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INDONESIA
Jurnal Sains Farmasi dan Kesehatan
Published by CV ITTC Indonesia
ISSN : -     EISSN : 30249368     DOI : 10.47233/jfkes
Core Subject : Health, Science,
Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary
Jurnal Sains Farmasi dan Kesehatan (JFKES) E-ISSN : 3024-9368 is an open access journal which is a media of research publication and review article on all aspects of pharmaceutical science that is innovative, creative, original and based on scientific. Articles published in this journal include Pharmaceutical Technology, Pharmacology, Pharmaceutical Chemistry, Traditional Medicine, Food and beverages, and the field of public health
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 111 Documents
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A Systematic Literature Review: Pengobatan Mandiri Pada Lansia Analisis Tahun 2020-2022 Maharani Dwi Pratiwi; Evi Nurul Hidayati; Okky Intan Mawarni
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 1 (2025): Mei - Agustus
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Era modern saat ini, praktik pengobatan mandiri semakin sering dilakukan oleh masyarakat untuk menangani keluhan kesehatannya. Umumnya, individu memperoleh obat tanpa resep dari apotek terdekat. Meskipun demikian, penggunaan obat secara mandiri dapat meningkatkan risiko efek samping yang tidak terpantau dengan baik. Kelompok usia lanjut, terutama yang berusia di atas 65 tahun, memiliki kerentanan lebih tinggi terhadap reaksi obat yang merugikan (Adverse Drug Reaction/ADR). Tujuan dari artikel ini adalah untuk mengeksplorasi praktik pengobatan mandiri pada populasi lansia. Data diperoleh dari basis data Google Scholar dan NCBI dengan strategi pencarian pada MEDLINE menggunakan kata kunci seperti ‘obat bebas’, ‘reaksi obat merugikan’, ‘obat yang diresepkan sendiri’, dan ‘obat tanpa resep’. Artikel yang tidak relevan dikeluarkan dari analisis. Hasil tinjauan menunjukkan bahwa sebagian besar lansia menggunakan pengobatan mandiri berdasarkan pengalaman pribadi, anggapan bahwa kondisi tidak serius, serta saran dari lingkungan sekitar. Keluhan umum yang diatasi dengan pengobatan mandiri antara lain nyeri perut, sakit kepala, batuk, nyeri sendi, dan demam. Obat yang paling sering digunakan adalah analgesik, yang umumnya diperoleh langsung dari apotek. Meskipun banyak lansia menyadari risiko penggunaan obat tanpa pengawasan medis, konsultasi dengan apoteker dinilai dapat menjadi solusi preventif. Oleh karena itu, keterlibatan apoteker memiliki peranan penting dalam praktik pengobatan mandiri.
Tinjauan Teknik Spektroskopi dalam Analisis Senyawa Kimia dan Bahan Alam Rahima, Ghina; Anisa Nazwa; Khairatunnisa; Lili Sa’adah; Nabila Syifa Firdaus; Nita Rahmadani; Nur Prettiya Shalha; Sofi Agusti Putri
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 1 (2025): Mei - Agustus
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i1.3187

