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Jurnal MedScientiae
Published by Universitas Kristen Krida Wacana
ISSN : -     EISSN : 28291166     DOI : https://doi.org/10.36452/jmedscientiae
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Nursing Public Health
Jurnal MedScientiae adalah jurnal yang dikelola oleh Fakultas Kedokteran dan Ilmu Kesehatan Universitas Kristen Krida Wacana. Jurnal ini mempublikasikan artikel-artikel secara open access dalam lingkup bidang kedokteran dan kesehatan seperti kedokteran dasar, bioetika kedokteran, biologi sel, biologi molekuler, genetika, fisiologi, biokimia, bioinformatika, anatomi, farmakologi, kesehatan masyarakat, dan ilmu biomedik lainnya. Tim editorial menerima naskah berupa artikel penelitian, literature dan systematic review, dan laporan kasus. Naskah yang dikirimkan hendaknya belum pernah diterbitkan sebelumnya di jurnal maupun media yang lain dan disiapkan sesuai dengan template atau format yang telah ditentukan. Setiap naskah yang memenuhi kriteria jurnal akan direview oleh pakar yang sesuai (peer reviewer). Jurnal MedScientiae tidak mengenakan biaya selama proses mulai dari penerimaan naskah hingga publikasi. Jurnal MedScientiae terbit 3 kali dalam satu tahun, yaitu pada bulan April, Agustus dan Desember dengan cakupan keilmuan yang telah disebutkan di atas. Edisi pertama jurnal akan diterbikan di bulan Mei tahun 2022 dengan nomor ISSN 2829-1166.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 220 Documents
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Pharmacotherapy Study Of Albendazole And Mebendazole For Soil Transmitted Helminths Infections In Children Susanto, Inneke Kusumawati; William, William; Agatha, Nabila
Jurnal MedScientiae Vol. 3 No. 2 (2024): Agustus
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i2.3109

Abstract

Soil Transmitted Helminths (STH) infection is a nematode infection of the intestine that requires soil for its transmission. The worms that cause Soil Transmitted Helminths infection include; Ascaris lumbricoides, Trichuris trichiura, hookworms (Necator americanus and Ancylostoma duodenale. The incidence of STH infection is quite high with the highest spread of STH infection in the child age group. Treatment of cases of STH infection is by administering antihelmintic drugs or worming drugs. Although there are four The drugs recommended by WHO, only the two drugs most often used in the treatment of STH infections, namely albendazole and mebendazole. Both drugs have been used for more than 30 years, but cases of STH infection still have a high incidence. That is why this literature review was written aims to describe the efficacy of the two drugs for STH infection in children so that their effectiveness can be assessed.The research method used was a literature review, a literature search was sourced from Proquest, Google scholar, Pubmed, Elsevier and Europe PMC. keywords Albendazole, Mebendazole, Soil Transmitted Helminths Infections, Children. There are 10 selected literatures to be studied in this literature review. The results showed that albendazole had satisfactory efficacy in STH infections caused by Ascaris lumbricoides and hookworms, but reduced efficacy in Trichuris trichiura worms. Mebendazole has satisfactory efficacy in STH infections caused by Ascaris lumbricoides and Trichuris trichiura, but reduced efficacy in hookworms. Albendazole and mebendazole does not cause side effects.
E Efektivitas Albendazol Dosis Tunggal terhadap Infeksi Soil Transmitted Helminths (STH) Sari, Monica Puspa
Jurnal MedScientiae Vol. 3 No. 1 (2024): April
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i1.3110

Abstract

The problems of worm’s infection is still a problem for Indonesian people, especially children who live in endemic areas with a lack of sanitation and clean water. The two recommended treatment regiments are Albendazole 400 mg and Mebendazole 500 mg. Several studies report that the efficacy of albendazole varies. The aims of literature review is to assess the efficacy of albendazole against STH infections, and the factors that influence the efficacy of albendazole, factors that can increase efficacy and reduce efficacy. The research method used is a literature review with a descriptive approach based on literature from relevant research articles or journals. Library searches were searched via Google scholar, Pubmed, E-journal. The keywords and boolean operators used in the research are albendazole AND Soil transmitted helminths OR cure rate OR egg reduction rate. The CR of a single dose of albendazole against A. lumbricoides reaches 80-100%. 50-54% of hookworm infections occur due to frequent recurrent infections. There were differences in results regarding the CR of T. trichiura 12,8%-66,7% and 80-90%. This difference occurs due to differences in the degree of unfections. Single dose albendazole base on CR and ERR is less effective against T. trichiura infection. Albendazole should be given in combination with other drugs or in extra doses to eliminate STH infections.
Peran Vitamin D Dalam Menurunkan Risiko Penyakit Kardiovaskular Lim, Audi; Arsita, Elli
Jurnal MedScientiae Vol. 3 No. 1 (2024): April
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i1.3138

