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INDONESIA
Jurnal Sains Farmasi dan Kesehatan
Published by CV ITTC Indonesia
ISSN : -     EISSN : 30249368     DOI : 10.47233/jfkes
Core Subject : Health, Science,
Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary
Jurnal Sains Farmasi dan Kesehatan (JFKES) E-ISSN : 3024-9368 is an open access journal which is a media of research publication and review article on all aspects of pharmaceutical science that is innovative, creative, original and based on scientific. Articles published in this journal include Pharmaceutical Technology, Pharmacology, Pharmaceutical Chemistry, Traditional Medicine, Food and beverages, and the field of public health
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 111 Documents
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Formulasi Dan Evaluasi Sediaan Tablet Ibuprofen Menggunakan Berbagai Bahan Pengikat Dalam Metode Granulasi Basah Nor Aida; Nafach Olya Warasky; Laila manada; Annur tasya alfiati; Sofi agustia putri
Jurnal Sains Farmasi Dan Kesehatan Vol. 2 No. 2 (2024): September - Desember
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v2i2.1787

Abstract

The aim of this research is to conduct a study on the Formulation and Evaluation of Ibuprofen Tablet Preparations Using Various Binder Materials in the Wet Granulation Method. The method used in this research is a systematic literature review. The results of this study indicate that research on ibuprofen tablet formulations shows that the physical quality of tablets is greatly influenced by the selection of binders, disintegrants, lubricants, and other excipients. The appropriate binder ensures that the tablet has the correct hardness and can disintegrate properly, allowing the active ingredient to be effectively absorbed by the body. The right disintegrant is also crucial for speeding up the tablet's disintegration time, while the lubricant functions to reduce friction during tablet manufacturing, although it must be used in a balanced amount to avoid hindering dissolution. Furthermore, factors such as the moisture content of the granules and the physical properties of the granules also play a role in determining the tablet's quality. Studies show that the right formulation, such as a combination of CMC-Na, sorbitol, and amylum solani binders, can improve dissolution and bioavailability, leading to better therapeutic effectiveness. Overall, the selection of the appropriate materials and proportions in the formulation of ibuprofen tablets is crucial to produce tablets with high bioavailability and optimal therapeutic effects..
Inovasi Eksipien Untuk Tablet Cepat Hancur Muhammad hafiz adha; Nita Rahmadani; Anisa Nazwa; Khairatunnisa; Siti Noorlena
Jurnal Sains Farmasi Dan Kesehatan Vol. 2 No. 2 (2024): September - Desember
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v2i2.1788

Abstract

The main objective of this study is to review and explore various innovations in excipient materials used in the development of fast disintegrating tablets (FDT). This research utilizes the Systematic Literature Review (SLR) method, which is a comprehensive approach to systematically collect and analyze relevant literature. The results of the research indicate that overall, various studies have shown that innovations in tablet formulation, including excipient materials, production techniques, and drug delivery systems, significantly impact the effectiveness and comfort of drug use. The use of appropriate excipients, such as Biotapioka, avocado seed starch, and new technologies like edible paper and freeze drying, has been proven to address issues related to poor drug solubility and dissolution. With the right formulation, it is possible for tablets to disintegrate more rapidly in the mouth, allowing patients to experience the benefits of the medication more quickly, without the need for water or difficulty swallowing large tablets. This is especially important for patients who have trouble swallowing pills, such as the elderly, children, or patients with certain medical conditions.
Formulasi Dan Evaluasi Sedian Tablet Dengan Metode Kempa Langsung Aura Nasyafa; Novita Indira Sari; Lili Sa’adah; Nur Asyifa Ramadhanti; Tiara Maulida
Jurnal Sains Farmasi Dan Kesehatan Vol. 2 No. 2 (2024): September - Desember
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v2i2.1790

