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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 60 Documents
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Search results for , issue "JPS Volume 6 Nomor 3 (2023)" : 60 Documents clear
Perbandingan Aktivitas Antioksidan Infusa dan Dekokta Tanaman Galling (Cayratia trifolia (L.) Domin) Angel Mangiwa; Mirna Maulidah; Tipalmaton R Patulen; Dhea K Kende; Ismail Ismail; Desy A Lestari; Maulita Indrisari; Lukman Muslimin
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (311.537 KB) | DOI: 10.36490/journal-jps.com.v6i3.55

Abstract

The number of patients with neurodegenerative disorders increased, especially in the productive age. The neurodegenerative disorder can be prevented by synthetic and natural antioxidants such as from plants. The herb of galling, Cayratia trifolia (L.) Domin), has long been traditionally used to prevent degenerative diseases by drinking decoction. The current study aimed to compare the antioxidant capability between infusion and decoction of galling against DPPH. The herbs were extracted with two methods, namely infusion, and decoction. This study used 7 different serial concentrations ranging 7.81 till 500 µg/mL, while the optical density was recorded at 515 nm using a spectrophotometer. The results demostrated that both infusion and decoction have antioxidant activity against DPPH with IC50 values of 87.55±1.01 (strong category) and 65.38±2.26 µg/mL (strong category), respectively. There was a statistically significant (p<0.05) between the IC50 values of infusion and decoction. In conclusion, galling is efficacious as an antioxidant source for preventing and treating degenerative diseases.
Uji Efektivitas Ekstrak Etanol Daun Labu Siam (Sechium edule (Jacq.) Swartz) Sebagai Penyembuh Luka Sayat pada Tikus Putih (Rattus norvegicus) Charly J. Watung; Christel N. Sambou; Jabes W. Kanter; Reky R. Palandi
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (234.093 KB) | DOI: 10.36490/journal-jps.com.v6i3.168

Abstract

Herbal plants refer to plant species that can be used as medicinal herbs, either individually or in combinations, believed to prevent and facilitate wound healing. One such herbal plant commonly used by the community is the leaves of Chayote (Sechium edule (Jacq.) Swartz), believed to accelerate the healing of wounds. This research aims to determine the effectiveness of ethanol extract from Chayote leaves (Sechium edule (Jacq.) Swartz) in healing incision wounds in white rats (Rattus norvegicus). The samples used were 15 male rats. A 1 cm incision wound was made on the rats' backs using a surgical blade. The research employed a Completely Randomized Design (CRD) with 5 treatments: negative control, positive control (10% povidone iodine), and 3 concentrated extracts (5%, 10%, 15%) with 3 repetitions each. The treatments were administered twice a day for seven days. The calculation of wound healing percentage in rats based on the research results indicated that Chayote leaf extract with a concentration of 15% showed 100% effectiveness in healing incision wounds in white rats.
Formulasi sediaan body lotion dari ekstrak etanol buah bit (Beta vulgaris L.) sebagai pelembab kulit dan antioksidan Tri Putri Ananda; Yessi Febriani; Sudewi Sudewi
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.51

Abstract

Background; Antioxidants are molecules that can prevent cell damage by free radicals. Beets (Beta vulgaris L.) are known to contain flavonoids which are antioxidants. This study aims to examine the antioxidant activity and skin moisturizing effect without skin irritation in a product formulated as a body lotion from the ethanol extract of beets (Beta vulgaris L.) at a certain concentration. Methods; This research was conducted using an experimental method using beetroot (Beta vulgaris L.) test material obtained by soaking 96% ethanol extract made in body lotion preparations with concentrations of 1.5%, 2%, 2.5% and blank samples. Sample and preparation tests included phytochemical screening, homogeneity test, inoculum pH test, emulsion type test, inoculum stability test, irritation test, water content test and antioxidant activity test. Result; The results showed that beet-based body lotion (Beta vulgaris L.) was a homogeneous preparation with an M/A emulsion and had a pH range immediately after preparation of 6.2 - 6.3 and a pH after cycle test was 6.2 - 6.3. Formula with a concentration of 2.5% (F3) is able to provide moisture in the wet category with a recovery rate of 27.74% lower than similar hand lotions that are applied to wet areas with a recovery rate of 28.18%. The ethanol extract of beets at a concentration of 2.5% (F3) had an IC50 valueof 118.101 µg/mL which indicated a moderate antioxidant class, while the ethanol extract of beets had an IC50 valueof 36.869 µg/mL which was classified as a very strong antioxidant. All body compositions based on ethanol extract of beetroot do not irritate the skin
Formulasi sediaan pewarna pipi menggunakan pewarna alami kopigmentasi biji kesumba keling (Bixa orellana L.) dengan angkak merah Salman Salman; Sudewi; Aprilia Ulfa; Rahma Yulia; Meutia Indriana
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.63