Abstract

Cardiovascular disease is the main cause of death in the world. Vitamin D is known to have an influence on the cardiovascular system through the role of the vitamin D receptor (VDR) expressed by vascular endothelial smooth muscle cells and cardiomyocytes. This literature review analyze the role of vitamin D in relation to the risk of cardiovascular disease through a study of scientific articles from Google Scholar and Pubmed. The results showed that patients with severe vitamin D deficiency (serum 25(OH) levels <10 ng/ml) had an increased risk of myocardial infarction with OR 4.5 (95% CI 2.2–9.2), and increased risk of PAD with OR 3.872 (95% CI: 1.168–12.841), while vitamin D deficiency (serum 25(OH) levels <20 ng/ml) caused an increased risk of acute ischemic stroke with OR 16.64 (95% CI: 5 .66–42.92; p < 0.001). Administration of 1x 600,000IU or 2x300,000IU intramuscular vitamin D in coronary heart disease patients with deficiency showed significant reduction in the inflammatory marker hsCRP and improved endothelial function. However, in clinical trials, significant but inconsistent results were obtained due to differences in the cut off value for Vit D deficiency, diversity in age, gender, variations in polymorphisms, smoking habits, physical activity, body weight, and various comorbidities suffered by patients.
Potensi Sekretom Mesenchymal Stem Cell pada Terapi Regeratif Penyakit Paru Fibrosis Kartika, Ronald Winardi; Timotius, Kris Herawan
Jurnal MedScientiae Vol. 3 No. 2 (2024): Agustus
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i2.3142

Abstract

Fibrosis lung diseases such as chronic obstructive pulmonary disease, acute lung injury and post-Covid 19 fibrosis lung disease are considered as major health problems in the last decade. Cellular therapy with Mesenchymal Stem Cells (MSC) offers a novel therapeutic approach for fibrosis lung disease associated with anti-inflammatory, immunomodulatory, regenerative, pro-angiogenic and anti-fibrotic properties. Such therapeutic effects may be attributed to the MSC-secretome, which is made of free soluble proteins and extracellular vesicles (EVs). This review summarises some recent literature findings related to the efficacy and safety of MSC-derived products in pre-clinical models of lung diseases, demonstrating the biologically active substances contained in the MSC-secretome and its mechanisms involved in tissue regeneration. A perspective view is given on the secretome being a high-quality, safe and effective medicinal product,  
Perbandingan Efektivitas Injeksi Agen-Agen Anti-Vegf pada Pengobatan Age-Related Macular Degeneration Nahak, Petronela Bhoko; Arsita, Elli; Wastitiamurti, Ritsia Anindita
Jurnal MedScientiae Vol. 3 No. 1 (2024): April
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i1.3143

Abstract

Age-related macular degeneration (AMD) is one of the leading causes of blindness in people >60 years of age in developed countries. The pathogenesis of neovascular AMD involves increased choroidal vascular permeability, leading to hypoxia and the production of pro-inflammatory and pro-angiogenic factors, particularly vascular endothelial growth factor (VEGF). Treatment of neovascular AMD involves anti-VEGF therapy, which inhibits abnormal blood vessel growth. Numerous studies have demonstrated the effectivity and side effects of each Anti-VEGF agent. Based on this background, the author is interested in conducting a literature review that summarizes the effectivity and side effects of each Anti-VEGF agent. The method used was Literature Review. Journals were collected using GoogleScholar or Google Scholar, PubMed and Proquest within the last 10 years. A total of 10 journals that met the inclusion-exclusion criteria were reviewed and tested for eligibility with the Ottawa score. The results of this literature review showed that anti-VEGF agents including bevacizumab, ranibizumab, aflibercept, pegaptanib sodium, brolucizumab and abicipar pegol have been shown to be equally effective in improving vision and maintaining stable vision in neovascular AMD patients. However, these anti-VEGF treatments can also cause side effects such as intraocular inflammation, increased intraocular pressure and vascular problems.
GAMBARAN FOTO THORAX DAN DISTRIBUSI BAKTERI PATOGEN PADA PASIEN PNEUMONIA Finaldi, Fauzan
Jurnal MedScientiae Vol. 3 No. 2 (2024): Agustus
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i2.3144

Abstract

Pneumonia is an acute infectious or inflammatory disease that affects the lung parenchyma which can be caused by microorganisms such as bacteria, viruses and fungi. This study aims to determine the chest x-ray picture and the distribution of pathogenic bacteria in pneumonia patients, as well as to look at the chest x-ray picture of certain pathogens. The method in this study is to search for articles via Google Scholar and Pubmed. The results showed that the distribution of pathogenic bacteria in pneumonia cases varied, but the most common bacteria that cause pneumonia were Streptococcus pneumoniae, Klebsiella pneumoniae, and Mycoplasma pneumonia. On chest x-rays, the chest x-ray images obtained are quite diverse, and the commonly found results are consolidation, infiltrates and pleural effusion. In patients with pneumonia due to Mycoplasma pneumoniae, the chest x-ray picture that is often found is lobar pneumonia or lobar consolidation.
Risk Factors for Urinary Incontinence in the Elderly Regina, Kezia; Tamba, Ernawaty; Soesanto, Aries
Jurnal MedScientiae Vol. 3 No. 2 (2024): Agustus
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i2.3145

