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Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 654 Documents
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Formulasi Sabun Transparan Sari Wortel (Daucus carota L.) Sebagai Pelembab Kulit Miranza, Nona; Yuniarti, Rafita; Lubis , Minda Sari; Daulay, Anny Sartika
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.834

Abstract

Transparent soap is a type of soap that appears clear and attractive, with a finer foam. Carrots are one of the plants that contain compounds that can naturally moisturize the skin. The chemical compounds in carrots that can be used as skin moisturizers are present in high amounts. The aim of this study is to formulate transparent soap using carrot Juice as a skin moisturizer. The transparent soap formulation was made using carrot Juice at concentrations of 4%, 6%, and 8%. The evaluation of the transparent soap formulation included organoleptic testing, moisture content testing, foam height testing, pH testing, irritation testing, and hedonic testing. The results showed that the 8% concentration had the highest moisture content, at 14.45%. The highest foam height measurement was also observed at the 8% concentration, with an average of 8.3. The highest pH level was recorded at 8% concentration, with a value of 9.34. Skin analyzer testing indicated that the highest skin moisture level was achieved at 8% concentration, reaching 48%. The transparent carrot Juice soap met the standards set by the Indonesian National Standard (SNI) in terms of organoleptic properties, moisture content, foam height, pH, skin analyzer results, irritation testing, and hedonic testing. The conclusion of this study is that carrot Juice can be formulated into transparent soap that meets SNI requirements.
Perbedaan Media Fermentasi Terhadap Produksi Protein Sel Tunggal (PST) Menggunakan Kultur Saccharomyces cerevisiae Rahayu, Yayuk Putri; Nasution , Haris Munandar; Prasetyo , Healthy Aldriany
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.846

Abstract

Utilization of pineapple peel waste and tofu liquid waste can reduce environmental impacts and is an alternative fermentation medium containing cheap and easily obtained carbohydrate sources and has the potential for the growth of Saccharomyces cerevisiae. Single Cell Protein (SCP) is a protein derived from microbes such as yeast. The purpose of this study was to determine the differences between pineapple peel waste and tofu liquid waste with the addition of different nutrients to SCP production using S. cervisiae. The research method was experimental. The independent variables were fermentation medium MK1 (pineapple peel waste; KH2PO4; sugar); MK2 (pineapple peel waste; KH2PO4; (NH4)2SO4; sugar), MT1 (tofu liquid waste; KH2PO4; sugar); and MT2 (tofu liquid waste; KH2PO4; (NH4)2SO4; sugar). The fermentation period was 0, 2, 4, and 6 days. The dependent variables were protein content, cell dry weight, glucose content, pH and temperature. The results of the SCP production research obtained the highest percentage increase in protein content in MT2 media (tofu liquid waste; KH2PO4; (NH4)2SO4; sugar) was 33.33% (day-2, increase in dry cell weight 84.90%), followed by MK2 media (pineapple peel waste; KH2PO4; (NH4)2SO4; sugar) was 13.15% (day-4, increase in dry cell weight 2.77%). The conclusion is that from both pineapple peel waste and tofu liquid waste substrates, the best PST production was obtained with the highest protein content in MT2 (tofu liquid waste media with the addition of KH2PO4; (NH4)2SO4; and sugar).
Evaluasi In Vivo Biokompatibilitas Implan Hidrogel Hidrokoloid Alami Untuk Aplikasi Biomedis Humayra , Sitiya; Sabira, Anisa; Sonia, Gina; Salman, Salman; Yulia, Rahma
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.848

