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SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN

sainsmedika
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Published by Universitas Islam Sultan Agung

ISSN : 20851545 EISSN : 2339093X DOI : -

Core Subject : Health,

Health Professions Medicine & Pharmacology

Sains Medika is journal of medicine and health, is a peer-reviewed and open access journal that focuses on promoting medical sciences generated from Biomedical Sciences, Public Health, Clinical Sciences, and Medical Education to integrate researches in all aspects of human health. This journal publishes original articles, reviews article, and also interesting case reports.

Arjuna Subject : -

Articles 235 Documents

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Scope of Visum Et Repertum as a Legal Mean of Proof in Crime Related to Human Body in Rumah Sakit Bhayangkara Semarang Trisnadi, Setyo
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 5, No 2 (2013): July-December 2013
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Visum et repertum (VER) is part of forensic and medico-legal science. VER is a written report by a sworn doctor and has the authority of what he/shehas seen and and found in the evidence presented and conclude the evaluation for the trial process in the investigation to decide the suspect, for the basis ofprosecution, prove that an accused person is guilty, at the level of investigation, the request of VER is the authority of investigator of POLRI (The IndonesianNational Police). VER is prepared by a doctor with a special expertise under oath or medical professional and legal responsibilities and liabilities. Therehas been dualism concerning to the evidence of expert witness. First, an expert witness provides a sworn testimony in the trial as it is explicitly mentionedin article 184 of KUHAP (Code of Criminal Procedure). Second, VER is part of legal means of proof of expert testimony given by a legal medical doctoras stated in 184 KUHAP. The expert testimony in form of VER can be legal means of proof which can be used before the court. It is, however, not alwaysnecessary for prosecutor to use it for the adjudicating criminal case. However, criminal case related to human body, it was found that the prosecutorsmake the judgment based on the VER. The autopsy data of RS Bhayangkara in January to October 2012 showed that there were more male victim (58)compared to female victim (51) .The most common cause of death was persecution (91 ). The most common wound was bruise.

DIFFERENCE IN THE LEVELS OF FERRITIN, HEMOGLOBIN, AND ERYTHROCYTE COUNT OF STAGE 5 CHRONIC KIDNEY DISEASE PATIENTS AFTER ONE, THREE AND SIX MONTHS OF HEMODIALYSIS Wibowo, Subur; Chasani, Shofa; Wibowo, Joko Wahyu; Nasihun, Taufiqurrachman
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 10, No 1 (2019): June 2019
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

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INTRODUCTION: 77,892 chronic kidney disease patients in Indonesia undergo hemodialysis in 2017. However, the effects of period of undergoing hemodialysis on hemoglobin level, erythrocyte count, and ferritin level are still unclear.OBJECTIVE: This research aims at examining the effects of period of undergoing hemodialysis on the levels of ferritin, hemoglobin, and erythrocyte count of stage 5 of chronic kidney disease patients.METHODS: In the analytical observational research with a cross sectional design, 30 men meet the inclusion criteria and are randomly divided into 3 groups: one month group (1M-G), three months group (3M-G), and six months group (6M-G). Each of the research objects has undergone hemodialysis for one, three and six months. The levels of ferritin, hemoglobin, and erythrocyte count are analyzed with an immunoflourescence method.RESULTS: The Post Hoc LSD analysis states that the ferritin levels of 3M-G (718Â±63.61) and 6M-G (947Â±66.22) are significantly higher than that of 1M-G (383.77), p< 0.01. The ferritin level of 6M-G is significantly higher than that of 3M-G, p<0.01. The hemoglobin levels and erythrocyte counts between 1M-G (9.45Â±0.84) & (3.26Â±0.55), 3M-G (9.10Â±1.22) & (3.21Â±0.50) and 6M-G (8.35Â±1.21) & (2.92Â±0.40) are insignificant, p>0.05.CONCLUSION: After undergoing hemodialysis for three and six months, the ferritin levels improve significantly compared to that of one month of hemodialysis, and there is no significant difference in hemoglobin levels and erythrocyte counts.

