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INDONESIA
Jurnal MedScientiae
Published by Universitas Kristen Krida Wacana
ISSN : -     EISSN : 28291166     DOI : https://doi.org/10.36452/jmedscientiae
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Nursing Public Health
Jurnal MedScientiae adalah jurnal yang dikelola oleh Fakultas Kedokteran dan Ilmu Kesehatan Universitas Kristen Krida Wacana. Jurnal ini mempublikasikan artikel-artikel secara open access dalam lingkup bidang kedokteran dan kesehatan seperti kedokteran dasar, bioetika kedokteran, biologi sel, biologi molekuler, genetika, fisiologi, biokimia, bioinformatika, anatomi, farmakologi, kesehatan masyarakat, dan ilmu biomedik lainnya. Tim editorial menerima naskah berupa artikel penelitian, literature dan systematic review, dan laporan kasus. Naskah yang dikirimkan hendaknya belum pernah diterbitkan sebelumnya di jurnal maupun media yang lain dan disiapkan sesuai dengan template atau format yang telah ditentukan. Setiap naskah yang memenuhi kriteria jurnal akan direview oleh pakar yang sesuai (peer reviewer). Jurnal MedScientiae tidak mengenakan biaya selama proses mulai dari penerimaan naskah hingga publikasi. Jurnal MedScientiae terbit 3 kali dalam satu tahun, yaitu pada bulan April, Agustus dan Desember dengan cakupan keilmuan yang telah disebutkan di atas. Edisi pertama jurnal akan diterbikan di bulan Mei tahun 2022 dengan nomor ISSN 2829-1166.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 220 Documents
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Aspek Klinis dan Pemeriksaan Laboratorium Sindrom Hiperimunoglobulin-M Sihombing, Martina Rentauli
Jurnal MedScientiae Vol. 3 No. 2 (2024): Agustus
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i2.3324

Abstract

Hyperimmunoglobulin-M Syndrome (HIGM) is a set of symptomps  due to primary immunodeficiency characterized by low levels of immunoglobulin G (IgG), immunoglobulin A (IgA), immunoglobulin E (IgE), and normal or increased levels of immunoglobulin M (IgM) or recurrent infections. HIGM syndrome was initially thought to be caused by genetic defects related to the X chromosome only, but along with advances in molecular technology in detecting genetic abnormalities, other autosomal-type defects were found. Genetic defects in HIGM Syndrome cause disruption of the maturation process of humoral immunity, especially diversity through CSR, and increased affinity through SHM. Clinical manifestation of HIGM patients varies greatly and depends on the defect in the CD40L or CD40 signal pathway. Current therapy given for HIGM patients aim to resolve those clinical manifestation and fix the production of high-affinity antibody. Life expectancy of patients without a bone marrow transplant is estimated to be less than 30 years.
Depresi pada Pasien Diabetes Melitus Tipe 2 Jenarut, Yohana Fransisca; Tania, Elly; Suparto; Ingkiriwang, Elly
Jurnal MedScientiae Vol. 3 No. 2 (2024): Agustus
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae. V3i2. 3333

Abstract

Patients with diabetes mellitus have a 2-3 times higher risk of experiencing depression compared to the general population, which can potentially exacerbate their overall health condition. This literature review aimed to investigate the prevalence of depression among type 2 diabetes mellitus patients and to identify its associated risk factors. This literature review was conducted by searching electronic databases including Google Scholar, PubMed, and ProQuest. Twelve studies met the inclusion criteria and were included in the analysis. The results revealed that the prevalence of depression among type 2 diabetes mellitus patients varied from 23.20% to 83.80%, with a majority of cases classified as mild to moderate. To identify risk factors contributing to the high prevalence of depression in type 2 diabetes mellitus patients, additional studies were explored. Based on this literature review, it can be concluded that the prevalence of depression among type 2 diabetes mellitus patients is quite high. Several consistently identified risk factors include advanced age, female gender, low education level, unstable or unemployed work status, low income, marital status, and longer duration of diabetes. Early detection and appropriate management of depression in individuals with type 2 diabetes mellitus are essential for enhancing quality of life and optimizing treatment outcomes.
Prevalence And Description Of Lower Extremity Peripheral Artery Disease Based On Abi Value In Elderly Inpatient At Ukrida Hospital Patty, Kevin Emmanuel; Kurniadhi, Didi; Winaktu, Gracia JMT
Jurnal MedScientiae Vol. 3 No. 2 (2024): Agustus
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae. v3i2. 3337