Abstract

Hydrogels are promising biomaterials for biomedical applications due to their high biocompatibility, three-dimensional structure resembling biological tissue, and their ability to gradually degrade within the body. Notably, hydrocolloid hydrogels based on natural polymers, such as porang-sago glucomannan, demonstrate significant potential for applications like drug delivery systems and tissue engineering. The biocompatibility of these materials is crucial to ensure they are well accepted by body tissues without causing adverse reactions. Therefore, this study aims to evaluate the in vivo biocompatibility of hydrocolloid hydrogel implants made from crosslinked porang-sago glucomannan using citric acid, with a focus on biomedical applications. The method used in this study involved the implantation of hydrogel implants in male mice weighing approximately 25 grams, divided into four groups: three groups with different hydrogel implant formulations and one control group without implants. After 10–20 days post-implantation, the tissue surrounding the implant was evaluated through histopathological analysis using Hematoxylin-Eosin (H&E) staining. The results showed that the hydrogel implants exhibited good biocompatibility, with a mild inflammatory response predominantly characterized by macrophages and moderate fibrotic capsule formation. No pathological signs such as necrosis or granulomas were observed in the tissue surrounding the implant. Formulations F1 and F5 demonstrated better biocompatibility profiles compared to F3, showing lower inflammatory responses. In conclusion, hydrocolloid hydrogel implants based on porang-sago glucomannan exhibit good biocompatibility potential for subcutaneous and skeletal muscle applications. However, further optimization is required to improve tissue integration and minimize the gap between the implant and surrounding tissue. This study provides a foundation for the further development of hydrocolloid hydrogels as biomaterials for biomedical applications, such as drug delivery systems and tissue engineering.
Formulasi dan Evaluasi Sediaan Permen Marshmalow Sari Buah Anggur Merah (Vitis vinifera L.) Nuratika, Eli; Dalimunthe , Gabena Indrayani; Lubis , Minda Sari; Yuniarti, Rafita
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.860

Abstract

Candy serves as a high-calorie source often consumed during activities such as working, exercising, and studying. Typically, the most common candies available in the market are soft candies with a chewy texture. When made with real fruit juice, these candies can provide additional nutrients, minerals, and vitamins to the body. This study aimed to formulate marshmallow candy using red grape juice (Vitis vinifera L.) as the main ingredient, with variations of sucrose and honey, to create a product with appealing taste, texture, and nutritional value suitable for both children and adults. The study also evaluated the physical quality of the formulated marshmallow candy. Methods: This experimental research utilized the open pan method to produce marshmallow candy. The evaluation included organoleptic tests (shape, color, aroma, taste, texture), pH testing, weight uniformity analysis, moisture content measurement, ash content determination, and hedonic testing involving 15-21 panelists. Results: All formulations (F1, F2, F3) met physicochemical quality standards, with a pH of 5, moisture content of 6.5-8.1%, ash content of 1.3-1.8%, and weight variation coefficients of 2.55-2.73%. Based on hedonic testing, formulation F2 (5 g sucrose + 44 g honey) was the most preferred, receiving the highest scores for taste, shape, and texture. Conclusion: Red grape juice was successfully formulated into marshmallow candy that meets standard physicochemical quality requirements. The combination of sucrose and honey significantly influenced product characteristics, with F2 being the optimal formulation based on consumer preference. This study contributes to the development of functional food products using natural, nutrient-rich ingredients.
Hubungan Kepuasaan Pasien Terhadap Niat Kunjungan Ulang Masyarakat Terhadap Pelayanan Rawat Inap di Rumah Sakit Bhayangkara Kediri Jawa Timur Nugraheni, Reny; Astutik , Wahyu Sri
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.509

Abstract

The degree to which hospital services are perfected to meet the needs of the public for health care that complies with professional service standards and service standards while taking into account the capabilities and limitations of the public and government and making reasonable, efficient, and effective use of all available resources to provide safe, satisfactory care that complies with legal ethics and norms. The outcome of interdependent relationships and dependencies between different parts or facets of the hospital as a system is the quality of hospital services. Finding out how satisfied the community was with hospital inpatient services was the aim of the study. The study design measures patient satisfaction with hospital quality control using quantitative analysis. The research was conducted in August-December 2022. The study population was 11,017 respondents. The community satisfaction survey sample is part of the population calculated based on The Open Epi Collection of Epidemiologic Calculators. The public satisfaction survey instrument is a questionnaire developed in the form of an application where satisfaction assessment is given by the sample by giving an asterisk to the components in the questionnaire. SPSS was used to examine the data. Confidentiality, relevant information, and scientific advancement are all applied in this study. The results of bivariate analysis with the chi square test, it can be seen that most respondents were satisfied with inpatient services at the hospital and made a return visit to the hospital when sick by 214 respondents (76.1%), while the fewest respondents were not satisfied with inpatient services at the hospital, but made a return visit to the hospital when sick by 1 respondent (0.4%). The resulting p value is 0.014, which means that there is a relationship between inpatient services and patient re-visits at the hospital. The resulting relationship strength (OR) value is 10.19, which means that respondents who are satisfied with hospital inpatient services will make a return visit when sick to the same hospital 10.19 times greater than respondents who are not satisfied with hospital inpatient services. The research conclusion is that hospital customer satisfaction will reflect the quality of service that exists from the start of the patient or customer entering the hospital environment to going home or leaving and waiting to return.
Pendekatan Berbasis Pangan untuk Mengatasi Anemia Kehamilan: Evaluasi Efektivitas Puding Daun Kelor dalam Meningkatkan Kadar Hemoglobin Arma, Nuriah; Nurrahmaton, Nurrahmaton; Juliani , Sri; Pratiwi , Debby; Wibawanto , Salsabila
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.541