Abstract

Background; annatto (Bixa orellana L.) is a plant planted in the house or roadside gardens, containing alkaloids, flavonoids, and carotenoids. Red yeast rice is a natural product from China, resulting from traditional fermentation. This study aims to determine the co-pigmentation of annatto and red yeast rice seeds in the form of ethanol extract, which can be formulated as a natural dye into blush on preparations that, at specific concentrations, produce natural colors that meet the requirements and do not cause skin irritation. Methods; the study used an experimental approach using the test material of annatto seeds (Bixa orellana L.) and red yeast rice. The study was initiated by sampling, plant identification, Simplicia processing, and co-pigmentation of annatto (Bixa orellana L.) and red yeast rice seeds by maceration using 96% ethanol extract, p; phytochemical screening was carried out. The basic modified formulation of blush on a ratio of 1:2 between annatto seeds and red yeast rice seeds was made in 3 preparations with a concentration of 3%, 6%, and 9%, and blank. Examination of the physical quality of the preparation includes color dispersion test (homogeneity), polish test, stability test, and irritation test. Result; the results of the study concluded that the copigmentation of annatto (Bixa orellana L.) seeds and red yeast rice in the form of ethanol extract could be formulated into blush on preparations as natural dyes, which are homogeneous, easy to apply,y and stable for 12 days of storage. Produces different colors depending on the concentration contained in the preparation of the cheek dye. The co-pigmented cheek dyes made from ethanol extract of annatto (Bixa orellana L.) and red yeast rice seeds were non- irritating to the skin.
studi penggunaan pewarna kopigmentasi biji kesumba keling (Bixa orellana L.) Dan Angkak Merah Dalam Formulasi Suspensi Parasetamol Salman Salman; Sudewi Sudewi; Jazilul Amira; Meutia Indriana
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.64

Abstract

Background; Annatto seeds (Bixa orellana L.) is a plant originating from the Americas, which is widely cultivated in tropical and subtropical areas. Red yeast rice is white rice that has undergone a fermentation process from rice and mold (Monascus purpereus). This study aims to determine the copigmentation of annatto seeds (Bixa orellana L.) and red yeast rice in the form of ethanol extract that can be formulated as a dye into paracetamol suspension which at certain concentrations can produce colors that meet the requirements and are able to provide color stability. Methods; His study used an experimental method, using the test material of annatto seeds (Bixa orellana L.) and red yeast rice with a ratio of 1:2 using maceration method using 96% ethanol solvent, formulated into paracetamol suspension preparations with concentrations of 0.25%, 0.50% , 0.75%, as well as blanks. Examination of the physical quality of the preparation includes, organoleptic examination, determination of the pH of the preparation, observation of the stability of the preparation against storage, and viscosity test. Result; The results showed that the seeds of annatto seeds (Bixa orellana L.) and red yeast in the form of ethanol extract could be formulated as a dye into the preparation of paracetamol suspension. Copigmented paracetamol suspension preparations of ethanol extract of annatto seeds (Bixa orellana L.) seeds and red yeast rice with a ratio of 1:2 are stable preparations and have a pH range of 4.1-4.4 and pH after cycling test 4.0-4.3 . Has a different color for each concentration contained with a viscosity of 102.0-136.0 dPa.s. The preparation of paracetamol suspension of formula I with a concentration of 0.25% produces a red color (+), the preparation of formula II with a concentration of 0.50% produces a red color (++), the preparation of formula III with a concentration of 0.75% produces a red color (++ +) and white blank preparations.
Evaluation of Coffee Mistletoe Leaf Ethanol Extract on Burn Healing Activity on White Male Rat M. Rifqi Efendi; Diah Riski Gusti; Annisa Dhita Syahrial; Mesa Sukmadani Rusdi
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.72

