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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 654 Documents
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Formulasi dan Evaluasi Fisik Sediaan Granul Stevia Sebagai Pemanis Alami Dengan Penambahan Polivinilpirolidon (PVP) Sebagai Pengikat Al-Hakim, Nur Achsan; Ratih , Hestiary; Sabrilla , Niken
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.661

Abstract

The development of natural sweetener discoveries continues to be carried out to realize healthy living behavior in its use in food and beverage products, including in the formulation of pharmaceutical preparations. Stevia (Stevia rebaudiana) is a plant that contains high sweetness and has the lowest caloric value. This study aims to formulate and physically evaluate stevia extract granule preparations using the wet granulation method with the addition of varying concentrations of Polyvinylpyrrolidone (PVP) as a binder, F0 (without PVP), F1 (1%), F2 (3%), and F3 (5%). Physical evaluation of stevia granule preparation includes organoleptic test, moisture content, flow rate, angle of repose, compressibility index and granule dissolving time in water. The results of the physical evaluation of granule preparations during 28 days storage showed that F3 was the best formula compared to other formulas, as evidenced by the results of statistical analysis using the one-way ANOVA method showing significant differences (p<0.05) between formulations. The evaluation results obtained were moisture content (<3%), flow rate (10.23 g/sec), angle of repose (27°), compressibility index (10%) and granule dissolving time (<1 minute). This study shows that the use of 5% PVP concentration in F3 as a binder can improve the physical properties of stevia granule preparations to be better than 1% and 3% concentrations.
Review Artikel: Perbandingan Efektivitas dan Efek Samping Pembrolizumab Kombinasi Kemoterapi Dengan Kemoterapi Tunggal Dalam Pengobatan Non-Small Cell Lung Cancer (NSCLC) Dzannuba, Fadya Laila; Hilmi , Indah Laily; Sudarjat , Hadi; Shadrina , Jahra Almas; Affandhy , Adhwa’a Kaylla
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.684

Abstract

This review article aims to compare the effectiveness and side effects of pembrolizumab combined with chemotherapy versus chemotherapy alone in the treatment of advanced Non-Small Cell Lung Cancer (NSCLC). A systematic review was conducted using literature published between 2015 and 2024. Relevant studies were identified through databases such as Google Scholar, using keywords like "Pembrolizumab," "Side Effects," "Effectiveness," "Overall Survival (OS)," and "Progression-Free Survival (PFS)." The results showed that pembrolizumab combined with chemotherapy significantly improved Overall Survival (OS) and Progression-Free Survival (PFS) compared to chemotherapy alone. However, this combination therapy was associated with a higher frequency of side effects, such as pneumonitis and hypothyroidism. In conclusion, pembrolizumab combined with chemotherapy offers superior efficacy in prolonging survival and controlling disease progression in advanced NSCLC. However, its use requires careful patient selection and close monitoring of toxicity. These findings support pembrolizumab as a promising first-line therapy for advanced NSCLC.
Review Artikel: Pengaruh Perbandingan Fase Gerak Dalam Analisis Senyawa Hidrokuinon Pada Sediaan Kosmetik Menggunakan Metode High Performance Liquid Chromatography (HPLC) Basmalah, Nur; Hariadi , Nayla Nur Azkia; Mulki , Munir Alinu
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.687

Abstract

Hydroquinone is a compound that is often used in cosmetic products because of its ability to brighten the skin by inhibiting melanin production. However, its use can cause dangerous side effects such as irritation, hyperpigmentation and the risk of cancer, so its use in cosmetics has been limited by BPOM. High Performance Liquid Chromatography (HPLC) is an analytical method commonly used to detect hydroquinone in cosmetic preparations because of its sensitivity and ability to separate compounds with high complexity. This article is a literature review which aims to determine the effect of mobile phase comparison on hydroquinone analysis using the HPLC method. The research results show that selecting the right mobile phase is very important to guarantee accurate, precise and efficient analysis results. The combination of a polarity-based mobile phase that matches the properties of hydroquinone provides good resolution, high sensitivity, and optimal retention time. This research is expected to provide guidance in optimizing the HPLC method for hydroquinone analysis, and is expected to support cosmetic safety monitoring.
Uji Efektivitas Ekstrak Daun Renggak (Amomum dealbatum Roxb.) Sebagai Antihiperurisemia Pada Mencit Sovia, Fitriwati; Al-Adawiyah , Rosita; Yuliana , Tri Puspita
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.747