The Potency of Bixa orellana Seedcouts ExtractÃ¢â‚¬â„¢s as Antiimflamation Drug Hussaana, Atina; Suparmi, Suparmi
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 4, No 2 (2012): Juli-Desember 2012
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Background: Bixin is an orange-yellow carotenoid derived from the outer seed coats of annatto (Bixa orellana L.), which antioxidant activity. However, the use of this colorant in drug potency as antiimflamatory have been explored yet. The effect of crude extract from the outer seed coats of annatto on the inflammatory was investigated to determine its antiimflamation potency.Design and Method: This study was post test only control group design. Twenty four mice is selected randomly then divided into four groups, KI (extract 0.09 mg), K.II (extract 0.18 mg dose), K.III (aspirin 90 mg), and K.IV (CMCNa 0.125%). Oedema volume was measured before injection karagenin 1%, two, 2.5, three and four hours after injection karagenin. The mean reduction in inflammation were tested by one way anova and pos hoc LSD. Result: Greatest reduction in inflammation indicated by K.III (0.100 ml), then in K.II (0.067 ml), KI (0.072 ml), and lowest in K.IV (-0.017 ml). Differences in the reduction of inflammation significantly different between KI and K.II K.IV; and K.III whereas no significant difference was found between KI and K.III K.II.Conclusion: The extract of the outer seed coats of annatto (Bixa orellana L.) have antiimflamantory activity in mice that was induced by karagenin 1% (Sains Medika, 4(2):134-141).

Invitro Antioxidant and Cytotoxic Potential of Ficus carica L. and Olea europeae L. Against Cervical Cancer Widyaningrum, Naniek; Hussaana, Atina; Puspitasari, Nesya Ayu
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 11, No 1 (2020): June 2020
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

INTRODUCTION:Cervical cancer is a malignant infectious disease caused by Human Papilloma Virus (HPV) in the cervix. Fig and olive oil containing flavonoid has been shown to have antioxidant and anticancer activity.OBJECTIVE:This study aimed to evaluate antioxidant and cytotoxic activity of combined Ficus carica L. and Olea europeae L. against HeLa cervical cancer cells.METHODS: This is an experimental study with a post-test only control group design. The HeLa cells were divided into 5 groups: fig extract, olive oil, combined fig extract and olive oil (at the ratio of 1:3, 1:1, 3:1), positive control (doxorubicin). The cytotoxic and antioxidant activity were evaluated by using MTT Assay and DPPH, respectively. The cytotoxic results were analyzed using probit and antioxidant activity was analyzed by using linear regression to obtain IC50 values.RESULTS:The IC50 cytotoxic of fig extract, olive oil, combined fig extract and olive oil (at the ratio of 1:3, 1:1, 3:1) with positive control (doxorubicin) were 13063,915 Î¼g/mL, 679,593 Î¼g/mL, 1562,356 Î¼g/mL, 746,923Î¼g/mL, 563,626 Î¼g/mL and 13,707 Î¼g/mL respectively. The IC50 antioxidant of fig extract, olive oil, and combination of fig extract and olive oil (3:1) was 105.9272 ppm, 23.1276 ppm, and 21,0689 ppm respectively.CONCLUSION:The combination of fig extract and olive oil (3:1) was shown to have the highest antioxidant and cytotoxic activity against HeLa cervical cancer cells.

The Study of Mouth Washing Duration with Boiled Uncaria gambir on the Dental Plague Formation Susilowati, Aning; Sumarawati, Titiek
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 4, No 1 (2012): Januari-Juni 2012
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Background: Dental plague has been known to be the major agent causing dental carries and periodontal disease which are the most common dental and soft tissue diseases with the prevalence of 70-80%. The preventive measure including the use of chemical substance of catechin having anti-plague activity in the form of mouth wash has been shown to have effects on the dental plague formation. The objective of this study was to find out the duration of mouth washing with boiled gambir (Uncaria ambir) on the plague formation in Pondok Pesantren Al-Badriyah Mranggen, Demak.Design and Method: In this study using Pretest-Posttest Control Group Design, 44 samples of subjects was divided into 4 groups of 11 each. Group I, II, II were treated with the mouth wash of Uncaria gambir boiled 2, 3, 4 minutes respectively. Group IV serving as control was treated with mouth wash of water for 3 minutes. The data was analyzed with non parametric test using Kruskal-Wallis followed by Mann-Whitney test with p < 0.05.Result: Kruskal Wallis analysis showed a significant difference in mean of plague before and after the treatment among the four groups (p < 0.05). Mann-Whitney test showed no significant difference between group I and III ( p> 0.05) and significant difference for the rest of the groups (p < 0.05). Conclusion: The mouth rinse duration using boiled Gambir has been shown to have an effect on the dental plague formation. 3 minute mouth washing shows the optimum effect (Sains Medika, 4(1):57-62).

