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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 75 Documents
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Search results for , issue "JPS Volume 8 Nomor 3 (2025)" : 75 Documents clear
Efek Nefroptotektif Ekstak Etanol Bawang Putih (Allium sativum L.) Pada Tikus Yang Diinduksi Rifampicin Fadira, Nurazra; Lubis , Asyrun Alkhairi; Yunus , Muhammad
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1020

Abstract

Background: Drug-induced nephrotoxicity, particularly caused by rifampicin—a first-line antituberculosis drug is a significant contributor to acute kidney dysfunction. The search for effective and safe nephroprotective agents to mitigate this side effect is crucial, and garlic (Allium sativum L.), with its potent antioxidant content, has emerged as a promising candidate. Objective: To evaluate the nephroprotective effect of ethanol extract of garlic (EEG) in male white rats (Rattus norvegicus) induced with rifampicin, based on serum creatinine levels, relative kidney weight, and histopathological findings. Methods: An in vivo experimental study was conducted on 25 rats randomly divided into five groups: (GI) normal control (distilled water); (GII) negative control (rifampicin 100 mg/kg BW, intraperitoneal); and three treatment groups (GIII, GIV, GV) receiving rifampicin 100 mg/kg BW and EEG at doses of 50, 120, and 300 mg/kg BW orally. Treatments were administered for 10 days. The measured parameters were serum creatinine levels, relative kidney weight, and histopathological damage scores (degeneration, necrosis, inflammatory cell infiltration). Results: Rifampicin induction (GII) significantly increased serum creatinine levels (1.28 ± 0.79 mg/dL) compared to the normal control (0.57 ± 0.05 mg/dL) (p<0.001). Administration of EEG at doses of 50, 120, and 300 mg/kg BW significantly reduced creatinine levels (0.53 ± 0.05; 0.51 ± 0.18; 0.51 ± 0.04 mg/dL, respectively). The relative kidney weight was highest in GII (1.6%), whereas treatment groups showed values close to normal. Histopathological analysis revealed the highest damage score in GII (score 2; 25–50%), while treatment groups, particularly the 300 mg/kg BW dose, showed the mildest damage (score 1; 5–25%). Conclusion: Ethanol extract of garlic exerts nephroprotective effects against rifampicin-induced kidney damage in rats, as evidenced by reduced serum creatinine levels, improvement in relative kidney weight, and amelioration of histopathological structures. These protective effects were dose-dependent, with the 300 mg/kg BW dose showing the most optimal outcome.
Efek Nefroprotektif Ekstrak Etanol Jahe Merah (Zingiber officinale var. rubrum) Terhadap Gambaran Histopatologi Ginjal Tikus (Rattus norvegicus) Yang Diinduksi oleh Etilen Glikol Anselia , Bella; Lubis , Asyrun Alkhairi; Sembiring, Novitaria Br
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1021

Abstract

Background: The kidney is a vital organ susceptible to damage from exposure to nephrotoxic compounds such as ethylene glycol. Red ginger (Zingiber officinale var. rubrum) is known to contain bioactive compounds with antioxidant and anti-inflammatory potential that may protect the kidney from injury. However, its effectiveness as a nephroprotective agent needs to be scientifically validated. Objective: To evaluate the nephroprotective effect of ethanol extract of red ginger against ethylene glycol–induced kidney damage in male white rats (Rattus norvegicus), Wistar strain. Methods: An experimental study using a post-test only control group design was conducted to minimize bias by ensuring equivalent baseline conditions among groups. A total of 25 rats were divided into five groups: normal control (distilled water), negative control (0.75% ethylene glycol), and three treatment groups (ethylene glycol + red ginger extract at doses of 100, 200, and 300 mg/kgBW/day). Parameters measured included serum creatinine levels and kidney histopathology. Data were analyzed using one-way ANOVA (p < 0.05) followed by LSD post hoc test. Results: Red ginger extract significantly reduced serum creatinine levels (p < 0.05), with the greatest reduction observed at a dose of 300 mg/kgBW (0.528 ± 0.082 mg/dL). Histopathological improvement of the kidney was also evident, indicated by decreased necrosis, cellular degeneration, and inflammatory cell infiltration. The kidney damage score in the treatment groups (score 1) was lower than in the negative control group (score 2). Conclusion: Ethanol extract of red ginger exhibits a nephroprotective effect against ethylene glycol–induced kidney injury, with the optimal dose being 300 mg/kgBW/day. These findings support the potential of red ginger as an alternative therapy for kidney disorders, although further studies are needed to elucidate the molecular mechanisms and conduct clinical trials.
Penetapan Kadar Flavonoid Total dari Fraksi Etil Asetat Daun Sirsak (Annona muricata L.) Dengan Metode Spektrofotometri Uv-Vis Ananda , Nadia; Pulungan, Ainil Fithri; Nasution , Haris Munandar; Daulay , Anny Sartika
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1023