Abstract

Background: Hyperuricemia, resulting from excessive uric acid levels, can trigger chronic inflammation and increase the risk of gout. Conventional therapies such as allopurinol are associated with adverse effects, highlighting the need for natural alternatives. Renggak leaves (Amomum dealbatum Roxb.), an endemic plant from Lombok rich in flavonoids, have potential as xanthine oxidase inhibitors but remain underexplored. Objective: To evaluate the antihyperuricemic effect of renggak leaf extract in male white mice, determine the optimal dosage, and compare its efficacy with allopurinol. Methods: This study employed a pretest-posttest control group design. Hyperuricemia was induced using chicken liver juice administered for 14 days. The animals were divided into five groups: negative control (1% CMC-Na), positive control (allopurinol 10 mg/kg BW), and three extract-treated groups (50, 250, and 500 mg/kg BW), which received the extract for 21 days. Results: All extract doses significantly reduced uric acid levels (P < 0.05). The 500 mg/kg BW dose was the most effective (44.54% reduction), showing no significant difference compared to allopurinol (48.52%; p = 0.490). The effect is presumed to occur through xanthine oxidase inhibition by flavonoids. Conclusion: Renggak leaf extract, particularly at a dose of 500 mg/kgBW, shows potential as an alternative therapy for hyperuricemia with efficacy comparable to allopurinol. However, further studies such as toxicity tests, pharmacokinetic evaluations, and clinical trials are needed to validate its broader application.
Hubungan Status Gizi dan Kekambuhan Tuberkulosis di Balai Besar Kesehatan Paru Masyarakat Surakarta Febriyanti , Eka; Amelia, Ayu; Meilanda , Rastria; Syahputra , Ghalib Syukrillah
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.792

Abstract

Malnutrition can weaken the immune system, thereby increasing the risk of Mycobacterium tuberculosis infection. The aim of this study was to determine the risk of tuberculosis (TB) recurrence associated with the nutritional status of TB patients. This study was conducted at the Surakarta Center for Lung Health in 2017 using a case-control design. The study included 15 individuals in the control group (patients who had been cured of TB) and 15 individuals in the case group (patients who experienced TB recurrence). Inclusion criteria for this study were TB patients aged 18-65 years, both male and female, who had completed the full course of TB treatment, and who had complete data on nutritional status measured through Body Mass Index (BMI) and documented dietary intake in medical records. Patients with metabolic disorders or chronic diseases other than TB that could influence nutritional status were excluded. Data were collected from medical records and analyzed using SPSS version 25. The results showed that patients with poor nutritional status (below the normal BMI) had a significantly higher risk of TB recurrence (p = 0.028). Another finding indicated that patients who had a habit of consuming alcohol also had a higher likelihood of TB recurrence (p = 0.001). The conclusion of this study is that poor nutritional status plays a role in the occurrence of recurrent tuberculosis.
Penurunan Kadar Asam Sianida (HCN) pada Umbi Gadung (Dioscorea Hispida Dennst) Melalui Proses Ekstraksi dengan Kombinasi Konsentrasi NaHCO₃ dan NaCl. Nazua, Hanani; Ainurrohmah, Syafika; Saputro, Erwan Adi; Triana, Nurul Widji
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.802

