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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 654 Documents
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Pengetahuan dan Sikap Ibu Hamil Trimester Tiga Tentang Edukasi ASI Eksklusif Samosir , Hernawati Romauli; Saputri , Fatmawaty; Buulolo , Eunike Stefhani; Simangunsong , Eva Zhurnita; Sitanggang, Ester Aprilda; Paninsari, Debora
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.836

Abstract

Background: According to data from the World Health Organization (WHO), only 38% of infants aged 0–6 months worldwide were exclusively breastfed, with an increase to 44% in 2020. The low coverage of exclusive breastfeeding is influenced by mothers’ lack of knowledge and attitudes regarding its importance. Objective: This study aims to examine the effect of education on the knowledge and attitudes of third-trimester pregnant women regarding exclusive breastfeeding. Methods: A quantitative approach was employed using a one-group pretest and posttest design within a cross-sectional framework. The sample consisted of 35 third-trimester pregnant women selected through total sampling at BPM Juliana Dalimunthe, S.Keb., Bdn, located in Tembung, Deli Serdang Regency, in November 2024. Data were collected using questionnaires and analyzed using the paired sample t-test. Results: There was a significant improvement in the knowledge and attitudes of pregnant women after receiving the educational intervention. The mean knowledge score increased from 70.86 to 76.00, and the attitude score from 72.11 to 79.71, with a p-value of 0.00 (< 0.05) for both variables. Conclusion: Education on exclusive breastfeeding has a significant effect on improving the knowledge and attitudes of third-trimester pregnant women. These findings highlight the importance of health education in preparing mothers for successful exclusive breastfeeding.
Hubungan Pengetahuan dan Pola Asuh Ibu Dengan Tumbuh Kembang Bayi 3-12 Bulan Musanna, Khadijatul; Lase, Eltin Murni; Laia, Endang Karnita Nevi; Silalahi , Farida Linawati; Hidayat, Anisa Nur; Nababan, Tiarnida
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.837

Abstract

Background: The World Health Organization (WHO) reports that 52.9 million infants worldwide experience developmental disorders, with 54% of these cases potentially exhibiting developmental abnormalities. In low- and middle-income countries, nearly 95% of individuals face developmental delays, while in the United States, behavioral or developmental issues affect 15-18% of children. Research Objectives: This study aims to analyze the influence of maternal attitudes and practices on the growth and development of infants aged 3-12 months in Tanjung Gusta Subdistrict, Klambir IV Region, specifically at Midwife Elly's Clinic. Methods: Employing a quantitative approach with a cross-sectional design, this study utilized non-probability sampling through quota sampling technique. Seventy-one participants were included as research subjects. Results: The findings at Midwife Elly's Independent Practice Clinic revealed a significant correlation between parental knowledge and child development in infants aged 3-12 months (p-value = 0.000; p < 0.05 based on chi-square test). Additionally, the study identified an association between maternal knowledge and emotional well-being with child development within this age range.
Efektivitas Penyembuhan Luka Bakar Derajat II Sediaan Gel Ektrak Buah Belimbing Wuluh (Averroa bilimbi L.) Terhadap Tikus Jantan Galur Wistar Astuti , Dina Puji; Fadhilah, Arini
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.847

Abstract

Burns are lesions on body tissues that occur due to exposure to heat sources such as fire, chemicals, or electric currents. Bilimbi (Averroa bilimbi L.) is thought to have therapeutic properties to treat burns in male Wistar rats. Burn healing is divided into 3 phases of inflammation, proliferation, and maturation. This study was to prove the ability of the ethanol extract gel preparation of bilimbi in the process of healing burns. Bilimbi extract gel was formulated in three concentration variations, namely 2.5%, 5%, and 10%. Control testing of the preparation included organoleptic, homogeneity, spreadability, viscosity, and adhesion. The bilimbi extract gel preparation with a series of concentrations of 2.5%, 5%, and 10% gave an effect in healing second-degree burns. The percentage data of burn diameter were analyzed using ANOVA. The results of statistical analysis showed that the preparation of ethanol extract gel from star fruit with a concentration of 10% gave a healing effect with a healing percentage of 86% which was almost the same as the positive control. This healing effect is thought to come from the content of star fruit such as alkaloids, flavonoids, saponins.
Tingkat Penggunaan Antibiotik dan Pola Peresepannya Pada Infeksi Saluran Pernapasan (ICD-10: J00-J99) di Indonesia Selama Pandemi COVID-19 Misworo, Misworo; Kusuma, Ikhwan Yuda; Kurniasih, Khamdiyah Indah; Nurkholis, Fiqih; Fauziah , Fauziah
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.849

