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Jurnal Katalisator
Published by Lembaga Layanan Pendidikan Tinggi Wilayah X
ISSN : -     EISSN : 25020943     DOI : https://doi.org/10.22216/katalisator
Core Subject : Science, Agriculture,
Agriculture, Biological Sciences & Forestry Chemistry
Jurnal Katalisator (ISSN Online : 2502-0943) is a journal containing scientific articles through a review by peer reviewers in chemistry. Jurnal Katalisator publishes original manuscripts, short review reviews on the branches of chemistry including: organic chemistry, inorganic chemistry, physical chemistry, analytical chemistry, biochemistry and applied chemistry. The Catalyst Journal is published 2 (two) times a year, April and October
Arjuna Subject : Biokimia, Genetika dan Biologi Molekuler - Biokimia, Genetika dan Biologi Molekuler (Lain-Lain)
Articles 152 Documents
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ANTIOXIDANT POTENTIAL OF EXTRACT OF BLACK RICE, BAJAKAH WOOD ROOT AND KEBIUL SEED Yesti, Yulia; Kintoko, Kintoko; Nugraha, Ari Satia; Putra, Billy Harnaldo; Gusriyani, Sri; Saputra, Harry Ade; Alfarisyi, Muhammad Iqbal
JURNAL KATALISATOR Vol. 10 No. 2 (2025): Jurnal Katalisator, Volume 10 No 2 Oktober 2025
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v10i2.3457

Abstract

Exposure to free radicals and oxidative stress are major factors in various degenerative diseases, such as cardiovascular disease, diabetes, cancer, and neurodegenerative diseases. Therefore, the use of natural antioxidant sources is important to reduce the negative effects of free radicals. This study compares the natural antioxidant potential of black rice, bajakah root, and kebiul seeds, whereas previous studies have only identified the antioxidant potential of a single natural ingredient. This study aims to measure the antioxidant potential, such as total polyphenols, total flavonoids, and antioxidant activity, of these three natural materials using distilled water, 70% ethanol, and 96% ethanol as solvents. The experimental research method involved testing antioxidant activity and measuring total phenolics and flavonoids. The results showed that the 70% ethanol extract of black rice had the highest total polyphenol content at 6.83±0.28 mgGAE/g (0.007±0.00%), the 70% ethanol extract of bajakah wood root had the highest flavonoid content at 8.77±0.02 mgQE/g (0.009±0.00%), and the distilled water extract of kebiul seeds showed the strongest antioxidant activity based on an IC50 value of 5.96 ± 0.01 ppm. This study concluded that black rice has potential as a primary source of phenolics and anthocyanins, while bajakah wood root and kebiul seeds are sources of flavonoids with strong antioxidant activity.
Α-GLUCOSIDASE ENZYME INHIBITOR ACTIVITY OF ETLINGERA ELATIOR LEAF EXTRACT WITH SOLVENT VARIATION Imrawati Imrawati; Yuri Pratiwi Utami; Yuniar Dwi Yanti; Tuti Handayani; Nurzadrina wahyuddin; Zahira Amody; Aulia Debby Pelu; Rahmah Mustarin; Indri Indri
JURNAL KATALISATOR Vol. 10 No. 2 (2025): Jurnal Katalisator, Volume 10 No 2 Oktober 2025
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v10i2.3462

