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Jurnal Katalisator
Published by Lembaga Layanan Pendidikan Tinggi Wilayah X
ISSN : -     EISSN : 25020943     DOI : https://doi.org/10.22216/katalisator
Core Subject : Science, Agriculture,
Agriculture, Biological Sciences & Forestry Chemistry
Jurnal Katalisator (ISSN Online : 2502-0943) is a journal containing scientific articles through a review by peer reviewers in chemistry. Jurnal Katalisator publishes original manuscripts, short review reviews on the branches of chemistry including: organic chemistry, inorganic chemistry, physical chemistry, analytical chemistry, biochemistry and applied chemistry. The Catalyst Journal is published 2 (two) times a year, April and October
Arjuna Subject : Biokimia, Genetika dan Biologi Molekuler - Biokimia, Genetika dan Biologi Molekuler (Lain-Lain)
Articles 145 Documents
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TEST OF BURN HEALING ACTIVITY OF TIBARAU ROOT FRACTION (Saccaharum spontaneum L.) IN MALE WHITE MICE rahmi, miftahur; Ria Afrianti; Wahilman Syahmi; Anggari Zulfian Siregar
JURNAL KATALISATOR Vol. 9 No. 2 (2024): Jurnal Katalisator Volume 9 No.2, Oktober 2024
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v9i2.3057

Abstract

Reed root (Saccharum spontaneum L.) is thought to have very strong antioxidant and anti- inflammatory activity that can help the wound healing process. Burns are injuries caused by exposure to heat. This study aimed to determine the burn healing activity of the extract and fraction of reed root. Extraction and fractionation methods. A total of 18 male white mice were burned and treated using extracts and fractions at a concentration of 15% in the form of ointment, each 3 mice in 6 groups, namely 15% ethanol extract, 15% n-hexane fraction, 15% ethyl acetate fraction, 15% n- butanol fraction, positive control, and experimental comparison. The test parameters were the percentage of wound healing, epithelialization time, and histopathology. Visually the 15% n-Butanol fraction has the best anti-burn activity with the average percentage of wound healing on the 7th; 14th; and 21st days, respectively 66.24%; 88.48%; 99 ,98%; epithelialization time 14,33. Histopathology on day 21 showed dense collagen fiber density, complete epithelialization cells and many fibroblast cells. Calculations using the One-Way ANOVA SPSS 16.0 statistical test followed by Duncan's test stated (P<0.05) the 15% n-Butanol fraction group was significantly different from the 15% ethyl acetate fraction group, comparison, 15% ethanol extract, n-Hexane fraction 15 % and positive control. From these results, it was concluded that the 15% n-Butanol fraction had the best burn healing activity.
ISOLATION AND CHARACTERIZATION OF LACTIC ACID BACTERIA FROM BREAST MILK Indrayati, Sri; Susanto, Vetra
JURNAL KATALISATOR Vol. 9 No. 2 (2024): Jurnal Katalisator Volume 9 No.2, Oktober 2024
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v9i2.3099

Abstract

Breast milk (breast milk) is one of the sources of Lactic Acid Bacteria (BAL), which functions to maintain the balance of the baby's digestive microflora. BAL derived from breast milk has high viability in the digestive tract and is more adaptive if it comes from the human body. Some BALs are also called probiotics. If Lactic Acid Bacteria Isolate is obtained from breast milk, it can be used as a probiotic candidate in the prevention of stunting and infectious diseases in children. This research applies new biotechnology to produce a food product that is healthy, contains probiotics, and is preferred by the community. The purpose of the study is to isolate and test the probiotic potential of BAL strains isolated from breast milk so that it can have the potential to be applied in the food industry. This research method is an exploratory study to obtain Lactic Acid Bacteria isolate from Breast Milk. The results of the study showed that 14 Lactic Acid Bacteria Isolate was obtained which was shown by the formation of a clear zone area around the colony. Based on the results of biochemical identification, of the 14 BAL isolates that have been successfully identified biochemically, consisting of several genera of BAL, namely Lactobacillus dan Pediococcus.
ANTIBACTERIA ACTIVITY ETHANOL EXTRACT OF ACHRAS ZAPOTA L. FRUIT AND LAGENARIA SICERARIA (MOLINA) STANDL. AGAINST SALMONELLA TYPHI Saldi Hapiwaty; Yuri Pratiwi Utami; Imrawati; Mahfuzun Bone; Nurjannah Bachri; Rahmah Mustarin; Ainun Jariah; Zahira Amody; Benedikta Winne Angela
JURNAL KATALISATOR Vol. 9 No. 2 (2024): Jurnal Katalisator Volume 9 No.2, Oktober 2024
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v9i2.3103

