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SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN

sainsmedika
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Published by Universitas Islam Sultan Agung

ISSN : 20851545 EISSN : 2339093X DOI : -

Core Subject : Health,

Health Professions Medicine & Pharmacology

Sains Medika is journal of medicine and health, is a peer-reviewed and open access journal that focuses on promoting medical sciences generated from Biomedical Sciences, Public Health, Clinical Sciences, and Medical Education to integrate researches in all aspects of human health. This journal publishes original articles, reviews article, and also interesting case reports.

Arjuna Subject : -

Articles 235 Documents

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EFFECT OF ANISAKIS SPP. PARASITE ON HUMAN DIGESTION SYSTEM Endiputra, Osa
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 10, No 1 (2019): June 2019
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

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Anisakis spp. is a genus of parasitic nematode which can be transmitted to human through seafood like fish and marine mammals. Anisakis may cause health problems in digestive system and allergic reactions when a raw or undercooked fish containing anisakis larvae in third stage of life is consumed. Three species have evidently caused diseases for human: Anisakis simplex sensu stricto, Anisakis simplex C and Anisakis pegreffi. The main symptoms are abdominal pain, nausea, vomiting and urticaria. Some larvae are resistant to heat and digestive enzymes, thus, incidents of this worm induced disease still occur.

Mahkota Dewa Mesocarp Infusion Improved Testicular Damage and Sperm Count In Diabetic Rat Sulistyoningrum, Evy; Setiawati, Setiawati; Nindyastuti, Herlina; Putra, Adrian Nugraha
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 4, No 2 (2012): Juli-Desember 2012
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Background: Global prevalence of Diabetes Mellitus (DM) is predicted to be increasing with worldwide population increase, longer life expectancy, urbanization, change in lifestyle and higher incidence of obesity. Diabetes Mellitus which is characterized by increasing level of blood glucose can induce increasing activity of ROS (Reactive Oxygen Species) which can further lead to abnormality in male reproductive system, especially testis. Mahkota dewa (Phaleria macrocarpa (Scheff.) Boerl.=PM) contain flavonoid, alkaloid and saponin which can prevent further negative effect on ROS increase in male reproductive system. The aim of this study was to know effect of PM mesocarp infusion on testicular damage and sperm count in alloxan induced diabetic rat.Design and Method: The design of this study was post test only with control group design. Rats in this study were divided into 4 groups (6 rats each group): control group, diabetic group, diabetic group treated with PM mesocarp infusion (9% and 13.5%). Diabetes was induced by alloxan 50 mg/BW single dose injection intramuscularly. PM mesocarpâ€™s infusion was given in 4 weeks. Testicular damage was observed in hematoxylin-eosin stain using Johnsen criteria for spermatogenesis level and tubulus seminiferousâ€™ diameter. Sperm count was performed on the semen taken from vas defferens using Giemsa stain.Result: PM mesocarp infusion group has higher spermatogenic level (p < 0,05), higher tubulus seminiferus diameter and sperm count (p < 0,05) than diabetic group.Conclusion: Mahkota dewa mesocarp infusion improved testicular damage and sperm count in alloxan-induced diabetic rat (Sains Medika, 4(2):115-123).

