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Journal of Pharmaceutical and Sciences.

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Published by Universitas Tjut Nyak Dhien

ISSN : - EISSN : 26563088 DOI : https://doi.org/10.36490/journal-jps.com

Core Subject : Health, Science, Agriculture, Engineering,

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

Journal of Pharmaceutical and Sciences (JPS) with e-ISSN: 2656-3088 is a scholarly peer-reviewed open access journal related to Pharmaceutics, Pharmacology, biotechnology, Pharmacognosy & Phytochemistry, Pharmaceutical Chemistry, Pharmaceutical Biotechnology, Pharmacy practice, Pharmacogenomics, Medicinal Chemistry, Molecular Pharmacology, Novel drug delivery system, Nanotechnology, Analytical Chemistry, Organic Chemistry, Natural Chemistry, Polymer Sciences, Clinical Pharmacy, pharmaceutical management, pharmacoeconomics, pharmacoepidemiology, clinical pharmacy, community pharmacy, social pharmacy, pharmaceutical marketing, government policies related to pharmacy, pharmaceutical care, Medical Biotechnology, Biochemistry, food chemistry, health and applied sciences relevant to the field of pharmacy. Journal of Pharmaceutical and Sciences (JPS) accepts manuscripts in Indonesian Language (Bahasa Indonesia) with titles and abstracts in bilingual, both Indonesian and English. We accept article manuscripts in the form of original research, literature reviews, and systematic reviews. We do not accept articles in the form of case reports

Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)

Articles 616 Documents

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Formulasi Dan Evaluasi Sediaan Lipstik Dari Ekstrak Buah Naga Merah (Hylocereus polyrhizus) Dan Ekstrak Lidah Buaya (Aloe vera) Sebagai Pewarna Dan Pelembab Alami Athaillah Athaillah; Dwi Sundari; Aswan Pangondian; Putra Chandra
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Red dragon fruit (Hylocereus polyrhizus) contains the chemical betacyanin, which functions as a natural dye, and aloe vera (Aloe vera) also has a polysaccharide derivative lignin which functions as a binder of skin moisture. The combination of red dragon fruit extract and aloe vera can be made as a pharmaceutical preparation in the form of lipstick. This study aimed to determine the optimum concentration of red dragon fruit extract and aloe vera on the physical properties of lipstick. This research is an experimental study with the stages of making extracts by maceration method with betacyanin phytochemical test on red dragon fruit and infundation method with a phytochemical test of lignin on aloe vera before making lipstick. Making lipstick with six variations of concentration of red dragon fruit extract 30,25,20,15,10,5% (w/v) and aloe vera 5,10,15,20,25,30% (w/v) and organoleptic test, homogeneity test, pH test, smear test, melting point test, hardness test, irritation test and tested the physical stability of lipstick preparation with a stability test of 3 cycles. The result of maceration on red dragon fruit was 57 ml, and aloe vera infundation was 57 ml. The results of the phytochemical test showed that the red dragon fruit extract was positive for betacyanin and the aloe vera extract was positive for lignin. The formula (F) in this study is concentration. The results showed that the concentration of red dragon fruit extract by an organoleptic test with Formula 1 (F1) to formula 6 (F6) produced good color, smell, and shape. The pH test results of all formulas have a pH below the standard range of skin pH, namely pH 8. The smear test results show that all formulas have good smearing power. The melting point test results show that formula 4 (F4) has a melting point of 66̊ C. The hardness test results showed that Formula 6 (F6) produces a strong textural power. The results of the irritation test showed that all of the formulas did not produce an itchy or swollen effect when applied successively for three days and the results of the stability test showed that formulas 3 (F3) to formula 6 (F6) produced discoloration such as drastic fading and melting texture at the bottom of the preparation happened on day 4 of being at extreme temperatures. The optimum lipstick formulation in the standard range is formula 1 (F1) with a concentration of 30% red dragon fruit and 5% aloe vera, which is quite good and can be formulated as a lipstick preparation.

