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INDONESIA
Jurnal Sains Farmasi dan Kesehatan
Published by CV ITTC Indonesia
ISSN : -     EISSN : 30249368     DOI : 10.47233/jfkes
Core Subject : Health, Science,
Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary
Jurnal Sains Farmasi dan Kesehatan (JFKES) E-ISSN : 3024-9368 is an open access journal which is a media of research publication and review article on all aspects of pharmaceutical science that is innovative, creative, original and based on scientific. Articles published in this journal include Pharmaceutical Technology, Pharmacology, Pharmaceutical Chemistry, Traditional Medicine, Food and beverages, and the field of public health
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 111 Documents
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Uji Anti Hiperglikemik Ekstrak Etanol Daun Salam (Syzygium Polyanthum (Wight.) Walp) Dan Daun Cepcepan (Castanopsis Costata (Blume) A. Dc.) Terhadap Tikus Putih Devortivo Hartono Putra; Erida Novriani; Razoki
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 2 (2025): September - Desember
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i2.3399

Abstract

Hyperglycemia, characterized by elevated blood glucose levels, is a key clinical feature of diabetes mellitus. In recent years, medicinal plants have gained attention as alternative therapies due to their relatively minimal side effects. This study aimed to explore the potential of acombined ethanol extract of bay leaf (Syzgium polyanthum) and cepcepan leaf (castanopsis costata) in lowering blood flucose leveles in white rats (Rattus norvegicus) induced with alloxan. The extraction process was carried out using the maceration methos with 96% ethanol. Phytochemical screening revealed the presence of active compounds such as flavonoids, alkoloids, tannins, saponins, and steroid. The rats were divided into six groups: a normal group. A negative control group (alloxan only), a positive control group (glibenclamide 0.45 mg/kgBB), and three treatment groups receiving the combined extract at doses of 120 mg/kgBW, 250mg/kgBW, and 500mg/kgBW. Blood glucose levels were monitored from day 0 to day 15. ANOVA analysis showed a reduction in glucose levels among the treatment groups, althought the results were not statistically significant (p > 0.05). nevertheless, a consistent downward trend was observed, particularyl in the group receiving 250mg/kgBW. These findings suggest that the ethanol extract combination of bay and cepcepan leaves holds promise as an antihyperlycemic agent. However, frurther research is necessary to confirm its efficacy and fully understand its mechanism of action.
Hubungan Tingkat Pengetahuan Pasien Hipertansi Terhadap Kepatuhan Minum Obat Pada Pasien Rawat Jalan Di Rumah Sakit Royal Prima Adelia Pratiwi; Muhammad Yunus; Roy Indrianto Bangar
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 2 (2025): September - Desember
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i2.3416

Abstract

Hypertension s a chronic condition with a high prevalence that can lead to cardiovascular complications if patients do not adhere to medication regimens and the medication adherence is on of the primary key to therapeutic success. However, low adherence rates remain a significant challenge, often linked to insufficient patient understanding. This study aimed to analyze the relationship between the level of knowledge of hypertensive patients and their medication adherence at Royal Prima Hospital. This research method employed a quantitative correlational design with a cross-sectional approach involving 78 outpatient respondents selected through purposive sampling. Demographic data were analyzed using the Chi-Square Test, while the relationship between the main variables was tested with Spearman Correlation. The results showed that the majority of respondents had a sufficient level of knowledge (52.6%) and moderate adherence (48.7%). The Spearman Correlation test yielded a coefficient value (rₛ) of 0.803 with p < 0.001, indicating a very strong and significant positive relationship between the level of knowledge and medication adherence. Conversely, the Chi-Square Test results showed no significant association between demographic characteristics and adherence. It is concluded that knowledge is a crucial determinant influencing treatment adherence among hypertensive patients.
Gambaran Tingkat Kepatuhan Pengobatan pada Pasien Diabetes Mellitus di Puskesmas Boja 1 Kendal Rahma Fajrin Novitasari; Ida Nur Imamah; Norman Wijaya Gati
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 2 (2025): September - Desember
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i2.3420