The Effect of CMCE Propolis Extract Administrations on Interleukin-1 (IL-1) Levels and the Hepatocyte HistopathologicalFindings of Ratsâ€™ Induced with CCl4 Lestari, Catur Retno; Sumarawati, Titiek; Nasihun, Taufiqurrachman
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 11, No 1 (2020): June 2020
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Introduction:Liver exposure to toxic substances will disrupt the metabolic system. Carbon tetrachloride (CCl4) is a hepatotoxic substance causing a liver damage. Continuous multi-stage countercurrent extraction(CMCE) propolis extract contains active balsamic substances, caffeic acid, phenethyl esters and flavonoids.Objective: to prove the effect of CMCE propolis extract on IL-1 levels and the hepatocyte histopathology findingsof male wistar ratsâ€™induced by CCl4.Methods:In the posttest only control group design, the total sample of 28 rats was divided into 4 groups: positive control group (K-0; standard feed); group P-1 (propolis3.6 mg/200 g); P-2 (propolis7.2mg/200gr and P-3 (propolis14.4mg/200g) were respectively given for 14 days,yet those on the 14thday were given CCl4. The IL-1 level was measured with the ELISA method, while the male wistar ratsâ€™hepatocyte histopathology findings was determined by the HE staining methods. IL-1 levelswere analyzed usingOne Way Anova test,followed by the Post Hoc LSD test. Hepatic cell histopathology was analyzed usingKruskal Wallis, followed by Mann-Whitney U.Results:Post Hoc LSD analysis shows that the levels of IL-1 in P-1 (983.54 Â±19.67), P-2 (841.58Â±19.47), and P-3 (755.50Â±31.63) are significantlylower thanthosein K-0 (1131.69Â±14.91) withp<0.05. Mann-Whitney U analysis shows that the hepatocyte histopathology in the P-1 group (2.55Â±0.39), P-2 (1.24Â±0.94) and P-3 (1.20Â±0.93) is significantlylower thanthatinK-0 (2.94Â±0.16) with p<0.05.Conclusion: The administration of CMCE propolis extract may reduce IL-1 levels and improve the male wistar ratsâ€™hepatic cell histopathologyinduced with carbon tetrachloride (CCl4).

The Correlation of Exercise and Range of Motion (ROM) on Elderly Knee Observasional Study on Elderly People in Pedurungan Semarang Widyantoro, Adhitya Putra; Rosdiana, Ika; Fasitasari, Minidian
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 4, No 1 (2012): Januari-Juni 2012
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Background: In aging process, decreasing of musculosceletal capabilities will reduce physical activity and excercise, as well as Range Of Motion (ROM). In order to maintain the normality of ROM, joints and muscles should be moved regularly. However many elderly people are still less physically active, due to lack of knowledge, no free time for physical activity, and lack of support from the social environment. This study aimed to determine the correlation of excercise on ROM of knee in the elderly in Pedurungan District, Semarang.Design and Method: Observastional study with a cross sectional design 80 elderly men and women were divided into 2 groups: gymnastics group in the Social Rehabilitation Unit Of Pucang Gading (n=40) and unexcercises group in the Penggaron village (n=40). In both groups, the degree of ROM of knee was assessed using the Goniometer. To evaluate the value of its significance, the data were analyzed using the Mann Withney test followed by SpearmannÃ¢â‚¬â„¢s rho test.Result: ROM for gymnastic(exercised group) and unexercised group were 115.50Ã‚Â°Ã‚Â±11.591Ã‚Â°, 95.38Ã‚Â°Ã‚Â±12.780Ã‚Â° respectively with p<0. 001. Resuts showed that doing exercise was useful for maintaining ROM of knee in elderly people. SpearmannÃ¢â‚¬â„¢s rho test resulted in a strong correlation between ROM and exercise with r value of 0.652.Conclusion: exercise correlates with ROM of knee in elderly (Sains Medika, 4(1):39-45).

The Behavioral Factor Associated with The Incidence of Malariain Endemic Area Zulaikhah, Siti Thomas; Etika, Dhanny Rona; Mashoedi, Imam Djamaludin
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 3, No 2 (2011): Juli-Desember 2011
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Background: Magelang Regency is one of the endemic area of malaria in central Java. The working area of Health centre of Kajoran I, Banjaretno, has the highest incidence of malaria annually (Dinkes Magelang, 2010). Malaria is is transmitted through the bite of female Anopheles infected by Plasmodium sp. Its most effective prevention is vector eradication. This study was aimed at finding out the behavioral risk for the incidence of malaria.Design and Methods: In this observasional study using case control design include 40 cases and 40 controls using the simple random sampling. Chi square test followed by double-logistic regression was applied for the data analysis with p=5%. Results: Bivariate analysis on the 6 factors resulted in p<0.05 and 2 factors resulted in p>0.05. multivariate analysis showed that the habit factor of going out in the evening, installing wire gauze on the ventilation, hanging used clothes, mowing lawn, the existence of closed waste basket, washing the curtain resulted in the p=0.010 (OR = 10; 95% CI = 3.4-39.2), p=0.001 (OR = 4.1; 95% CI = 3.5-15.8), p=0.018 (OR = 3.3; 95% CI = 1.9 -16.2), p=0.044 (OR = 6.5; 95% CI = 2.1-30.9), p=0.380 (OR = 0.43; 95% CI = 0.1-1.2), p=0.002 (OR = 2.4; 95% CI =3.4 -5.6) respectively.Conclusion: The habit of going out in the evening has been shown to be most important behavioral factor associated with the malaria incidence (Sains Medika, 3(2):168-184).

