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Jurnal MedScientiae
Published by Universitas Kristen Krida Wacana
ISSN : -     EISSN : 28291166     DOI : https://doi.org/10.36452/jmedscientiae
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Nursing Public Health
Jurnal MedScientiae adalah jurnal yang dikelola oleh Fakultas Kedokteran dan Ilmu Kesehatan Universitas Kristen Krida Wacana. Jurnal ini mempublikasikan artikel-artikel secara open access dalam lingkup bidang kedokteran dan kesehatan seperti kedokteran dasar, bioetika kedokteran, biologi sel, biologi molekuler, genetika, fisiologi, biokimia, bioinformatika, anatomi, farmakologi, kesehatan masyarakat, dan ilmu biomedik lainnya. Tim editorial menerima naskah berupa artikel penelitian, literature dan systematic review, dan laporan kasus. Naskah yang dikirimkan hendaknya belum pernah diterbitkan sebelumnya di jurnal maupun media yang lain dan disiapkan sesuai dengan template atau format yang telah ditentukan. Setiap naskah yang memenuhi kriteria jurnal akan direview oleh pakar yang sesuai (peer reviewer). Jurnal MedScientiae tidak mengenakan biaya selama proses mulai dari penerimaan naskah hingga publikasi. Jurnal MedScientiae terbit 3 kali dalam satu tahun, yaitu pada bulan April, Agustus dan Desember dengan cakupan keilmuan yang telah disebutkan di atas. Edisi pertama jurnal akan diterbikan di bulan Mei tahun 2022 dengan nomor ISSN 2829-1166.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 249 Documents
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Hubungan Antara Screen Time dengan Angka Kejadian Miopia Pada Anak Sebelum dan Setelah Masa Pandemi Covid-19 : Sebuah Tinjauan Pustaka Anugrahsari, Santi; Shania Audrianisa; Cahya Virgin Septyany; Appy, Enjeline Grecielya; Rohy, Charlos Ivanly Jusuf
Jurnal MedScientiae Vol 3 No 3 (2024): December
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i3.3047

Abstract

The COVID-19 pandemic policies, outdoor activity restrictions, and distance learning have significantly impacted the occurrence of myopia in children. These changes are associated with increased screen time, decreased outdoor activities, and insufficient sleep duration, indicating potential long-term effects on myopia prevalence and development. This literature review utilizes articles from research journal databases searched through the internet. The internet databases used include Google Scholar and PubMed, using keywords: "Children," "Epidemiology," "Risk Factor," and "Myopia." Inclusion criteria for this literature are English articles, published within the last 10 years, and research publication types. Exclusion criteria include duplications and articles with only abstracts or without full text. The combined findings of these studies consistently demonstrate that school-age myopia is influenced by genetic and environmental factors, with screen time, near work, and urban residence being significant risk factors. The protective role of outdoor activities against myopia is evident in various geographic regions. The COVID-19 pandemic has exacerbated this issue, emphasizing the need for interventions focused on reducing screen time and increasing outdoor activities to manage and prevent myopia progression.
Efektivitas Terapi Target Sorafenib dalam Penanganan Hepatocellular Carcinoma: Literature Review Dharma, Herbert; Purnamawati; Angeline, Reni
Jurnal MedScientiae Vol 3 No 3 (2024): December
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i3.3141

Abstract

Liver cancer is the sixth most common cancer and the third leading cause of death in the world. The main cause of liver cancer is the Hepatitis B or Hepatitis C virus which causes patient to experience chronic liver disease which can worsen and develop into liver cancer. Sorafenib targeted therapy can be used to treat patients with advanced liver cancer. This drug can suppress tumor cell proliferation and inhibit tumor angiogenesis. This study aims to determine the benefits of targeted therapy in treating Hepatocellular Carcinoma. The method used in this study is by searching for articles in electronic databases via the internet using Google Scholar and Pubmed. The results showed that the combination of sorafenib targeted therapy with conventional therapy, such as TACE and radiofrequency ablation, could significantly increase survival rates and time to progression. In conclusion, sorafenib targeted therapy when combined with conventional therapy has higher benefits and effectiveness compared to other therapies. The disadvantage of sorafenib targeted therapy is that it can cause many side effects for the patients.
TINJAUAN ILMIAH MENGENAI PERBANDINGAN EFEKTIVITAS DAN KEAMANAN ERDOSTEIN, KARBOSISTEIN, DAN N-ASETILSISTEIN PADA PASIEN PENYAKIT PARU OBSTRUKTIF KRONIK EKSASERBASI AKUT Walter, Bryan; Wiliam, Wiliam; Citraningtyas, Theresia
Jurnal MedScientiae Vol 3 No 3 (2024): December
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i3.3145