Abstract

Penelitian ini bertujuan untuk mengkaji dan mengevaluasi efektivitas empat teknik spektroskopi utama—FTIR, UV-Vis, GC-MS, dan NMR—dalam analisis senyawa kimia dan bahan alam. Kajian ini menggunakan metode studi pustaka dengan menganalisis berbagai sumber ilmiah yang relevan untuk memahami peran dan penerapan teknik-teknik tersebut dalam identifikasi dan karakterisasi senyawa aktif pada tanaman obat, produk farmasi, kosmetik, hingga pangan. FTIR digunakan secara luas untuk mendeteksi gugus fungsi dalam senyawa bioaktif seperti flavonoid dan alkaloid secara cepat dan non-destruktif. UV-Vis menonjol dalam analisis kuantitatif senyawa fenolik dan flavonoid melalui pengukuran absorbansi pada panjang gelombang tertentu. Sementara itu, GC-MS mampu memisahkan dan mengidentifikasi senyawa volatil secara presisi melalui kombinasi kromatografi dan spektrometri massa, seperti dalam minyak atsiri atau senyawa aromatik. Teknik NMR memberikan informasi struktural paling lengkap dan akurat terhadap susunan atom dan interaksi molekul dalam senyawa organik, meskipun memerlukan biaya dan keahlian tinggi. Setiap teknik memiliki kekuatan dan keterbatasan tersendiri, namun integrasi penggunaannya dapat memperkuat validasi dan akurasi dalam studi senyawa bahan alam. Dalam banyak penelitian, kombinasi spektroskopi dan pendekatan kemometrik seperti PCA dan PLS juga memperkuat akurasi identifikasi dan deteksi kualitas produk. Hasil tinjauan ini menunjukkan bahwa pemanfaatan spektrum spektroskopi secara sinergis sangat penting untuk mendukung pengembangan obat herbal, kosmetik alami, dan produk pangan berbasis tumbuhan secara efisien, akurat, dan berstandar ilmiah.
Asuhan Keperawatan Pada Pasien Halusinasi Pendengaran Dengan Penerapan Terapi Aktivitas Menggambar Di Ruangan Mandau 2 RSJ Tampan Provinsi Riau Windi Okdwi Delta Maulina; Rina Herniyanti; Ifon Driposwana Putra; Fitry Erlin
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 1 (2025): Mei - Agustus
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i1.3212

Abstract

The impact that can be caused by patients experiencing auditory hallucinations is a loss of self-control. Patients experience panic and their behavior is controlled by their hallucinations. In this situation, patients can commit suicide, kill others (homicide), and even damage the environment. To minimize the impact of hallucinations, appropriate hallucination treatment is needed. One way to manage hallucinations is through generalist therapy and drawing activities. Drawing activity therapy aims to minimize the patient's interaction with their world, express thoughts, feelings, and emotions that influence behavior, provide motivation and happiness, entertain and distract the patient, so that attention is not focused. The purpose of this study is to provide therapy for patients with auditory hallucinations using drawing activity therapy. The method used in this scientific work is drawing therapy intervention. The sample of this study was 1 schizophrenia patient with a nursing diagnosis of auditory hallucinations. The study was conducted on April 24-26, 2025. The results showed that after drawing therapy on the third day, the patient said that sometimes he still heard whispers but the voices had decreased and the patient said he wanted to go home immediately.
Review: Evaluasi Kepatuhan Pasien Terhadap Penggunaan Obat Antihipertensi Di Rumah Sakit Dan Puskesmas Maulidya Rachma Az Zahra; Bella Fevi Aristia; Alfu Laila; Eka Putri Nurhidayah
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 1 (2025): Mei - Agustus
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i1.3233

Abstract

Hypertension is a condition of persistent blood pressure above normal (≥140/90 mmHg) that affects 1.28 billion adults globally, with an increasing prevalence in developing countries including Indonesia (34.1% in 2018). The purpose of this review article is to determine the level of patient compliance in the use of antihypertensive drugs in hospitals and health centers. The method used is a narrative literature review by searching 9 articles published between 2020 and 2025. The literature review search was conducted through academic databases from Google Scholar, ResearchGate, and ScienceDirect. The selected articles must be relevant to the topic of patient compliance in the use of antihypertensive drugs and meet the predetermined inclusion criteria. The results showed that the level of patient compliance varied, with most patients showing moderate compliance. Several factors that influence patient compliance include the number of drugs consumed and the duration of treatment. Through this review, it is hoped that it can improve readers' understanding in order to improve the level of patient compliance in undergoing hypertension therapy.
Pola Konsumsi Natrium Pada Petani Padi di Kecamatan Gadingrejo Putri Rahma Azzahra; Diana Mayasari; Intan Kusumaningtyas; Ari Wahyuni
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 1 (2025): Mei - Agustus
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i1.3235