Abstract

Diabetes mellitus (DM) is a chronic metabolic disease characterized by hyperglycemia due to impaired insulin production or utilization. The increasing prevalence of diabetes, especially type 2, is a global concern due to the risk of complications it poses. One approach in treating type 2 diabetes is to inhibit the α-glucosidase enzyme to slow down glucose absorption. This research aims to identify the potential of patikala leaf extract as an α-glucosidase enzyme inhibitor. Using an experimental method with patikala leaf samples collected from Mariri Hamlet, Banyuurip Village, Bone-bone District, North Luwu Regency. Extraction was performed using the maceration method with variations in solvents: 70% ethanol, ethyl acetate, and n-hexane. The α-glucosidase enzyme inhibition activity was measured using a microplate reader and analyzed to determine the IC50 value. From the percentage inhibition data, the IC50 values obtained for 30% ethanol extract of patikala leaves were 351.95 µg/mL, for 70% ethanol extract of patikala leaves were 444.83 µg/mL, for 96% ethanol extract of patikala leaves were 362.27 µg/mL, for ethyl acetate extract of patikala leaves were 163.59 µg/mL, and for n-hexane extract of patikala leaves were 294.90 µg/mL, indicating that patikala leaf extracts with variations in solvent or extraction method exhibited very weak α-glucosidase enzyme inhibition activity. In conclusion, based on the research results obtained, the extract with variations in the solvent or extractant. Patikala leaf extract has an inhibitory activity against the α-glucosidase enzyme, which is categorized as very weak because it has an IC50 value > 100 µg/mL. In comparison, the control (acarbose) is in the weak category with an IC50 value of 50-100 µg/mL.
ANTIOXIDANT ACTIVITY OF SOURSOP (ANNONA MURICATA L.) LEAF JELLY CONFECTIONS FORMULATED WITH MULTIPLE GEL MATRICES Jumalia Aswar; Dewi Yuliana; Nasrul Haq; Zufiayu Sapiun; Abdul Rasyid, Faradiba
JURNAL KATALISATOR Vol. 10 No. 2 (2025): Jurnal Katalisator, Volume 10 No 2 Oktober 2025
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v10i2.3463

Abstract

Jelly confections represent promising nutraceutical products by incorporating bioactive compounds with health-promoting properties. Soursop leaves (Annona muricata L.) are recognized as a potential source of antioxidant and antibacterial agents, yet their application in functional foods remains limited. This study evaluated the antioxidant activity of soursop leaf jelly confections prepared with different gel matrix combinations. Formulation optimization was carried out using three gel matrices, namely carrageenan: agar (9:6), carrageenan: konjac (5:1), and konjac: agar (7:3). Antioxidant activity was assessed by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay using a microplate reader spectrophotometer. The results demonstrated IC₅₀ values of 28.95 µg/mL for carrageenan: agar, 8.82 µg/mL for carrageenan: konjac, and 30.33 µg/mL for konjac: agar formulations. Among these, the carrageenan: konjac (5:1) formulation exhibited the most potent antioxidant activity, indicating its potential for developing functional jelly-based nutraceuticals.
ASPARTATE TRANSAMINASE IN CHRONIC HEPATITIS B PATIENTS AT AWALBROS BATAM HOSPITAL Suryani, Suryani; Dwika, Nubbeliano; Lestari, Rinda; Abrar, Mardhatillah
JURNAL KATALISATOR Vol. 10 No. 2 (2025): Jurnal Katalisator, Volume 10 No 2 Oktober 2025
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v10i2.3477

Abstract

Chronic hepatitis B (HBV) is a liver infection characterized by persistent replication of Hepatitis B virus (HBV). Viral load is a parameter often used to evaluate viral replication activity, while Alanine Transaminase (ALT) and Aspartate Transaminase (AST) often used as biomarkers to assess liver damage. Objective: This study aims to evaluate the correlation of HBV viral load to ALT and AST in patients with chronic hepatitis B at Awalbros Batam Hospital. Methods: This research used descriptive study by data collected from patients with chronic hepatitis B who had undergone testing assessments of HBV viral load, ALT and AST. Results: The results of this study is indicate a significant correlation of HBV viral load to ALT levels. Approximately 40% of patients showed elevated ALT levels in line with increasing HBV load, while AST increase was observed in only about 5% of patients. The stronger correlation was noted in ALT, likely due to its higher specificity to liver tissue compared to AST. Conclusion: Quantitative HBV load significantly influences ALT levels but has a less notable effect on AST levels. These findings support the role of ALT as a more reliable indicator of chronic HBV infection. The study also simplifies the clinical phases of infection into two main categories: active and inactive, based on presumed similarities in clinical patterns.  
ADSORPTION STUDY OF LEAD (Pb²⁺) IONS USING CASSAVA PEEL BIOCHAR: EFFECT OF pH AND CONTACT TIME Elfia, Mega; Etriyanto Arman; Eduwin Saputra; Alfin Surya; Yoravika Dwiwibangga; Vicka Andini; Aidil Onasis; Nadya Br Debora
JURNAL KATALISATOR Vol. 10 No. 2 (2025): Jurnal Katalisator, Volume 10 No 2 Oktober 2025
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v10i2.3484