Abstract

The objective of this research is to study the formulation and evaluation of tablet preparations using the direct compression method. The method used in this research is a Systematic Literature Review. The findings of the study explain that the direct compression method is an efficient and economical technique in tablet production, especially in the pharmaceutical industry. With the advancement of technology, this method is increasingly used to produce tablets directly from a mixture of active ingredients and excipients without going through granulation processes, whether wet or dry. This process allows for time and cost savings in production, as well as reducing the use of machinery and labor. The main advantage of direct compression is its ability to produce tablets with better disintegration and dissolution times, especially for active ingredients sensitive to heat and moisture. The selection of the appropriate fillers and binders, such as modified starch, pregelatinized potato starch, and Avicel, significantly impacts the physical quality of the tablets, including hardness, friability, and flowability. Furthermore, the research results show that the correct formulation, both in terms of the composition of excipients and the concentration of binders, can improve the physical properties of the tablets and meet the desired quality standards. Therefore, while the direct compression method offers many advantages, it is important to continue exploring and optimizing formulations, both in terms of excipient selection and mixing ratios, to achieve tablets with the best quality that meet pharmaceutical needs and are accepted by consumers.
Formulasi Sediaan Tablet Dan Evaluasi Dari Jenis Zat Aktif Dengan Metode Granulasi Basah Jaida Rahma; Alya Puspita Dewi; Septia Miranti; Hendri Anugrah Wibowo; Nabila Syifa Firdaus
Jurnal Sains Farmasi Dan Kesehatan Vol. 2 No. 2 (2024): September - Desember
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v2i2.1791

Abstract

This study aims to understand how the wet granulation technique can affect the physical quality and the effectiveness of active ingredient release in tablets. In this review, various types of active ingredients will be analyzed to evaluate how their chemical and physical properties, such as solubility, compressibility, and stability, influence the resulting tablet formulation. Wet granulation was chosen due to its ability to improve the flow, compressibility, and stability of the mixture of active ingredients and excipients, resulting in tablets with better quality. To achieve this objective, the study uses a Systematic Literature Review (SLR) approach, which gathers and analyzes relevant literature related to tablet formulations with active ingredients using wet granulation. The results of the review show that wet granulation is effective in improving the physical quality of tablet and granule preparations. Wet granulation can enhance flow, compressibility, and active ingredient release control, although it has drawbacks, such as high costs and multiple stages that require validation. Increasing the concentration of gelatin in the tablet formulation of Eugenia polyantha extract improved the physical strength and dissolution rate of the tablets. Similarly, research on acetaminophen demonstrated that wet granulation produces tablets with physical qualities that meet the required standards for tablet physical testing. Finally, this study shows that Tectona grandis leaf extract can be formulated into granules with optimal quality that meets the physical evaluation criteria. Overall, wet granulation has proven to be effective in improving the quality and release of active ingredients in tablets and granules, with the selection of appropriate materials and concentrations greatly affecting the final formulation results.
Hubungan Pemberian Asi Eksklusif Dan Pola Asuh Terhadap Status Gizi Balita Usia 6-24 Bulan Di Puskesmas GODEAN I Aulia Afita Sari; Evi Wahyuntari
Jurnal Sains Farmasi Dan Kesehatan Vol. 2 No. 2 (2024): September - Desember
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v2i2.1826

Abstract

Nutritional problems in Indonesia cause more than 80% of child mortality. One of the efforts that can be done to improve or repair nutrition in infants is by providing exclusive breastfeeding. Parenting patterns can indirectly affect nutritional status. Mothers with good parenting patterns will have toddlers with good nutritional status. The study aims to determine the correlation between exclusive breastfeeding and parenting patterns to the nutritional status of toddlers aged 6-24 months. The research design in this study applied cross-sectional method, and the sampling technique used cluster random sampling with a sample size of 58 respondents. The research instruments used was an exclusive breastfeeding questionnaire, a parenting questionnaire, and anthropometric data. The data were analyzed by using the chi-square test. The results of the study showed that the p value was 0.001, which means <0.05, meaning that there is a relationship between exclusive breastfeeding and the nutritional status of toddlers. The OR value was 9.167, which means that exclusive breastfeeding tends to have a good nutritional status for toddlers. The results of the study showed that the p value was 0.035, which means <0.05, meaning that there is a relationship between parenting patterns and the nutritional status of toddlers. The OR value was 6.450, which means that good parenting patterns tend to have a good nutritional status for toddlers. It can be concluded that there is a correlation between exclusive breastfeeding and parenting patterns and the nutritional status of toddlers aged 6-24 months at Puskesmas (Community Health Center) Godean I.
Analisis Faktor Penghambat Penerapan Sistem Informasi Manajemen Puskesmas di Indonesia: Literature Review Yuskaini Hadijah Rambe; Salwa Muthi’ah Siregar; Zahra Andini; Sri Hajijah Purba
Jurnal Sains Farmasi Dan Kesehatan Vol. 2 No. 2 (2024): September - Desember
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v2i2.1902