Abstract

Peripheral artery disease (PAD) is a disease caused by blockage of blood vessels by fat that occurs in the lower extremities with symptoms of pain in the lower extremities and intermittent claudication. PAP occurs in patients aged 60 years and over with risk factors of diabetes, smoking and hypertension. PAP can be detected through an Ankle Brachial Index (ABI) examination. This study aims to determine the description and prevalence of PAD based on ABI values ​​in elderly people hospitalized at UKRIDA Hospital, West Jakarta. The research is observational using a descriptive research design with a cross-sectional approach. Sampling is in the form of consecutive sampling, where all elderly people hospitalized at UKRIDA Hospital will be taken as research samples according to the inclusion criteria until they meet the minimum threshold. Using the Lemeshow formula, the sample size was 76 elderly people. The results of the study showed that the prevalence of PAD was 10.5% with the gender that suffered the most from PAP being women, 6 elderly people (75%) and 2 elderly men (25%). Risk factors for PAD sufferers include hypertension (62.5%), diabetes mellitus (37.5%), smoking (25%), and obesity (12.5%). The ABI results in PAD elderly were 2 mild ABI (0.75-0.9) (25%) and 6 severe ABI (<0.9%) (75%). Using the Fontaine classification, the clinical manifestations of PAD elderly were 7 at level I (87.5%) and 1 at level IV (12.5%).
Persepsi Mahasiswa Kedokteran Ukrida Angkatan 2020 terhadap Proses Pembelajaran Daring Arsana, Gabriel Ferdinan; Hartono, Budiman; Josephine, Jodie
Jurnal MedScientiae Vol. 3 No. 3 (2024): Desember
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i3.2921

Abstract

Online learning is leaning that utilizes online media or the internet in learning. The learning process that is carried out online makes students’ psychological and mental activities trained in the environment, which results in a pile of changes in knowledge and understanding, skills and attitude values. Perception is a point of view or understanding of material or information received during learning activities. This study has four operational definitions, namely online learning, problem-based learning, skills lab, and integration. From the results of this study, it was concluded that students have perceptions of online learning satisfaction because students can study anywhere during the pandemic and can understand the material presented by lecturers. Based on the level of achievement of student respondents, they can take part in online learning without affecting the learning process or behavior.  
LITERATURE REVIEW RESIKO KANKER LEHER DAN KEPALA PADA PENGUNAAN TEMBAKAU KUNYAH Tuhumury, Filian; Kertadjaya, Wiwi; Purnamawati, Purnamawati
Jurnal MedScientiae Vol. 3 No. 3 (2024): Desember
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i3.2980

Abstract

Cancer is a disease characterized by abnormal growth of body tissue cells that then turn into cancer cells. Among the many types of cancer, head and neck cancer is one type of cancer that develops around the tissues and organs of the head and neck. Some risk factors that can increase a person's chances of developing head and neck cancer are tobacco smoking, including chewing tobacco. The use of chewed tobacco produces more than 70 carcinogens, such as tobacco specific nitrosamines (TSNA), polycyclic aromatic hydrocarbons (PAHs), aldehydes, and heavy metals. as the main cause of head and neck cancer. This literature review was made to determine the risk of neck and head cancer in the use of chewing tobacco. The method in making this review literature is in the form of a literature review by collecting several theoretical foundations from various research journals, the internet, and other scientific articles. Collect research journals from various databases for analysis. Journals or articles obtained are the results of searches on Google Scholar, ProQuest and PubMed. The results of this literature review show that there is a significant association between the risk of head cancer and the use of chewing tobacco.
Prevalensi Defisiensi Penglihatan Warna Anak Usia Sekolah Dasar Di Sekolah-X Tanjung Duren Selatan 05 Sinaga, Natasya Advelin; Silaen, Desi Hartati; Goenawan, Kristian
Jurnal MedScientiae Vol. 3 No. 3 (2024): Desember
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i3.3002