Abstract

Diabetes Mellitus (DM) merupakan penyakit kronis dengan prevalensi tinggi yang memerlukan kepatuhan pengobatan jangka panjang untuk mencegah komplikasi. Namun, ketidakpatuhan pasien terhadap pengobatan masih menjadi tantangan di layanan primer. Penelitian ini bertujuan untuk menggambarkan tingkat kepatuhan pengobatan pada pasien Diabetes Mellitus di Puskesmas Boja 1 Kendal. Desain penelitian menggunakan deskriptif dengan pendekatan kuantitatif. Sampel berjumlah 30 responden yang dipilih dengan teknik total sampling, dengan kriteria inklusi pasien DM berusia ≥18 tahun dan telah menjalani terapi minimal tiga bulan. Hasil penelitian menunjukkan bahwa sebagian besar responden memiliki tingkat kepatuhan sedang yaitu sebanyak 12 orang (40,0%), kepatuhan tinggi sebanyak 10 orang (33,3%), dan kepatuhan rendah sebanyak 8 orang (26,7%). Karakteristik responden didominasi oleh usia pertengahan (40–60 tahun), tingkat pendidikan perguruan tinggi (53,4%), serta status bekerja (53,3%), dengan distribusi jenis kelamin seimbang. Temuan ini mengindikasikan bahwa kepatuhan pengobatan pasien DM di Puskesmas Boja 1 Kendal masih berada pada kategori sedang. Oleh karena itu, diperlukan upaya peningkatan edukasi, motivasi, dan pendampingan oleh tenaga kesehatan untuk mendorong pasien mencapai kepatuhan optimal.
Sosialisasi dan Demonstrasi Pembuatan Antiseptik Aloe Vera Masyarakat di Desa Galengdowo Nungky Taniasari; Daifiana Nur Fadhila
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 2 (2025): September - Desember
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i2.3430

Abstract

A socialization and demonstration activity on making antiseptic hand soap from Aloe vera was held in Galengdowo Village, Wonosalam District, Jombang Regency. This program aims to increase the knowledge and skills of the community, especially PKK mothers, in utilizing aloe vera as a basic ingredient for herbal soap that is beneficial for health and has economic value. The activity method included a pretest, material delivery, soap making demonstration, packaging, and a posttest. The evaluation results showed an increase in participants' understanding of the use of Aloe vera as an antiseptic material, from an average pretest score of 90.62% to 96.87% in the posttest. This increase indicates that the majority of participants have achieved a high level of understanding regarding the benefits of Aloe vera and how to process it into antiseptic hand soap. The conclusion of this activity is effective in increasing community knowledge and skills, while encouraging the use of local potential to support clean and healthy living behaviors and economic opportunities.
Gambaran Penyimpanan Obat di Apotek X Kota Pekalongan Kurniawan, Andre; Khafid Mahbub
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 2 (2025): September - Desember
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i2.3476

Abstract

The storage of pharmaceutical supplies is an essential activity in the management of medicines in pharmacies, aiming to maintain the quality, stability, and safety of drugs. This study aimed to assess the compliance of pharmaceutical storage practices in a pharmacy with applicable standards. The research used a descriptive approach through direct observation of facilities, procedures, and storage systems. The results showed that most storage activities were in accordance with standards, such as drug arrangement in alphabetical order, the application of FIFO and FEFO methods, and maintaining cleanliness in the storage area. However, several aspects still need improvement, including the absence of thermometers and temperature recording cards in refrigerators, as well as the lack of separation and special labeling for LASA and High Alert medications. In conclusion, the pharmaceutical storage practices in the pharmacy were generally good, but improvements are needed in monitoring high-risk drugs and temperature control to ensure the quality and safety of medicines.
Pembuatan Gel Antiseptik Berbasis Ekstrak Etanol Buah Rhizophora apiculata sebagai Alternatif Antibakteri terhadap Staphylococcus aureus dan Escherichia coli: Studi In Vitro Ani latifah; Misbakhul munir
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 2 (2025): September - Desember
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i2.3480

