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Sanus Medical Journal
Published by Universitas Muhammadiyah Prof. Dr. Hamka
ISSN : -     EISSN : 2745868     DOI : https://doi.org/10.22236/sanus
Core Subject : Health, Science,
Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health
Sanus Medical Journal is a peer-reviewed medical and health journal published periodically every six months. Sanus Medical Journal publishes descriptive, analytical, and experimental studies, reviews, systematic reviews, case reports, letters, and editorials in the fields of Medicine, Health, Medical and Health Education, and Islamic Medicine. The scope of Sanus Medical Journal goes beyond the boundaries of discussions in the fields of clinical medicine and health in general, by providing new insights into etiologies, determinants, distribution, management and prevention of diseases in individuals and communities. Sanus Medical Journal attempts to meet the demands of rapid developments in information and medical and health research by committing to reduce the range of online publications to around six weeks after the submission of a manuscript. Articles will be published online in advance, and the printed version included in the next scheduled edition. Sanus Medical Journal will continue to strive to improve its scientific reputation by publishing quality articles reviewed by experts who are highly competent in their respective fields. Sanus Medical Journal greatly appreciates the contributions of authors from related disciplines. Manuscripts can be sent via email to: smjournal@uhamka.ac.id or via the website https://journal.uhamka.ac.id/index.php/smj.
Arjuna Subject : Kedokteran - Farmakologi (Medis)
Articles 89 Documents
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Kejadian Delirium pada Pasien Penderita Covid-19 dan Kemungkinan Perburukannya menjadi Gejala Demensia Pandhita S, Gea; Abdul Gofir
Sanus Medical Journal Vol. 2 No. 2 (2021)
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v2i2.7452

Abstract

Delirium merupakan suatu sindrom neurobehavioral (perubahan perilaku terkait gangguan neurologis) yang disebabkan oleh gangguan sementara aktivitas neuron (sel saraf otak) sebagai akibat sekunder dari gangguan sistemik. Prevalensi delirium pada pasien yang dirawat inap di rumah sakit cukup tinggi. Kejadian delirium lebih tinggi pada pasien dengan kasus kritis dan pada pasien penderita Covid-19. Kejadian delirium pada pasien dengan kasus kritis yang dirawat di rumah sakit adalah sekitar 31,8%. Angka kejadian ini meningkat menjadi sekitar 55% pada penderita Covid-19. Beberapa penelitian menunjukkan bahwa terdapat mekanisme patofisiologi delirium pada pasien penderita Covid-19 yang serupa dengan kejadian delirium pada pasien non-Covid-19. Bukti epidemiologi menunjukkan keterkaitan kejadian delirium pada pasien non-Covid-19 dengan kejadian demensia beberapa periode waktu setelahnya (Probabilitas sekitar 30%). Bukti radiologis dan patologi anatomi juga menunjukkan adanya proses patologis di otak akibat Covid-19 yang dapat mengakibatkan gangguan saraf otak ireversibel dan berkontribusi pada penurunan kognitif jangka panjang. Hal-hal tersebut menunjukkan kemungkinan besar dapat terjadi keterkaitan antara kejadian delirium yang dialami pasien penderita Covid-19 dengan kejadian demensia di masa mendatang.
Strategi Pemasaran pada Sistem Layanan Kesehatan Purwowiyoto, Sidhi Laksono; Ananda Vilda, Cattleya; Indri Priyobodo, Dionisius; Raisa Cicilia, Ivana
Sanus Medical Journal Vol. 4 No. 2 (2022)
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v4i2.8062

Abstract

Health marketing is interdisciplinary because it uses certain concepts, methods, and techniques for classical and social marketing. The specialty of health marketing is that there are services and markets but no money equivalent.  Healthcare marketing differs mainly by the nature of the demand for health services. The beneficiary may not be the target of a marketing campaign, and the physician decides what, where, when, and how much to provide for a particular service. To understand the impact of marketing strategies on healthcare quality, it is essential to understand today's medical consumers who prefer to seek medical information online. They also have many health services, healthcare providers, and reviews from patients who contact providers.
A Rare Case of Metaplastic Breast Carcinoma with Squamous Differentiation in Young Female: A Case Report Agustina, Rohana
Sanus Medical Journal Vol. 4 No. 1 (2022)
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v4i1.8090

