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Mohammad Rizki Fadhil Pratama
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Borneo Journal of Pharmacy
Published by Universitas Muhammadiyah Palangkaraya
ISSN : -     EISSN : 26214814     DOI : https://doi.org/10.33084/bjop
Core Subject : Health,
Medicine & Pharmacology
Borneo Journal of Pharmacy publishes various scientific articles covering Pharmacy and Pharmaceutical Sciences in the field but not limited to: Pharmacology-Toxicology, including pharmacokinetics, pharmacodynamics, pharmacotherapy, and toxicology. Pharmacognosy-Phytochemistry, including pharmacognosy, phytochemistry, ethnobotany, and ethnopharmacology. Pharmaceuticals, including biopharmaceuticals, pharmaceutical technology, formulations, and biotechnology. Analytical Pharmacy-Medicinal Chemistry, including pharmaceutical chemistry, chemical analysis, medicinal chemistry, bioinformatics, pharmacy physics, pharmaceutical analysis, and method validation. Microbiology Pharmacy, including the antibacterial, antifungal, and antiviral activity test. Natural Product Development, including testing the pharmacological activity of extracts, fractions, and plant isolates. Clinical-Community Pharmacy, including monitoring usage, side effects, counseling, and drug use evaluation. Management Pharmacy, including drug management, drug use profiles, pharmaceutical administration, and marketing.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 300 Documents
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Cover, Content, and Editorial Note from Borneo J Pharm Vol. 7 No. 1 February 2024 Borneo J Pharm, Chief Editor of
Borneo Journal of Pharmacy Vol. 7 No. 1 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i1.7020

Abstract

Assalamu’alaikum Wr. Wb. Alhamdulillahirabbil ‘alamin. The next edition of the Borneo Journal of Pharmacy (Borneo J Pharm) was published in February 2024. This edition contains ten articles: Pharmacognosy-Phytochemistry, Analytical Pharmacy-Medicinal Chemistry, and Clinical-Community Pharmacy. This edition includes writings from four countries: India, Indonesia, South Africa, and Thailand. The authors come from several institutions, including Universitas Muhammadiyah Kalimantan Timur, Universitas Gadjah Mada, Khon Kaen University, Universitas Muhammadiyah Surakarta, University of the Witwatersrand, Universitas Sanata Dharma, Universitas Halu Oleo, Universitas Bhakti Kencana, Universitas Negeri Gorontalo, Sekolah Tinggi Farmasi Mahaganesha, Universitas Tanjungpura, National Research and Innovation Agency of the Republic of Indonesia, Universitas Surabaya, Universitas Airlangga, Universitas Indonesia, M. S. Ramaiah University of Applied Sciences, and Universitas Muhammadiyah Yogyakarta. Editorial boards are fully aware that this edition has room for improvement. Hence, with all humility, we are willing to accept constructive suggestions and feedback for improvements to the publication for the next editions. The editorial board would like to thank all editors, reviewers, and contributors of the scientific articles who have provided the repertoire in this issue. We hope all parties, especially the contributors, can re-participate in the publication in the next edition in May 2024. Wassalamu’alaikum Wr. Wb.
Affinity of Nintedanib Towards New Candidate Target for Idiopathic Pulmonary Fibrosis Balasubramanian, Hari Baskar; Biswas, Sima; Talmon, Maria; Patrucco, Filippo; Balbo, Piero Emilio; Fresu, Luigia Grazia; Bagchi, Angshuman
Borneo Journal of Pharmacy Vol. 7 No. 3 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i3.7218

Abstract

Idiopathic pulmonary fibrosis (IPF) is a progressive disease due to aggregation of fibroblasts on lung parenchyma. Nintedanib, an indolinone-derived tyrosine kinase inhibitor (TKi) has been approved for the treatment of IPF and it is a well-known inhibitor of platelet-derived growth factor (PDGF) receptor-α and -β, fibroblast growth factor (FGF) receptor-1–3 and vascular endothelial growth factor (VEGF) receptor-1–3. This study aims to evaluate the binding interaction between new therapeutic protein candidates for IPF such as autotaxin, galectin-3, interleukin-13, chitotriosidase-1, JNK, RhoE-ROCK-1, ROCK-2 against nintedanib. In this investigation we predicted, computed, and analyzed the binding interactions of the drug nintedanib using an in silico approach called molecular docking. Our docking studies demonstrated that RhoE-ROCK1 and autotaxin showed strong binding affinities towards nintedanib compared to known targets such as VEGFR2 and FGFR1. We can therefore hypothesize a further contribution of nintedanib to the improvement of pathology due to its affinity towards new targets in the pathogenesis of IPF. The next step will be to evaluate the effects of this affinity in vitro on specific cellular models.
Ethnomedicine Study of Medicinal Plants for Therapy of Elderly Sleep Disorders in Tengger Tribe Lahardo, Devanus; Ekasari, Wiwied; Widyawaruyanti, Aty
Borneo Journal of Pharmacy Vol. 7 No. 3 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i3.7272