Abstract

Rhizophora apiculata is a mangrove species whose fruit is known to contain secondary metabolites such as flavonoids, tannins, saponins, alkaloids, terpenoids, phenolics, and steroids, which have potential as natural antibacterial agents. This study aims to evaluate the antibacterial activity of hand sanitizer gel formulated with ethanol extract of R. apiculata fruit using the disk diffusion method against Staphylococcus aureus and Escherichia coli, and to determine the best formulation among three extract concentrations: F1 (5%), F2 (10%), and F3 (15%). Extraction was carried out by maceration using 96% ethanol, yielding an extract with a rendement of 37.5%. Phytochemical screening confirmed the presence of flavonoids, tannins, alkaloids, saponins, phenolics, terpenoids, and steroids. Antibacterial activity tests showed inhibition zones against S. aureus of 4.20 mm, 4.20 mm, and 4.35 mm for F1, F2, and F3, respectively, and against E. coli of 4.23 mm, 4.33 mm, and 4.37 mm. The F3 formulation, with 15% extract, exhibited the highest antibacterial activity and was determined to be the most effective. With stable physical characteristics, skin-safe pH, and proven antibacterial activity, R. apiculata fruit extract shows great potential as an active ingredient in eco-friendly hand sanitizer formulations.
Peran Dinas Kesehatan Provinsi Riau Dalam Manajemen Risiko K3 Saat Penanggulangan Kejadian Luar Biasa (KLB) Di Provinsi Riau Hariyanto , Didik Budi; Hetty Ismainar
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 2 (2025): September - Desember
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i2.3496

Abstract

The year 2022 was a critical period for Riau Province in managing public health emergencies. According to data from the Riau Provincial Health Office (2022), several outbreaks occurred during this period, including an increase in Dengue Hemorrhagic Fever (DHF) cases in eight districts/cities, a surge in leptospirosis cases in flood-prone areas, and zoonotic rabies incidents in border regions. This study aims to analyze the role of the Riau Provincial Health Office in occupational health and safety (OHS) risk management during outbreak response. Data analysis was conducted using the Fishbone method to identify root causes and the Urgency, Seriousness, and Growth (USG) method to determine problem priorities. Based on the USG assessment, the main priority issue requiring immediate intervention was the unequal availability and distribution of personal protective equipment (PPE) for healthcare workers across affected areas. Interventions for outbreak management in Riau Province in 2022 focused on five components—man, method, money, material, and machine—which were developed based on field analysis. Several factors influencing the implementation of OHS in outbreak management include the availability of PPE, compliance of health workers in using PPE, the implementation of OHS training, and the effectiveness of supervision in applying outbreak response standard operating procedures (SOPs).
Asuhan Persalinan Normal Kala I–IV pada Grandemultipara dengan Pemberian Edukasi menggunakan Kalender Kesehatan di PMB Leni Triyana, S.Keb., Bdn Kota Banjarmasin Ratnawati; Syahrida Wahyu Utami; Lellyawaty
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 2 (2025): September - Desember
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i2.3543