Abstract

The utilization of gadung tubers as an alternative food has limitations due to the presence of cyanide content, which can cause poisoning. The cyanide content is cyanogenic glycosides, which can be enzymatically hydrolyzed to form cyanide acid compounds (HCN). The cyanide content in gadung tubers averages around 362 ppm, while the safe limit for consumption of cyanide acid levels is ≤ 10 ppm. This study aims to reduce the cyanide acid content in gadung tubers through a maceration extraction process with a combination of Sodium Bicarbonate (NaHCO₃) and Sodium Chloride (NaCl) solvents so that it complies with the World Health Organization (WHO) standards. Gadung tuber extract was obtained from maceration extraction for 30 minutes in each solvent. Testing methods for cyanide acid in Gadung tubers include Titrimetry, Spectrophotometry, and Organoleptic. The combination of high concentrations of Sodium Bicarbonate (NaHCO₃) and Sodium Chloride (NaCl) can help reduce cyanide acid levels in gadung tubers. The initial cyanide acid level of 47.02 mg/kg can be reduced with the best concentration combination (10:15)%, where the analysis results in titrimetry amounted to 9 mg/kg, while in spectrophotometry it was 9.5 mg/kg. This shows that cyanide acid levels can be reduced by 80-81% so that these levels meet World Health Organization (WHO) standards.
Pengaruh Media Promosi Kesehatan Terhadap Pengetahuan Nutrisi Pada Penderita Hipertensi Peserta Prolanis di Puskesmas Banda Sakti Kota Lhokseumawe Zara, Noviana; Munthe , Kania Wiritanaya; Nadira , Cut Sidrah
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.804

Abstract

Hypertension is known as the "silent killer," responsible for over 10 million deaths worldwide each year. In Indonesia, there are more than 1 million cases of hypertension, yet only 38.2% of sufferers receive healthcare services according to standards. Data from the Aceh Health Office in 2022 recorded over 44,000 cases of hypertension in Lhokseumawe City. One of the factors contributing to the increase in hypertension cases is the low level of public knowledge regarding the management of this condition. Hypertension management can be achieved through a low-salt diet, low-cholesterol diet, and high-fiber diet. One of the efforts to enhance knowledge about proper nutrition for hypertension patients is through health promotion using audiovisual media, which presents information in both visual and auditory forms. This study aims to identify the effect of health promotion media on nutrition knowledge in hypertension patients who are participants in the Chronic Disease Management Program (Prolanis) at Banda Sakti Health Center. The research employed a quasi-experimental design with a one-group pretest-posttest design, involving 40 Prolanis participants. The results show that the majority of respondents were elderly, female, unemployed, and had completed high school. After the intervention, there was a 92.5% increase in knowledge about hypertension nutrition, with the knowledge categorized as good. Statistical analysis using the Wilcoxon test revealed a significant effect of audiovisual media on improving hypertension nutrition knowledge, with a p-value < 0.05. The conclusion of this study is that health promotion media has a significant effect on improving nutrition knowledge in hypertension patients who are participants in the Prolanis program at Banda Sakti Health Center.
Hubungan Pemberian Susu Formula Dan Makanan Pendamping ASI (MP-ASI) Dini Dengan Kejadian Diare Pada Bayi Usia 0-6 Bulan Limois , Celine; Aidila , Diah Chairin; Halawa , Devilina; Dakhi , Bernadet Desni Irma Dewi; Fatemaluo, Aliran; Nababan, Tiarnida
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.819

Abstract

Background : Infant and toddler mortality in developing countries is primarily caused by diarrhea. Formula feeding and early introduction of complementary feeding can contribute to diarrhea in infants under 6 months. Purpose : To gain knowledge about the relationship between formula feeding and early introduction of complementary feeding with the incidence of diarrhea in infants aged 0–6 months at Posyandu Balita in Helvetia Village. Methods : This research is quantitative, employing an analytic survey design and a cross-sectional approach. Out of 125 mothers with infants aged 0–6 months across all Posyandu Balita in Helvetia Village, 75 mothers were selected as samples using accidental sampling technique. Questionnaires were distributed to collect data, which was then analyzed using the chi-square test (α = 0.05). Results : There is a significant relationship between formula feeding and the incidence of diarrhea in infants aged 0–6 months, with a p-value of 0.042 (p < α). On the other hand, early MP-ASI introduction does not show a significant relationship with the incidence of diarrhea in infants aged 0–6 months, with a p-value of 0.078 (p > α). Conclusion : Mothers are encouraged to practice exclusive breastfeeding, maintain personal and baby equipment hygiene, and actively seek information about preventing diarrhea or other diseases.
Faktor-Faktor Yang Mempengaruhi Kepatuhan Minum Obat Anti Tuberkulosis di UPTD Rumah Sakit Khusus Paru Provinsi Sumatera Utara Laowo, Oktorisman; Dachi, Rahmat Alyakin; Tarigan, Frida Lina; Manurung , Kesaktian; Sinaga, Janno
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.821