Abstract

Background: The use of plants as traditional medicine is supported by their bioactive compounds, particularly secondary metabolites such as flavonoids. Soursop leaves (Annona muricata L.) are known to be rich in these compounds; however, quantitative data, especially in specific fractions, remain limited. Determining the total flavonoid content is essential for the standardization of herbal raw materials. Objective: This study aimed to identify the classes of chemical compounds present in the ethanol extract and ethyl acetate fraction of soursop leaves and to determine the total flavonoid content of both samples. Methods: Soursop leaf simplicia was extracted using 70% ethanol by the maceration method. The resulting ethanol extract was then fractionated with ethyl acetate. Phytochemical screening was conducted to identify compound classes, while the determination of total flavonoid content was quantitatively analyzed using the UV-Vis spectrophotometry method with quercetin as the standard. Results: Phytochemical screening revealed that both the ethanol extract and the ethyl acetate fraction tested positive for alkaloids, flavonoids, tannins, and steroids/triterpenoids. The total flavonoid content obtained in the ethanol extract was 31.524 ± 0.1524 mg QE/g, while the ethyl acetate fraction showed a significantly higher content of 41.425 ± 0.1363 mg QE/g. Conclusion: Fractionation with ethyl acetate effectively concentrated flavonoid compounds from the crude soursop leaf extract, as indicated by the higher total flavonoid content in the ethyl acetate fraction. These findings support the potential of the ethyl acetate fraction of soursop leaves as a source of flavonoids for the development of standardized herbal medicines.
Faktor-Faktor Yang Berhubungan Dengan Partisipasi Ibu Dalam Memilih Metode Kontrasepsi Metode Operasi Wanita (MOW) Di Kelurahan Pintusona Kecamatan Pangururan Kabupaten Samosir Sinurat , Astriatalita Lastiar; Manurung, Kesaktian; Tarigan , Frida Lina; Dachi, Rahmat Alyakin; Sitorus, Mido E
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1025

Abstract

Background: The continuous increase in population growth is a serious concern, including in Indonesia. Samosir Regency has a Total Fertility Rate (TFR) of 3.2, higher than the provincial average (2.7), necessitating population control efforts through the use of Long-Term Contraceptive Methods (LTCM), including Female Sterilization (Tubectomy). However, mothers' participation in choosing tubectomy in Pintusona Village remains low (34.8%), influenced by factors such as knowledge, husband's support, and cultural perceptions. Objective: This study aims to analyze the factors associated with mothers' participation in choosing tubectomy as a contraceptive method in Pintusona Village, Pangururan District, Samosir Regency. Methods: This study used a cross-sectional design with a quantitative approach. The sample consisted of 70 women of reproductive age who met the inclusion criteria. Data were collected through questionnaires and analyzed using univariate, bivariate (Chi-Square test), and multivariate (logistic regression) methods.Results: Bivariate analysis showed significant associations between husband's support (p=0.003), healthcare workers' support (p=0.048), income level (p=0.000), maternal knowledge (p=0.035), and maternal attitude (p=0.024) with the selection of tubectomy. Multivariate analysis identified husband's support as the most dominant factor (OR=4.898), followed by income level. Conclusion: Husband's support and family income level are key factors influencing mothers' participation in choosing tubectomy. Family planning programs should involve husbands in education and improve access to information about tubectomy to increase its acceptance.
Aktivitas antibakteri ekstrak daun benalu Dendrophthoe pentandra pada tanaman Citrus microcarpa Bunge terhadap Mycobacterium smegmatis, Escherichia coli dan Salmonella typhi Kanter, Jabes Wolter; Mongi, Jeane; Kalangi, Only Imando; Maarisit, Wilmar; Pareta, Douglas Natan; Sambou, Christel Natanael; Tulandi, Selvana S.
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1027