Abstract

Acute exacerbation of Chronic Obstructive Pulmonary Disease (COPD) is a worsening of stable COPD/respiratory symptoms. The 2020 Global Initiative for Chronic Obstructive Lung Disease (GOLD) shows erdostein, carbocysteine, and n-acetylcysteine can reduce the risk of acute exacerbations in COPD. The aim of this writing is to determine and compare the effectiveness and safety of erdostein, carbocysteine, and n-acetylcysteine in acute exacerbations of COPD. The scientific review takes the form of a literature review by searching for data using books, journals and websites. Sixteen articles were obtained with the results that erdosteine, carbocysteine, and n-acetylcysteine reduced the risk of acute exacerbations of COPD. The best effectiveness results depend on the dose of the drug and the length of use. The best reduction in the risk of exacerbation was oral erdostein, dose 900 mg daily for 10 days (39.1%), Carbocysteine 1500 mg daily for 6-12 months (p < 0.00001) and n-acetylcysteine 1,200 mg/day for 3 months (p<0.05). Erdostein was well tolerated and there were no treatment-related side effects. The frequency of side effects of respiratory tract infections was not detected for erdostein, but for carbocysteine it was found to be 0.56% and NAC 10.85%. Two patients dropped out of the study because of gastrointestinal disturbances related to carbocysteine side effects. The conclusion of this scientific review is that the use of erdostein 900 mg/day for 10 days has the best effectiveness in reducing COPD exacerbations, then carbocysteine 1500 mg/day for 6-12 months, then n-acetylcysteine 1200 mg/day for 3 months.    
Dilema Etik bagi Tenaga Kesehatan dalam Menentukan Pilihan Tindakan Medis Berdasarkan Prinsip Berbuat Baik (Beneficence) atau Prinsip Otonomi (Autonomy) Saputra, Warren; Djai Yen, Liauw
Jurnal MedScientiae Vol 3 No 3 (2024): December
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i3.3212

Abstract

The primary goal of the medical profession is to alleviate suffering and restore health to patients through medical practice. This practice is based on ethics and morals. The principle of beneficence requires doctors to act for the good of the patient, while the principle of autonomy emphasizes the individual's right to make their own decisions. These principles are prima facie obligations that in situations of conflict, must be assessed for their respective weight based on context to determine the best course of action for the patient. The literature review was conducted from the reference source, PubMed. The articles obtained were selected according to the inclusion criteria, and the final result obtained 10 articles. Beneficence and autonomy are key moral duties in bioethics, and the interaction between the two requires careful consideration in determining the best way to act.  In some cases, such as the practice of allergy, ethical dilemmas may arise. Deepening the science of ethics and using appropriate communication with soft paternalism are options in the solution of such problems. In medical practice, the principles of beneficence and autonomy often pose dilemmas, especially when the doctor's preference to do good conflicts with the patient's medical decisions, such as in cases of physical restraints, plastic surgery, pediatric patients, and mental patients. Persuasive conversations can help achieve care that meets the patient's goals, without compromising the principles of beneficence and autonomy.
Gene Therapy Revolution: Recent Advances and Modern Biomedical Laboratory Techniques Antoni, Marcel; Susilowati, Rina Priastini
Jurnal MedScientiae Vol 3 No 3 (2024): December
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i3.3258