Abstract

Tuberculosis (TB) is a preventable and usually curable disease. Yet, it remains one of the leading causes of death in the world, especially in high TB-burden countries such as Indonesia. In 2021, there was a significant increase in TB incidence and mortality in Indonesia, especially in North Sumatra province, which reported many TB cases, including drug-resistant TB (MDR-TB). Patient non-adherence to treatment is a significant factor exacerbating this situation, leading to increased drug resistance and broader transmission. Strategic efforts and treatment adherence are needed to address the TB epidemic, in line with the global TB elimination target by 2030. This study aims to determine the factors influencing adherence to anti-tuberculosis drugs at the UPTD Pulmonology Hospital of North Sumatra Province. The study was a quantitative study with a cross-sectional research design. The sample in this study was 37 people, with sampling using accidental sampling, and the data were analysed univariate, bivariate with the Chi-Square test at α = 5% level, and multivariate with multiple logistic regression test. The results of this study showed that there was an influence of knowledge on adherence to taking anti-tuberculosis drugs (p-value = 0.038), employment (p-value = 0.018), access to health services (p-value = 0.003), and family support (p-value = 0.006). There was no influence of medication's side effects on adherence to anti-tuberculosis drugs (p-value = 1) at the UPTD Pulmonology Hospital of North Sumatra Province. The dominant factor in this study was family support, which tended to be more compliant with taking anti-tuberculosis drugs by 19 times compared to respondents who received less family support. This study recommends that the UPTD Pulmonology Hospital of North Sumatra Province increase family involvement and education in supporting the treatment of tuberculosis patients, including family assistance programs, counselling on the importance of family support, and providing information related to drug side effects so that families can provide proper motivation and understanding to patients.
Hubungan Pengetahuan Ibu Tentang MP-ASI Dengan Praktik Pemberian MP-ASI Yang Benar Sembiring , Elva Elvionita Br; Suyoko, Cica; Bidaya, Delni Suarsih; Tambunan, Jesika Triana; Paninsari, Debora
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.835

Abstract

Background: Complementary foods are designed to increase a baby's energy and nutrient intake because breast milk alone cannot meet the baby's daily nutritional needs. However, complementary foods must be introduced at the right time. The practice of providing complementary foods (MP-ASI) is a crucial step in fulfilling a baby's nutritional requirements. Objective: This study aims to determine the relationship between maternal knowledge about complementary foods and the proper practice of providing complementary foods. Method: This research employs a quantitative approach, specifically a correlation method with a cross-sectional design. The sample consists of 30 mothers with babies aged 6–12 months. Data analysis includes univariate and bivariate analysis using the Wilcoxon Signed Ranks Test. Results: Analysis of the N ties value revealed that 10 respondents showed an improvement in their level of knowledge after being provided with documentation on the proper provision of complementary foods. Based on the Wilcoxon test results, the p-value score was 0.004 (< 0.05), leading to the rejection of Ho and acceptance of Ha. Conclusion: There is a significant relationship between maternal knowledge about complementary foods (MP-ASI) and the proper practice of providing complementary foods. Mothers with a good understanding of complementary foods tend to provide them in accordance with correct guidelines, including food types, feeding timing, and presentation. In contrast, mothers with limited knowledge about complementary foods often fail to provide them appropriately, which can negatively impact the baby's nutritional status and development.

Page 44 of 66 | Total Record : 654

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