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Mandala of Health : A Scientific Journal

mandala
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Published by Universitas Jenderal Soedirman

ISSN : - EISSN : 26156954 DOI : https://doi.org/10.20884/1.mandala

Core Subject : Health,

Dentistry Health Professions Public Health

Mandala of Health : A Scientific Journal is a medical scientific journal with open access published by the Faculty of Medicine, Jenderal Soedirman University, containing research articles, systematic reviews, and case reports in all areas of basic medical science, clinical medicine, biomedical science, medical biotechnology, and public health.

Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)

Articles 131 Documents

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THE EFFECT OF CIPLUKAN EXTRACT (Physalis angulata L.) TO THE NUMBER OF FIBROBLASTS IN IMIQUIMOD INDUCES PSORIASIS MICE MODEL Irse Priyaganda Bani Musa; Thianti Sylviningrum; Dody Novrial; Muhamad Salman Fareza
Mandala Of Health Vol 14 No 1 (2021): Mandala Of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Imiquimod induces activation of Th17 cells and dendritic cells that play a role in psoriasis. Ciplukan extract ( Physalis angulata L.) contains steroid compounds, flavonoids, alkaloids, and saponins such as Physalin B, Physalin F, Physalin G which have anti-inflammatory activity in psoriasis pathophysiology. This research is an experimental research with post test only with control group design. Thirty five female mice were divided into 7 groups. Group A: negative control, group B: positive control, group C induced by imiquimod and given with ciplukan extract 400 mg/kg BW for 7 days, group D induced by imiquimod and given with ciplukan extract 800 mg/kg BW for 7 days, group E induced imiquimod and given with ciplukan extract 1,200 mg/kg BW for 7 days, group F induced by imiquimod and given with methotrexate 1 mg/kg BW for 7 days, and group G induced by imiquimod and given with a combination of ciplukan extract 1,200 mg/kgBW and methotrexate 1mg/kgBW for 7 days. 7 days. The number of fibroblast cells was counted on the fifteenth day by taken a sample of mouse skin and made histological preparations and then counted manually used a microscope. The mean number of fibroblast cells in groups A, B, C, D, E, F, and G were 21.6±2.3, respectively; 39.2±5.5; 30.6±1.3; 24.0±2.8; 24.8±2.9; 28,4±3,0;28,2±3,2 . The results of the test One Way ANOVA showed a value of p = 0.000 (p < 0.05), so that the results are significant. Keywords: ciplukan extract, fibroblast, methotrexate , Physalis angulata

THE EFFECT OF CIPLUKAN EXTRACT (Physalis angulata L.) AS ANTIPSORIATIC AND TO LYMPHOCYTES COUNT OF SKIN TISSUE IN PSORIASIS MICE MODEL Putri Nur'afni Sa'adah; Thianti Sylviningrum; Dody Novrial; Fajar Wahyu Pribadi; Wahyu Dwi Kusdaryanto; Muhamad Salman Fareza
Mandala Of Health Vol 14 No 1 (2021): Mandala Of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

ABSTRACT Psoriasis is a chronic skin disease in form of papule-shaped lesion and erythematous plaques with thick white scales. The pathogenesis of psoriasis involves IL-23/Th-17 cytokine pathway that contributes the activation of T-lymphocytes and proinflammatory cytokines. Treatment of psoriasis using methotrexate has inhibitory effect of the synthesis of nucleic acid towards T-lymphocytes and keratinocytes. Ciplukan (Physalis angulata L.) has anti-inflammatory potential effect which contains steroid, flavonoid, alkaloid, and physalin that may inhibit lymphocyte activation and proinflammatory cytokine production. The study is used the method of experimental study with post test only with control group design. Thirty five female mices were divided into 7 groups. The parameters of this study is anti-psoriatic (PASI and Baker’s score) and lymphocytes count in psoriasis mice model. The results of Kruskal-Wallis, PASI and Baker’s score showed that p=0,001 (p<0,05) and the result of lymphocytes count using One Way ANOVA showed that p=0,001 (p<0,05). The 800 mg/kgBW dose of ciplukan extract showed the largest decrease on PASI score and lymphocytes count, and the 1200 mg/kgBW dose one showed the largest decrease on the Baker’s score. The present of the 800 mg/kgBW dose of ciplukan extract gives the most optimal effect in reducing PASI score and skin tissue lymphocytes count in psoriasis mice model that were not significantly different with the treatment control group, while 1200 mg/kgBW dose one gives the most optimal effect in reducing Baker’s score that were significantly different with the treatment control group. Keywords: Ciplukan extract, lymphocytes, methotrexate, Physalis angulata L