Abstract

Individuals aged sixty years or older who require more care are referred to as seniors. Urinary incontinence in the elderly is a common problem. Uncontrolled urine production is known as urinary incontinence. Elderly people often experience this health problem. As we age, pelvic muscles weaken, resulting in changes in the anatomical function of the urinary tract organs and an increased risk of urinary incontinence. The aim of the research is to review related research on risk factors for urinary incontinence in the elderly. This research uses literature study. Where using a search for journals in Indonesian and English for 2013 - 2023 which was carried out using the WHO, PubMed, NCBI databases with the keywords Urinary incontinence in the elderly and found 10 journals selected according to the inclusion criteria with elderly subjects ≥ 45 years, cross sectional design and descriptive. The results show that urinary incontinence in the elderly has a significant relationship with risk factors for urinary incontinence such as diabetes, smoking, vaginal delivery and quality of life in the elderly. It can be concluded that there is a relationship between the two variables and most studies show that urinary incontinence is an important factor that can cause stress in the elderly.  
Pengaruh Pemberian Steroid Topikal Terhadap Tekanan Intra Okular : Sebuah Tinjauan Pustaka Lauw, Jessica Amelia; Muthia, Annisa Sri Rachma; Pangaribuan, Beatric Ruth Fransiska; Anugrahsari, Santi
Jurnal MedScientiae Vol. 3 No. 1 (2024): April
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i1.3162

Abstract

The use of topical corticosteroids, especially in the periocular area, has been associated with increased intraocular pressure (IOP), potentially leading to glaucoma and other eye complications. This study evaluated the risk of IOP elevation due to topical corticosteroid use and its influencing factors. This study is a literature review investigating the relationship between topical corticosteroid use and IOP elevation. Data were collected from studies reporting the effect of topical corticosteroids on IOP, including the type of steroid, duration of use, frequency of administration, and patient age. The findings suggest that the use of topical corticosteroids can lead to a significant increase in IOP, with the risk varying depending on the type of steroid, duration, and frequency of use, as well as individual patient characteristics such as age. Although some studies showed a significant increase in risk, other results showed minimal risk, suggesting the need for close monitoring of IOP in patients using topical corticosteroids. The use of topical corticosteroids in the periocular area requires careful consideration of the potential risk of increased IOP. It is important to choose steroids with low anti-inflammatory potential and monitor IOP regularly to reduce the risk of IOP-related side effects. Further studies are needed to fully understand the risks associated with using periocular topical corticosteroids and develop guidelines for safe use.
Tinjauan Pustaka Penggunaan Gawai dengan Kejadian Miopia Anugrahsari, Santi; Nugraha, Abraham William; Septrilla, Gladys; Veronica Agrippina
Jurnal MedScientiae Vol. 3 No. 1 (2024): April
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i1.3164

Abstract

Lifestyle changes during the pandemic has impacted the lives of almost every human being in the world. This lifestyle changes, especially the increase in the duration and frequency of gadget use for everyday routine can cause various unwanted side effects such as refractive disorders, especially myopia. This study aims to evaluate the correlation between gadget use and myopia and other relevant ocular biometric parameters such as axial length (AL) and spherical equivalent (SE). The literatures used in this study is taken from an electronic database using NCBI, ProQuest and Google Scholar with English keywords “Gadget”, “Myopia”, and “Vision Impairment” and in Indonesian “Gawai”, “Miopi”, dan “Kelainan Refraksi ”. The articles found was published between January 2012 and Juni 2022, which was then sorted according to the objective of this study and we found fifteen journals that we include in this study. The distance in which gadgets were used was found to have a correlation with myopia. Laying down while using gadgets was also found to be correlated with myopia. Meanwhile, the duration of gadget use has not been found to be correlated with myopia. Gadget use can be one of the risk factors for refractive disorders. Based on the literature we collected, it was found that gadget use distance less than 30 cm and laying down while using gadgets has a correlation with refractive disorders meanwhile the duration of gadget use was found to not be correlated with refractive disorders.
Inhibitor Transient Receptor Potential Vanilloid Type 1: Penggunaan Topikal pada Berbagai Dermatosis Muhammad, Parikesit; Paramitha Wibawa, Larisa; Keumala Budianti, Windy; Legiawati, Lili; Menaldi, Sri Linuwih; Rosdiana, Dewi Selvina
Jurnal MedScientiae Vol. 3 No. 2 (2024): Agustus
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i2.3179

Abstract

Transient receptor potential vanilloid type 1 (TRPV1) plays an important role in the pathophysiology of pruritus and pain. TRPV1 inhibitors can reduce the sensation of itching and pain by blocking nociceptive signals from peripheral nerve fibers to the central nervous system. Topical TRPV1 inhibitors is also thought to improve skin barrier function. Therefore, TRPV1 inhibitors are considered as potential therapy in various dermatoses. Topical TRPV1 inhibitors that are currently being studied are asivatrep for atopic dermatitis and trans-4-tert-butylcyclohexanol for various dermatoses associated with sensitive skin. Further studies with better quality and longer duration are needed to assess the efficacy and safety profile of TRPV1 inhibitors.

Page 15 of 22 | Total Record : 220

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