Abstract

Color vision deficiency is the inability of the eye to distinguish colors, this can occur both congenitally and acquired. Color vision deficiency can affect a person's quality of life performance and the selection of advanced study programs in children. This study aims to determine the prevalence and characteristics of color vision deficiency in detail in elementary school-age children. This study used a total sampling technique with a cross sectional method with 366 respondents. Data collection was carried out from September to October. In this study, 5.2% (10 people) of respondents experienced color vision deficiency. As many as 2.2% (8 people) of respondents had partial color vision deficiency and 0.5% (2 people) of respondents had color blindness (monochromat). Of the 195 male respondents, 4.6% of them suffered from color vision deficiency while of the 171 female respondents, 0.6% of them suffered from color vision deficiency. Color vision is related to cone cell photoreceptors. Each type of cone cell plays a role in color vision. The prevalence of students with color vision deficiency is 2.7%. In this study it was found that students had partial and total color vision deficiency (monochromat). The most common type of red-green color vision deficiency. The highest prevalence is in male students. It is recommended to the government and schools to carry out a complete eye examination including a color vision examination so that it can support the learning process and the selection of advanced study programs according to the child's condition.
Indonesia Correlation of Degree of Asthenopia in Corrected and Uncorrected Refractive Errors of 2020 Faculty of Medicine and Health Sciences Students: Korelasi Derajat Astenopia pada Kelainan Refraksi Terkoreksi dan Tidak Terkoreksi Mahasiswa Fakultas Kedokteran dan Ilmu Kesehatan Ilahi, Luthfiyana; Wihardjo, Erning; Goenawan, Kristian
Jurnal MedScientiae Vol. 3 No. 3 (2024): Desember
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i3.3011

Abstract

Asthenopia, or what is usually called tired eyes, is the occurrence of tension in the ciliary muscles in the eyes caused by intensive visual activity. The symptoms of asthenopia that are felt are subjective visual discomfort, which causes decreased concentration, academic performance, and work ability. This study aims to determine the correlation between the degree of asthenopia in corrected and uncorrected refractive errors in FKIK Ukrida students in the class of 2020. This study used a total sampling technique with a cross-sectional method with 159 respondents. Data collection was carried out in December. In this study, the number of respondents who had corrected refractive errors consisted of 30 (21.3%) people who did not experience asthenopia, 56 (39.7%) experienced mild asthenopia, 15 (10.6%) people experienced moderate asthenopia, and 1 (0.7%) experienced severe asthenopia. Respondents who had uncorrected refractive errors consisted of 10 (7.1%) people who did not have asthenopia, 13 (9.2%) had mild asthenopia, 14 (9.9%) people, and 2 people did not have severe asthenopia. The degree of asthenopia and the corrected refractive error are correlated, according to the Spearman test findings, with a p-value of 0.032. Symptoms of asthenopia can cause a decrease in visual quality and work ability. The results of this research found that FKIK students experienced more corrected refractive errors. Symptoms of asthenopia are many. Asthenopia is often found in corrected refractive errors. So, education is needed to prevent asthenopia in FKIK students.
Hubungan Antara Screen Time dengan Angka Kejadian Miopia Pada Anak Sebelum dan Setelah Masa Pandemi Covid-19 : Sebuah Tinjauan Pustaka Anugrahsari, Santi; Shania Audrianisa; Cahya Virgin Septyany; Appy, Enjeline Grecielya; Rohy, Charlos Ivanly Jusuf
Jurnal MedScientiae Vol. 3 No. 3 (2024): Desember
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i3.3047