Abstract

The Synergistic of antibacterial is an interaction of two antibacterial agents that produces a greater inhibitory effect on bacteria, compared to the individual antibacterial effects of the two agents. The purpose of this study was to determine the synergistic effect of anti-bacterial extract of sapodilla fruit (Achras zapota L.) and water gourd (Lagenaria siceraria (Molina) Standl.) extract against Salmonella typhi bacteria. Extraction of sapodilla fruit and water gourd fruit was carried out by maceration method using 96% ethanol (1:10). Determination of the value of the minimum inhibitory concentration (MIC) of anti-bacterial sapodilla manila fruit and water gourd fruit was carried out by the checkerboard assay method using a 96 wells microplate by calculating the Fractional Inhibition Concentration Index (FICI) value. The results showed that the single MIC value of sapodilla manila fruit and water gourd fruit respectively are 50 mg/mL and 100 mg/mL. The interaction between the two is expressed as a Fractional Inhibitory Concentration Index (FICI) with a value of 1.5. The FICI values ​​indicate different antibacterial effects of the combination of sapodilla fruit and water gourd fruit against Salmonella typhi. Keywords: Synergistic, Salmonella typhi, Achras zapota L., Lagenaria siceraria (Molina) Standl., FICI
ISOLATION AND ANTIBACTERIAL ACTIVITY OF ENDOPHYTIC MOLD FROM DAHLIA TUBER PLANTS (Dahlia variabilis) AGAINST Stapylococcus aureus and Stenotrophomonasmaltophilia strainW1-2 Diki, Muhammad; Rita Permatasari; Dewi Yudiana Shinta; Mohd Fadly Md Ahid; Evana Kamarudin
JURNAL KATALISATOR Vol. 9 No. 2 (2024): Jurnal Katalisator Volume 9 No.2, Oktober 2024
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Antibiotic resistance to pathogenic bacteria has developed in a short period of time and is faster than has been thought. Therefore, it is necessary to find new antibiotic alternatives that are sourced from natural materials such as endophytic molds of dahlia tubers. This study was conducted to test the antibacterial activity of endophytic molds isolated from dahlia bulbs against Staphylococcus aureus and Stenotrophomonasmaltophilia strain W1-2. The results of the selection of antimicrobial activity of endophytic mold isolated from the dahlia tuber were fermented using the shaking method on Potato Dextrose Broth medium. The results of fermentation are tested for antibacterial activity using the disc diffusion method. Of the 10 isolated endophytic molds, two isolates with antibacterial activity were obtained, namely A-1 and A-7 isolates. The results of the antibacterial activity test of A-1 isolate against Staphylococcus aureus bacteria had the highest inhibition zone of 32.75 mm and Stenotrophomonasmaltophilia strain W1-2 had the highest inhibition zone of 19.25 mm. In A-7 isolate against Staphylococcus aureus bacteria had the highest inhibition zone of 29.5 mm and against Stenotrophomonasmaltophilia strain W1-2 had the highest inhibition zone of 15.25 mm. Based on the results of the antibacterial activity test carried out by the isolate, the isolate mold isolates with codes A-1 and A-7 have the highest antibacterial activity against Staphylococcus aureus and have a strong inhibitory power against Stenotrophomonasmaltophilia strain W1-2. The results showed that molds A-1 and A-7 had the potential to be antibacterial agents and GC-MS analysis of antibiotic compounds detected by hexanorlabdane. Molecular identification using the ITS gene observed that the A-1 mold isolate was 100% similar to the genomic2011f6MT558940.1 strain of Aspergillus Fumigatus
QUERCETIN AND PIPERINE CONTENT OF FRACTION N-HEXANE : ETHYL ACETATE SESEWANUA LEAF (CLERODENDRUM FRAGRANS WILD.) Imran, Arlan; Zulfiayu; Ahmad Aswad
JURNAL KATALISATOR Vol. 10 No. 1 (2025): Jurnal Katalisator ( On Progres)
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v10i1.3403