RISK FACTORS ASSOCIATED WITH THE EVENT OF PROSTATE CANCER (CASE STUDY IN Prof. Dr. MARGONO SOEKARJO PURWOKERTO HOSPITAL) Viva Ratih Bening Ati
Mandala Of Health Vol 14 No 2 (2021): Mandala Of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

The incidence of prostate cancer (PCa) is closely related to increasing age and other factors such as family history, obesity, smoking habits, vasectomy history, and alcohol consumption. As the number of cases increases, understanding the risk factors associated with the incidence of PCa becomes very important. Therefore, this study was conducted to determine the risk factors for PCa in Prof. Dr. Margono Soekarjo Purwokerto’s Hospital as an approach to the identification and prevention of PCa events. Observational research using cased control was conducted at the Urology Surgery Polyclinic of Prof. Dr. Margono Soekarjo Purwokerto Hospital. 15 PCa patients and controls in the form of participants diagnosed with other cancers as many as 8 people. Univariate analysis using SPSS was conducted to determine the relationship of risk factors to the incidence of PCa with a significance of p<0.05. The results showed that some of the prominent characteristics of PCa respondents were age >60 years (66.7%), married (80%), not suffering from diabetes mellitus (93.3%), normal lifestyle (80%), and not consuming alcohol (100%). In the control group, age >60 years (62.5%), no family history of prostate cancer (100%), normal lifestyle (100%), and smoking (50%). From the results of the study, it was concluded that the characteristics of respondents in the case group were mostly aged > 60 years, had low education, worked as farmers, and had no history of prostate cancer in their family.

PROFILE OF CD14 PROTEIN EXPRESSION IN URINE OF PROSTATE CANCER PATIENTS: PRELIMINARY STUDY AS A NON-INVASIVE BIOMARKERS CANDIDATE DEVELOPMENT hajid rahmadianto
Mandala Of Health Vol 14 No 2 (2021): Mandala Of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Prostate cancer (Pca) is a malignancy with a high incidence and mortality accompanied by advanced stage conditions in Indonesia. The delay in diagnosis is due to the absence of specific non-invasive biomarkers that can detect Pca early. CD14 protein is known to play a major role in the occurrence of malignancy in Pca. However, the role and alterations expressions in the urine of Pca are unclear. This study uses an analytical observational study using urine samples to detect CD14 protein expression using Elisa.Twelve urine samples of Pca and BPH were collected after obtaining ethical clearance and informed consent to participate in this study. Bioinformatics analysis using the TCGA database determines how changes in CD14 expression in tissue samples and sequence changes due to mutations and their relationship with poor prognosis for patients.GO Functional Analysis was carried out to determine the mechanism and role of the CD14. Data analysis was performed using GraphPad PRISM version 6 (GraphPad Software Inc., La Jolla, CA) dan curve expert 1.4.patient characteristics showed the median age of Pca patients was 63.5 years compared to 64 years of BPH patients. Pca patients in the metastatic group dominant at ISUP grade 5 (25%).On average, Pca patients have higher CD14 rates (0.208 ng/mL) compared to BPH (0.114 ng/mL) (p <0.05).Alteration of CD14 expression is known to have a role in the inflammatory response and is closely related to poor prognosis with patient survival rates with increased CD14 expression (p < 0.5). The conclusion of this study shows an increase in CD14 protein expression in urine Pca and is related to changes in function and poor prognosis.