Abstract

Diseases caused by bacteria infections are renowned for hurting human health and may become fatal when not treated with appropriate medical therapy. Meanwhile, several bacteria, including Mycobacterium smegmatis, Escherichia coli, and Salmonella typhi, are resistant to numerous antibiotics. Therefore, this study aimed to find new compounds from plants with antibacterial potential. The results showed that based on phytochemical screening, Dendrophthoe pentandra mistletoe leaf on Citrus microcarpa Bunge plants had compounds with antibacterial activity, namely alkaloids, flavonoids, tannins, and phenolics. According to Gas Chromatography-Mass Spectrometry (GC-MS) analysis, eight compounds have antibacterial properties, namely 2-Myristynoyl pantetheine; 2H-Indeno[1,2-b]furan-2-one, 3,3a,4,5,6,7,8,8b-octahydro-8,8-dimethyl; Acetamide, N-methyl-N-[4-(3-hydroxypyrrolidinyl)-2-butynyl]-; Ethyl iso-allocholate; a-D-Glucopyranoside, methyl 2-(acetylamino)-2-deoxy-3-O-(trimethylsilyl)-, cyclic methylboronate; tert-Hexadecanethiol; Sarreroside; and d-Mannose. D. pentandra mistletoe leaf extract had a better effect or activity on inhibiting the growth of M. smegmatis than E. coli and S. typhi. It was concluded that D. pentandra mistletoe leaf on Citrus microcarpa Bunge plants had antibacterial activity.
Evaluasi Penggunaan Obat Antihipertensi pada Resep Pasien BPJS RSUD Kota Mataram yang Ditebus di Apotek KF 134 Pejanggik dan KF 458 Catur Warga Berdasarkan ATC/DDD dan DU 90% Hamzani, Yogi Mujizat; Andayani , Tri Murti; Dewi, Lucia Vita Inandha
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1028

Abstract

Background: Hypertension is a persistent condition of high blood pressure (systolic >140 mmHg or diastolic >90 mmHg). As a chronic disease requiring long-term treatment, the therapy for hypertensive patients needs to be evaluated regularly. Objective: This study aimed to determine the consumption profile of antihypertensive drugs using the ATC/DDD and DU 90% methods and to assess their compliance with the National Formulary (FORNAS). Methods: This research used a cross-sectional design with retrospective data collection. The samples were prescriptions for BPJS hypertension patients from Mataram City Hospital for the period of January-December 2024, redeemed at KF 134 Pejanggik Pharmacy and KF 458 Catur Warga Pharmacy. The data were analyzed using the Anatomical Therapeutic Chemical/Defined Daily Dose (ATC/DDD) and Drug Utilization 90% (DU 90%) methods. Results: The results showed that the most consumed antihypertensive class was ARBs, specifically candesartan, with a value of 13,082.25 DDD/1000 PPD at KF 134 Pejanggik and 7,215.33 DDD/1000 PPD at KF 458 Catur Warga. The drugs included in the DU 90% segment were candesartan, ramipril, amlodipine, and bisoprolol at both pharmacies, with the addition of valsartan at KF 134 Pejanggik. Compliance with drug use guidelines for FORNAS was 92% at KF 134 Pejanggik Pharmacy and 90% at KF 458 Catur Warga Pharmacy. Conclusion: The use of antihypertensive drugs in both pharmacies is in accordance with FORNAS, with high compliance percentages, indicating rational drug prescribing practices.
Pengaruh pemberian ekstrak rimpang kunyit (Curcuma longa L.) sebagai neuroprotektor terhadap gambaran histopatologi sel otak tikus putih (Rattus norvegicus) jantan galur wistar model alzheimer Balqis, Ferisha Aulia; Maulina, Meutia; Novalia, Vera
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.798