Abstract

Burns are injuries that can be caused by heat (fire, hot liquids/fats, hot vapors), radiation, electricity, or chemicals. Coffee mistletoe leaves (Loranthus ferruginous Roxb) are one type of plant that contains secondary metabolite compounds, such as flavonoids, tannins, saponins, alkaloids, and phenolics, which play a role in the burn healing effects. This research was conducted using an experimental research method with a Completely Randomized Design (CRD) and a post-test only control group design approach. A total of 25 rats were divided into five treatment groups for the study. The groups included a positive control group treated with Bioplacenton gel, a negative control group treated with yellow vaseline, and three experimental groups treated with different concentrations of ethanol extract of coffee mistletoe leaves. The concentrations used were 5% (P1), 10% (P2), and 15% (P3). The burn healing activity and hydroxyproline content were observed as outcome measures. The data were presented as mean ± SD and analyzed using one-way ANOVA. Subsequently, Duncan's multiple rank test was performed to determine any significant differences. A significance level of p<0.05 was considered to define statistically significant results. The results of the study showed that ethanol extract of coffee mistletoe leaves has an effect as a burn treatment, with the best concentration found at 15% concentration, which had a healing percentage of 62.5%, although its effectiveness did not exceed that of the positive control group (72,48%). The hydroxyproline content of the coffee mistletoe leaf extract group demonstrated significant difference when compared to control negative groups, especially P1 group (53.62±6.52 μg/mL), and statistically not different with positive control (64.34 ±6.02 μg/mL). For the P2 and P3 groups, the hydroxyproline content were increased but did not reach significant value. Wound-healing activity owing to its richness in various effective chemical compounds present in the extract such as phenolics, saponin, flavonoid and alkaloid. Further investigation is necessary to identify and understand these additional components and their mechanisms of action in the healing process.
Isolasi dan identifikasi dengan gen 16s rRNA bakteri endofit dari tanaman pepaya (Carica papaya L.) serta uji aktivitas antibakterinya Irwandi; Lola Azyenela; Hera Purnama Sari; Epi Supri Wardi; Diza Sartika
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.82

Abstract

Endophytic bacteria live symbiotically in host plant tissues and can produce the same bioactive compounds as their host plants, including antibacterial agents. This study aimed to isolate and test the antibacterial activity of endophytic bacteria from the Carica papaya plant and to carry out molecular identification using the 16S rRNA gene against bacterial isolates with the most excellent antibacterial activity. A total of six isolates of endophytic bacteria were successfully separated through the purification process. Through microscopic identification using gram staining, all endophytic bacterial isolates belong to gram-positive bacteria. The results of the antibacterial activity test showed that the six isolates of papaya plant endophytic bacteria could cause the growth of Escherichia coli bacteria but not against Staphylococcus aureus bacteria. The average diameter of the inhibition zone against Escherichia coli bacteria is as follows: RB1: 9.35 mm; RB2: 9.4mm; RB3: 9.15mm; CB1: 9.1mm; CB2: 9.2mm; CB3: 8.8mm; FB1: 8.45mm; FB2: 8.75mm; and FB3: 8.6mm. All papaya plant endophytic bacterial isolates had an inhibition zone categorized as weak. Bacterial isolate RB2, which has the most excellent antibacterial activity, is identified molecularly as Bacillus cereus.
Aktivitas hepatoprotektor ektrak etanol daun durian ((Durio zibethinus Murr.) pada mencit yang diinduksi parasetamol Puspa Dwi Pratiwi; Nazrah Tiara; Intan lestari
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.92