Abstract

Introduction: Respiratory tract infections (RTIs) contribute substantially to global antibiotic consumption, raising concerns about antimicrobial resistance (AMR). This study aimed to analyze antibiotic prescribing patterns for respiratory disorders in an Indonesian teaching hospital during the COVID-19 pandemic. Methods: This retrospective, cross-sectional study examined systemic antibiotic prescriptions based on the Anatomical Therapeutic Classification (ATC: J01) for respiratory diseases (ICD-10: J00-J99) at Cilacap Government Teaching Hospital between January and December 2021. Data were extracted from electronic medical records (e-MR), including patient demographics (i.e. age and sex), ICD codes and name of antibiotics. We analyzed WHO AWaRe classifications, administration routes, and seasonal patterns based on patient’s entry and antibiotic use. Results: The study included 2,395 patients with antibiotic prescriptions for respiratory disorders. The Watch group antibiotics accounted for 85.6% of prescriptions, with the highest use among adults (86.2%). Parenteral administration (71.5%) was more common than oral administration (28.5%). Pneumonia (38.2%) and chronic obstructive pulmonary disease (27%) were the most common indications. Antibiotic use peaked in December (n=529) and was lowest in July (n=84). Ceftriaxone (n=838), azithromycin (n=270), cefixime (n=262), levofloxacin (n=216), and meropenem (n=56) were among the top prescribed antibiotics. Conclusion: The study highlights the predominant use of broad-spectrum and parenteral antibiotics for respiratory disorders, raising concerns about AMR. Factors such as seasonality, disease patterns, and diagnostic challenges may have influenced prescribing practices. Implementing antimicrobial stewardship programs, promoting evidence-based guidelines, and addressing modifiable risk factors are crucial to combat AMR and optimize patient outcomes during and beyond the COVID-19 pandemic.
Peningkatan Disolusi Tablet Tadalafil Dengan Metode Kompleks Inklusi Betasiklodekstrin dan Variasi Eksipien Penghancur. Rachmawan, Rifky Fitrah; Setianto , Arif Budi; Wahyuningsih , Iis
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.850

Abstract

Tadalafil (TDL) is a drug clinically proven to treat erectile dysfunction, benign prostatic hyperplasia, and pulmonary hypertension. TDL is classified as a BCS Class II drug, which means it has high permeability but low solubility. Solubility enhancement is achieved through the inclusion complex method and verified by dissolution testing. This study aims to determine the dissolution profile of tadalafil inclusion complex tablets using the β-cyclodextrin (βCD) inclusion complex method with disintegrant variations. The results show that the tablet hardness is: R1 = 6.6 ± 0.5 kgf, R2 = 6.48 ± 1.4 kgf, and R3 = 6.6 ± 1.3 kgf. The disintegration time evaluation shows: R1 = 4.66 ± 1.08 minutes, R2 = 5.08 ± 0.91 minutes, and R3 = 5.1 ± 1.1 minutes. Each formulation's tensile strength test results are: R1 = 1.3 MPa, R2 = 1.3 MPa, and R3 = 1.1 MPa. The average drug content in the inclusion complex tablets is: R1 = 104.11 ± 1%, R2 = 106.23 ± 0.1%, and R3 = 105.09 ± 1.9%. The dissolution profile of the inclusion complex tablets at the 30-minute mark is: R1 = 85.2 ± 4.2%, R2 = 79.7 ± 3.6%, and R3 = 77.4 ± 5.3%. Variations in disintegrants significantly affect the dissolution profile during the early minutes, which impacts the overall dissolution profile. The TDL-βCD inclusion complex method successfully achieved the Q value by the monograph specifications.
Pembuatan dan Aktivitas Anti-Acne Nano Essence Sheet Mask Ekstrak Bonggol Nanas (Ananas comosus (L.) Merr) Ritonga , Nur Sakina; Lubis, Minda Sari; Yuniarti , Rafita; Rani , Zulmai
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.852