Low Birth Weight as The Risk factor of Coronary Heart Diseases Wibowo, Joko Wahyu
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 3, No 2 (2011): Juli-Desember 2011
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Low birth weight, a nutritional deficiency is related to the increased in the coronary heart disease insidence. Low birth weight is correlated with the hipotalamus-pituitary-adrenal responsible for the the concentration of cortisol in sirculation, increased in homosistein, insuline resistence and increased C reactive protein playing role on the aterosclerosis process predispose the corronary disease. This paper will discuss the relationship between the low birth weight and the ateroclesoris process leading to coronary heart disesase (Sains Medika, 3(2):185-200).

Effect of White Turmeric Extract (Curcuma zedoaria) Using Zam-zam Solvent Compare with Ethanol Solvent Against Breast Cancer Cell T47D Hudaya, Isna; Nasihun, Taufiqurrahman; Sumarawati, Titiek
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 6, No 2 (2015): July-December 2015
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Introduction: Curcuma zedoaria is one of the herbal plants potentially protects and cures many diseases, particularly as anti-cancer and anti-tumor. Anti-cancer active compounds of it are flavonoid, phenolic, and saponin. Objectives: This study aimed to explore the cytotoxicity of Curcuma zedoria extract (CZE). Methods: Experimental Quasi with post test non equivalent control group design on T47D cell line at Biology laboratory, Faculty of Medicine, Sultan Agung Islamic University, Semarang. The research was consisted of 2 groups, namely: intervention group with CZE zam-zam solvent and intervention group with CZE ethanol solvent given 10 different dosages each for 1.000 ÃŽÂ¼g/mL; 500 ÃŽÂ¼g/mL; 250 ÃŽÂ¼g/mL; 125 ÃŽÂ¼g/mL; 62.5 ÃŽÂ¼g/mL; 31.25 ÃŽÂ¼g/mL; 15.62 ÃŽÂ¼g/mL; 7.81 ÃŽÂ¼g/mL; 3.90 ÃŽÂ¼g/mL; 1.95 ÃŽÂ¼g/mL. Cytotoxicity test of IC50 using direct counting method and analyzed by probit analysis. Results: IC50 value of CZE in zam-zam and ethanol solvent were 28.24 ÃŽÂ¼g/ml and 13.71 Ã‚Âµg/ml respectively at the same 24 hours incubation period. Chi-square test revealed p value was 0.000 (ÃŽÂ± = 0.05), meaning that there was significant relationship. Conclusion: CZE activity using ethanol is highly active while CZE using zam-zam water is moderate and both of them have the toxicity on breast cancer cell. As the result, apoptosis process may occur.

Stem Cell Mesenchymal Injection Increases Platelet-Derived Growth Factors Level and Percentage of Collagen in Third-Degree Burn injured Mice Ridawati, Erna; Nasihun, Taufiqurrachman; Wiratno, Wiratno
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 7, No 2 (2016): December 2016
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Introduction: Mesenchymal stem cell (MSC) has been demonstrated to accelerate wound healing. Platelet-derived growth factor (PDGF) and collagen have an important role in wound healing. However, the effect of MSC on levels of PDGF and number of collagen has not been established. Objectives: To determine the effect of MSC on the levels of PDGF and the percentage of collagen in the burns healing. Methods: in this experimental study, 20 BALB /c mice were divided into 4 groups: a control group (G-0) injected with 2 ml of distilled water and group 1 (G-1), Group 2 (G-2), and group 3 (G- 3) injected with MSC at the dose of 1 x 104, 2 x 104, and 4 x 104 respectively. The burn wound was made by attaching a metal nail that had been heated for 20 seconds at the feet of mice. Levels of PDGF on day 2 (PDGF-2) and 7 (PDGF-7) was assessed by ELISA, while on day 10 excision of skin was done to calculate the percentage of collagen. Results: There was a significant difference in the levels of PDGF-2, PDGF-7, and the percentage of collagen ( P <0.05). Posthoc analysis showed that the levels of PDGF-2, PDGF-7, and percentage of collagen in the G-2 and G-3 was significantly higher than that of G-0, p <0.05. While the levels of PDGF-2, PDGF-7, and the percentage of collagen in the G-3 was significantly higher than that of G-2 and G-1 (p <0.05). Conclusion: Injection of MSC at a dose of 2 x 1044 and 4 x 1044 increases the levels of PDGF and the percentage of collagen.