Abstract

Background. Metaplastic breast carcinoma is a very rare breast cancer, only about 0.2"‘1% of all invasive breast carcinomas. The prognosis of these cancer is poor and aggressive, reported to have lower response rates to conventional adjuvant chemotherapy and a worse clinical outcome after chemotherapy than other forms triple"‘negative breast carcinomas. Histopathologically, metaplastic breast carcinoma has distinct patterns with different outcomes. Among the types of metaplastic carcinoma, squamous cell, high grade spindle cell and high grade adenosquamous carcinoma are associated with the worst prognosis. We report one case of metaplastic breast carcinoma with squamous differentiation in young patient. Methods. We examined the breast tumor tissue of a female patient, evaluated the macroscopic and microscopic features and asked the patient about the clinical course of the disease. Inform consent was obtained from the patient for publication of this case report and accompanying images. Results. We reported a young female patient with final diagnosis of pathology Mixed Infiltrating Duct Carcinoma of No Special Type Grade 3 and Metaplastic Breast Carcinoma with Squamous Differentiation (30%) that has invaded fat tissue with Ductal Carcinoma Insitu of High Nuclear Grade 3 with basis of the operation is still positive for the tumor mass. Patients lost follow"‘up and did not continue therapy. Conclusion. Morphology of metaplastic breast carcinoma are important factors influencing patient outcome. Early diagnosis and wide local excision of the squamous"‘type metaplastic breast carcinoma mass can make a better prognosis.
Laporan Kasus Karsinoma Sel Skuamosa yang Berkembang dari Papiloma Tipe Inverted Sinonasal pada Pekerja Pabrik Cermin Riani, Fety; Marlita Sari, Ita
Sanus Medical Journal Vol. 4 No. 1 (2022)
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v4i1.8103

Abstract

Background. Sinonasal inverted (PI) papilloma is a benign tumor of the mucosal epithelium of the nasal cavity and paranasal sinuses with an endophytic growth pattern. PI is more common in men in the fifth and sixth decades of life. These tumors have local aggressive behavior, high recurrence rates, and can undergo malignant transformation. Squamous cell carcinoma (SCC) is the most common malignancy developed from sinonasal PI. SSC developed from PI (KSS/PI) is related to exposure in the work environment. Methods. We report a sinonasal SCC/PI case by describing the clinical manifestations, radiological features, and histopathological features of a young male patient who was a non"‘smoker mirror"‘making factory worker. Results. Clinical manifestations of pain, epistaxis, and proptosis in patients suggest malignancy. Computed Tomography (CT) results showed lesions of the nasal cavity and paranasal sinuses with bone destruction and expansion of the mass to the intracranial point of the aggressive behavior of the tumor. Microscopic histopathological examination revealed endophytic squamous epithelial growth characteristic of an inverted papilloma accompanied by cell atypia, invasive components, connective tissue desmoplasia, and keratin pearls, suggesting a well"‘differentiated keratinized squamous cell carcinoma that developed from the sinonasal inverted papilloma. Exposure to dust in the work environment is related to malignancy in this patient. Conclusion. Support of clinical and radiological data, adequate sampling, and identification of malignancy morphology routinely on histopathological examination is critical to avoid misdiagnosis of sinonasal SCC/PI. A complete history directed at extracting risk factors can add value in establishing a diagnosis.
Karakteristik Mutasi EGFR pada Pasien Kanker Paru Jenis Adenokarsinoma yang Diterapi dengan Tyrosien Kinase Inhibitor (TKI) di Rumah Sakit Paru Dr. H.A Rotinsulu Bandung Puspita, Desi; Dwi Astuti, Vitri; Rina; Sampurno, Edi
Sanus Medical Journal Vol. 4 No. 1 (2022)
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v4i1.8431

Abstract

This descriptive study describes the proportion of Epidermal Growth Factor Receptor (EGFR) mutations in lung cancer Adenocarcinoma patients at Rumah Sakit Paru (RS Paru) Dr. H. A Rotinsulu Bandung in the range of 2018 to 2020. EGFR mutations were examined using RGQ thera screen technology Real"‘Time Polymerase Chain Reaction from FFPE or cytology smear. There are 44 data point mutations after examining the EGFR mutation. 59% cases were 40"‘60 years old group dan 52 % were female. It was found that in this group 86% patient with single mutation and 16% had doube mutations. EGFR mutations occurred in Exon 21 L858R in 13 cases (30 %), Exon 21 L861Q in 1 case (2%), Exon 19del in 24 cases (55%), double mutation Exon 19 and Exon 20 T790M type in 2 cases (4%), double mutation Exon 19del and Exon 21 in 4 cases (9%).
Pengaruh Nyeri Kronik dalam Penurunan Fungsi kognitif Fahreza Arraisyi; Imran, Yudhisman
Sanus Medical Journal Vol. 4 No. 1 (2022)
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v4i1.8525