Abstract

Genetic therapy is a revolutionary innovation in the medical world that aims to treat or prevent diseases through the modification of the patient's genetic material. This literature review examines the latest advances in genetic therapy, including the biomedical laboratory techniques used. Techniques such as Polymerase Chain Reaction (PCR), DNA sequencing, CRISPR-Cas9, and Prime Editing have provided the ability to modify genes with high precision. Genetic therapy has shown success in various diseases, including monogenic genetic diseases such as hemophilia and Duchenne Muscular Dystrophy, as well as cancer through Chimeric Antigen Receptor T-cell (CAR-T) therapy. Additionally, research shows the potential of genetic therapy in addressing complex diseases such as cardiovascular disease and diabetes, as well as in regenerative treatment for degenerative diseases like Parkinson's. Despite being promising, challenges related to ethics, safety, and accessibility still need to be addressed. Case studies indicate that although there are many successes, there are still obstacles to be overcome to improve the effectiveness and safety of this therapy. This literature review concludes that genetic therapy has great potential to become an important pillar of modern treatment in the future, provided that further research and development are needed to overcome the various existing barriers.
Hubungan Antara Kelainan Refraksi Dengan Perilaku Membaca Pada Siswa Anggota Jemaat Gereja Kristen Nafiri Sion Fajar Kemuliaan Tahun 2023 Indrajanti, Mirza; Wijaya, Esther; Nila, Seri; Sinaga, Natasya Advelin; Gosali, Vincentio Owen; Kencana, Billy Gadi
Jurnal MedScientiae Vol 3 No 3 (2024): December
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i3.3332

Abstract

Myopia is an eye disorder in which parallel rays coming from an infinite distance are refracted in front of the retina. Astigmatism is an optical condition of the eye, in which parallel rays are not refracted at a single focal point, so that the focus is unclear, vision is blurred and often dizzy. Anisometropia is a difference in refractive error between the two eyes of 1-2 Diopters (D) in one or more meridians. This can cause aniseikonia, namely a difference in shadow both in shape and size that causes difficulty in fusion. Hypermetropia / Hyperopia / farsightedness is a condition of not being able to see close objects clearly, this condition is the opposite of farsightedness (myopia). The symptoms of hypermetropia are similar to presbyopia in the elderly. Research objective is to educate students about visual health. Method is data collection was conducted through anamnesis, visual acuity examination using refraction instruments and distributing questionnaires to students of the Nafiri Sion Fajar Kemuliaan Christian Church aged 12-22 years, totaling 62 people, then diagnosed with refractive disorders. There is a relationship between refractive disorders and students' reading behavior.
Kecemasan Preoperasi pada Pasien yang Akan Menjalani Operasi Appendiktomi: Kecemasan Preoperasi pada Pasien yang Akan Menjalani Operasi Appendiktomi Ramba, Erni; Tania, Elly; Citraningtyas, Theresia
Jurnal MedScientiae Vol 3 No 3 (2024): December
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i3.3351

Abstract

Anxiety is an individual's reaction to unexpected situations that everyone often experiences in life, providing warnings and directing someone to try to protect themselves. The process of surgery or surgery can cause anxiety reactions. This literature review aims to determine the description of anxiety in preoperative appendicitis patients and the factors that can influence the patient's preoperative anxiety level. Research articles in the form of clinical trials and randomized control trials were reviewed using the Google Scholar search engine, using specific keywords such as anxiety AND "preoperative" AND appendectomy AND comparison. A total of five relevant journals based on the purpose of the literature review. The conclusion from this literature review is that methods that can be implemented and are effective in reducing anxiety in pre-appendectomy patients include communication and education, implementation of the finger grip technique. Knowledge of surgical procedures can reduce anxiety. It should be noted in this literature review that the number of responses from each journal is still considered insufficient.
Trabekuloplasti pada Glaukoma: Sebuah Tinjauan Pustaka Terkini Lily, Lia Listya; Kalangi, Geraldi Marcelino; Manufandu, Gracea Sintike; Anugrahsari, Santi
Jurnal MedScientiae Vol 3 No 3 (2024): December
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i3.3360