Profil Pasien Hospital-Acquired Pneumonia (HAP) Pasca Kraniotomi di ICU RSUD Prof.Dr.Margono Soekarjo Wisnu Budi Pramono; Shila Suryani; Hermin Prihartini
Mandala Of Health Vol 14 No 2 (2021): Mandala Of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Kraniotomi adalah tindakan yang banyak dilakukan di RSUD Prof.DR.Margono Soekarjo (RSMS) dan rentan terkena infeksi nosokomial, salah satunya adalah Hospital-Aqcuired Pneumonia (HAP). Berdasarkan HAP dibagi menjadi dua : pertama HAP karena penggunaan ventilator 48 jam, kedua HAP karena masa rawatan di rumah sakit. Penelitian ini bertujuan untuk mendapatkan profil HAP pasien pasca kraniotomi di ICU RSUP.Prof.Dr.Margono. Jenis penelitian ini adalah deskriptif retrospektif dengan metode non probability sampling. Sampel adalah pasien berusia diatas 18 tahun yang mengalami pneumonia pasca kraniotomi. Data diambil dari ruang IBS,IGD,ICU dan rekam medik RSMS. Hasil insidensi HAP pasca kraniotomi sebesar17%, angka kematian 39%, dengan usia terbanyak diperoleh 51-65 thn (41%), jenis kelamin laki-laki 61%, oprasi emergensi (61%), karna trauma(48%), dengan lama oprasi 2-4 jam(76%), preop GCS <9 (50%), perokok(33%), penyakit paru/trauma paru (13%), diabetes mellitus(9% ),peny jantung (17%), penggunaan ventilator 48 jam 43%, dan kadar albumin <2,5 g/dl (70%). Kuman hasil kultur adalah serretia mercescens (35%). Simpulan: Pasien HAP pasca kraniotomi di ICU RSMS banyak terjadi pada pasien usia 51-65 tahun, laki-laki, menjalani oprasi emergensi dengan penyebab trauma, preoperasi GCS <9, lama oprasi 2-4 jam, memiliki komorbiditas merokok atau diabetes melitus atau penyakit jantung, lama rawatan sebelum HAP > 7 hari, kadar albumin < 2,5 g/dl dengan perkiraan kuman terbanyak adalah serretia mercescens. peny jantung (17%), penggunaan ventilator 48 jam 43%, dan kadar albumin <2,5 g/dl (70%). Kuman hasil kultur adalah serretia mercescens (35%). Simpulan: Pasien HAP pasca kraniotomi di ICU RSMS banyak terjadi pada pasien usia 51-65 tahun, laki-laki, menjalani oprasi emergensi dengan penyebab trauma, preoperasi GCS <9, lama oprasi 2-4 jam, memiliki komorbiditas merokok atau diabetes melitus atau penyakit jantung, lama rawatan sebelum HAP > 7 hari, kadar albumin < 2,5 g/dl dengan perkiraan kuman terbanyak adalah serretia mercescens. peny jantung (17%), penggunaan ventilator 48 jam 43%, dan kadar albumin <2,5 g/dl (70%). Kuman hasil kultur adalah serretia mercescens (35%). Simpulan: Pasien HAP pasca kraniotomi di ICU RSMS banyak terjadi pada pasien usia 51-65 tahun, laki-laki, menjalani oprasi emergensi dengan penyebab trauma, preoperasi GCS <9, lama oprasi 2-4 jam, memiliki komorbiditas merokok atau diabetes melitus atau penyakit jantung, lama rawatan sebelum HAP > 7 hari, kadar albumin < 2,5 g/dl dengan perkiraan kuman terbanyak adalah serretia mercescens. Kata kunci : kraniotomi, HAP,VAP

IN SILICO PHYLOGENETIC ANALYSIS, CHEMORECEPTOR AND SIGNAL TRANSDUCTION OF BACTERIAL CONTAMINATION DENTAL UNIT tirta wardana
Mandala Of Health Vol 14 No 2 (2021): Mandala Of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

The importance of patient safety when carrying out dental and oral care processes is essential. However, the high levels of contamination that have been reported in dental units are of particular concern, so it is necessary to identify and study the patterns of bacterial contaminants and the transduction mechanisms of bacterial responses to their environment. This study investigates the diversity of bacterial contamination in dental units, chemotaxtic signals, and pathways from chemoreceptors through in silico approched. In silico research was carried out using several online and offline software tools utilizing a genomic sequence database from bacteria-contaminated with dental units. Phylogenetic analysis of the tree based on the 16s rRNA gene using MEGA 6 software, protein signaling interactions were analyzed using MiST 3.0 (https://mistdb.com/), signal transduction and protein structure (https://pfam.xfam.org/), the role of chemotaxis using interPro Ebi (https://www.ebi.ac.uk/interpro/structure/), dan biological process using Ebi QuickGo (https://www.ebi.ac.uk/QuickGO/). The analysis showed that 58 species of bacterial contamination showed a similarity test > 95%. Chemosensory pathway analysis of P. aeruginosa with a genome length of 6.538 Mbp through 8 signaling mechanism pathways for a total of 48 MCP. Signaling pathways.MCP signaling analysis classes are 24H, 36H, 40H, and 44H, while the identification of MCP classes is grouped based on chemosensory classes, namely CheW, CheA, CheR, CheB, Chev, CheD, and CheZ. The conclusion of this study, the complexity of the chemoreceptor interaction pathway in adapting quickly to the environment.