The Level of SGOT and SGPT after The Administration of Powdered Colorant Pigment Isolated from Kesumba Kelingâ€™s (Bixa Orellana) Seed Coats An experimental study in Balb/C Mice Suparmi, Suparmi; Isradji, Israhnanto; Fatmawati, Dina
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 3, No 1 (2011): Januari-Juni 2011
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Background: There has been an effort to explore pigment from kesumba kelingâ€™s (Bixa orellana) seed coats for a source of natural food colorant. Consumption of pigment from kesumba keling (Bixa orellana) was assumed to cause adverse effects on heart as an important organ in detoxification or inactivation of drugs or other toxic compounds. This study conducted to determine the levels of SGOT and SGPT blood serum of mice (Mus musculus) Balb/C after administration of colorant powder pigment of B. orellana seed coatâ€™s at various concentrations.Design and Methods: The research is an experimental research with Factorial Design with 2 factors. Food Colorant Powder was made from bixin, norbixin, and crude extract pigment isolated from B. orellana seed coatâ€™s. A total of 60 male mice were divided into 10 treatment groups. Powdered colorant solution at the concentration of 0% (control), 1%, 5%, and 10% were orally administered using gavage as much as 1 ml a day for 30 days.Results: Kruskal Wallis test results shows a not significant difference SGOT and SGPT level among the groups (p > 0.05), thus consumption of colorant powder of bixin, norbixin, and the crude extract with various concentrations did not affect the SGOT and SGPT.Conclusion: Colorant powder isolated from B. orellana seed coatâ€™s has been shown to have no effect on the liver function, so it is safe as food colorant (Sains Medika, 3(1):69-77).

The Effect of Fasting on the Concentration of Enzimatic Antioxidants (Superoxide Dismutase and Glutathione Peroxidase) in Rats Jannah, Muliatul; Nasihun, Taufiqurrahman; Sumarawati, Titiek
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 7, No 1 (2016): January - June 2016
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Introduction: Consumption of excessive calories can increase the incidence of degenerative diseases mediated by ROS. Caloric restriction, have been shown to increase levels of antioxidants superoxide dismutase (SOD) and Gluthatione Peroxidase (GPx). Fasting like Ramadan fasting (FLRF) is a form of calorie restriction, but its effect on levels of SOD and GPx remains unclear. Objectives: to investigate the effect of fasting on levels of SOD and GPx. Methods: in a post-test only control group design, sample of 24 rats Sprague Dawley Rats aged 3-month-old, weighing 250-300 grams, were randomly divided into 4 groups. Group 1 (P-70), 2 (P-100), and 3 (P-140) were fasted for 6 hours/day, each group received of 70%, 100% and 140% calories respectively. Group 4 (C-AL) received 100% calories, ad libitum. Day 16 blood was taken and levels of SOD and GPx were determined by ELISA. Data were analyzed using one-way ANOVAs, followed by post hoc LSD tests, p<0.05 was considered statistically significant. Results: the results showed that the levels of SOD and GPx occur significant differences between the groups, p = 0.000. The test results post hoc SOD (318.64) and GPx (89.16) group P-70, compared with group C-AL (278.60 and 57.20) was significantly higher (p = 0.00). SOD and GPx P-70 group compared with the group P-140 (92.03 and 48.79), significantly higher (p = 0.00). Compared with group P-100 (296.70 and 75.71) SOD and GPx in group P-70 was significantly higher, p = 0.000. Conclusion: Fasting with calorie intake of 70% and 100% for 15 days can increases levels of SOD and GPx in male rats.