Abstract

Excessive sodium intake is widely recognized as a major risk factor for elevated blood pressure and cardiovascular diseases such as stroke and chronic kidney disease. While the human body physiologically requires only around 500 mg of sodium daily, actual consumption levels often exceed the World Health Organization’s (WHO) recommendation of a maximum 2,000 mg per day or 5 grams of table salt. In Indonesia, most sodium intake stems from the frequent use of salt and seasonings in household cooking, rather than from processed foods alone. Rice farmers represent a uniquely vulnerable population due to their physically demanding work and traditional diets that often involve excessive salt and monosodium glutamate use. This study aimed to describe the daily sodium intake patterns among rice farmers in Gadingrejo Subdistrict, Pringsewu, and to identify influencing factors. A cross-sectional descriptive survey was conducted on 102 farmers, using two-day 24-hour food records to estimate sodium intake. Results showed that 36.3% of respondents consumed high levels of sodium (≥ 2,000 mg/day), while 63.7% remained below the WHO threshold. Most participants were aged 45–59 years and had completed only elementary or junior secondary education. Limited nutritional knowledge, cultural cooking norms, and poor access to health education were identified as key contributors to excessive intake. Therefore, implementing context-based nutrition education alongside low-sodium, high-potassium salt substitute (LSSS) policies is strongly recommended to reduce non-communicable disease burden sustainably among rural farmers.
Efektifitas Daun Kersen (Muntingia Calabura L.) Terhadap Profil Histologi Tikus Putih Jantan (Rattus Norvrgicus) Diabetes Mellitus Telaumbanua, David Charles; Erida Novriani; Razoki
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 1 (2025): Mei - Agustus
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i1.3242

Abstract

Diabetic mellitus (DM) is a degenerative condition marked by high blood suger levels brought on by a malfunction in the metabolisme of insulin. Serious side effect, such as harm to organs including the pancreas can result from uncontrolled diabetes mellitus the use of medicanal plants, such the kersen leaf (Muntingia calabura L.), which includes active substances like flavonoids, alkaloids, saponins and tannins whith possible antidiabetetic effects, is one altenate therapy option that is presently being investigated. Using male white rats (Rattus norvegicus) with diabetes, this study intends to assess the impact of an ethanolic extract of (Muntingia calabura L.) leaves on the pancreas and identify the optimal dosage for mitigating pancreatic cell damage. Five groups are used in this pure experimental study: three treatment groups that get extract doses of 150,300 and 600 mg/kgBW; a positive control that receives glibencalmide; and a negative control that receives Na CMC. Assessments were made of pancreatic histology and blood glucose levels. The results should offer scientific validation for the long-standing practice of using cherry leaves to treat diabetes.
Peran Komunikasi Empatik Bidan Dalam Menurunkan Kecemasan Ibu Primigravida Saat Bersalin Indra Fara Nisa; Aditia Silvia Fazila; Laode Aharuddin Kapege
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 1 (2025): Mei - Agustus
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i1.3243

Abstract

High levels of anxiety in primigravida mothers during childbirth can adversely affect the labor process, both physiologically and psychologically. Empathetic communication by midwives, as primary care providers, plays a crucial role in establishing a therapeutic relationship that supports the mother’s emotional well-being. This study aims to analyze the role of midwives' empathetic communication in reducing anxiety levels among primigravida mothers during labor. A quantitative research approach was employed using a quasi-experimental pretest-posttest design with a control group. The results showed a significant reduction in anxiety levels in the group that received empathetic communication compared to the control group. These findings confirm that empathetic communication is an effective strategy for managing anxiety in primigravida mothers.
Review : Aplikasi Fraksinasi Pada Pemisahan Senyawa-Senyawa Bahan Alam Putri, Peni Oktariyani; Septia Miranti; Mirnawati; Oktriyisa Tantia Mini; Nafach Olya Warasky; Helsy Indarwat; Yolla Rizka Amalia
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 1 (2025): Mei - Agustus
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i1.3249

Abstract

Fractionation is an important technique in the separation of secondary metabolites from natural products. This method separates compounds based on differences in polarity, size, or affinity for the stationary phase, resulting in more homogeneous and potentially bioactive fractions. This article reviews various fractionation techniques used to separate compounds from medicinal plant extracts, such as vacuum liquid chromatography (VLC), flash column chromatography, centrifugal chromatography (CLC), and fractionation based on solvents of varying polarity. The studies analyzed demonstrate that appropriate fractionation strategies can produce fractions or isolates with biological activity, including antibacterial, antifungal, antioxidant, and anticancer activities. Therefore, the systematic application of fractionation methods is a crucial step in the development of natural products as drug candidates.
Evaluasi Kesesuaian Obat Dan Dosis Antihipertensi Pada Pasien Hipertensi Rawat Jalan Di Rumah Sakit Royal Prima Sosa Ester Kristiani Lase; Muhammad Yunus; Astriani Natalia Br Ginting
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 1 (2025): Mei - Agustus
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i1.3252