HUBUNGAN PREHOSPITAL DELAY DENGAN KEPARAHAN STROKE ISKEMIK BERDASARKAN KRITERIA NIHSS DI RSUD PROF. DR. MARGONO SOEKARJO Haniy Thri Afifaningrum; Prasetyo Tri Kuncoro; Agus Budi Setiawan
Mandala Of Health Vol 15 No 1 (2022): Mandala Of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Pasien stroke di Indonesia banyak mengalami keterlambatan kedatangan ke rumah sakit atau prehospital delay. Pencegahan dalam mengurangi kematian dan meminimalkan kerusakan otak adalah penanganan yang cepat dan tepat sesuai golden period. Prehospital delay akan menghalangi terapi reperfusi pada pasien stroke iskemia. Derajat kerusakan saraf pada pasien stroke akan mempengaruhi kualitas hidup pasien. Penelitian ini betujuan untuk mengetahui hubungan antara prehospital delay dengan derajat kerusakan saraf pada pasien stroke iskemia. Desain dari penelitian ini adalah analitik observasional dengan pendekatan cross sectional dengan data sekunder dari rekam medik NIHSS pasien stroke iskemia di RSUD Margono Soekarjo dari bulan April sampai dengan November 2021. Didapatkan sebanyak 78 pasien yang memenuhi kriteria eksklusi dan inklusi terdiri dari 43 pasien yang mengalami prehospital delay < 24 jam dan 35 pasien yang mengalami prehospital delay > 24 jam. Hasil analisis bivariat antara prehospital delay dengan derajat kerusakan saraf berdasarkan kriteria NIHSS menunjukkan nilai (p= 0,831 dan r= -0,25) pada pasien stroke iskemia. Tidak terdapat korelasi yang bermakna antara prehospital delay dengan derajat kerusakan saraf pada pasien stroke iskemia dengan kekuatan korelasi yang lemah dan arah korelasi negatif, artinya semakin rendah skor NIHSS semakin lama prehospital delay. Kesimpulan penelitian ini adalah tidak terdapat korelasi prehospital delay dengan derajat kerusakan saraf berdasarkan kriteria NIHSS pada pasien stroke iskemia di RSUD Margono Soekarjo

HUBUNGAN STRATEGI COPING DENGAN TINGKAT KECEMASAN PADA ORANG TUA YANG MEMPUNYAI ANAK USIA SD DALAM MENGHADAPI PEMBELAJARAN DARING Vania Sahda Inka Prasanti
Mandala Of Health Vol 15 No 2 (2022): Mandala Of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Pandemi Covid-19 memberikan dampak besar bagi berbagai kebijakan di Indonesia seperti penutupan sekolah yang menyebabkan pembelajaran dilakukan secara daring. Pembelajaran daring pada anak usia SD memerlukan peran besar orang tua karena kemampuan anak masih terbatas. Kewalahan orang tua dalam melakukan pendampingan pembelajaran daring dapat menimbulkan kecemasan. Penelitian hubungan strategi coping dengan tingkat kecemasan pada orang tua yang mempunyai anak usia SD dalam menghadapi pembelajaran daring di Purwokerto belum pernah dilakukan. Tujuan penelitian ini adalah untuk mengetahui hubungan strategi coping dengan tingkat kecemasan pada orang tua yang mempunyai anak usia SD dalam menghadapi pembelajaran daring. Desain penelitian ini adalah observasional analitik dengan pendekatan cross sectional yang dilakukan di SDN 2 Sokaraja Tengah. Subjek penelitian berjumlah 80 orang. Pengambilan sampel diperoleh dari data primer melalui kuesioner. Data dianalisis menggunakan uji korelasi Spearman. Terdapat hubungan signifikan dengan korelasi searah antara strategi coping adaptif terhadap tingkat kecemasan dengan nilai p-value 0,013 (p<0,05) dan strategi coping maladaptif terhadap tingkat kecemasan dengan nilai p-value 0,001 (p<0,05). Analisis kekuatan hubungan yaitu berkorelasi lemah untuk strategi coping adaptif (r=0,276) dan berkorelasi lemah untuk strategi coping maladaptif (r=0,374). Dapat disimpulkan, terdapat hubungan yang signifikan antara strategi coping adaptif dan strategi coping maladaptif dengan tingkat kecemasan pada orang tua yang mempunyai anak usia SD dalam menghadapi pembelajaran daring. Kekuatan hubungan antara strategi coping adaptif dan strategi coping maladaptif terhadap tingkat kecemasan yaitu berkorelasi lemah dengan arah korelasi yang searah.

