeding. Nevertheless, its effectiveness in reducing mortality needs further investigation. Future research should look into its complications and cost-effectiveness in developing countries like Indonesia.
Incidence and Characteristic of Gastroesophageal Reflux Disease (GERD): Before and During Covid-19 Pandemic Lubis, Masrul; Sianturi, Yolanda Anastasia
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 2 (2023): VOLUME 24, NUMBER 2, August, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2422023116-121

Abstract

Background: The incident numbers of gastroesophageal reflux disease (GERD) in Asia is increasing gradually from year to year. Activity restriction (lockdown) that happened during COVID-19 pandemic affects society’s eating habit and life style which are risk factors of GERD and the incidence of gastroesophageal reflux. This study was conducted to find the incidence and characteristics of GERD during COVID-19 pandemic and compared with the previous situation in patients who met the diagnostic criteria at H. Adam Malik General Hospital. Method: This research is a descriptive research study with a cross sectional design study where data were taken based on data from medical records at H. Adam Malik General Hospital in 2017–2022 with the sampling technique used is total sampling, where the research subjects were all patients diagnosed GERD that met the inclusion criteria.Results: The incidence of GERD before (2017–2019) and during the COVID-19 pandemic (2020–2022) were 21 and 37 patients respectively (there was a 76% escalation in the incidence of GERD during the COVID-19 pandemic compared to before the COVID-19 pandemic). The similar characteristics of GERD patients before and during the COVID-19 pandemic are age 40 years, work as an employee, high school graduate, and overweight body mass index (BMI).Conclusion: The incidence of GERD has increased during the COVID-19 pandemic compared to before the pandemic.
Relationship between Helicobacter pylori Infection and Gastroesophageal Reflux Disease (GERD) Halim, Silvikarina Erfanti Dewi
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 3 (2023): VOLUME 24, NUMBER 3, December, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2432023201

Abstract

Background: Helicobacter pylori infection is a gastrointestinal infection that affects about 50% of the world's population, however, its prevalence varies across geographic areas. The actual relationship of H. pylori with gastroesophageal reflux disease (GERD) is still unclear because some studies report a high prevalence of H. pylori in GERD patients, but some studies report the opposite. This study aims to determine the relationship between H. pylori infection and GERD and the prevalence of Helicobacter pylori infection in GERD patients at Eka Hospital Pekanbaru.Method: This study was a cross-sectional study of GERD patients who had undergone endoscopy at Eka Hospital Pekanbaru from January 2021 to December 2022. There were 219 patients. This research was then analyzed with the chi-square test using SPSS version 22.Results: A total of 219 GERD patients met the criteria for this study. 108 of them were positive for H. pylori from the results of endoscopic biopsies. The prevalence of GERD patients infected with H. pylori is 49.3%. 108 of them were positive patients, 14 (13%) GERD patients were ≥ 60 years old and 94 (87%) were 60 years old. Of the 108 positive patients, 53 (49.1%) were male, 55 (50.9%) were female. Where age and gender did not significantly increase the risk of H. pylori infection (p 0.05). The most common endoscopic biopsy finding is chronic erosive gastritis.Conclusion: Although the prevalence of GERD patients infected with H. pylori was quite large (49.3%), there was no significant association between GERD patients and the incidence of H. pylori infection.
A Bad GERD Is A Bad Life Utari, Amanda Pitarini
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 2 (2023): VOLUME 24, NUMBER 2, August, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2422023101

Abstract

Gut Microbiota and Non-Alcoholic Fatty Liver Disease: Current Pathogenic Paradigm and Therapeutic Aspect Maimunah, Ummi; Soelistijo, Soebagijo Adi; Hadisuwarno, Wiharjo; Miftahussurur, Muhammad
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 2 (2023): VOLUME 24, NUMBER 2, August, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2422023154-162

Abstract

Changes in the gut microbiota are essential factors that cause non-alcoholic fatty liver disease (NAFLD), obesity, and diabetes. Small intestine bacteria overgrowth is discovered in NAFLD patients. Disruptions in the gut-liver axis include environmental factors that induce microbiota dysbiosis and/or increased intestinal permeability that causes liver inflammation. The most recommended therapy for NAFLD patients is still limited to lifestyle changes. This review will describe the role of the gut microbiota in the pathogenesis and therapeutic intervention of NAFLD. Recent evidence reveals that the gut microbiota is one of the main factors in the pathogenesis and progression of NAFLD through several mechanisms, particularly dysbiosis. This significant role makes the gut microbiota a non-invasive biomarker for NAFLD examination and a more effective therapeutic target.
Current Diagnosis and Treatment of Choledocholithiasis Renaldi, Kaka; Firman, Fauzan Hertrisno
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 3 (2023): VOLUME 24, NUMBER 3, December, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2432023256