Abstract

Latar Belakang: World Health Organization (WHO) melaporkan pada tahun 2024 terdapat 287.000 kematian ibu di seluruh dunia, setara dengan 800 kematian per hari atau satu kematian setiap dua menit. Angka ini masih sangat tinggi, terutama akibat perdarahan postpartum, hipertensi dalam kehamilan, dan komplikasi obstetri lainnya. Salah satu kelompok risiko tinggi adalah grandemultipara (paritas ≥5), yang rentan mengalami inersia uteri, atonia uteri, serta perdarahan postpartum akibat perubahan fisiologi uterus setelah persalinan berulang. Upaya promotif dan preventif diperlukan untuk menekan angka kematian ibu, salah satunya melalui edukasi dengan media sederhana seperti kalender kesehatan. Tujuan: Mendeskripsikan asuhan persalinan normal kala I–IV pada ibu grandemultipara dengan pemberian edukasi menggunakan kalender kesehatan. Metode: Penelitian ini merupakan studi kasus deskriptif dengan pendekatan SOAP. Subjek adalah Ny. E, 29 tahun, G6P5A0, hamil 39 minggu, yang menjalani persalinan di TPMB Leni Triyana, S.Keb., Bdn Kota Banjarmasin pada 19 Juni 2025. Data dikumpulkan melalui anamnesis, pemeriksaan fisik, observasi proses persalinan, serta dokumentasi partograf. Hasil: Persalinan berlangsung normal pada kala I–IV tanpa komplikasi. Edukasi dengan kalender kesehatan diberikan selama proses asuhan dan terbukti meningkatkan pemahaman ibu mengenai tanda bahaya kehamilan, risiko perdarahan postpartum, serta pentingnya perawatan pascapersalinan. Kesimpulan: Asuhan persalinan normal kala I–IV pada ibu grandemultipara dapat berjalan sesuai standar pelayanan kebidanan. Media kalender kesehatan efektif digunakan sebagai sarana edukasi untuk meningkatkan kesadaran ibu terhadap risiko persalinan berulang serta pencegahan komplikasi.
Studi Literatur: Aktivitas Antibakteri dan Antioksidan Daun Kelor (Moringa oleifera) serta Potensinya dalam Inovasi Sediaan Farmasi Berbasis Bahan Alam I Dewa Ayu Widya Candraswari; I Komang Gede Triyana Wahyu Nanda
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 2 (2025): September - Desember
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i2.3544

Abstract

Pemanfaatan bahan alam sebagai alternatif antibakteri dan antioksidan semakin mendapat perhatian seiring meningkatnya resistensi antibiotik dan paparan radikal bebas. Daun kelor (Moringa oleifera) mengandung senyawa bioaktif seperti flavonoid, alkaloid, tanin, dan saponin yang berperan dalam menghambat pertumbuhan bakteri serta menangkal radikal bebas. Studi ini bertujuan untuk meninjau aktivitas antibakteri dan antioksidan daun kelor berdasarkan literatur ilmiah serta mengeksplorasi inovasi sediaan farmasi yang telah dikembangkan. Hasil menunjukkan bahwa ekstrak daun kelor efektif terhadap berbagai bakteri Gram positif dan Gram negatif, dengan daya hambat bervariasi tergantung konsentrasi dan metode ekstraksi. Aktivitas antioksidan juga terbukti kuat, terutama dengan metode DPPH, di mana nilai IC50 menunjukkan efektivitas tinggi dalam sediaan lotion dan gel. Inovasi sediaan seperti infusa, nanoemulsi, nanohidrogel, nanopartikel, dan transdermal patch memperluas potensi aplikatif daun kelor dalam dunia farmasi.
Progresivitas Lesi Prakanker Menuju Kanker Serviks: Tinjauan Komprehensif Peran Infeksi HPV Risiko Tinggi dan Mekanisme Molekuler di Zona Transformasi Septikasari, Abrista
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 2 (2025): September - Desember
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i2.3554

Abstract

Cervical cancer is the fourth most common cancer in women globally, with the majority of deaths occurring in developing countries. This disease is mostly associated with high-risk Human Papillomavirus (HPV) infection, especially types 16 and 18, which trigger the development of abnormal cells or precancerous lesions (SIL/CIN). A deep understanding of the mechanisms of precancerous lesion progression is crucial for improving early detection and increasing the chances of recovery. This literature review was compiled using 18 relevant reference articles, such as journals, book, and official websites. Cervical cancer occurs through a progressive change from low-grade lesions (LSIL/CIN 1) to high-grade lesions (HSIL/CIN 2 and 3). The process of carcinogenesis is driven by the entry of HPV DNA into the basal cells within the transformation zone (SCJ), which triggers the production of viral oncoproteins E6 and E7. The E6 and E7 proteins interfere with the cell cycle and the regulation of apoptosis, consequently causing dysplasia and increases the progression to malignancy. A comprehensive understanding of the mechanism of precancerous lesion progression can improve and enhance the system for early detection and diagnosis enforcement to prevent the spread of cancer cells and increase the chances of recovery. In-depth molecular research is required to support the development of a therapeutic HPV vaccine, which may prevent recurrence and promote the regression of low-grade lesions.

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