HUBUNGAN STRATEGI KOPING DENGAN TINGKAT STRES P[ADA ORANG TUA YANG MEMPUNYAI ANAK USIA SD DALAM MENGHADAPI PEMEBLAJARAN DARING Yudhistira Tri Wardhana; dyah woro Dwi Lestari; Octavia Permata Sari; wahyudin wahyudin
Mandala Of Health Vol 15 No 1 (2022): Mandala Of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

ABSTRAK Latar belakang : Pandemi COVID-19 mengganggu berbagai sektor kehidupan termasuk sektor pendidikan. Siswa SD terpaksa memberlakukan pembelajaran daring. Beban menjadi pengajar dan permasalahan lain selama COVID-19 berpotensi menjadi stresor bagi orang tua. Perlu diadakan penelitian yang meneliti hubungan antara strategi koping dengan tingkat stres pada orang tua siswa SD untuk memahami fenomena yang sedang marak terjadi ini. SD Negeri 2 Sokaraja Tengah dipilih dengan harapan mampu mepresentasikan kondisi wilayah pinggiran kota di Indonesia. Tujuan : Mengetahui apakah ada hubungan antara strategi koping dengan tingkat stres orang tua siswa SD Negeri 2 Sokaraja Tengah. Metode : Analitik observasional dengan pendekatan cross-sectional mengambil data melalui kuesioner yang disebarkan langsung ke orang tua. Tingkat stres diukur dengan skala DASS-21 sedangkan strategi koping diukur dengan BRIEF COPE-Scale Inventory. Uji analisis Spearman digunakan sebagai metode analisis bivariat dengan tingkat kepercayaan 90%. Hasil : Ditemukan korelasi negatif signifikan pada adaptive coping (p: -0,389, sig: 0,000) dan maladaptive coping (p: -0,374, sig: 0,001). Sebagai subskala adaptive coping, ditemukan: active coping (p: -0,372, sig: 0,001), humor (p: -0,378, sig: 0,001), dan positive reframing (p: -0,382, sig: 0,000) dengan subskala lain tidak signifikan. Dari subskala maladaptive coping, ditemukan: denial (p: -0,327, sig: 0,003), self-blame (p: -0,320, sig: 0,004), dan self-disengagement (p: -0,291, sig: 0,009) dengan subskala lain tidak signifikan. Kesimpulan : Terdapat hubungan negatif bermakna pada strategi koping adaptive yang meliputi: active coping, humor, dan positive reframing, serta pada strategi koping maladaptive yang meliputi: denial, self-blame, self-disengagement ABSTRACT Background: COVID-19 pandemic disrupts many aspect of life including education aspect. Elementary school students are required to do online learning. Burden of teaching and other affected lives aspects are potential stressor source for parents. Hence, it is necessary to study correlation between coping strategies that parents used with stress level that they are affected to, so that we can better understand this booming phenomenon. Elementary School 2 of Sokaraja Tengah is chosen with means to represents suburbs of Indonesia. Objective: To understand whether there would be a correlation between coping strategies and stress level on elementary school students’ parents. Methods: Observational analytic with cross-sectional approach. Questionnaire are directly given to parents. Stress level is measured with DASS-21 scale, while coping strategies are measured with BRIEF COPE-Scale Inventory. Spearman bivariate analysis are chosen as the method of bivariate analytic with confidence interval of 90%. Results: Significant negative correlation was found in adaptive coping (p: -0,389, sig: 0,000) and maladaptive coping (p: -0,374, sig: 0,001). As subscales of adaptive coping, it was found: active coping (p: -0,372, sig: 0,001), humor (p: -0,378, sig: 0,001), and positive reframing (p: -0,382, sig: 0,000) while other subscales are not significant. From subscales of maladaptive coping, it was found: denial (p: -0,327, sig: 0,003), self-blame (p: -0,320, sig: 0,004), and self-disengagement (p: -0,291, sig: 0,009) while other subscales are not significant Conclusion: There is a negative correlation between coping strategies which include: adaptive coping (active coping, humor, and positive reframing), and maladaptive coping (denial, self-blame, and self-disengagement) with stress level of Elementary School 2 of Sokaraja Tengah