Abstract

The presence of gallstones in the common biliary duct is known as choledocholithiasis. Obstructive jaundice is the main clinical manifestation, which can cause acute cholangitis characterized by fever, jaundice, and right upper quadrant abdominal pain. The best diagnostic modality for choledocholithiasis is magnetic resonance cholangiopancreatography (MRCP). The treatment of choledocholithiasis involves extraction of gallstones using endoscopic retrograde cholangiopancreatography (ERCP), followed by stenting, and then cholecystectomy.
Acute Pancreatitis with Abdominal Bloating and Normal Transabdominal Ultrasound Halim, Silvikarina Erfanti Dewi
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 3 (2023): VOLUME 24, NUMBER 3, December, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2432023270

Abstract

Acute pancreatitis (AP) is an inflammatory disorder of the pancreas, and its correct diagnosis is an area of interest for clinicians. A 44-year-old man, presented with bloating for 1 month and getting worsened 1 day before admission to emergency room (ER), accompanied by discomfort in the upper left abdomen. The patient had abdominal distension, no vomiting or severe abdominal pain. Ultrasonography (USG) transabdominal revealed polyp gallbladder, no stone or pancreatitis. Magnetic resonance imaging (MRI) 2 months before at the ER, showed multiple stone in gallbladder and normal pancreas. Leukocytes 15 x 103/L, serum glutamic pyruvic transaminase (SGPT) 262, serum glutamic oxaloacetic transaminase (SGOT) 249, gamma glutamyl transferase (GGT) 1369 U/L, total bilirubin (TBIL) 2.44, direct bilirubin (DBIL) 2.08, lipase 14,690 U/L, amylase 3,693 U/L. Patient refused computerized tomography scan (CT scan) or MRI repeated, based on Atlanta criteria, abdominal discomfort with high amylase/lipase and a history of gallstones, the diagnosis was made. After 3 days, SGPT 44, SGOT 19, GGT 732 U/L, lipase 46 U/L, amylase 38 U/L. Based on Atlanta classification, AP diagnosed if at least 2 of the following 3 criteria are fulfilled: abdominal pain, serum lipase or amylase at least 3x the upper limit of normal (ULN) or characteristic findings on imaging. Gallstones are the most cause of AP. Abdominal bloating in this patient couldn’t be explained by common causes, such as ascites, bowel edema, hematoma, ileus which led us to suspect pancreatitis. CT scan contrast or MRI was essential in patients with normal USG and no classic sign abdominal pain.
Phenotype and Conditioning Medium on Umbilical Cord-Mesenchymal Stem Cell (UC-MSC) Kusnanto, Paulus; Purwanto, Bambang; Wasita, Brian; Widyaningsih, Vitri
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 2 (2023): VOLUME 24, NUMBER 2, August, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/2422023127-131

Abstract

Stem cells are unspecialized cells that differentiate into more specialized cells for various tissues in the human body. Stem cells have the characteristics and ability to become themselves by performing various mitoses and differentiating different cells. Stem cells also have great potential for tissue regeneration. Detection and isolation of specific cells is very important in understanding biological processes such as development, aging, regeneration, and cell pathogenesis. Therefore, stem cells are present as an invaluable therapeutic option. Before stem cells can be applied, it is important to know the characteristics of the specific function cells or phenotypic markers. Isolation and characteristics of stem cells on culture morphology or immunotaining on specific markers. Immunohistochemistry can provide a general description of the expression of markers in a cell under certain conditions. Surface markers are the basis for identifying the characteristics and isolation of stem cells. The basic characteristics of stem cells are one that influences the outcome of the therapy to be carried out. The presence of marker cell surface expressions can also be a differentiator in searching for the origin of the stem cells used6. MSC culture method was performed with DMEM + 5% HPL. UC-MSCs with phenotype differentiation were found to be CD73+, CD90+, CD105+, Lin- while the parameters found were IL-6, SDF-1, BDNF, FGF, NGF, IL-12p70, IL-23, IL-18, IL-10 , VEGF, EGF, IL-17A, IFN-, IL-1β, PDGF, MCP-1.The results obtained are in accordance with the standard content of UC-MSC cells which can be continued as cell research.

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