Abstract

Ethnomedicine offers valuable insights into plant-based therapies, potentially leading to the discovery of novel drugs. Sleep disturbances, including difficulty falling asleep, maintaining sleep, and early morning awakening, are prevalent among the elderly population and can significantly worsen Alzheimer's disease progression. This study explores the medicinal plants utilized by the Tengger tribe's elderly population for treating sleep disorders. Employing a mixed-methods approach, the study involved qualitative data collection through snowball sampling and in-depth interviews with 99 elderly participants and three traditional healers of the Tengger tribe. Quantitative data was obtained through questionnaires administered during field surveys. Participants were selected based on specific criteria: elderly individuals over 60 years of age, native Tengger tribe members with a history of using medicinal plants for sleep disorders; traditional healers were required to be native Tengger tribe members with knowledge passed down through generations. The study identified a total of 11 medicinal plants used for sleep disorders. Five plant species emerged as the most dominant based on the highest citation value (FC) analysis: kale (Ipomoea reptans), agarwood (Aquilaria malaccensis), sintok (Cinnamomum sintoc), Broadleaf plantain (Plantago major), and soursop (Annona muricata). The most commonly used plant parts were leaves, bark, and roots. Traditional preparation methods included boiling and burning the plant materials. Notably, knowledge of these medicinal plants is primarily transmitted orally within the community. Our findings highlight five medicinal plants employed by the Tengger elderly to manage sleep disorders, with limited documented evidence of their efficacy.
Thiourea Derivatives as Estrogen Receptor Alpha Inhibitors for Breast Cancer Therapy: An In Silico Evaluation with ADMET Prediction and Molecular Docking Puspaweni, Hestining; Purwanto, Bambang Tri; Widiandani, Tri; Siswodihardjo, Siswandono; Muchlisin, M. Artabah
Borneo Journal of Pharmacy Vol. 7 No. 3 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i3.7396

Abstract

Breast cancer remains a significant public health concern, necessitating the discovery of novel therapeutic agents. This study investigates the potential of thiourea derivatives, specifically HU, HTMX, and BMPTU compounds, as estrogen receptor alpha (ERα) inhibitors using computational approaches. Drug-likeness assessments using Lipinski's Ro5 confirmed the oral bioavailability of all compounds. Additionally, ADMET analysis indicated favorable pharmacokinetic properties, with minimal metabolic interactions and acceptable safety profiles, except for BMPTU2, which showed potential hepatotoxicity. Molecular docking simulations revealed strong binding affinities between BMPTU derivatives, particularly BMPTU2, BMPTU3, and BMPTU4, and key ERα residues. These interactions suggest their potential as ERα modulators, warranting further in silico and experimental validation. In conclusion, the findings highlight the potential of BMPTU derivatives, especially BMPTU2, BMPTU3, and BMPTU4, as promising lead compounds for developing novel ERα-targeted breast cancer therapies. Further optimization and validation are crucial to fully elucidate their therapeutic potential.
Cover, Content, and Editorial Note from Borneo J Pharm Vol. 7 No. 2 May 2024 Borneo J Pharm, Chief Editor of
Borneo Journal of Pharmacy Vol. 7 No. 2 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i2.7527