Abstract

This study was conducted to assess the appropriateness of antihypertensive medication selection and dosage and to analyze the cost-efficiency of therapy in outpatients with hypertension at Royal Prima Hospital, Medan. This study used a retrospective descriptive method, with data collected from the medical records of 42 patients. Evaluation of therapy effectiveness and costs was conducted using a Cost-Effectiveness Analysis (AEB) approach, calculating the Average Cost-Effectiveness Ratio (ACER) and the Incremental Cost-Effectiveness Ratio (ICER). Symptoms associated with hypertension can be avoided by reducing excess weight (obesity), controlling salt intake, engaging in regular physical activity, quitting smoking, and taking medication regularly. A hypertension prevalence survey found that the prevalence of hypertension in Indonesia among the population aged 18 years and over is 31.3% for men and 31.9% for women, out of the total population aged 18 years and older. In 2008, the number of hypertension sufferers reached 32%, with the majority of patients aged > 25 years. The results showed that all patients (100%) received appropriate antihypertensive therapy based on standard clinical guidelines, both in terms of drug selection and dosage. The most commonly used drug combination was ARB and CCB, found in 23.81% of patients. The combination of a non-DHP CCB + ARB + ​​loop diuretic + alpha-blocker demonstrated the highest therapeutic effectiveness (100%) with the lowest average cost of IDR 680,000, thus being considered the most cost-effective regimen according to the ICER analysis. Meanwhile, several other therapy combinations that required higher costs but provided less effectiveness were categorized as cost-inefficient. These findings emphasize the importance of rational evaluation of antihypertensive therapy, particularly in terms of treatment appropriateness and cost-efficiency, to support optimal clinical outcomes and appropriate resource utilization.
Uji Daya Hambat Gel Semprot Ekstrak Daun Kersen (Mutingia Calabura L.) Terhadap Bakteri Staphylococcus Aureus Pada Pasien Penderita Luka Diabetes Melitus Dhea Lovita Nasution; Astriani Natalia; Rena Meutia; Nerly Juli Pranita Simanjuntak
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 1 (2025): Mei - Agustus
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i1.3265

Abstract

Diabetes mellitus (DM) is caused by a metabolic disorder that affects the pancreas and is characterized by elevated blood sugar levels, also known as a metabolic disorder, which is caused by a decrease in the amount of insulin produced by the pancreas. Elevated blood sugar levels are also known as hyperglycemia. DM can potentially cause several complications, both macro- and microvascular. DM can cause cardiovascular disorders, which are serious and can be effectively managed if treated promptly, potentially leading to hypertension and heart attacks. Based on the above background, the researcher aims to study the effects of ethanol extract from Kersen leaves (Muntingia Calabura L.) on Staphylococcus aureus bacteria in diabetic patients with wounds, using varying concentrations of 1%, 1.25%, 1.5%, 1.75%, and 2%. Methods: The Kersen leaf extract was obtained through 96% ethanol maceration, then formulated into a spray gel using Carbopol 940 as a base. Stability evaluation included organoleptic testing, pH measurement, drying time, and spray pattern assessment. Antibacterial activity was tested using the disk diffusion method.Results: The spray gel demonstrated good physical stability over 21 days of storage. The antibacterial test yielded inhibition zones with diameters of 9.97 mm (1%), 16.01 mm (1.5%), 15.24 mm (1.75%), and 14.37 mm (2%), classified as moderate efficacy. The 1.5% concentration provided the highest inhibitory effect, although it was still below the positive control (clindamycin 1%). Conclusion: It has been demonstrated that the kersen leaf extract gel spray (Mutigia calabura L.) exhibits antibacterial activity in inhibiting the growth of S. Aureus bacteria, as evidenced by the formation of clear zones (inhibition zones) around the disk medium during testing. There is a direct correlation between the concentration of kersen leaf extract in the gel spray formulation and its antibacterial efficacy, with the highest efficacy at a concentration of 1.5%. This study provides a potential alternative for the treatment of diabetic wound infections using natural ingredients.

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