cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Salman
Contact Email
salman.kimia@gmail.com
Phone
+6285277011177
Journal Mail Official
admin@journal-jps.com
Editorial Address
Fakultas Farmasi Universitas Tjut Nyak Dhien Jl. Gatot Subroto Gg. Rasmi No. 28, Sei Sikambing C. II, Medan Helvetia, Kota Medan, Sumatera Utara 20123
Location
Kota medan,
Sumatera utara
INDONESIA
Journal of Pharmaceutical and Sciences.
Published by Universitas Tjut Nyak Dhien
ISSN : -     EISSN : 26563088     DOI : https://doi.org/10.36490/journal-jps.com
Core Subject : Health, Science, Agriculture, Engineering,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health
Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 654 Documents
 40   41   42   43   44 
Uji toksisitas menggunakan metode BSLT dan uji antibakteri Staphylococcus aureus dan Escherichia coli ekstrak dan fraksi batang karamunting (Rhodomyrtus tomentosa (Aiton) Hassk.) Siregar , Anisah; Ridwanto, Ridwanto; Daulay , Anny Sartika; Nasution , Haris Munandar
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.822

Abstract

Natural ingredients have been widely used in medicine, commonly referred to as "back to nature," meaning "kembali ke alam." Herbal medicine is recognized as one of the most practical and effective treatment modalities available. One medicinal plant is the stem of Rhodomyrtus tomentosa (Aiton) Hassk., which belongs to the Myrtaceae family and has the potential as an antibacterial remedy. To ensure traditional medicine fulfills its responsibility, scientific research, such as toxicity testing, is necessary. The Brine Shrimp Lethality Test (BSLT) is a preliminary test to assess the toxic effects of plants. This study aims to determine the secondary metabolite compounds, toxicity levels, and antibacterial activity of ethanol extract and n-hexane and ethyl acetate fractions of Rhodomyrtus tomentosa stem. The study includes characterization, phytochemical screening, and toxicity testing by observing the mortality rate of Artemia salina Leach larvae, expressed as LC50. Antibacterial testing against Staphylococcus aureus and Escherichia coli was conducted using the disc diffusion method. The results of phytochemical screening of simplicia powder, ethanol extract, and n-hexane and ethyl acetate fractions of Rhodomyrtus tomentosa stem tested positive for alkaloids and triterpenoids/steroids. Simplicia powder, ethanol extract, and the ethyl acetate fraction also contained secondary metabolites such as flavonoids, tannins, and saponins. The toxicity test results using probit analysis showed that the LC50 value of the extract was 97.6787 µg/mL, the LC50 value of the ethyl acetate fraction was 71.4331 µg/mL, and the LC50 value of the n-hexane fraction was 57.4910 µg/mL. Therefore, it can be concluded that the extract and the n-hexane and ethyl acetate fractions of Rhodomyrtus tomentosa stem are toxic. The antibacterial test results showed that the extract and the n-hexane and ethyl acetate fractions exhibited inhibitory activity against Staphylococcus aureus and Escherichia coli.
Uji toksisitas menggunakan metode BSLT dan uji antibakteri Staphylococcus aureus dan Escherichia coli ekstrak dan fraksi daun karamunting (Rhodomyrtus tomentosa (Aiton) Hassk.) Sagala , Vipi Zetiara; Ridwanto, Ridwanto; Daulay , Anny Sartika; Pulungan , Ainil Fithri
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.823

Abstract

Karamunting leaves are a Myrtaceae family plant used as an antioxidant, antimicrobial, antiviral, anticancer, and antibacterial. This research aimed to determine secondary metabolite compounds, toxicity effects, and antibacterial activity in extracts and fractions of karamunting (Rhodomyrtus tomentosa (Aiton) Hassk.) leaves. This research includes characteristics, phytochemical screening, a BSLT (Brine Shrimp Lethality Test) method toxicity test, and an antibacterial test using the paper disc method. Toxicity tests were carried out with concentrations of (100, 200, 300, 400, 500, 600, 700, 800, 900, 1000) µg/mL, and antibacterial tests against staphylococcus aureus and Escherichia coli were carried out with concentrations of 10, 20 and 30%. The ethanol extract and ethyl acetate fraction results contain alkaloids, flavonoids, triterpenoids or steroids, tannins, and saponins. And the n-hexane fraction contains triterpenoids or steroids. Toxicity test of ethanol extract, n-hexane fraction, and ethyl acetate of karamunting leaves (Rhodomyrtus tomentosa (Aiton) Hassk.) has a toxic effect on Artemia Salina Leach. In the ethanol extract, an LC50 value of 92.593 µg/mL was obtained, followed by the n-hexane fraction with an LC50 value of 153.3829 µg/mL. Then, the ethyl acetate fraction LC50 value was 75.9328 µg/mL. LC50 value. Based on the results obtained from the ethanol extract, the n-hexane and ethyl acetate fractions of caramunting leaves (Rhodomyrtus tomentosa (Aiton) Hassk.) were classified in the toxic category, and the antibacterial test of the ethanol extract, the n-hexane and ethyl acetate fractions of caramunting leaves (Rhodomyrtus tomentosa (Aiton) Hassk.) has antibacterial activity against Staphylococcus aureus and Escherichia coli bacteria. The most potent inhibitory power was found in the ethyl acetate fraction with a concentration of 30% against staphylococcus aureus 16.1 mm and Escherichia coli 17.1 mm in the strong category.
Skrining Fitokimia dan Uji Aktivitas Antioksidan Ekstrak Etanol Daun Ciplukan (Physalis angulata L) Dikawasan Manifestasi Geothermal Seulawah Agam Farida , Mutia; Azhari , Saiful; Darsa , Dimas Dwi; Mahmudi , Mahmudi
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.826