Abstract

Pineapple tubers, which are often considered waste, contain chemical compounds such as flavonoids, alkaloids, aPineapple tubers, which are often considered waste, contain chemical compounds such as flavonoids, alkaloids, saponins, tannins, and glycosides. This compound has antibacterial effects, especially against Propionibacterium acnes, which are gram-positive bacteria that cause acne. Anti-acne masks effectively prevent acne by disrupting the growth or killing bacteria through inhibiting microbial metabolism. This research is experimental in nature with Independent Variables: Extract, pineapple tuber simplicia, essence preparation, and nano essence sheet mask. Dependent variables include the physical characteristics of the preparation, as well as anti-acne activity. The extract was made using the maceration method, and then the antibacterial test of the extract was conducted. The preparations were subjected to physical quality tests, irritation tests, and antibacterial tests using the disc method. Orientation test results for the antibacterial activity of pineapple tuber extract against Propionibacterium acne s using the agar diffusion method with disc paper, namely, 3.25% (4.1 mm), 6.25% (4.9 mm), 12.5% (6.4 mm), 25% (7.5 mm), 50% (7.8 mm). The concentration of the preparation was obtained at 12.5% and then tested by PSA ( Particle Size Analyzer ). All particles were below 1000 nm, meeting the requirements. The results of the antibacterial activity test of the preparation showed the following inhibition zones: Blank (0 mm), Essence (9.5 mm), Nano Essence (11.13 mm), Comparator (25.3 mm), Clindamycin (32.3 mm). Good physical quality and can be used as an anti-acne.saponins, tannins and glycosides. This compound has antibacterial effects, especially against Propionibacterium acne s, gram-positive bacteria that cause acne. Anti- acne masks are effective in preventing acne by disrupting the growth or killing bacteria through inhibiting microbial metabolism. This research is experimental in nature with Independent Variables: Extract, pineapple tuber simplicia, essence preparation and nano essence sheet mask. Dependent variables include the physical characteristics of the preparation, as well as anti- acne activity . The extract was made using the maceration method, then the antibacterial test of the extract was oriented.The preparations were subjected to physical quality tests and irritation tests, as well as antibacterial tests using the disc method. Orientation test results for the antibacterial activity of pineapple tuber extract against Propionibacterium acne s using the agar diffusion method with disc paper, namely, 3.25% (4.1 mm), 6.25% (4.9 mm), 12.5% (6.4 mm), 25% (7.5 mm), 50% (7.8 mm). The concentration of the preparation was obtained at 12.5% and then tested by PSA ( Particle Size Analyzer ). All particles were below 1000 nm, meeting the requirements. The results of the antibacterial activity test of the preparation showed the following inhibition zones: Blank (0 mm), Essence (9.5 mm), Nano Essence (11.13 mm), Comparator (25.3 mm), Clindamycin (32.3 mm). Good physical quality and can be used as an anti -acne.
Pengaruh Perbedaan Metode Ekstraksi Maceration dan Microwave Assisted Extraction (MAE) Terhadap Penetapan Kadar Flavonoid Total Buah Ara (Ficus racemosa L.) Andry, Muhammad; Ligo, Azzura; Anggi, Reza Destri; Pradita, Diding; Luthvia, Luthvia; Nasution, Muhammad Amin; Pertiwi, Nia Novranda; Arifin, Arfiani
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.859

Abstract

Figs (Ficus racemosa L.) are an essential source of bioactive components such as phenols, terpenoids, flavonoids, and alkaloids with antioxidant properties. Two extraction methods are used to extract flavonoids from figs: conventional and non-conventional. This study aimed to determine the effect of different extraction methods—maceration and Microwave Assisted Extraction (MAE)—on the total flavonoid content in figs (Ficus racemosa L.). The research was conducted using a laboratory experimental method. The procedures included collecting and preparing plant materials, producing simplicia, evaluating simplicia characteristics, conducting phytochemical screening, preparing extracts, and determining total flavonoid content. The results showed that the maximum wavelength of quercetin was 438 nm, with a regression equation of Y = 0.0669x + 0.0084. The average absorbance values of fig extract using the maceration method were 0.216 with methanol, while the MAE method was 0.280 with methanol. The average percentage of flavonoid content using the maceration method was 0.1245% with methanol, while with the MAE method, it was 0.1623% with methanol. The total flavonoid content of fig extract using the maceration method was 1.2451 mgQE/g extract with methanol, while with the MAE method, it was 1.6238 mgQE/g extract with methanol. The study concluded that the highest total flavonoid content was found in the methanol extract obtained through MAE. This extract had a value of 1.6238 mgQE/g extract.
Kajian Etnofarmasi Tumbuhan Obat di Kawasan Geotermal Ie Seum, Aceh Besar: Eksplorasi Pengetahuan Tradisional dan Potensi Farmakologis. Fakri, Fajar; Isnaini , Nadia; Nasution , Muhammad Amin; Bakri , Tedy Kurniawan; Illian , Didi Nurhadi; Muhni , Akmal; Andry , Muhammad
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.864