Abstract

This study evaluates the adsorption performance of NaOH-activated cassava peel biochar (Manihot esculenta Crantz) for the removal of Pb²⁺ ions from aqueous solutions, with particular focus on the effects of solution pH and contact time. Cassava peel biochar was produced via pyrolysis at 180–350 °C and chemically activated using 0.1 M NaOH. Surface functional groups and morphology were characterized using Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy–Energy Dispersive X-ray (SEM–EDX). Batch adsorption experiments were conducted by varying solution pH (3–8) and contact time (30–120 min), while Pb²⁺ concentrations before and after adsorption were analyzed using Atomic Absorption Spectroscopy (AAS). The results showed that solution pH significantly affected Pb²⁺ adsorption, with the highest adsorption capacity of 9.94 mg/g achieved at pH 5. Contact time also influenced adsorption performance, and the optimum condition was obtained at 90 min, yielding a maximum adsorption capacity of 9.94 mg/g. These findings indicate that NaOH-activated cassava peel biochar exhibits stable and effective Pb²⁺ adsorption under slightly acidic conditions and moderate contact time, highlighting its potential as a low-cost and environmentally friendly adsorbent for Pb²⁺ removal from contaminated wastewater.
ISOLATION OF ANTIOXIDANT COMPOUNDS FROM KEBIUL (CAESALPINIA BONDUC L) SEED SHELLS Mohd Abdus salam; Indah Permata Yuda; Juniarti
JURNAL KATALISATOR Vol. 11 No. 1 (2026): Jurnal Katalisator, Volume 11 No 1 April 2026
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/yyx6jb26

Abstract

Caesalpinia bonduc L. is a medicinal plant widely distributed in tropical and subtropical regions and has long been utilized in traditional medicine for the treatment of various ailments. Its seeds are recognized as a rich source of bioactive secondary metabolites, particularly flavonoids, phenolic compounds, terpenoids, and diterpenes, which have been associated with antioxidant, anti-inflammatory, antimicrobial, and antidiabetic activities. However, studies focusing on the isolation, purification, and characterization of individual bioactive compounds from C. bonduc seeds remain limited. Therefore, this study aimed to isolate, purify, identify, and evaluate the antioxidant activity of bioactive compounds obtained from C. bonduc L. seeds. Bioactive compounds were isolated from the seed extract through successive extraction, chromatographic separation, and purification procedures. The purified compound was subsequently characterized by phytochemical identification and evaluated for its free radical scavenging activity using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. The isolated compound was identified as a flavonoid based on its chemical characteristics. Antioxidant evaluation demonstrated that the isolated flavonoid exhibited potent free radical scavenging activity, with a half-maximal inhibitory concentration (IC₅₀) of 3.31 ± 0.12 µg/mL, indicating a very strong antioxidant capacity. The findings demonstrate that C. bonduc seeds constitute a valuable source of naturally occurring antioxidant compounds and support their traditional medicinal use.  
PREPARASI DAN STANDARISASI EKSTRAK HASIL FERMENTASI KULIT BUAH DELIMA (Punica granatum L) Rosmawati; Faizatun; Ratna Djamil; Nur Miftahurrohmah
JURNAL KATALISATOR Vol. 11 No. 1 (2026): Jurnal Katalisator, Volume 11 No 1 April 2026
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/fq97ff66