Abstract

Sesewanua (Clerodendrum fragrans Wild.) is used as an anti-inflammatory (anti-rheumatoid arthritis) topically and orally and as an antioxidant with very strong potential. The n-hexane fraction: ethyl acetate of sesewanua leaves contains secondary metabolites of flavonoids and alkaloids. This study aimed to measure the levels of the flavonoid quercetin and the levels of the alkaloid piperine in the n-hexane: ethyl acetate fraction of the ethanol extract of sesewanua leaves. This research method: The n-hexane:ethyl acetate fraction was determined for its flavonoid content at a wavelength of 256 nm and piperine alkaloids at a wavelength of 342.5 nm using the UV-Vis spectrophotometry method. The results obtained from the n -hexane:ethyl acetate fraction of the ethanol extract of sesewanua leaves contained the flavonoid compound quercetin as much as 6.385 PPM and the alkaloid compound piperine as much as 5.854 PPM. Conclusion: The statistical results of the Independent T. Test show that there are significant levels of the flavonoid quercetin and alkaloid piperine, which means that the levels of the flavonoid quercetin in the n-hexane: ethyl acetate fraction of the ethanol extract of sesewanua leaves are higher than the alkaloid piperine compound.
RELATIONSHIP BETWEEN ANTIPSYCHOTIC THERAPY WITH CREATININE LEVELS IN SCHIZOPHRENIA PATIENTS Marisa, Marisa; Endang Suriani; Rinda Lestari; Lisa Fradisa
JURNAL KATALISATOR Vol. 10 No. 1 (2025): Jurnal Katalisator ( On Progres)
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v10i1.3427

Abstract

Schizophrenia is a condition of severe mental disorder, characterized by many disturbances in thinking, language, perception and sense of awareness. The use of antipsychotic therapy in the long term can cause damage to kidney function and aggravate the work of the kidneys marked by increased creatinine levels. The purpose of this study was to determine the relationship between duration of antipsychotic therapy and creatinine levels in schizophrenic patients at the Mendawai Health Center. The type of research used is analytic research with a cross sectional approach. In this study the sampling technique used was purposive sampling. This study used the T-Independent Sample T Test. The results showed that there was a relationship between duration of antipsychotic therapy and creatinine levels in schizophrenic patients. It can be seen that the average value of respondents in the category of long antipsychotic therapy is 1.06 and short antipsychotic therapy is 0.71 and the value of equal variance assumed has a sig (2 Talled) p-value of 0.005 (<0.05), so Ha is accepted. So in conclusion there is a significant relationship between the duration of antipsychotic therapy and creatinine levels in schizophrenic patients at the Mendawai Health Center. It is recommended to pay more attention to the side effects of the treatment carried out for further therapy.
ANTI-AGING ACTIVITY WITH TYROSINASE INHIBITORS AND ANTIOXIDANTS FROM BADUY OUTER TRIBE PLANTS AS COSMETICS: REVIEW Yuri Pratiwi Utami; Anto Apriyanto; Nurhayani; Agus Firmansyah; Firdaus
JURNAL KATALISATOR Vol. 10 No. 1 (2025): Jurnal Katalisator ( On Progres)
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v10i1.3439

Abstract

Aging is an unavoidable physiological process. The process of premature aging is prevented using natural anti-aging cosmetics derived from plants. Cosmetics can be used as anti-aging products. Therefore, plants can be used as substitutes for anti-aging chemicals with fewer side effects. There are many herbal plants that are empirically used by the Baduy community and have potential as anti-aging agents with tyrosinase inhibitory and antioxidant activities. Evidence of anti-aging activity can be obtained by testing the effects of each herbal plant, which has been conducted by several researchers previously. The purpose of this article is to provide information on which plants have the potential as anti-aging agents for cosmetic raw materials thru a literature review of journals in electronic databases. The results obtained from several plants such as Carica papaya L., Kaempferia galanga, Psidium guajava, Zingiber officinale var. Rubrum, Piper bettle, Caesalpinia sappan L, and Etlingera elatior (Jack) R.M. Sm have tyrosinase inhibitory activity. Orthosiphon stamineus B., Coleus scutellarioides (L.) Benth, and Imperata cylindrica (L) Beauv., the cogongrass plant, use an antioxidant approach as anti-aging. In conclusion, all herbal plants from the Baduy tribe have the potential as raw materials for anti-aging cosmetics
THE REMAINING CHEMICAL COMPOUNDS OF THE BODY'S METABOLISM ARE REDUCED THROUGH THE HEMODIALYSIS METHOD Susanto, Vetra; Dewi AS, Mutia; Suryani, Suryani; Suriani, Endang; Dasa Wardhani, Sri Muri
JURNAL KATALISATOR Vol. 10 No. 1 (2025): Jurnal Katalisator ( On Progres)
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v10i1.3450