Abstract

Alzheimer’s disease is a neurodegenerative disorder that leads to cognitive decline and memory loss, eventually impairing daily activities. Turmeric (Curcuma longa L.) has neuroprotective potential due to its curcumin content, which possesses anti-inflammatory, antioxidant, and neuroprotective properties. This study aims to examine the effect of different doses of turmeric rhizome extract on the histopathological features of brain cells in Wistar rats (Rattus norvegicus) induced with Alzheimer’s disease. An experimental study with a post-test only control group design was conducted using simple random sampling. A total of 24 male Wistar rats were divided into four groups: K1 (Alzheimer-induced without treatment), K2 (administered 20 mg/kgBW memantine), P1 (Alzheimer-induced with 36 mg/kgBW turmeric extract), and P2 (Alzheimer-induced with 54 mg/kgBW turmeric extract). The results showed the highest percentage of cell necrosis in K1 (19.7%), while the lowest was in K2 (1.67%), followed by P2 (2.5%) and P1 (5%). The Kruskal-Wallis test indicated a significant difference between groups p = 0.030 (p < 0.05). The Post Hoc Mann-Whitney test revealed a significant difference between K1 and both K2 and P2. These findings suggest that turmeric rhizome extract at a dose of 54 mg/kgBW has a neuroprotective effect by reducing neuronal necrosis in Alzheimer-induced rats. However, no significant difference was observed between the memantine-treated group and the turmeric extract-treated groups. There was no significant difference between the group given memantine treatment and the group given turmeric rhizome extract (Curcuma Longa L.).
Analisis faktor yang mempengaruhi perilaku seksual pada remaja SMA kota Lhokseumawe Lubis, Putri Sabrina; Khairunnisa , Cut; Wahyuni , Hendra
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.799

Abstract

Adolescent sexual behavior is an important issue in health education. This can be influenced by knowledge, attitudes, the role of parents, peers, information media, religion, and the role of teachers and schools. This study aims to analyze the factors that affect the sexual behavior of adolescents of Lhokseumawe City State High School. This research method uses a descriptive analytical research design with a cross-sectional approach. The sample in this study was 342 students of Lhokseumawe City State High School. Sampling used stratified random sampling technique and data collection was carried out using a questionnaire. The results of the study showed that most teenagers were in the age range of 17-19 years and most were female, the sexual behavior of high school teenagers in Lhokseumawe City showed that most were not involved in deviant sexual behavior. Factors that influence the sexual behavior of high school teenagers in Lhokseumawe City show that adolescent knowledge is generally good. Most show positive attitudes, have good parental roles, are significantly influenced by peers, and only a few access information media related to pornography. The data obtained were analyzed using the Chi-square test. This proves that there is a significant relationship between knowledge, attitude, parental role, peer role, and information media with adolescent sexual behavior in Lhokseumawe City State High School. with the results of the study showing p < (0.05). Thus, the research is expected to contribute positively to understanding and addressing deviant sexual behavior among adolescents and to support the development of better protection policies for adolescents in Lhokseumawe.
Pengaruh Perbedaan Gelling Agent terhadap Karakteristik Fisik Masker Gel Peel Off Ekstrak Daun Murbei (Morus alba L.) Rahmiati, Nur; Afra , Fairuz Yaumil; Dharmayati , Evy; Septiani , Dewi Ayu
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.1019