Abstract

ABSTRAK Kulit buah delima kaya akan tanin yang dapat terhidrolisis terutama punicalagin yang merupakan prekursor senyawa aktif asam elagat yang banyak digunakan sebagai senyawa aktif untuk perawatan kulit. Proses fermentasi merupakan metode yang dapat meningkatkan kandungan asam elagat yang ramah lingkungan. Penelitian ini dilakukan untuk melakukan standarisasi ekstrak hasil fermentasi kulit buah delima (Punica granatum L) yang dikembangkan sebagai bahan baku pada sediaan kosmetik dengan menentukan parameter spesifik dan nonspesifik. Hasil yang diperoleh menunjukan pada penentuan parameter spesifik yang diuji meliputi identitas ekstrak, uji organoleptik, skrining fitokimia ekstrak positif terdapat senyawa alkaloid, antraquinon, glikosida, flavonoid, terpenoid, tanin, dan saponin. Pengujian parameter nonspesifik yang telah dilakukan antara lain nilai kadar air 0,19%, kadar abu total sebanyak 1,4%, kadar abu larut asam sebanyak 0,0034%, cemaran bakteri mikroba ALT dan AKK diperoleh 0 cfu/ml. Hasil penelitian memenuhi standarisasi mutu ekstrak. Data yang diperoleh diharapkan dapat menjadi informasi tambahan mengenai ekstrak hasil fermentasi kulit buah delima yang memenuhi standar mutu dalam pengembangan sebagai bahan baku sediaan kosmetika. Kata kunci : Kulit buah delima, standarisasi ekstrak, parameter spesifik ekstrak, parameter nonspesifik ekstrak ABSTRACT Pomegranate peel is rich punicalagin compounds a group of hydrolyzable tannins which is a precursor of the active compound ellagic acid, which is widely used as an active compound for skin care. The fermentation process is a method that can increase the content of ellagic acid that is environmentally friendly. This study was conducted to standardize the fermented extract of pomegranate peel (Punica granatum L) used as a raw material in cosmetic preparations by determining specific and nonspecific parameters. The specific parameter tests conducted were extract identity, organoleptic test, and phytochemical screening. Phytochemical screening showed that the extract contained positive alkaloids, anthraquinones, glycosides, terpenoids, flavonoids, saponins, and tannins. Non-specific parameter tests conducted included water content of 0.19%, total ash content of 1.4%, acid-soluble ash content of 0.0034%, microbial contamination of ALT and AKK obtained 0 cfu/ml. The results of the study met the extract quality standards. The data obtained are expected to be additional information regarding the fermented extract of pomegranate peel that meets quality standards in development as a raw material for cosmetic preparations. Keywords: Pomegranate peel, specific parametric extract, nonspessific parametric extract
DISSOLUTION TEST OF SESEWANUWA LEAF FRACTION TABLETS WITH VARIOUS BINDERS USING UV-VIS SPECTROPHOTOMETRY Arlan Imran; Adinda Dj Tawape; Zulfiayu Sapiun; Prisca S Wicita
JURNAL KATALISATOR Vol. 11 No. 1 (2026): Jurnal Katalisator, Volume 11 No 1 April 2026
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v11i1.3525