Abstract

Background: Anemia in pregnant women increases the risk of complications such as preterm birth and low birth weight. Although iron supplements are the primary treatment, side effects like nausea and constipation often reduce compliance. Moringa leaves (Moringa oleifera), a natural source of iron and vitamin C, show potential as an alternative. The innovation of processing moringa leaves into pudding offers a more appealing, practical, and acceptable solution for pregnant women. Objective: To examine the effect of moringa leaf pudding on increasing hemoglobin (Hb) levels in anemic pregnant women at Pratama Shanti Clinic. Methods: A quasi-experimental study with a one-group pretest-posttest design was conducted. The sample comprised 15 anemic pregnant women selected through purposive sampling. Data were analyzed using the Wilcoxon test. Results: The mean Hb level increased significantly from 9.91 g/dL (pre-intervention) to 11.38 g/dL (post-intervention) (p=0.002). Hb improvement was observed in 86.7% of respondents, with a maximum increase of 2.00 g/dL. Conclusion: Moringa leaf pudding effectively increases Hb levels in anemic pregnant women and can serve as a local food-based nutritional intervention alternative.
Formulasi dan Uji Aktivitas Antioksidan Sediaan Gel Ekstrak Etanol 70% Bawang Putih Tunggal (Allium sativum L.) Ambarwati , Nadya; Nabillah Zahro, Syarifah; Rahayu , Asti
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.582

Abstract

Single garlic (Allium sativum L.) contains higher bioactive compounds compared to regular garlic. Some of them are organosulfur compounds that give a distinctive aroma and polyphenol compounds as antioxidants. This study aims to formulate a single garlic extract in a gel preparation that can prevent irritation and increase comfort when applied. This study aimed to determine the physicochemical characteristics, including organoleptic properties, pH, viscosity, spreadability, particle size, and antioxidant activity using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method. The results of the physicochemical characteristics test include the organoleptic test, which has a clear yellow gel texture with a distinctive odor of garlic, pH test on F1, F2, and F3, namely (4.70; 5.07; 5.10), viscosity is (9925.3; 9925.3; 9925 mPas), the spreadability test has met the requirements, and the particle size is (194.23; 206.19; 1751.495 nm). The IC50 values for F1, F2, and F3 gel preparations were 128.2451 ppm, 110.279 ppm, and 89.2796 ppm, respectively, indicating moderate antioxidant activity for F1 and F2, and strong antioxidant activity for F3. It can be concluded that the three gel preparations have met the requirements of the physicochemical characteristics test, then statistically analyzed using the OneWay ANOVA method so that it shows the effect of the amount of single garlic extract concentration on the three gel preparations. The IC50 results of the three gel preparations were analyzed by Paired T-test, showing the effect of the amount of concentration of a single garlic extract as evidenced by a sig value of 0.012 <0.05.
Uji Toksisitas Akut Oral Ekstrak Etanol Akar Tanaman Bungkus (Smilax rotundifolia L.) pada Tikus Putih Jantan (Rattus nervegicus) Wulandari, Ayu; Patala , Recky; Mariyani , Mariyani; Prinasari , Rezan
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.605