Abstract

Ciplukan leaves (Physalis angulata L.) from the Seulawah Agam geothermal manifestation area exhibit strong potential as a natural antioxidant source. This study investigates the phytochemical content and antioxidant activity of ethanol extract from ciplukan leaves using UV-Vis spectrophotometry. The research begins with sample collection and plant determination, followed by phytochemical screening and antioxidant activity testing using the DPPH method. Phytochemical screening results reveal the presence of alkaloids, flavonoids, tannins, saponins, and steroids. Antioxidant activity testing using the DPPH method yields an IC50 value of 14.99 μg/mL, significantly lower than the positive control, ascorbic acid (19.40 μg/mL), indicating strong antioxidant activity. At the highest tested concentration (50 μg/mL), the extract exhibits an inhibition percentage of 81.84%, while at the lowest concentration (10 μg/mL), it shows an inhibition of 41.41%. These findings confirm that the ethanol extract of ciplukan leaves from the geothermal area possesses high antioxidant content and has great potential for applications in the development of natural-based pharmaceutical and nutraceutical products.
Penetapan Kadar Rhodamin B Pada Bumbu Tabur Dengan Metode KLT Dan KCKT Munthe, Ariska; Daulay, Anny Sartika; Ridwanto, Ridwanto; Pulungan , Ainil Fithri
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.845

Abstract

Rhodamine B is a colouring substance in the form of green or reddish-purple crystals, which are odourless and in the form of a bright red solution (fluorescent). Rhodamin B is a colouring substance that can only be used in the textile, paint, paper, or clothing industries, so it cannot be added to food. Rhodamine B is often used as a coloring agent in paper and textiles. This substance is the most dangerous; if consumed, it can cause problems with liver function and liver cancer. The stages of this research include a sample solution, making Rhodamin B standard stock solution, and making a mobile phase. Examination of qualitative analysis using thin layer chromatography and determination of Rhodamine B levels in seasoning performance liquid chromatography method. The results of the research showed that in the qualitative examination, there were two samples containing Rhodamin B. Rhodamin B levels were determined by determining the retention time and calculating Rhodamin B levels using the high-performance liquid chromatography method. The result of deciding Rhodamine B levels in the two samples containing Rhodamin B was sample A; 2,8915 mcg/g  ,sampel B ; 19,6702 mcg/g  Mcg/g. Then, the highest levels of Rhodamin B are found in sample B.
Kajian Fitokimia dan Analisis Kadar Fenolik Total Ekstrak Metanol Kulit Batang Merawan (Hopea mengarawan Miq.) Pratibha, Muhammad Govindo Ibra; Rahmadanti, Diah Vio; Elviana, Dina; Ramadhan, Muhammad Farras; Pratama, Ngakan Putu Agung Dharma; Pramudia , Rista Anggi; Noviany, Noviany
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.580

Abstract

Dipterocarpaceae is a family of plants that has good wood quality and durability. Apart from that, wood for this family is known to contain the compound resveratrol which has bioactivity, such as anti-cancer and anti-inflammatory. Several genus and species of this family are threatened with extinction. Merawan (Hopea mengarawan Miq.) is one of  extinct species from Dipterocarpaceae which according to several research contains secondary metabolite compounds. The objective of this research was to determine the content of secondary metabolite compounds and determine the total phenolic content of merawan. The maceration method was used to extract the stem bark of H. mengarawan Miq., then continued with phitochemical screening, and total phenolic content analysis. Phytochemical screening was carried out to identify secondary metabolite compounds contained in the methanol extract of H. mengarawan Miq. stem bark qualittatively. Determination of total phenolic content was carried out using the colorimetric method with Folin-Ciocalteu reagent and gallic acid as a comparison standard. The result of this study indicate that the methanol extract of stem bark of  H. mengarawan Miq. contains secondary metabolite compounds, such as saponins, steroids, tannins, alkaloids, flavonoids, and phenolic with the total phenolic content of 13,518±0,228 mg GAE/g.
Sintesis Etil 4-(3,5-dimetil-4-fenoksifenil)-6-metil-2-okso-1,2,3,4-tetrahidropirimidin-5-Karboksilat dan Uji Aktivitas Sitotoksik Terhadap Sel T47D Maulina, Fariha Mufidah; Fauzi, Ahmad; Ramadhan, Muhammad Reza; Hakimah, Wafiq Kholifatul
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.772

