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Jurnal Komunitas Farmasi Nasional
Published by Akademi Farmasi Yarsi Pontianak
ISSN : 27988704     EISSN : -     DOI : -
Core Subject : Health,
Medicine & Pharmacology Public Health
Jurnal Komunitas Farmasi Nasional adalah jurnal akses terbuka dan peer-review yang diterbitkan oleh Akademi Farmasi Yarsi Pontianak. Jurnal ini diterbitkan dua kali per tahun pada bulan Juni dan Desember. Jurnal Komunitas Farmasi Nasional menerbitkan artikel penelitian di bidang farmasi dan ilmu kesehatan terkait.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 81 Documents
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FORMULASI DAN TINGKAT KESUKAAN KONSUMEN PADA MINUMAN SERBUK INSTAN DARI TANAMAN EMPON-EMPON DENGAN KOMPOSISI JAHE, TEMULAWAK, KUNYIT DAN SEREH Husnani Husnani; Syarifah Nadia H
Jurnal Komunitas Farmasi Nasional Vol. 1 No. 2 (2021): Jurnal Komunitas Farmasi Nasional
Publisher : Akademi Farmasi Yarsi Pontianak

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Abstract

Instant powder drink is a preparation made from plants which is processed into powder form, and ready to use by mixing it with warm water. The empon-empon plant has been widely used traditionally to treat various diseases, especially it is useful to increase body immunity, but it is not liked by the public because of its complicated use and unpleasant taste and aroma, therefore it needs to be made in practical dosage forms and good for consumption. and can be stored for a long time as a healthy instant dry form. This study aims to determine the best formula seen from the physical quality of the preparation and the formula that consumers like. This research was conducted experimentally using variations in the addition of granulated sugar to each formula. The parameters observed included yield, solubility time, pH, water content and organoleptic tests covering color, aroma and taste (hedonic scale).
ISOLASI DAN IDENTIFIKASI SENYAWA ALKALOID DALAM EKSTRAK ETANOL DAUN PANDAN HUTAN JENIS BARU (Freycinetia sessiliflora Rizki) Ade Ferdinan; Fitri Sri Rizki; Nunik Rahmawati
Jurnal Komunitas Farmasi Nasional Vol. 1 No. 2 (2021): Jurnal Komunitas Farmasi Nasional
Publisher : Akademi Farmasi Yarsi Pontianak

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Purpose of this research to isolate and identify the alkaloid compounds found in forest pandan leaves (Freycinetia sessiliflora Rizki). Phytochemical screening using Mayer, Dragendorff and Wagner reagents, phytochemical screening results for alkaloids with two reagents showed positive results, there is brownish orange precipitate on Dragendorff's reagent and yellow to brownish precipitate on Wagner's reagent. Isolation using Thin Layer Chromatography (TLC) and Column Chromatography with ethyl acetate: methanol: NH4OH (85: 10: 5), showing Rf values of 0.25-0.62. Wavelength analysis using UV-Vis spectrophotometry showed that the content of forest pandan leaf alkaloid compounds (Freycinetia sessiliflora Rizki) was at a wavelength of 262-266 nm.
PENETAPAN KADAR FLAVONOID EKSTRAK DAUN ANDONG (Cordyline Fruticosa (L.) A. Cheval) BERDASARKAN VARIASI PELARUT EKSTRAKSI MENGGUNAKAN METODE SPEKTROFOTOMETRI ULTRA VIOLET -VISIBEL Imas Maesaroh; Linda Alfiani; Wawang Anwarudin; Herliningsih Herliningsih
Jurnal Komunitas Farmasi Nasional Vol. 1 No. 2 (2021): Jurnal Komunitas Farmasi Nasional
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Abstract