Abstract

Background: Smilax rotundifolia, commonly known as "bungkus" plant, is an indigenous species from Papua recognized for its potential as an aphrodisiac agent. Traditionally, the local population applies parts of the plant directly to the male genital area, a method that causes itching and highlights the need for development into a safer and more user-friendly formulation. Objective: This study aimed to evaluate the safety of the ethanol extract of Smilax rotundifolia roots through acute toxicity testing, with observation parameters including signs of toxicity, body weight changes, and LD₅₀ value. Methods: Acute toxicity testing was conducted on male white rats (Rattus norvegicus) divided into five groups: normal control and treatment groups receiving extract doses of 5, 50, 300, and 2000 mg/kg body weight. Toxic signs were observed at 0; 0.5; 1; 2; 4; 6; and 24 hours post-administration, while body weight was monitored over a 14-day period. Results: No mortality was observed in any of the treatment groups up to day 14. The rats’ body weights did not show significant changes, and no notable macroscopic organ abnormalities were found, even in the group receiving the highest dose (2000 mg/kgBW). Conclusion: Based on these findings, the ethanol extract of Smilax rotundifolia root is classified as low toxicity (Category 5) or practically non-toxic.
Pembuatan dan Evaluasi Sediaan Masker Gel Peel Off dari Ekstrak Air Mikroalga Spirulina Platensis Kirani , Zabilla; Putra , Billy Harnaldo; Rahmadasmi, Nola; Fitriani , Oryza Sativa; Nanda , Nanda; Andika, Miming; Hasanah , Rizqa; Haq. AH, Ahdi Dinil; Wulandari , Desti
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.620

Abstract

Background: The microalgae Spirulina platensis is a microalgae with numerous benefits, particularly in the fields of health and cosmetics. One of its active compounds, phycocyanin, is a water-soluble antioxidant that is beneficial for facial skincare. A peel-off gel mask is a practical cosmetic product that can be peeled off directly after drying. Objective: This study aimed to develop a peel-off gel mask containing Spirulina platensis water extract and evaluate its physical quality. Methods: The peel-off gel mask was prepared by adding Spirulina platensis water extract at three different concentrations: 0.25% (F1), 0.5% (F2), and 0.75% (F3). Physical quality evaluation included organoleptic testing, homogeneity, viscosity, pH, drying time, adhesiveness, and stability at 4°C and 40°C. A comparison was also made with a commercial spirulina mask product (F4, 0.25%). Results: The physical quality assessment showed that all formulations met the requirements for organoleptic properties, homogeneity, viscosity, pH, drying time, and adhesiveness. In the stability test, the base formula (F0) and F1 (0.25%) were the most stable in terms of organoleptic parameters, while all formulations remained stable in pH. The viscosity of all four formulations remained stable after two months of storage. The commercial mask (F4) exhibited similar physical quality results to F1, with both meeting all requirements. Conclusion: The peel-off gel mask containing Spirulina platensis water extract was successfully developed with satisfactory physical quality. The 0.25% concentration formula (F1) demonstrated good stability, comparable to commercially available products.
Formulasi dan Karakterisasi Fisik Sediaan Emulgel Facial wash dengan Menggunakan Kombinasi Minyak Almond (Prunus amygdalus dulcis) dan Surfaktan Sodium Lauryl Sulfate Paneo, Mohamad Aprianto; Thomas , Nur Ain; Latif, Multiani S; Tuloli, Teti Sutriyati; Nurkamiden, Sri Devi Maharani
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.640

Abstract

Background: Prunus amygdalus dulcis (almond) is a plant whose seeds produce oil with significant benefits for skin health. Almond oil contains essential compounds, such as oleic acid and other bioactive substances, which possess anti-inflammatory and moisturizing properties, making it a potential ingredient in cosmetic pharmaceutical formulations. Objective: This study aimed to formulate a facial wash containing almond oil and to evaluate its physical and organoleptic characteristics in combination with Sodium Lauryl Sulfate (SLS) as a surfactant. Methods: Three emulgel formulations were developed with varying concentrations of almond oil (10%, 15%, 20%) and SLS (1%, 1.5%, 2%). Evaluations included organoleptic tests, pH, viscosity, spreadability, foam height, irritation, and hedonic tests. Results: All formulations exhibited a white color, emulgel texture, and were odorless. Formula F1 had a pH of 7.3, F2 had 8.2, and F3 had 8.6. The highest viscosity was observed in F3 (4,200 cP), optimal spreadability in F2 and F3 (5.9 cm), and the highest foam height in F3 (4.6 cm). Only F1 approached the ideal skin pH range (4.5–6.5), although all formulations passed stability and organoleptic evaluations. Conclusion: Almond oil shows potential as an active ingredient in facial wash formulations. Formula F1 is considered the most suitable based on pH compatibility, while F3 excels in viscosity and foaming properties.

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