Abstract

Cancer is one of the biggest health problems in the world, including in Indonesia. Previous studies have found that DHPM compounds have various pharmacological activities such as anticancer, antifungal, antibacterial, antituberculosis, and antioxidant. Based on this potential, it is interesting to conduct further research with the aim of synthesizing and developing new Dihydropyrimidinone (DHPM) compound derivatives that have potential as anticancer. The synthesis of DHPM derivatives was carried out to obtain ethyl 4-(4-hydroxy-3,5-dimethylphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (M1). Then the compound was developed by Mitsunobu reaction using a sonicator to obtain a new compound ethyl 4-(3,5-dimethyl-4-phenoxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (C2) which will be tested for cytotoxic activity against T47D cancer cells. Characterization of the compound was done using FT-IR, LC-MS, and melting point. Cytotoxic test against T47D cells as anticancer agent using MTT method [3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide] assay. The test results of compound C2 had cytotoxic activity with IC50 of 202.22 µg/mL. The results showed that compound C2 has cytotoxic activity but it is mild because the IC50 produced is high. These findings suggest that compound C2 has anticancer potential, but further structure optimization is needed to increase its effectiveness.
Efektivitas Kombinasi Agen Pendeplesi Glutathione (GSH) dan Inhibitor Glutathione S-Transferase (GST) pada Resistensi Cisplatin terhadap Sel Kanker: Systematic Literature Review Nursoleha, Eva; Utami, Wahyu
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.777

Abstract

Cisplatin is a platinum-based chemotherapy agent used for the treatment of various types of cancer. However, the use of cisplatin as a chemotherapy agent is limited by drug resistance and side effects due to the formation of inactive metabolites from the conjugation reaction between cisplatin and Glutathione S-Transferase (GST). Thus, Glutathione (GSH) and Glutathione S-Transferase (GST) are essential in controlling cisplatin resistance. This study aims to evaluate the use of a combination of cisplatin with GSH-depleting agents and GST inhibitors to overcome or reduce cisplatin resistance in various cancer cell types in vitro and enhance cisplatin's cytotoxic activity. This research was conducted using a systematic literature review method, with a literature search across two international databases, PubMed and Science Direct, for publications from 2013 to 2024. From 15 selected journals, various GSH-depleting agents and GST inhibitors were found to improve the cytotoxic effects of cisplatin, as analyzed based on data on the levels of GSH and GST in the cells and the percentage of viable cells (% cell viability), which showed a significant decrease. The findings of this study are expected to provide insights into the development of cancer therapies using cisplatin as a chemotherapy agent.
Hubungan Usia, Konsumsi Makanan dan Hygiene Mulut Dengan Gejala Tonsilitis Pada Anak di Sekolah Dasar Negeri 1 Banda Sakti Kota Lhokseumawe. Febyola, Febby Fadya; Fardian , Nur; Putri , Baluqia Iskandar; Mauliza, Mauliza; Surayya, Rahmi
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.794

Abstract

Tonsillitis is an inflammation and swelling of the palatine tonsils, which is part of an upper respiratory tract infection. The World Health Organization (WHO) estimates that there are approximately 287,000 cases of tonsillitis in children under 15 years of age. In Indonesia, the prevalence of tonsillitis is reported to be 214,666 cases, or about 23%. Several factors increase the risk of developing tonsillitis, such as age, food consumption, oral hygiene, and environmental factors. This study aims to examine the relationship between age, food consumption, and oral hygiene with tonsillitis symptoms in children at SDN 1 Banda Sakti, Lhokseumawe City. This is an analytic survey with a cross-sectional design. Data were collected through questionnaires completed by 100 children, selected using a proportionate stratified random sampling technique. The results showed that the majority of respondents were between 6 and 9 years old, female, had risky food consumption habits, maintained good oral hygiene, and exhibited symptoms of tonsillitis. The Chi-square test results indicated a significant relationship between age and tonsillitis symptoms (p = 0.001), food consumption and tonsillitis symptoms (p = 0.025), and oral hygiene and tonsillitis symptoms (p = 0.026). These findings suggest a significant relationship between age, food consumption, and oral hygiene with tonsillitis symptoms in children at SDN 1 Banda Sakti, Lhokseumawe City.
Potensi Sitotoksik Ekstrak Rizoma Jahe Merah (Zingiber officinale var. rubrum) terhadap Sel Kanker Payudara 4T1 Dwi Oktaviani, Nadia; Maryati, Maryati
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.796