Andong leaves (Cordyline fruticosa (L.) A. Cheval) contain secondary metabolites including saponins, tannins, flavonoids, steroids, polyphenols, polysaccharides, calcium oxalate, and iron. This study aims to determine the levels of flavonoids in andong leaf extract (Cordyline fruticosa (L.) A. Cheval) using 70% ethanol extraction solvent and 96% ethanol using Ultra Violet – Visible spectrophotometric method. The research method used in this research is experimental laboratory. The results of the qualitative test on both samples showed the presence of flavonoids contained in the leaves of Andong (Cordyline fruticosa (L.) A. Cheval). Absorbance measurements were carried out on the sample, carried out at a wavelength of 400 nm. The results of the quantitative test of flavonoid content in 70% ethanol solvent were 0.811% and flavonoid levels in 96% ethanol solvent were 0.769%.
SKRINING FITOKIMIA EKSTRAK ETANOL DAUN MATOA YANG BERASAL DARI PONTIANAK TIMUR DENGAN VARIASI KONSENTRASI PELARUT Erwan Kurnianto; Ika Ristia Rahman; Hairunnisa Hairunnisa
Jurnal Komunitas Farmasi Nasional Vol. 1 No. 2 (2021): Jurnal Komunitas Farmasi Nasional
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Matoa (Pometia pinnata J.R. Forst. & G. Forst.), a plant of the Sapindaceae family, has been widely used as traditional medicine by specific ethnic communities. Matoa leaves have pharmacological activities such as anti-diabetic, antibacterial and antioxidant. This study aims to determine the chemical content of various solvent concentrations. The solvents used in this study were ethanol 50%, ethanol 70% and ethanol 96%. The method used is a qualitative method with a colouring test. The results showed that 50% and 70% ethanolic matoa leaf extract contained flavonoids and tannins. Matoa leaf extract with 96% ethanol solvent contains secondary metabolites of flavonoids, tannins and saponins.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN GAHARU (Aquilaria microcarpa Baill.) TERHADAP BAKTERI Salmonella typhi dan Bacillus subtilis SECARA IN VITRO Rafika Sari; Frans Kristian; Inarah Fajriaty
Jurnal Komunitas Farmasi Nasional Vol. 1 No. 2 (2021): Jurnal Komunitas Farmasi Nasional
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Infections caused by pathogens such as salmonella typhi and Bacillus subtilis causes gastrointestinal infections and lead researchers to found a material that has potential as an antibacterial that has optimal efficacy by using the leaves of agarwood (Aquilaria microcarpa Baill.). The purpose of this study was to determine the compound class of secondary metabolites and antibacterial activity against salmonella typhi and bacillus subtilis of ethanol extract of agarwood leaves. The method used in the maceration and antibacterial activity test was diffusion method (Kirby-Bauer). Result are the ethanol extract of the agarwood leaves contain the compound flavonoids, saponins, tannins, steroids, and the solubility extract in water and ethanol are 21,80 ± 1,77% and 22,86 ± 2,78%. Shrinkage drying 26,25 ± 1,03%. Specific gravity 1% ethanol extract 1,0120mg/ml. Based on the research results antibacterial activity with the concentration of extract 300mg/ml, 400mg/ml, 500mg/ml toward salmonella typhi with an average diameter of inhibition zone 11,74 ± 0,44 mm, 13,55 ± 0,30 mm, 14,69 ± 0,67 mm and Bacillus subtillis with an average diameter of inhibition zone 10,29 ± 0,16 mm, 12,23 ± 0,21 mm, 13,56 ± 0,66 mm. The conclution is 500mg/ml concentration had a better antibacterial activity.
IDENTIFIKASI SENYAWA FLAVONOID EKSTRAK ETANOL AKAR BAJAKAH (Spatholobus littoralis Hassk.) Elinur Natasa; Ade Ferdinan; Erwan Kurnianto
Jurnal Komunitas Farmasi Nasional Vol. 1 No. 2 (2021): Jurnal Komunitas Farmasi Nasional
Publisher : Akademi Farmasi Yarsi Pontianak