PREVALENCE AND RISK FACTOR THAT CAUSED ASTHMA IN CHILDREN AT SUMBANG 1 PUBLIC HEALTH CENTER PERIOD OF JANUARY 2018- DECEMBER 2020 Abiel Amazia Putri; Indah Rahmawati; Hajid Rahmadianto Mardihusodo
Mandala Of Health Vol 15 No 1 (2022): Mandala Of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

ABSTRAK Asma merupakan penyakit kronik dengan kumpulan tanda dan gejala berupa batuk, sesak nafas dan mengi secara episodik dan bersifat reversibel akibat dari reaksi inflamasi kronik saluran pernafasan yang mengakibatkan bronkus menjadi hipereaktif terhadap berbagai rangsangan. Prevalensi asma tertinggi terjadi pada usia anak-anak. Terdapat 3 faktor risiko penyebab asma yaitu, faktor genetik, faktor risiko lingkungan dan faktor lainnya. Penelitian ini bertujuan untuk mengetahui prevalensi dan faktor-faktor risiko penyebab asma pada anak di Puskesmas Sumbang 1 periode Januari 2018- Desember 2020. Penelitian ini menggunakan survei deskriptif observasional dengan analisis univariat dan penyajian data menggunakan tabel proporsi dan grafik kolom. Pengambilan sampel menggunakan teknik total sampling dengan jumlah responden sebanyak 30 pasien anak dari Puskesmas Sumbang 1 periode Januari 2018- Desember 2020. Pengambilan data dilakukan dengan wawancara dan pengisian kuisioner. Hasil penelitian didapatkan 30 responden penderita asma dengan faktor genetik yang terdiri dari riwayat keluarga asma terdapat 20 responden (66,67%). Pada faktor lingkungan yaitu alergen bulu hewan peliharaan terdapat 12 responden (40%) dan alergen tungau debu terdapat 17 responden (56,67), sedangkan faktor lainya yaitu paparan asap rokok terdapat 17 responden (56,67%), polusi udara terdapat 11 responden (36,67%), udara dingin terdapat 20 responden (66,67%) serta riwayat infeksi terdapat 16 orang (53,33%). Berdasarkan hasil penelitian ini maka dapat disimpulkan bahwa faktor risiko penyebab asma tertinggi di Puskesmas Sumbang 1 periode Januari 2018- Desember 2020 adalah faktor genetik dan udara dingin dan faktor terendah penyebab asma di Puskesmas Sumbang 1 periode Januari 2018- Desember 2020 adalah faktor lainnya yaitu polusi udara. Kata kunci: Asma, Anak, Faktor Risiko Asma ABSTRACT Asthma is a chronic disease with a collection of signs and symptoms in the form of coughing, shortness of breath, and wheezing in an episodic and reversible nature due to chronic inflammatory reactions of the respiratory tract which causes the bronchi to become hyperreactive to various stimuli. The highest prevalence of asthma occurs in childhood. 3 risk factors cause asthma, namely, genetic factors, environmental risk factors, and other factors. This study aims to determine the prevalence and risk factors for asthma in children at Sumbang 1 Public Health Center Period of January 2018- December 2020. This study used an observational descriptive survey with univariate analysis and data presentation using proportion tables and column graphs. Sampling used a total sampling technique with a total of 30 pediatric patients from the Sumbang 1 Public Health Center for the period January 2018-December 2020. Data collection was carried out by interviewing and filling out questionnaires. The results showed that 30 respondents with asthma with genetic factors consisting of a family history of asthma were 20 respondents (66.67%). Based on the result of this study, there are 12 respondents (40%) on environmental factors namely pet fur allergens and there are 17 respondents (56.67%) on dust mite allergens, while other factors namely exposure to cigarette smoke there are 17 respondents (56.67%), air pollution there are 11 respondents (36,67%), cold air there are 20 respondents (66.67%), and a history of infection there were 16 people (53.33%). Based on the results of this study, it can be concluded that the highest risk factors for asthma in the Sumbang 1 Public Health Center for the period January 2018-December 2020 are genetic factors and cold air and the lowest risk factor causing asthma in the Sumbang 1 Public Health Center for the period January 2018-December 2020 is another factor, namely air pollution. Keywords: Asthma, Children, Risk Factors of Asthma.

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