Abstract

Background: 4T1 breast cancer is a type of Triple-Negative murine breast cancer (TNBC) that has a strong ability to metastasise. Plant metabolite compounds are one of the strategies that must be explored to develop breast cancer treatments. Red ginger rhizome is one of the candidate plants that have anticancer activity. Previously, cytotoxic studies have been conducted on Widr and HeLa cancer cells. However, research on breast cancer cells is still lacking, so it needs to be developed. Materials and Methods: This study aims to determine the potential cytotoxicity in vitro using the MTT test. The red ginger rhizome extract is obtained by maceration using 96% ethanol solvent, which is then analysed for secondary metabolite compounds. Results: The results showed that red ginger rhizome extract contains flavonoids, phenolic, alkaloid, saponin, and tannin compounds. While in the cytotoxic test, red ginger rhizome extract and doxorubicin have good cytotoxic potential with IC50 values of 69.86 µg/ml and 0.4 µg/ml, respectively. The red ginger rhizome extract and doxorubicin are classified as active and highly active cytotoxics. Conclusion: It can be concluded that red ginger rhizome extract shows cytotoxic potential as a therapeutic candidate that can inhibit the growth of 4T1 breast cancer cells by 50%. Therefore, red ginger rhizome extract has the potential to be further developed as a chemotherapeutic agent.
Efektivitas Antibakteri Ekstrak Daun Glodokan Tiang (Polyalthia longifolia) Terhadap Cutibacterium acnes dan Staphylococcus epidermidis Girsang, Valentina; Nufus , Nunky; Saptawati , Tunik; Sa’adah , Anifatus; Wibowo, Anisa Devi Kharisma; Vidiani , Anak Agung Pradnya Paramitha
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 2 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i2.815

Abstract

Introduction: Polyalthia longifolia, commonly known as Glodokan tiang, is a plant typically found along roadsides, serving as shade and an ornamental feature in gardens. In addition to its aesthetic function, the leaves of this plant have been found to contain compounds with effective antibacterial activity. Natural ingredients with antibacterial properties, such as Polyalthia longifolia leaf extract, can be an alternative acne treatment due to their lower side effects than chemical drugs. Research Objective: This study aims to test the antibacterial activity of Polyalthia longifolia leaf extract in inhibiting the growth of Staphylococcus epidermidis and Cutibacterium acnes, which are significant causes of acne. Research Method: Polyalthia longifolia leaves were extracted using a maceration method with 70% ethanol as the solvent. The resulting extract was then tested for antibacterial activity using the disc diffusion method at 30%, 35%, 40%, 45%, and 50%. The bacteria used in the tests were Staphylococcus epidermidis and Cutibacterium acnes. Clindamycin was used as a positive control, and sterile water was used as a negative control. The data obtained from the tests were analyzed using the Kruskal-Wallis and post-hoc Games-Howell tests. Results: The study showed that Polyalthia longifolia leaf extract at various concentrations (30%, 35%, 40%, 45%, 50%) exhibited significant antibacterial activity against both bacteria tested. At a concentration of 50%, the extract demonstrated the most potent inhibitory effect on Cutibacterium acnes and Staphylococcus epidermidis, with inhibition zones reaching 15.82 mm and 15.74 mm, respectively. Conclusion: Polyalthia longifolia leaf extract shows significant antibacterial potential against Staphylococcus epidermidis and Cutibacterium acnes. The 50% extract concentration exhibited the most potent inhibitory effect, making it a promising candidate for natural acne treatment with minimal side effects.

Page 42 of 66 | Total Record : 654

 40   41   42   43   44 

Filter by Year

2018 2026


Reset
Filter By Issues
All Issue JPS Volume 9 Nomor 1 (2026) JPS Volume 8 Nomor 4 (2025) JPS Volume 8 Nomor 3 (2025) JPS Volume 8 Nomor 2 (2025) JPS Volume 8 Nomor 1 (2025) JPS Volume 7 Nomor 4 (2024) JPS Volume 7 Nomor 3 (2024) JPS Volume 7 Nomor 2 (2024) JPS Volume 7 Nomor 1 (2024) JPS Volume 6 Nomor 4 (2023) JPS Volume 6 Nomor 3 (2023) JPS Volume 6 Nomor 2 (2023) JPS Volume 6 Nomor 1 (2023) Suppl. 1, No. 1 (2023) JPS Volume 1 Nomor 1 (2018) More Issue