Abstract

There are a number of challenges facing Indonesia's Community Health Center Management Information System (SIMPUS) adoption. The application of SIMPUS is hampered by a number of variables, according to earlier studies. The purpose of this study is to investigate the barriers to SIMPUS implementation, as demonstrated by Indonesian Community Health Centers. This study is a literature review that utilizes secondary data from publications published in the Google Scholar database between 2018 and 2023 and is relevant to the topic of discussion. The results showed that there were 892 articles that matched the search terms, but 871 articles were excluded because they were duplicates, could not be accessed in full paper form, did not match the topic, exceeded the specified year, or were indicated as assignments/thesis/dissertation. This left 24 articles to be tested for eligibility, which resulted in 17 articles that passed the feasibility test and would undergo narrative synthesis. Analysis shows that obstacles to implementing SIMPUS in Indonesia are caused by various factors including technology, infrastructure, human resources, policies and management support, as well as benefits.
Gambaran Kadar Kolesterol Total Pada Lansia Di Puskesmas Rumbai Fatma; Eli Yusrita; Rosa Devitria; Mega Elfia; Mentari Dwi Anggraini
Jurnal Sains Farmasi Dan Kesehatan Vol. 2 No. 2 (2024): September - Desember
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v2i2.2025

Abstract

Seiring dengan berkembangnya zaman dan modernisasi yang terus terjadi menyebabkan perubahan pola dan gaya hidup masyarakat terutama di daerah perkotaan. Kadar kolesterol total yang tinggi akan membentuk asterosklerosis yang dapat menyebabkan hipertensi dan penyumbatan pembuluh darah otak, jantung dan pembuluh darah tungkai. Sedangkan penyumbatan pada pembuluh darah tungkai dapat menyebabkan penyakit pembuluh darah tepi. Keadaan ini sering terjadi pada kaki yang dapat menimbulkan rasa nyeri, kram. Beberapa penyebab kolesterol berlebih yaitu obesitas, kurang bergerak, umur dan jenis kelamin, merokok, sejarah keluarga pada dan pola makan sehari-hari. Kadar kolesterol banyak diderita oleh para lansia itu dikarenakan faktor usia yang semakin lama badan akan semakin malas untuk di gerakkan, sehingga kolesterol di dalam tubuh menumpuk kedalam hati, oleh sebab itu dibutuhkan gerakan yang seimbang antar pola makanan dan olahraga agar para lansia terhindar dari kolesetrol berlebih. . Tujuan dari penelitian ini adalah untuk mengetahui bagimana gambaran kadar kolesterol total lansia di puskesmas rumbai. Metode yang digunakan pada penelitian ini adalah metode POCT (Point Of Care Testing). Penelitian ini merupakan penelitian deskriptif. .Hasil pemeriksaan secara langsung menggunakan alat Easy Touch GCU dapat diketahui dari 30 responden, terdapat sebanyak 6 orang (20%) memiliki kadar kolesterol normal, 12 orang (40%) memiliki kadar kolesterol sedang, dan 12 orang (40%) memiliki kadar kolesterol total tinggi. Nilai rerata dari data hasil keseluruhan kadar kolestrol total pada lansia di Puskesmas Rumbai adalah 231.23 mg/dl.
Review: Karakterisasi Modifikasi Bahan Aktif Farmasi Menjadi Kokristal Menggunakan Instrument Ftir, Sem, Xrd, Dan Dsc Muhamad Reza Pahlevi; Ratu Fania Aprilyanti; Ariqa Hidayatun Nisa; Aliyya Kurniasih Agustiani; Nurul Rahmalia; Garnadi Jafar; Novaliana Devianti Sagita
Jurnal Sains Farmasi Dan Kesehatan Vol. 2 No. 3 (2025): Januari - April
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v2i3.2124