Analisa Zat Warna Rhodamin B Pada Lipstik Gloss Dan Matte Yang Dijual Dikota Banda Aceh Dengan Metode Kromatografi Lapis Tipis Azmalina Adriani; Rizki Andalia; Rinaldi Rinaldi; Nadhira Ulya
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Cosmetics are a very important need for women, one type of cosmetics that must be owned by women is lipstick. Lipstick is a lip color that has many colors. Rhodamine B is a synthetic dye that is prohibited for use in cosmetics and is declared a dangerous substance. This study aims to identify the presence or absence of Rhodamine B in gloss and matte sold in the city of Banda Aceh using the Thin Layer Chromatography (TLC) method. The population in this study was a sample of lipstick sold in the city of Banda Aceh with a sampling technique using a purposive sampling method. The criteria for lipstick taken from the gloss liquid, homogeneous, sharp smelling, red and purplish pink in color. Whereas matte has a semi-solid and smooth texture, has a purplish pink color and smells of lipstick in general and has a BPOM or not BPOM statement. Observations were made by looking at the stains under a 254 nm UV lamp. The results of this study were that of the eight samples, non-BPOM SS samples tested positive for Rhodamine B, with an Rf of 0.68 which is in line with the standard Rf value. In accordance with the requirements of the Regulation of the Food and Drug Supervisory Agency of the Republic of Indonesia Number 23 of 2019 concerning technical requirements for prohibited dyestuffs in cosmetics.

KOMBINASI VIRGIN COCONUT OIL (VCO) DAN EKSTRAK ETANOL KELOPAK JANTUNG PISANG KEPOK (Musa paradisiaca L.) PADA FORMULASI SEDIAAN POMADE Siti Fatimah Hanum; Pebry Nursanti Sihombing; Evi Ekayanti Ginting; Fahma Shufyani; Jefri Naldi
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Background; Pomade is an oily or waxy substance used for hairstyles. The pomade looks shiny, smooth and not dry. The properties of pomade make hairstyles look neater, while long-lasting moisturizing properties are popular with textured individuals. Method; This research was carried out experimentally, including the manufacture of ethanol extract of the banana flower petals of Kepok (Musa paradisiaca L.) using the maceration method of a combination of VCO (Virgin Coconut Oil) oil with the fishing method as a pomade preparation, with a concentration of 2%, 4%, 6%. Physical quality examination, namely organoleptic test, pH, homogeneity, stability, spreadability, irritation based on SNI 16-4955-1998, and effectiveness test using volunteers. Results; In this study, it was found that preparations that showed or showed good orgnoleptic at a concentration of 2%, 4%, 6%, fulfilled the homogeneity requirements at a concentration of 2%, 4%, 6%, good dispersion at a concentration of 4%, the irritation test did not irritate. skin, pH test has a pH value according to the pH value of pomade, good stability aimed at a concentration of 2% for 14 days. The results of the effectiveness test of pomade preparations concentrations of 2%, 4%, 6% obtained effective results at 5 hours of use compared to those on days 1, 2, 3.Use 5 hours with the category of tidy 100%, durable 66.67%, no durable 33.33%, and easy 100% of 9 volunteers. Conclusion; From this research, the ethanol extract of Kepok banana flower petals with a combination of VCO (Virgin Coconut Oil) can be formulated into pomade preparations and the stable formula is one that contains ethanol extract of Kepok banana flower petals with a 2% concentration of VCO (Virgin Coconut Oil).