Abstract

Assalamu’alaikum Wr. Wb. Alhamdulillahirabbil ‘alamin. The next edition of the Borneo Journal of Pharmacy (Borneo J Pharm), has been published in May 2024. This edition contains ten articles: Pharmacology-Toxicology, Pharmacognosy-Phytochemistry, Pharmaceutical, Analytical Pharmacy-Medicinal Chemistry, Microbiology Pharmacy, Natural Product Development, Clinical-Community Pharmacy, and Management Pharmacy. This edition includes writings from five countries: Indonesia, Malaysia, Nigeria, Sierra Leone, and Uganda. The authors come from several institutions, including Institut Teknologi Bandung, Universitas Darussalam Gontor, Universitas Koperasi Indonesia, Universitas Lambung Mangkurat, Universitas Muhammadiyah Prof. DR. HAMKA, Institut Pertanian Bogor, Biomatics Indonesia, Indonesian Institute of Bioinformatics, Universitas Nasional, University of Ilorin, Summit University, Ambrose Alli University, Mbarara University of Science and Technology, Kampala International University, Premium Medical Services, Kebbi State University of Science and Technology, Clarke International University, Universitas Muhammadiyah Yogyakarta, International Islamic University Malaysia, Universitas Mahasaraswati Denpasar, Universitas Indonesia, National Research and Innovation Agency of the Republic of Indonesia, Menur National Mental Hospital, and East Java Provincial Health Service. Editorial boards are fully aware that there is still room for improvement in this edition, hence with all humility willing to accept constructive suggestions and feedback for improvements to the publication for the next editions. The editorial board would like to thank all editors and reviewers, and contributors of the scientific articles who have provided the repertoire in this issue. We hope that all parties, especially the contributors, could re-participate for publication in the next edition on August 2024. Wassalamu’alaikum Wr. Wb.
Stability Evaluation on Diminazene Diaceturate and Phenazone in Bulk and Combined Formulations using Validated Chromatographic Method Mubarak, Amna; Shantier, Shaza Wagiealla; Mohamed, Magdi Awadalla; Gadkariem, Elrasheed Ahmed
Borneo Journal of Pharmacy Vol. 7 No. 4 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i4.3588

Abstract

The combined therapy of diminazene aceturate (DMZ) and phenazone (PHENZ) is widely used in veterinary medicine to combat trypanosomiasis and babesiosis. This study presents a novel, validated HPLC method for accurately quantifying DMZ and PHENZ in various pharmaceutical formulations, including bulk powders, sachets, vials, and injectables. The chromatographic separation was achieved using a C18 column (150 x 4.6 mm, 5 μm particle size) with a mobile phase composed of phosphate buffer (pH 3.0) and methanol (70:30 v/v) at a flow rate of 1 mL/minute. UV detection was set at 250 nm. The method demonstrated linearity over a concentration range of 20-100 μg/mL for DMZ and 25-125 μg/mL for PHENZ, with correlation coefficients exceeding 0.999. Forced degradation studies were conducted under various stress conditions to assess the method's stability-indicating power. DMZ exhibited first-order degradation under acidic pH conditions. While slight degradation (2.4-3.1%) was observed under alkaline, UV, and indoor room light conditions, PHENZ remained stable. The validated HPLC method effectively quantified DMZ and PHENZ in the presence of their degradation products and impurities, demonstrating its suitability for quality control and stability studies of these combined drug formulations.
Isolation and Identification of Marine Bacteria in Raja Ampat Islands West Papua Producing Antibacterial Against Salmonella typhi and Staphylococcus aureus Mahdiyah, Dede; Dharmawan, Muhammad Rifqi; Noval, Noval
Borneo Journal of Pharmacy Vol. 7 No. 4 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i4.3908

Abstract

Indonesia's vast archipelago harbors a wealth of natural resources, including marine bacteria with potential antibacterial properties. Given the increasing prevalence of antibiotic resistance, particularly against Salmonella typhi and Staphylococcus aureus, there is a pressing need to explore alternative antimicrobial agents. This study aimed to isolate and characterize marine bacteria with antibacterial activity and evaluate their efficacy against S. typhi and S. aureus. Isolation of marine bacteria was conducted using the spread plate method. Antibacterial activity screening of the secondary metabolites was performed using the well diffusion method. Minimum inhibitory concentration (MIC) was determined using the dilution method, while minimum bactericidal concentration (MBC) was determined using the spread plate method. Seven bacterial isolates were obtained, all identified as Gram-negative bacilli. The secondary metabolites of these marine bacteria demonstrated antibacterial activity against both S. typhi and S. aureus, with inhibition zones of 8.50 mm and 8.46 mm, respectively. The MIC for both bacteria was determined to be 1500 μg/mL. Statistical analysis revealed a significant difference in antibacterial activity between the isolates (Kruskal-Wallis Test, p-value = 0.007) and between S. typhi and S. aureus (Mann-Whitney Test, p-value = 0.025). While the secondary metabolites exhibited antibacterial activity against both bacteria, they did not demonstrate bactericidal activity as measured by the MBC test.
Antidiarrheal Potential of Maja (Crescentia cujete) Fruit Extract in Mice Teodhora, Teodhora; Manalu, Rosario Trijuliamos; Saputra, Richi Andika
Borneo Journal of Pharmacy Vol. 7 No. 4 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i4.4712