Abstract

The accumulation of metabolic residual chemical compounds, such as urea, and creatinine, is a major consequence of decreased glomerular filtration function in patients with chronic kidney disease (CKD). Increased concentrations of these compounds trigger internal homeostasis disorders and accelerate the progression of metabolic complications. Hemodialysis is a kidney replacement therapy that aims to eliminate toxic compounds and maintain the body's biochemical balance. The purpose of this study is to evaluate the effectiveness of hemodialysis in reducing urea, creatinine, and uric acid levels in CKD patients. The pre-post test research involved 30 stage V CKD patients who underwent routine hemodialysis at the Regional General Hospital (RSUD) Padang Panjang, West Sumatra. Venous blood samples were taken 15 minutes before and after a single hemodialysis session. Urea levels were analyzed using the urease-GLDH method, creatinine using the kinetic Jaffé method, and uric acid using the uricase-POD method. The data were analyzed using a paired t-test with a significance level of p<0.05.The results were obtained The average urea level decreased from 182.6 ± 28.7 mg/dL it was concluded that Hemodialysis significantly reduced the level of chemical compounds left over from the body's metabolism in patients to 76.3 ± 16.9 mg/dL (p<0.001), creatinine from 11.8 ± 2.9 mg/dL to 4.9 ± 1.3 mg/dL (p<0.001), and uric acid from 8.5 ± 1.8 mg/dL to 5.2 ± 1.1 mg/dL (p<0.001). It can be concluded that hemodialysis significantly reduces the level of chemical compounds left over from the body's metabolism in advanced CKD patients. Hemodialysis maintains biochemical homeostasis and reduces the risk of systemic complications.
EVALUATION OF ANTIBIOTIC USE FOR DIARRHEA THERAPY IN TODDLERS AT PUSKESMAS BEJI DEPOK CITY Masyithah, Lathvi; Rosmawati, Rosmawati; Suzana, Dona
JURNAL KATALISATOR Vol. 10 No. 2 (2025): Jurnal Katalisator, Volume 10 No 2 Oktober 2025
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v10i2.3452

Abstract

Acute diarrhea is diarrhea more than fourteen days and is generally caused by microbial infection. The principles management of acute diarrhea are rehydration, symptomatic therapy, and selective and rational antibiotic therapy. Previous study shown antibiotic prescriptions for diarrhea therapy are still quite high, a study at the Bangsal Puskesmas in Mojokerto Regency showed that 27% was inappropriate for the indication. The aim this study was to evaluate the rationality of using antibiotics for diarrhea in toddlers. This study is a descriptive study with retrospective data collection from the medical records of toddler diarrhea patients at the Puskesmas Beji in Depok City in 2021 who met the inclusion and exclusion criteria. The results of the study showed the use of antibiotics such as metronidazole, amoxicillin, and cotrimoxazole was the right choice because it was in accordance with the choice of antibiotic therapy for acute diarrhea with specific indications, however the results of the evaluation of antibiotic prescriptions were not appropriate indications there was still a high number 62,5% of antibiotic prescriptions for patients with non-specific acute diarrhea. Antibiotic prescriptions must be based on the bacteria causing the infection so it is very necessary to be supported by data from laboratory tests.
HPLC-DAD PROFILING OF SIDR LEAVES AND ROASTED CANDLENUT FOR ALOPECIA THERAPY Elfasyari, Trie Yuni; Zulfisa; Mevy Trisna
JURNAL KATALISATOR Vol. 10 No. 2 (2025): Jurnal Katalisator, Volume 10 No 2 Oktober 2025
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v10i2.3455

Abstract

Alopecia is a dermatological disorder characterised by progressive hair loss, often impairing patients’ quality of life. Conventional therapies, such as minoxidil and finasteride, have demonstrated efficacy; however, their adverse effects have prompted the search for natural-based alternatives. Sidr leaves (Ziziphus spina-christi L.) and roasted candlenut seeds (Aleurites moluccanus L.) have been traditionally employed in ethnopharmacology for hair treatment, yet scientific data on their phytochemical composition remain limited. This study aimed to identify and quantify the major bioactive constituents in purified aqueous extracts of sidr leaves and roasted candlenut seeds using high-performance liquid chromatography coupled with diode-array detection (HPLC-DAD), and to assess their potential implications in alopecia therapy. Powdered sidr leaves and roasted candlenut seeds were extracted, fractionated, and analysed on a C18 column using a gradient acetonitrile–water mobile phase. The results revealed that sidr leaves are rich in rutin hydrate (245.64 ± 0.73 mg/L), accompanied by gallic acid (47.63 ± 0.43 mg/L) and quercetin (6.85 mg/L), whereas roasted candlenut seeds predominantly contain quercetin (27.00 mg/L). Rutin functions as an antioxidant and angiogenesis stimulator, gallic acid exhibits anti-inflammatory activity, and quercetin acts as a 5α-reductase inhibitor relevant to androgenetic alopecia. In conclusion, the phytochemical profiles of sidr leaves and roasted candlenut seeds support their potential use as phytotherapeutic candidates for alopecia management.

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