Abstract

The sesewanua plant has potent anti-inflammatory activity, particularly in the n-Hexane: Ethyl Acetate fraction, which contains alkaloid compounds. However, consuming the fraction can cause discomfort, making it important to develop it into a tablet for more practical use. Binders are used in tablet formulations because they bind the tablet components and affect tablet quality. This study aimed to determine the effect of the type of binder (PVP, starch, and Na-CMC) on the dissolution test results of N-Hexane: Ethyl Acetate Fraction tablets using UV-Vis spectrophotometry. The dissolution test was conducted to evaluate how quickly the active ingredient dissolves from the tablet. Four formulas were tested: F0 (without binder), F1 (5% PVP), F2 (5% starch), and F3 (5% Na-CMC). The formula with the best results was F2, containing 5% starch as the binder, with a dissolution percentage of 80.91%. This is because starch is the best binding agent because it can increase the percentage of active ingredient dissolution in tablets. Therefore, it can be said that the addition of starch provides the best results with a dissolution percentage that meets the requirements.
POTENTIAL OF MORINGA LEAF EXTRACT GEL (Moringa oleifera Lam.) AS AN ANTIBACTERIAL AGAINST Staphylococcus aureus CAUSES OF ACNE Asiska Permata Dewi; Alfin Surya; Fahma Shufyani
JURNAL KATALISATOR Vol. 11 No. 1 (2026): Jurnal Katalisator, Volume 11 No 1 April 2026
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v11i1.3535

Abstract

Moringa leaves (Moringa oleifera Lam.) can be utilized by the community to heal wounds, beriberi, and fever; have anti-inflammatory and analgesic properties; and treat skin disorders caused by bacteria. One of the skin diseases is acne, which is caused by the bacterium Staphylococcus aureus. The aim of this study is to determine the antibacterial activity of a gel made from moringa leaf extract against Staphylococcus aureus and to identify the secondary metabolite compounds of the extract through phytochemical screening. This research is a laboratory experiment that involves creating moringa leaf extract gel at concentrations of 2%, 4%, 6%, and 8% to inhibit the growth of Staphylococcus aureus. Antibacterial testing was conducted using the well diffusion and disc diffusion methods and analyzed using one-way ANOVA. Based on the results of the phytochemical screening, the extract contains flavonoid, alkaloid, saponin, tannin, and terpenoid compounds. The results of the study showed that the antibacterial activity of the gel with the well method at concentrations of 2%, 4%, 6% and 8% obtained an average inhibition zone of 7.68 mm; 8.8 mm; 9.18 mm; 9.55 mm. While with the well method, the average inhibition zone at concentrations of 2%, 4%, 6% and 8% was 8.55 mm; 9.03 mm; 9.17 mm; 9.88 mm. The ANOVA test analysis obtained a result of p = 0.000 smaller than α = 0.05 which means there is a significant difference in the average diameter of the inhibition zone between the treatment groups.
Evaluation of Acid Mine Drainage Neutralization Using CaO and Alum Ridho Yovanda; Audrey Faiza Rosa; Finny Marsyah; Wiya Elsa Fitri; Adewirli Putra
JURNAL KATALISATOR Vol. 11 No. 1 (2026): Jurnal Katalisator, Volume 11 No 1 April 2026
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v11i1.3538

Abstract

Acid mine drainage (AMD) is a major environmental issue associated with coal mining activities, characterized by low pH and elevated concentrations of dissolved metals that can degrade water quality and harm aquatic ecosystems. Active treatment using alkaline materials such as quicklime (CaO) combined with coagulants like alum is widely applied to neutralize acidity and reduce metal content. This study aims to evaluate the effectiveness of CaO and alum in improving the pH of acid mine drainage. The research was conducted through a combination of field testing and laboratory analysis. The treatment process involved dosing quicklime and alum into acid mine drainage, followed by periodic pH measurements at inlet and outlet points over a one-month observation period. Data were analyzed using linear regression to determine the relationship between CaO dosage and pH changes. The results showed that the initial pH of acid mine drainage remained acidic, with an average value of 4.43, and increased slightly within the range of 4.43 to 4.76 after treatment. Regression analysis indicated a strong correlation (R² = 0.9537) between CaO dosage and pH increase, suggesting that higher dosages contribute to improved neutralization performance. However, the achieved pH values have not yet met the environmental quality standard (pH ≥ 6), indicating that further optimization of treatment dosage and process conditions is required. These findings highlight that while the combination of CaO and alum has potential in neutralizing acid mine drainage, its current application is not yet sufficient to achieve regulatory compliance and improvements in treatment design are necessary.

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