Abstract

Mulberry leaves extract (Morus alba L.) has an IC50 of 8.35 µg/mL which is classified as a very strong antioxidant so it can be used as an active substance in cosmetic preparations such as Peel Off gel masks. An important component in Peel Off gel preparations is Gelling Agent. The type and concentration of each Gelling Agent can affect the characteristics of the preparation. The purpose of this study was to determine the effect of different Gelling Agents on the physical characteristics of Peel Off gel mask preparations from mulberry leaf extract. Mulberry leaves were extracted using the maceration method with 70% ethanol solvent. Peel Off gel mask preparation is made in 9 formulas, namely formula 1-3 using Gelling Agent gelatin, formula 4-6 using Gelling Agent HPMC, formula 7-9 using Gelling Agent Carbopol 940. Physical characterization of the preparation includes organoleptic, homogeneity, pH, spreadability, adhesive power, viscosity and stability test Cycling Test. The results showed that all formulas had the same organoleptic before and after the stability test, formula 1-3 showed inhomogeneity after the stability test was carried out. The pH of formula 1-6 is in the good pH range (5.62-6.37) while F7-9 has a pH value of 7.04-7.31, the spreadability of the preparation decreased along with the increase in the concentration of Gelling Agent, namely from 17 g.cm/sec to 12 g.cm/sec for a load of 150 g, and the increase in the concentration of Gelling Agent affects the results of adhesive power and viscosity of the preparation. The viscosity values of F1-F3 are 3,666-110,000 mPa.s, F4-F7 with a range of 11,333-49,666 mPa.s, and F7-F9 44,333-162,333 mPa.s. Based on the results of the study, it can be concluded that the difference in Gelling Agent in Peel Off gel mask preparations can affect the physical characteristics of the preparation.
Pengaruh Pemberian Ekstrak Etanol Herba Anting-Anting (Acalypha indica) terhadap Ekspresi GLUT 2 pada Pankreas Tikus Diabetes Toding, Ficanata Adhiguna; Islamiati , Utami; Wulandari, Ayu; Nugroho , Agung Endro; Widodo, Gunawan Pamudji; Patala , Recky
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 3 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i3.597

Abstract

Background: Anting-anting herb (Acalypha indica L.) has been traditionally known for its antidiabetic properties. Its mechanism of action is presumed to involve the regeneration of damaged pancreatic β-cells; however, its effect on the expression of GLUT-2, a key glucose transporter in insulin secretion, remains to be further investigated. Objective: This study aimed to analyze the effect of ethanol extract of Anting-anting herb on GLUT-2 protein expression in pancreatic β-cells of Streptozotocin–Nicotinamide–induced diabetic rats. Methods: This laboratory experimental study used 25 male rats (Rattus norvegicus), randomly assigned into five groups: normal control, negative control (diabetes + 1% CMC), positive control (diabetes + glibenclamide 0.45 mg/kg BW), treatment 1 (diabetes + extract 100 mg/kg BW), and treatment 2 (diabetes + extract 200 mg/kg BW). Diabetes was induced intraperitoneally with Streptozotocin (50 mg/kg BW) and Nicotinamide (110 mg/kg BW). The treatments were administered orally for 14 days. GLUT-2 expression in pancreatic tissue was quantitatively analyzed using immunohistochemistry, and protein density was measured with ImageJ software. Data were analyzed using one-way ANOVA. Results: Phytochemical analysis revealed that the extract contained flavonoids, tannins, saponins, and steroids. The group treated with 200 mg/kg BW extract showed a significant increase in GLUT-2 protein density (11,608,400 molecules/µm²) compared with the negative control group (5,074,533 molecules/µm²) (p < 0.05). This value was even higher than that of the positive control (glibenclamide), which showed a density of 10,626,864 molecules/µm². Conclusion: Administration of ethanol extract of Anting-anting herb at a dose of 200 mg/kg BW significantly increased GLUT-2 expression in pancreatic β-cells of diabetic rats. This enhancement is strongly presumed to contribute to the antidiabetic mechanism of Anting-anting herb.

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