Abstract

Indonesia is recognised as one of the world's megadiverse countries, possessing extraordinary biological wealth, including the medicinal plant potential in the geothermal area of Ie Seum, Ie Seum Village, Mesjid Raya Subdistrict, Aceh Besar District. This study aimed to explore and document local communities' traditional knowledge regarding using medicinal plants through an ethnopharmaceutical approach. A descriptive qualitative method was employed, with data collected via semi-structured interviews and participatory observation involving purposively selected informants. The findings identified nine medicinal plant species, with Eupatorium inulifolium and Vitex pinnata demonstrating the highest use value (UV) scores of 0.750 and 0.438, respectively, indicating their dominant usage in traditional healing practices. Leaves were the most frequently utilised plant parts, with standard preparation methods including boiling and pounding. These plants have traditionally been used to treat various health conditions, including fever, wounds, skin infections, and digestive disorders. The findings highlight the richness of traditional knowledge in Ie Seum and its potential as a foundation for developing natural product-based medicines. The extreme environmental conditions of the geothermal area are believed to influence the bioactive metabolite composition of the plants, potentially enhancing their pharmacological properties. This study underscores the importance of preserving local knowledge and encourages further scientific exploration to support the sustainable use of medicinal plants in developing traditional medicines.
Analisis Kadar Protein Pada Beberapa Jenis Susu Tinggi Protein Dengan Metode Kjeldahl dan Spektrofotometri Visible Syahfitri , Adelya; Daulay, Anny Sartika; Ridwanto, Ridwanto; Yuniarti , Rafita
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.865

Abstract

Introduction: Protein is an essential nutrient that serves as an energy source and plays a crucial role in tissue formation. Protein deficiency can lead to various health disorders, ranging from hair loss to serious conditions such as death. High-protein milk serves as an ideal protein source as it contains essential amino acids and complete nutrients, though its consumption should be adjusted to individual needs to avoid side effects. Research Objectives: This study aims to: (1) analyze protein content in high-protein milk (Whey, Casein, and Gainer) using the Kjeldahl and Visible Spectrophotometry methods, and (2) verify the consistency between analysis results and protein content claims on product packaging. Research Methods: Analysis was conducted using two methods: the Kjeldahl method as a high-precision standard method and Visible Spectrophotometry using Biuret reagent which is more sensitive. Each sample was analyzed with six repetitions to ensure data accuracy. Samples were selected purposively based on best-selling products. Results: The results showed the highest protein content in Whey (525.87 mg/g with Kjeldahl; 873.75 mg/g with Spectrophotometry), followed by Casein (316.87 mg/g; 720.83 mg/g), and the lowest in Gainer (227.5 mg/g; 570.5 mg/g). This consistent pattern indicates conformity with packaging claims, although there were value differences between the two methods. Conclusion: The findings emphasize the importance of verifying protein content in supplement products to ensure nutritional information accuracy for consumers. The differences between the two analysis methods are presumably due to their different analytical principles. This study contributes to developing accurate protein analysis methods for high-protein milk products.  
Formulasi Tablet Ibuprofen Dengan Eksipien Pati Beras (Oryza Sativa L.) Pregelatinasi Dan Polyvinyl Pyrrolidon Menggunakan Metode Simplex Lattice Design Wibowo , Farrel Maulana; Rahmawati, Juwita
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.867

Abstract

Rice starch is a natural material that can be used as a tablet disintegrant to reduce reliance on synthetic pharmaceutical excipients, but it has poor flowability and low bulk density. Pregelatinization is one way to improve the physical properties of starch as a tablet disintegrant. This study aims to optimize the ibuprofen tablet formula using a combination of pregelatinized rice starch as a disintegrant and polyvinyl pyrrolidone as a binder. Both materials are optimized using the Design Expert V13 program using the Simplex Lattice Design method. The parameters of the granules evaluated include flow rate, angle of repose, and compressibility index. For tablets, physical properties are tested including hardness, brittleness, and disintegration time, as well as weight diversity for the optimal formula. Furthermore, verification is carried out for the optimal formula and weight diversity tests are added. The optimal ibuprofen tablet formula obtained is for 5.5% pregelatinized rice starch and 5% PVP with a desirability value of 0.909 shows the optimal design because the desirability value range is in the range 0-1. Confirmation of the optimal formula based on its physical properties includes a flow rate test of 11.96 g/s ± 0.06, an angle of repose of 32.06º ± 0.75, a compressibility index of 14.84% ± 2.65, a tablet hardness of 7.29 kg ± 0.28, a tablet friability of 0.63% ± 0.19, a tablet disintegration time of 11.02 minutes ± 0.07, and a weight diversity of 96.96% and NP of 8.324. The results of physical tests show that the optimal formula meets the requirements for good physical properties of tablets

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