Abstract

Durian (Durio zibethinus Murr.) have been studied and reported has antioxidant activity and its potential as hepatoprotector. This study was determined the hepatoprotector activity and effective dose of ethanol extract of durian (Durio zibethinus Murr.) leave on mice. This experiment was experimental study using completely randomized design (CDR) with a post-test only control group design used 35 mice were divided into 5 treatment groups: negative control (NaCMC), positive control (acetaminophen 5.07 mg/20g bodyweight), treatment 1 (125 mg extract/kg bodyweight), treatment 2 (250 mg extract/kg bodyweight), and treatment 3 (500 mg extract/kg bodyweight). Secondary metabolites of extract, SGPT and SGOT of mice’s blood, and histopathology of mice’s liver was observed. This study showed that extract contained alkaloid, flavonoid, phenolic, and saponis. From SGPT and SGOT value, the results showed that the higher the extract was given, the level of SGPT and SGOT value decreased. Our study revealed that ethanol extract of durian leaves has activity as hepatoprotector and the effective dose was 500 mg/kg bodyweight.
Factors Associated with Unsuccessful Treatment of Bedaquiline and or Delamanid Based Regimens in Multidrug-Resistant Tuberculosis: A Review Nugraha Putra, Oki; Faizah, Ana Khusnul; Wijayanti D.N, Nani
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.140

Abstract

Background: Multidrug-resistant tuberculosis (MDR-TB) is a serious health concern that is difficult to treat, requiring long and complex treatment with highly effective drugs. An all-oral regimen, bedaquiline and or delamanid have already shown low unsuccessful treatment in patients with MDR-TB. Method: We comprehensively reviewed factors associated with unsuccessful treatment (death, treatment failure, and loss to follow-up) related to all oral regimen containing bedaquiline and or delamanid in patients with MDR-TB. We conducted a scoping review under the PRISMA guideline for scoping review. Results: We included seven observational studies that met the inclusion criteria. Four studies reported the concomitant use of bedaquiline and delamanid. Unsuccessful treatment ranged from 7.8% to 36.6% in regimens containing bedaquiline, delamanid, or both at six months or after treatment completion. Low rates of treatment failure and loss to follow-up were reported in the included studies. Elderly, being underweight (BMI < 18.5 kg/m2), and hepatitis C coinfection among MDR-TB patients were associated with unsuccessful treatment in most studies. None studies reported pre-XDR and XDR-TB as risk factors for unsuccessful treatment. Conclusion: In MDR-TB patients receiving regimens containing bedaquiline and delamanid, age, BMI, and hepatitis C coinfection were associated with unsuccessful treatment.
Penetapan kadar flavonoid total ekstrak etanol buah asam kandis (Garcinia xanthochymus) dengan metode spektrofotometri Uv-Vis dan LCMS Hanafis Sastra Winata; Hendri Faisal; Muhammad Andry; Nurul Aulia; Muhammad Amin Nasution; Ika Julianti Tambunan
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.159

Abstract

Background: Kandis acid fruit (Garcinia xanthocymus Hook. f ex T. Anderson) is a plant of the Clusiase family with many species. Kandis acid fruit has various biological and pharmacological activities such as cytotoxic, anti-inflammatory, antimicrobial, antifungal and antioxidant. Purpose: To determine the content and total flavonoid content of tamarind kandis using quercetin as a reference standard. Method: This study used the TLC (Thin Layer Chromatography) method in qualitative analysis with the parameter Rf, then used the spectrophotometric method in the quantitative analysis with the parameter total flavonoid content (Value of mg QE/g sample) and the LCMS method (Liquid Chromatography Mass Spectrometry) with the parameter retention time (Rt). Result: Shows that tamarind kandis has an Rf value of 0.86 which states that tamarind kandis is positive for flavonoids with a reference standard of quercetin, total flavonoid content of 34.8364 mg QE/g sample with a standard deviation of 0.4355 and a percentage of 0.6967% and has five types of flavonoid compounds namely methyl dihydro quercetin, 1,5-Dihydroxy-3-methoxy xanthone, Afzelechin, Myricetin-3-O-ß-D-galactopiranoside, and Myricetin 7-glucoside. Methyl dihydro quercetin is the largest flavonoid with a composition of 49.57% with a retention time of 0.485 minutes. Conclusion: The identified total flavonoids have different types and levels

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