Abstract

Glaucoma is a progressive optic neuropathy that can lead to irreversible blindness, where intraocular pressure (IOP) serves as the only modifiable risk factor for disease control. Among the various treatment modalities, laser trabeculoplasty, especially Selective Laser Trabeculoplasty (SLT), has gained popularity as it improves aqueous humor outflow and reduces IOP. This review combines recent studies comparing SLT with other modalities such as Micropulse Laser Trabeculoplasty (MLT) and their clinical outcomes. The purpose of thisliterature review is to highlight the efficacy of Selective Laser Trabeculoplasty (SLT) in managing intraocular pressure (IOP)in glaucoma patients, especially primary open angle glaucoma (POAG), both as first-line therapy and as adjunctive therapy. Literature sources were selected through an internet search using articles in research journal databases on Google Scholar and Pubmed and 30 literatures were selected from these methods. The literature revealed that SLT, as a first-line therapy or adjunct to medical treatment, effectively lowers IOP and can be repeated safely with continued efficacy. In addition, SLT offers an alternative for patients who are unresponsive to topical treatment, providing a non-invasive optionthat may eliminate the need for surgery. This review also examines the role of SLT in long-term glaucoma management, its comparison with newer techniques, and the effectiveness of repeated treatments in maintaining IOP control. Further studies are recommended to validate the long-term outcomes of SLT, especially for various applications and its comparison with newer laser therapies.
Tinjauan Etik Rumah Sakit Berkontribusi Dalam Limbah Makanan Yen, Liauw Djai; Wea, Brigitta Yuliana; Tholib, Clemarie Natasha; Mai, Roy; Rasyiqah, Fajrina Rizki; Yurike, Vony; Ongga, Leonardo
Jurnal MedScientiae Vol 3 No 3 (2024): December
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i3.3456

Abstract

About a third of the food produced per year is thrown away and becomes food waste, affecting various fields on a global scale. According to Williams and Walton, food waste generated by hospitals is two to three times greater than in other service areas. If this food waste is processed and recycled, it will produce methane and CO2 emissions which will also worsen global warming. The purpose is to review the ethics of hospitals that contribute to food waste. This is a literature study that was carried out using the Pubmed and Google Scholar databases from 2014-2024 with the main keywords "food waste", "hospital", and "ethic", and obtained 17 journals in Indonesian and English. The results showed that vegetables were often the type of food left most in hospitals. Strategies to reduce food waste include attractive presentation, room service systems, and bioconversion innovations with BSF larvae. Indonesia itself has several policies to reduce food waste, but more focused management is still needed. It can be concluded that the main strategies for reducing food waste include improving food presentation, flexible services such as room service, bioconversion with BSF larvae, and recycling. More specific regulations for hospitals are needed in Indonesia
Effect of The Addition of Lime (Citrus aurantifolia) on Total Phenolic and Antioxidant of Turmeric Infusion (Curcuma domestica Val.) Rukmana, Dewi Samudra Putri Aliffa; Rumiati, Flora; Sudrajat, Susana Elya
Jurnal MedScientiae Vol 3 No 3 (2024): December
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i3.3459

Abstract

Turmeric is a traditional drink that has been known since ancient times in Indonesia. Turmeric is an herbal ingredient that is efficacious as an antioxidant and is usually combined with tamarind. The added tamarind serves to add to the efficacy of turmeric. In this study, the role of tamarind from sour turmeric drink was replaced with lime fruit. The purpose of this study was to determine the effect of lime powder on pH, antioxidant activity and total phenol of turmeric infusion. Lime turmeric infusion is made by adding water at 900C for 15 minutes. The lime turmeric infusion solution was then tested for pH, total phenol, and antioxidant levels using the DPPH method. Turmeric infusion without the addition of lime fruit powder has a pH of 4.8, total phenol content of 1.324 ± 0.013 mgGAE/g, and antioxidant of 312.55 ± 0.62 ppm. While the turmeric infusion with the addition of lime has a pH of 3.4, a total phenol content of 1.852 ± 0.004 mgGAE/g, and an antioxidant value of 31.80 ± 1.22 ppm. The addition of lime fruit to turmeric infusion resulted in a decrease in pH, an increase in total phenol levels, and antioxidant levels.

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