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This study aims to identify flavonoid compounds from ethanol extract of bajakah root using thin layer chromatography (TLC) with mobile phase variations. The results of the phytochemical examination carried out by the shinoda test gave a red color and the H2SO4 test gave an orange-red color, indicating that there were flavonoid compounds.The results of thin layer chromatography using ethyl acetate: methanol (3:2) mobile phase has an Rf value of 0.80, in the mobile phase n-butanol: acetic acid: water (4:1:5) an Rf value of 0.75 indicates the presence of flavonoid compounds.
UJI ANTIMIKROBA FRAKSI III DAUN KRATOM (Mitragyna speciosa) TERHADAP BAKTERI Staphylococcus aureus Tri Puji Lestari Sudarwati
Jurnal Komunitas Farmasi Nasional Vol. 1 No. 2 (2021): Jurnal Komunitas Farmasi Nasional
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Kratom (Mitragyna speciosa Korth) is a type of plant found in forest areas in Indonesia which contains chemical compounds such as alkaloids, flavonoids, phenols, terpenoids, steroids, triterpenoids, tannins, and saponins. In this study, the antimicrobial potency of fraction III of kratom leaves was tested by column chromatography separation. Kratom leaves have several benefits, one of which is as an antimicrobial. The extraction process chosen is the maceration method. The results obtained from column chromatography were then grouped based on RF values ​​using the thin layer chromatography method, from 80 vials the RF value calculated in the TLC test of kratom leaf methanol extract obtained a value of 0.84. Then the results obtained were made with concentrations of 2%, 4%, 6%, 8% and 10% for the antibacterial activity test. The antibacterial activity test was repeated 5 times and the results of the inhibition zone with an average concentration of 2% obtained data of 2,436 mm, a concentration of 4% obtained an average of 1,616 mm, a concentration of 6% obtained an average of 0.685 mm, a concentration of 8% obtained an average of 0.685 mm. an average of 0.596 mm, while for a concentration of 10% the average was 0.96. From the results of this study, it can be concluded that kratom leaf extract (Mitragyna speciosa) using methanol with column chromatography separation method has antibacterial activity against Staphylococcus aureus with a weak category.
FORMULASI GRANUL EFFERVESCENT EKSTRAK ETANOL KULIT BUAH PEPAYA (Carica papaya L.) Arianti Safitri
Jurnal Komunitas Farmasi Nasional Vol. 1 No. 2 (2021): Jurnal Komunitas Farmasi Nasional
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Papaya fruit of peel (Carica papaya L.) is one of the plants that contains antioxidants. Where the antioxidant activity of papaya fruit ethanol extract (IC50 95,824 ppm) is classified in the strong category. This research aims to formulate effervescent granules from papaya bark ethanol extract with wet granulation method and to find out the effervescent granule formula of papaya bark extract which produces the best properties. Papaya fruit rind macerated using 96% ethanol solvent. Then papaya bark extract is formulated in 3 formulas by varying the citric acid in formula I with a concentration of 10%, formula II 12.75%, formula III 14%, tartric acid in formula I with a concentration of 20%, formula II 25.5%, formula III 28%, and sodium bicarbonate in formula I with a concentration of 25%, formula II 37.5%, formula III 50%. The results showed formula I in the preparation of effervescent granules of ethanol extract of papaya rind met the best physical requirements including organoleptic testing in light yellow, papaya complex, and containing sour taste, pH 5, dispersed speed 3 minutes 16 seconds, water content 3 minutes 61 seconds , flow properties 2 minutes 64 seconds and rest angle 13.49°.
UJI AKTIVITAS DIURETIK EKSTRAK ETANOL UMBUT BATANG ROTAN (Calamus rotang L.) TERHADAP MENCIT PUTIH (Mus musculus) JANTAN GALUR SWISS WEBSTER Inderiyani Inderiyani
Jurnal Komunitas Farmasi Nasional Vol. 1 No. 2 (2021): Jurnal Komunitas Farmasi Nasional
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Diuretics are drugs that work on the kidneys to increase the excretion of water and sodium chloride. Diuretics are used to reduce edema in congestive heart failure, some kidney diseases, hepatic cirrhosis and hypertension therapy. One of the traditional medicinal plants that is thought to have diuretic activity is rattan (Calamus rotang L.). Rattan has secondary metabolites i.e. flavonoids, alkaloids and saponins where flavonoids have biological activity as a diuretic. The purpose of this study was to determine whether the ethanol extract of rattan stem (EEUMBR) has activity as a diuretic on male white mice (Mus musculus). They are 5 groups in this study i.e. group I as a negative control (Na.CMC 0.5%), group II as a positive control (furosemide 52 mg/kg bw), group III as EEUMBR group 0.25 g/kg bw, group IV as a group. group EEUMBR 0.5 g /kg bw and group V EEUMBR group 1 g/kg bw. Data obtained by observing the volume of urine excreted for 6 hours. Data showed that the amount of urine excreted in the EEUMBR group was greater than the negative control group i.e 1.39 mL (EEUMBR 0.25 g/kg bw), 1.47 mL (EEUMBR 0.25 g/kg bw), 1.69 mL (EEUMBR 0.25 g/kg bw) while the negative control group was 1.12 mL. The results of statistical analysis showed that the five experimental groups had significant differences with a sig value was 0.02 (p<0.05). Based on these data, it can be concluded that the ethanol extract of rattan stem umbut has activity as a diuretic.
AKTIVITAS MINYAK ATSIRI BUNGA LILY (Lilium auratum) TERHADAP BAKTERI Salmonella typhi Dwi Rizki Febrianti; Siska Musiam; Dani Kurniawan
Jurnal Komunitas Farmasi Nasional Vol. 1 No. 2 (2021): Jurnal Komunitas Farmasi Nasional
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Salmonella typhi infection caused by Salmonella typhi attacks the intestinal tract and breeds there. Types of raw food and seafood can be contaminated by this bacteria. The risk of infection is high in patients with congenital inflammatory bowel disease and immune problems. The potential of natural materials such as lilies has not been explored much. The components of lily essential oil compounds contain benzaldehyde, linalool, cement, borneol and osimen which can react with bacterial cell wall components causing damage to bacterial cell walls. The purpose of this study was to determine the potential of lily flower essential oil (Lilium auratum) in inhibiting the growth of salmonella typhi bacteria. Using with a concentration of 10%, 30%, 50% and 70%. The results of the test using the disc method showed that lily essential oil was able to inhibit bacteria with inhibition zones of 10% (13.83 mm), 30% (13.25 mm), 50% (15.05 mm) and 70% (15.26 mm) with a strong category.

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