Tuli pada Lingkungan Kerja Soemadi, Rochmat
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 1, No 1 (2009)
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

ABSTRACT Deaf according to Indro Soetirto and Jenny Bashiruddin is loss of hearing caused by loud enough and long enough noise. Noise is defined by physicist as a voice which is caused by acoustics waves with random intensity and frequency, while according to Indro Sutirto and Jenny Bashiruddin, noise is undesirable sound and in audio logic is pure tone mixture with various frequency. The fact that workers at place with environment like blacksmith, railway maker, and weaver, industry, step by step suffers from deafness after works through years. Problem generated by noise increasing, so protection program of hearing in industry should be done. Therefore, control noise is needed to prevent from deaf in the workplace. ABSTRAK Tuli menurut Indro Indro Soetirto dan Jenny Bashiruddin adalah kehilangan pendengaran oleh karena bising yang sangat dan lama. Bising didefinisikan sebagai suara yang disebabkan oleh getaran akustik dengan berbagai intensitas dan frekuensi, dimana menurut Indro Sutirto dan Jenny Bashiruddin, bising adalah bunyi yang tidak diharapkan. Fakta bahwa pekerja yang berada dalam lingkungan bising seperti tukang pandai besi, pekerja yang bekerja di rel kereta api, industri, sedikit demi sedikit akan mengalami ketulian setelah bekerja selama beberapa tahun. Masalah yang timbul akibat ketulian terus meningkat, jadi program proteksi pekerja yang bekerja di lingkungan bising harus dilakukan, yaitu dengan pembatasan kebisingan.

The Effect of Reality Therapy on the Level of Anxiety and Depression in Army Wife Fourida, Ibrahim Nasrul; Sudiyanto, Aris; Fanani, Moh.
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 8, No 2 (2017): December 2017
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

BACKGROUND: Anxiety and depression, are the most common psychopathological symptoms among army wives living in Kopassus (Indonesian army special force) dormitory, with the prevalence of 15-40%. Proper management with reality therapy for anxious and depressed army wives living in Kopassus dormitory is needed.OBJECTIVE: to determine the effect of reality therapy on anxiety and depression levels in army wives in Kopassus Group 2 dormitory.METHODS: This study was designed as a randomized control trial pretest and post-test two group design. Sampling was done by simple random technique. Thirty subjects were divided into two groups. Control group received regular interview, while experimental group received reality therapy. Respondents were asked to fill out The Lie Minnesota Multiphasic Personality Inventory questionnaire (L-MMPI), biodata, the Taylor Manifest Anxiety Scale questionnaire (TMAS), and the Beck Depression Inventory questionnaire (BDI). The Wilcoxon Rank Test and Mann-Whitney were applied for data analysis, with the significance level of p<0.05.RESULT: The Wilcoxon Rank Test in the TMAS (anxiety) and BDI (depression) showed a significant difference (p<0.05). The Mann-Whitney analysis of the anxiety and depression variables showed a significant difference between the reality therapy group and the control group (regular interview) (p <0.05). The experiment group has a TMAS and BDI score lower than that of the control group.CONCLUSION: The reality therapy is effective to lower the level of anxiety and depression in army wives.

Customers Perspective in Performance Assessment of Pharmacy Instillation of RSUD X with Balanced Scorecard Sulistyaningrum, Indriyati Hadi; Satibi, Satibi; Andayani, Tri Murti
Sains Medika : Jurnal Kedokteran dan Kesehatan Vol 5, No 2 (2013): July-December 2013
Publisher : Fakultas Kedokteran; Universitas Islam Sultan Agung (UNISSULA)

Balanced Scorecard performance measurement (financial perspective, customer perspective, internal business perspective, and learning and growth perspective) offers a more thorough and comprehensive evaluation in a public organization such as a hospital. The object of this study was the Department of Pharmacy of RSUD X. This study was descriptive non-experimental. The data were obtained retrospectively and prospectively. The qualitative data were obtained through questionnaires. The quantitative data were obtained through direct observation, surveys. From the research using the Balanced Scorecard data gathering, it has been found that: performance customer perspective showed that the average patient satisfaction was 88% of patients. They were satisfied with the service of the Department of Pharmacy, and the average growth of customers has increased by 10% each month. In conclusions, the working performance of the department of pharmacy was included in a good criteria, with some suggestions and improvements that need to be taken into consideration.

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