Abstract

Diarrhea, characterized by frequent, loose stools, can be treated with various approaches. This study investigated the antidiarrheal properties of maja (Cresentia cujete) fruit extract, which contains secondary metabolites like tannins and flavonoids with astringent properties. The objective was to determine the optimal dose of C. cujete fruit extract for treating diarrhea in mice. An in vivo experimental design was employed, inducing diarrhea in male mice using oleum ricini. The study assessed stools' onset, duration, consistency, frequency, and weight. Cresentia cujete fruit extract was administered orally at 125, 250, and 500 mg/kg BW doses. A comparison was made with negative control (CMC-NA) and positive controls (loperamide and attapulgite). Data analysis involved ANOVA followed by the Tukey test. The findings revealed that 500 mg/kg BW of C. cujete fruit extract was the most effective dose for treating diarrhea in mice. These results suggest the potential of C. cujete fruit extract as a promising natural antidiarrheal agent.
Standardized Herbal Extract for Wound Healing: A Comparative Study of Centella asiatica, Curcuma domestica, and Heterotrigona itama Honey Combination in Rabbits Diniatik, Diniatik; Kustiawan, Paula Mariana; Suryadini, Halida
Borneo Journal of Pharmacy Vol. 7 No. 4 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i4.5803

Abstract

Centella asiatica and Curcuma domestica are recognized for their wound-healing properties. This study investigated the synergistic effects of combining these plant extracts with stingless bee (Heterotrigona itama) honey on wound healing in rabbits. Ethanolic extracts of C. asiatica and C. domestica were prepared in a 1 : 10 ratio. Blended formulations containing 20% plant extracts and 80% honey were created in two ratios: 1 : 1 and 2 : 1. The total flavonoid and tannin content of the plant extracts were quantified. Male rabbits were subjected to a wound-healing model, and the formulations were applied topically for seven days. Wound healing was assessed, and the results were compared to a positive control. The ethanolic extracts of C. asiatica and C. domestica were rich in flavonoids and tannins. The blended honey formulations exhibited promising wound-healing effects, with Formula 2 (2 : 1 ratio of plant extracts) demonstrating slightly superior results compared to Formula 1 and the positive control. These findings suggest the potential of the combined extracts of C. asiatica, C. domestica, and H. itama honey as effective wound-healing agents.
Rationality of Tuberculosis Treatment for Drug-Susceptible Pulmonary Tuberculosis at a Primary Care in Bandung Islamiyah, Alfi Nurul; Syarifuddin, Syarifuddin; Akhsa, Morsalina; Rukmawati, Iis; Margayani, Eni; Suherman, Linda Purnamawati; Septiani, Vina; Ramdani, Robby
Borneo Journal of Pharmacy Vol. 7 No. 4 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i4.5896

Abstract

Tuberculosis (TB) remains a significant global health concern, particularly in Indonesia. Ensuring rational TB treatment is crucial for effective disease control and preventing the emergence of drug resistance. This study aimed to evaluate the rationality of TB treatment among newly diagnosed drug-susceptible pulmonary TB patients in a primary care center in Bandung. A descriptive-analytical study was conducted on 56 patients who met the inclusion and exclusion criteria. Treatment rationality was assessed based on the Indonesian Society of Respirology 2021 and the National Guidelines for Medical Services 2020. While 100% of patients received the correct medication for the right indication and dose, the duration of therapy was suboptimal for most patients (83.93%) due to drug unavailability. This resulted in a lower-than-ideal treatment regimen, potentially compromising treatment outcomes and increasing the risk of drug resistance. These findings highlight the need for improved drug supply management and adherence to treatment guidelines to optimize TB treatment outcomes and reduce the burden of TB in Indonesia.

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