Molecular Docking Senyawa Yang Berpotensi Sebagai Antikanker Payudara: Literature Review Anisa Fauziah; Adelia Fatharani; Cindhy Maulida Nurawaliah; Faizal Auladi Rivianto; Irene Virda Sakina; Marsah Rahmawati; Lina Nurfadhila
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Cancer is a degenerative disease that has claimed many victims. Currently breast cancer is the second most common cancer that causes death after lung cancer and is the most common cancer suffered by women. Treatment of breast cancer is generally done with chemotherapy, radiotherapy, hormone therapy and surgery. Several synthetic drugs have been used to inhibit the growth of cancer cells. However, these drugs have dangerous side effects for the body so other alternatives are needed, including developing drugs derived from plants. To predict the activity of compounds from plants that have potential as anti-breast cancer, the molecular docking method was used. This review aims to inform compounds that have the potential as anti-breast cancer based on the results of molecular docking. The research method used was a literature study of 15 journals searched on the Google Scholar and Google databases related to molecular docking of breast anticancer compounds. The results of the review show that several compounds have the potential to inhibit breast cancer receptors including mangiferin compounds which are the best at inhibiting HER-2 receptors, quercetin glycoside compounds which are the best at inhibiting Bcl-2 receptors, quinine compounds which are the best at inhibiting ER-α receptors, compounds 6,7 -dihydro-17-hydroxyerisotrin is the best at inhibiting EGFR receptors, curcumin compounds are the best at inhibiting COX-2 receptors and eugenol compounds are the best at inhibiting ER-β receptors.

Kajian Interaksi Obat Pada Peresepan Pasien Diabetes Melitus Di Salah Satu Rumah Sakit Di Kota Bandung Ameilia Ameilia; Sri Adi Sumiwi
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Introduction: Drug interactions are events that occur if the use of drugs in a shared time. The drug interactions that occur can produce adverse or beneficial effects. Purpose: to determine the potential interaction of drugs given to outpatients with diabetes mellitus diagnosis in one of the hospitals. Method: the study was conducted using a descriptive analysis design, by collecting retrospective data using prescription documents for diabetic patients in outpatient pharmacy installations in hospitals in the city of Bandung. Results: the study showed that the Biguanida group was often used as much as 82.4% and the interaction of the use of Glimepirid with metformin as many as 25 cases (21.2%) with a moderate level of interaction. Conclusion: The antidiabetic drug that is often used is the Biguanida group with a frequent interaction is Glimepirid with metformin.

Pemeriksaan Hemoglobin Pada Petugas SPBU Di Daerah Glugur Rimbun Kabupaten Deli Serdang Tahun 2021 Radina YM Ginting; Yuspita Wahyu
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Gas station workers are one of the workers who have a high risk of exposure to toxic substances that are exposed to fuel because every day they work in a place related to motorized vehicles, exposure to gases which, if inhaled, enter the human body in high levels, can inhibit the formation process. hemoglobin. Hemoglobin is a protein molecule in red blood cells that functions as a medium for transporting oxygen from the lungs throughout the body and carrying carbon dioxide from the body's tissues to the lungs. When hemoglobin is reduced, the body will become tired, lethargic, drowsy, and lose concentration more quickly. Hemoglobin that is too low can cause a disease known as Anemia. The purpose of this study was to determine hemoglobin levels in gas station attendants. This research was conducted using the blood cyanmethemoglobin method using Drabkins reagent. The population of this study were gas station attendants in the Glugur Rimbun area, Deli Serdang Regency with a sample of 14. This research was conducted at the North Sumatra Regional Health Laboratory. The results of this study showed that 21% had below normal Hb values.

Pengaruh Pemberian Obat Antidepresan terhadap Risiko Bunuh Diri: Literatur Review Febi Febriani Hasanah; Indah Laily Hilmi; Salman Salman
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Depression is a mental health disorder that often occurs to anyone regardless of age. Treatment of depression can be done with psychotherapy, administration of antidepressants, or a combination of both. However, the use of antidepressants is believed to increase the risk of suicidal behavior and ideation, especially in adolescent patients. The purpose of this study was to determine the effect of antidepressant therapy on the risk of suicide in adolescents. This research was conducted using the Literature Review method using the Google Scholar database. Articles obtained from the search process were then re-selected based on inclusion and exclusion criteria, so that 5 articles that match the criteria were obtained. The results of the study show that giving antidepressant drugs to patients can increase or decrease the risk of suicide in patients. Patients aged <18 years (children and adolescents) are considered to have a greater risk of suicide compared to adult and geriatric patients. Based on these results, it can be concluded that the use of antidepressant drugs must be done wisely. Patients need to receive supervision and support from the closest people in using antidepressant drugs to avoid the risk of suicide in patients.