The Effect of Green Tea Leaf Extract on Spatial Memory Function and Superoxyde Dismutase Enzyme Activity in Mice with D-galactose Induced Dimentia Gumay, Ainun Rahmasari; Bakri, Saekhol; Utomo, Astika Widy
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 8, No 1 (2017): June 2017
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Background:Â Oxidative stressÂ andÂ inflammationÂ playÂ an important role inÂ pathogenesis ofÂ brain agingÂ and neurodegenerative diseases such asÂ Alzheimer. Green teaÂ has been shown to have antioxidant, anti-inflammatory, anticancer, and neuroprotectiveÂ activity.Objectives: to determine the effect of green tea extract onÂ spatial memory function and superoxide dismutaseÂ enzyme activity in mice with D-galactose induced dementiaMethods:Â An experimental study using "post test only control group design".Â Twenty maleÂ BALB/c Mice aged 6-8Â weeks were divided intoÂ 4Â groups.Â Negative control groupÂ (NG)Â was induced by subcutaneous injection ofÂ D-galactoseÂ (150Â mg/kg BW)Â onceÂ daily forÂ 6Â weeks.Â GT-90, GT-270,Â GT-540Â were induced byÂ D-galactoseÂ and orally administered with 90, 270, and 540 mg/kg BW ofÂ green tea extractÂ once daily for 6 weeks.Â The spatial memory functions were assessed using Morris water maze andÂ SOD enzyme activitiesÂ were evaluated using ELISA.Â One-way Anova and Kruskal-Wallis were used for statistical analysis.Â Results: meanÂ percentage of latency time in the GT-90Â (35.29Â (SD=Â 2.69)%),Â GT-270Â (35.28 (SD= 2.62)%), andÂ GT-540Â (35.62Â (SD=5.05)%)Â wereÂ significantlyÂ higher compared to that of NGÂ (20.38Â (SD =Â 3.21)%), pÂ <0.05). SOD enzyme activity in theÂ GT-270Â (0.78 (SD = 0.07) U/ml)Â wasÂ significantlyÂ higherÂ compared to that of NGÂ (0.51 (SD = 0.01) UÂ ml), p= 0.004).Conclusion:Â Green tea extractÂ mayÂ improveÂ spatial memoryÂ functionÂ andÂ the activity ofÂ superoxide dismutaseÂ enzyme in miceÂ with D-galactose inducedÂ dementia.

Platelet Profile in Patients with Status Asmaticus in Kebumen Juwariyah, Juwariyah; Arjana, Adika Zhulhi; Rahayu, Ester Tri; Rosita, Linda; Irfan, Mohammad Rozan
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 8, No 2 (2017): December 2017
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

BACKGROUND: Asthma has been considered as type 1 hypersensitivity disease, but actually asthma involves a variety of inf lammatory factors.Based on pro-inf lammatory cells, asthma is classified into eosinophilic, non-eosinophilic, neutrophilic, and non-neutrophilic. Platelet plays a role inÂ pathophysiology of asthma through inf lammation. However, platelet profile in patients with asthma have not been established.OBJECTIVE: to determine the platelet indices of patients with status asmaticus of different phenotypes.METHODS: a cross-sectional study was conducted among a minimum sample size of 67 patients. Data were collected from medical records of patients in RSUD Kebumen. Platelet indices included mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT).RESULTS: There was no significant difference in the value of MPV and PDW in patients with eosinophilic and neutrophilic asthma (p> 0.05). But,there was a significant difference in PCT between the two groups (P <0.05)CONCLUSION: There was difference only in plateletcrit (PCT) between patients with eosinophilic and netrophilic asthma.

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