Abstract

Kokristalisasi merupakan salah satu teknik yang berkembang dalam modifikasi bahan aktif farmasi untuk meningkatkan karakteristik fisikokimia dari bahan aktif, khususnya yang memiliki kelarutan rendah. Penelitian ini bertujuan untuk mengevaluasi pengaruh metode karakterisasi, yaitu Fourier Transform Infrared (FTIR), Scanning Electron Microscopy (SEM), X-ray Diffractometry (XRD), dan Differential Scanning Calorimetry (DSC), terhadap kualitas kokristal bahan aktif farmasi dari tahun 2015 hingga 2024. Metode penelusuran pustaka dilakukan melalui Google Scholar. Hasil tinjauan literatur menunjukkan bahwa setiap teknik karakterisasi memiliki peran spesifik dalam memahami perubahan struktur dan sifat fisikokimia kokristal, seperti peningkatan kelarutan, stabilitas termal, dan morfologi permukaan. Berdasarkan hasil analisis pustaka, metode FTIR, SEM, XRD, dan DSC memberikan kontribusi penting dalam optimasi kualitas kokristal, yang berpotensi meningkatkan bioavailabilitas dan efektivitas bahan aktif farmasi.
Hubungan Perilaku Personal Hygiene Dengan Kejadian Keputihan Pada Remaja Putri Di SMA Negeri 1 Godean Listi Hari Muntasih; Fathiyatur Rohmah
Jurnal Sains Farmasi Dan Kesehatan Vol. 2 No. 3 (2025): Januari - April
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v2i3.2125

Abstract

Vaginal discharge is one of the things that often occurs in adolescent girls.this disorder is the second problem after menstrual disorders.vaginal discharge is often not handled properly by adolescent girls because it is considered a normal thing,in fact continuous vaginal discharge can be an indication of the presence of certain diseases, This often overlooked reproductive health problem can result in fatal consequences if not treated early or properly.can cause infertility and ectopic pregnancy (pregnancy outside the womb), The initial symptoms of uterine cancer usually start with vaginal discharge. The purpose of this study is to determine the relationship between personal hygiene behavior and the incidence of vaginal discharge in adolescent girls at SMA Negeri 1 Godean.Method: This study is a type of quantitative research with a cross sectional approach. The sampling technique in this study is a purposive sampling method with a sample of 60 respondents. The instrument in this study is using a questionnaire. The analysis of greeting data in this study uses chi square. Results: The results of the analysis with the chi square test obtained the results of bivariate analysis found that there was a relationship between personal hygiene behavior and the incidence of vaginal discharge, the value of pvalue=0.002 (pvalue=0.05). Conclusion: The conclusion of this study is that there is a relationship between personal hygiene behavior and the incidence of vaginal discharge in adolescent girls at SMA Negeri 1 Godean Yogyakarta in 2024.
Utilitas ChatGPT dalam pendidikan Sarjana Kefarmasian, dan praktik Kefarmasian: Tinjauan Sistematis tentang keuntungan dan kerugian Maharani Dwi Pratiwi; Evi Nurul Hidayati
Jurnal Sains Farmasi Dan Kesehatan Vol. 2 No. 3 (2025): Januari - April
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v2i3.2138

Abstract

ChatGPT adalah Large language model (LLM) berbasis kecerdasan buatan (AI). Aplikasi potensial LLM dalam pendidikan, penelitian, dan praktik kefarmasian bisa menjanjikan jika masalah diperiksa dan ditangani secara proaktif. Tinjauan sistematis penelitian ini bertujuan untuk menyelidiki Utilitas ChatGPT dalam pendidikan Sarjana Kefarmasian, dan praktik Kefarmasian. Dengan menggunakan metode penelitian literature review dengan pedoman PRIMSA, pencarian sistematis dilakukan di PubMed/MEDLINE dan Google Scholar (penelitian yang dipublikasikan atau pracetak) yang meneliti ChatGPT dalam konteks pendidikan, penelitian, atau praktik kefarmasian. Sebanyak 44 catatan memenuhi syarat. Hasil penelitian menyatakan Manfaat ChatGPT peningkatan penulisan ilmiah dan peningkatan ekuitas dan fleksibilitas penelitian dalam farmasi; utilitas dalam penelitian kefarmasian (analisis kumpulan data yang efisien, pembuatan kode, tinjauan pustaka, menghemat waktu untuk fokus pada desain eksperimental, dan penemuan dan pengembangan obat); manfaat dalam praktikkefarmasian (menyederhanakan alur kerja, penghematan biaya, dokumentasi, pengobatan yang dipersonalisasi, dan peningkatan literasi kesehatan); dan manfaat dalam pendidikan kefarmasian termasuk peningkatan pembelajaran yang dipersonalisasi dan fokus pada pemikiran kritis dan pembelajaran berbasis masalah.

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