Abstract

The COVID-19 pandemic policies, outdoor activity restrictions, and distance learning have significantly impacted the occurrence of myopia in children. These changes are associated with increased screen time, decreased outdoor activities, and insufficient sleep duration, indicating potential long-term effects on myopia prevalence and development. This literature review utilizes articles from research journal databases searched through the internet. The internet databases used include Google Scholar and PubMed, using keywords: "Children," "Epidemiology," "Risk Factor," and "Myopia." Inclusion criteria for this literature are English articles, published within the last 10 years, and research publication types. Exclusion criteria include duplications and articles with only abstracts or without full text. The combined findings of these studies consistently demonstrate that school-age myopia is influenced by genetic and environmental factors, with screen time, near work, and urban residence being significant risk factors. The protective role of outdoor activities against myopia is evident in various geographic regions. The COVID-19 pandemic has exacerbated this issue, emphasizing the need for interventions focused on reducing screen time and increasing outdoor activities to manage and prevent myopia progression.
Efektivitas Terapi Target Sorafenib dalam Penanganan Hepatocellular Carcinoma: Literature Review Dharma, Herbert; Purnamawati; Angeline, Reni
Jurnal MedScientiae Vol. 3 No. 3 (2024): Desember
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i3.3141

Abstract

Liver cancer is the sixth most common cancer and the third leading cause of death in the world. The main cause of liver cancer is the Hepatitis B or Hepatitis C virus which causes patient to experience chronic liver disease which can worsen and develop into liver cancer. Sorafenib targeted therapy can be used to treat patients with advanced liver cancer. This drug can suppress tumor cell proliferation and inhibit tumor angiogenesis. This study aims to determine the benefits of targeted therapy in treating Hepatocellular Carcinoma. The method used in this study is by searching for articles in electronic databases via the internet using Google Scholar and Pubmed. The results showed that the combination of sorafenib targeted therapy with conventional therapy, such as TACE and radiofrequency ablation, could significantly increase survival rates and time to progression. In conclusion, sorafenib targeted therapy when combined with conventional therapy has higher benefits and effectiveness compared to other therapies. The disadvantage of sorafenib targeted therapy is that it can cause many side effects for the patients.
TINJAUAN ILMIAH MENGENAI PERBANDINGAN EFEKTIVITAS DAN KEAMANAN ERDOSTEIN, KARBOSISTEIN, DAN N-ASETILSISTEIN PADA PASIEN PENYAKIT PARU OBSTRUKTIF KRONIK EKSASERBASI AKUT Walter, Bryan; Wiliam, Wiliam; Citraningtyas, Theresia
Jurnal MedScientiae Vol. 3 No. 3 (2024): Desember
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i3.3145

Abstract

Acute exacerbation of Chronic Obstructive Pulmonary Disease (COPD) is a worsening of stable COPD/respiratory symptoms. The 2020 Global Initiative for Chronic Obstructive Lung Disease (GOLD) shows erdostein, carbocysteine, and n-acetylcysteine can reduce the risk of acute exacerbations in COPD. The aim of this writing is to determine and compare the effectiveness and safety of erdostein, carbocysteine, and n-acetylcysteine in acute exacerbations of COPD. The scientific review takes the form of a literature review by searching for data using books, journals and websites. Sixteen articles were obtained with the results that erdosteine, carbocysteine, and n-acetylcysteine reduced the risk of acute exacerbations of COPD. The best effectiveness results depend on the dose of the drug and the length of use. The best reduction in the risk of exacerbation was oral erdostein, dose 900 mg daily for 10 days (39.1%), Carbocysteine 1500 mg daily for 6-12 months (p < 0.00001) and n-acetylcysteine 1,200 mg/day for 3 months (p<0.05). Erdostein was well tolerated and there were no treatment-related side effects. The frequency of side effects of respiratory tract infections was not detected for erdostein, but for carbocysteine it was found to be 0.56% and NAC 10.85%. Two patients dropped out of the study because of gastrointestinal disturbances related to carbocysteine side effects. The conclusion of this scientific review is that the use of erdostein 900 mg/day for 10 days has the best effectiveness in reducing COPD exacerbations, then carbocysteine 1500 mg/day for 6-12 months, then n-acetylcysteine 1200 mg/day for 3 months.    

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