Metode Analisis Natrium Benzoat pada Makanan dan Minuman: Literatur Review Erlangga Muhamad Prayuda; Febi Febriani Hasanah; Rika Valensia; Nurma Dwi Rahmawati; Marsah Rahmawati Utami
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Preservatives are food additives that can inhibit the growth of microorganisms so that food does not get stale easily. Sodium benzoate is one of the preservatives that is allowed to be used in food but within a predetermined limit of <1 g / kg according to BPOM RI. The purpose of this review is to find out an overview and provide information about the method of analyzing sodium benzoate levels in food and comparing the results with the provisions. The method used is literature review from various journals with a span of 10 years. The results of this study, the method of analyzing sodium benzoate in food can be carried out qualitatively and quantitatively. Qualitative tests can use the addition of FeCl3, test kits, and KLT, while quantitative tests can use KCKT, spectrophotometry UV-Vis and titration. The samples studied from 11 journals obtained were syrup, sauce (tomato and chili), soy sauce, beverage and strawberry jam products produced industrially and/or home-produced. The conclusion of the various methods tested is that there are still many food producers who use sodium benzoate as a preservative, but not all samples studied are in accordance with the provisions

Tingkat Pengetahuan Penggunaan Antibiotik Terhadap Resistensi Antolin Lamsar Rogabe Samosir; Indah Laily Hilmi; Salman Salman
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Antibiotics are drugs used to treat bacterial acaic infections. Unreasonable use of antibiotics will cause resistance to a bacterium. I did a review of this journal aimed at analyzing the level of knowledge of antibiotic use in the community to prevent the occurrence or increase of cases of resistance to a bacterium. For the results obtained from the results of journal reviews, the level of knowledge of the average antibiotic use is still relatively up and down.

Uji Aktivitas Antidiabetes Fraksi Etil Asetat Daun Seledri (Apium graveolens L.) Terhadap Tikus Jantan Wistar (Rattus norvegicus) Rena Meutia; Novitaria br Sembiring; Octavian Ashido Nababan; Nerly Simanjuntak; Erida Novriani; Nurasni Nurasni
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

The high population of diabetic patients every year is increasing, with the number of diabetic patients increasing by 463,000 in 2019. Estimates of Idiabetic foot in 2045 the number of the diabetic patient will be 700.000.000 patients. Celery leaves are used as an anti-diabetic (Apium graveolens L.). This study aimed to determine the anti-diabetic activity of the ethyl acetate fraction in celery leaves against male Wistar rats. Celery leaf Simplicia powder was extracted with 70% ethanol solvent in the maceration method. After obtaining 70% ethanol extract, then fractionation of n-hexane, ethanol-water, and ethyl acetate was carried out. The anti-diabetic test of the ethyl acetate fraction on celery leaves used the compound alloxan at a dose of 150 mg/kg BW. This study obtained the results of the ethyl acetate fraction in celery leaves at a dose of 300 mg/kg, which had the highest anti-diabetic activity with a reduction percentage of 65% compared to the positive control with a reduction percentage of 64%. The contents of chemical compounds from the ethyl acetate fraction in celery leaves are alkaloids, flavonoids and saponins.

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Home Page

OAI Link

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Contact Name Salman

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Phone +6285277011177

Journal Mail Official admin@journal-jps.com

Editorial Address Fakultas Farmasi Universitas Tjut Nyak Dhien Jl. Gatot Subroto Gg. Rasmi No. 28, Sei Sikambing C. II, Medan Helvetia, Kota Medan, Sumatera Utara 20123

Location Kota medan, Sumatera utara INDONESIA

Abstract

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Contact Name
Salman

Contact Email
salman.kimia@gmail.com

Phone
+6285277011177

Journal Mail Official
admin@journal-jps.com

Editorial Address
Fakultas Farmasi Universitas Tjut Nyak Dhien Jl. Gatot Subroto Gg. Rasmi No. 28, Sei Sikambing C. II, Medan Helvetia, Kota Medan, Sumatera Utara 20123

Location
Kota medan,

Sumatera utara

INDONESIA