Abstract

Nyeri merupakan gejala yang sering dikeluhkan masyarakat, Di Indonesia sendiri nyeri kronik adalah alasan paling umum pasien untuk berkunjung ke klinik rawat jalan. Nyeri kronik merujuk pada nyeri yang berkelanjutan lebih dari tiga bulan. Penyebab nyeri kronik tersering adalah nyeri punggung bawah kronik, diikuti oleh nyeri leher kronik, migrain, osteoartritis, gangguan muskuloskeletal lainnya, nyeri kepala akibat penggunaan obat yang berlebihan, dan polineuropati diabetikum Prevalensi nyeri kronik meningkat seiring dengan bertambahnya usia. Nyeri kronik merupakan masalah kesehatan di seluruh dunia, mempengaruhi 19% orang dewasa Eropa dan 20,4% di Amerika Serikat. Keluhan subjektif pasien nyeri kronik dari berbagai penelitian menunjukkan bahwa nyeri kronik dikaitkan dengan defisit kognitif. Pada pasien nyeri kronik terjadi interaksi antara nyeri dan fungsi kognitif secara lebih kompleks. Hal ini menyebabkan gangguan fungsi otak yang berkembang mengikuti progresi dari nyeri kronik. Pada nyeri kronik dijumpai aktifitas neuron yang berlebihan, disfungsi jaringan dan pengurangan volume grey matter. Kehilangan grey matter dijumpai dalam amigdala, korteks entorinal girus hipokampus, girus singulata anterior, thalamus dan insula. Hubungan antara nyeri kronik dan penurunan fungsi kognitif selayaknya diperhatikan lebih lanjut dikarenakan memiliki implikasi terhadap fungsi dan kualitas hidup individu. Berbagai penelitian menunjukkan hasil hubungan signifikan terbalik penurunan dari atensi, memori, proses informasi dan fungsi eksekutif pada pasien dengan nyeri kronik.
Narrow distance inter-pregnancies increase the incidence of Post-Partum hemorrhage Nadhira Farah Puspitasaria; Rachmiyani, Irmiya
Sanus Medical Journal Vol. 4 No. 1 (2022)
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v4i1.8569

Abstract

Background and Aims. Maternal Mortality Rate (MMR) is the parameters of women's health status in community. The single most common cause of maternal mortality is obstetric haemorrhage, generally occurring postpartum. Most postpartum haemorrhage cases are caused by uterus atony, myometrium tonus loss, placenta retention, and clotting disorders. Short pregnancy intervals can cause threefolds of anaemia than normal pregnancy intervals. Pregnant women who suffer from anaemia has the possibility experiencing a postpartum bleeding caused by atonia uteri. This research aims to acknowledge the effect of narrow distance interpregnancy on a postpartum haemorrhage. Methods. This study uses an observational analytic study with a cross"‘sectional design. The data used is secondary data of pregnant women based on medical record to calculate the distance of interpregnancy with the incidence of postpartum bleeding during childbirth at Budhi Asih General Hospital of East Jakarta. The inclusion criteria are women who underwent childbirth during 2017"‘2018, multiparity, and postpartum women between 20"‘35 years old. The exclusion criteria are women with a history of postpartum haemorrhages caused by placental retention, tear of the reproductive tract or blood coagulation), gemelli parturition, macrosomia, assisted childbirth, grande multiparity, induction childbirth, and dystocia. Results. The number of samples used in this study amounted to 111 people. Postpartum haemorrhage are significantly associated with short interpregnancy intervals (p=0,000). Conclusion. Narrower pregnancy interval will leads to postpartum haemorrhage. To prevent this, it is important to consider contraception utilization, to improve iron consumption for pregnant women, and to provide decent antenatal care.
Korelasi Lama Menjalani Hemodialisis Dengan Kualitas Hidup Pada Penderita Nefropati Diabetik Di RS Dinda Tangerang Dalam Periode 3 Tahun Nugraha, Dhiki; Hasan, Fahad; Gunawandjati, Dedy; Purwowiyoto, Sidhi Laksono; Stujana, Endin Nokik; Hidayat, Ahmad
Sanus Medical Journal Vol. 5 No. 1 (2023)
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v5i1.9601

Abstract

Pendahuluan: Salah satu komplikasi mikrovaskular dari diabetes yaitu nefropati diabetik. Penderita nefropati diabetik yang menjalani hemodialisis membutuhkan waktu yang lama dan membutuhkan kepatuhan dalam mengobati komorbid yang mendasarinya. Hal ini akan memberikan stresor baik fisiologis maupun psikologis penderita yang akan mempengaruhi kualitas hidup. Tujuan penelitian ini menentukan korelasi antara lamanya menjalani terapi hemodialisis pada penderita nefropatik diabetik dengan kualitas hidup di RS Dinda Tangerang. Metode: metode penelitian menggunakan analisis parametrik dengan metode pendekatan non parametrik. sampel penelitian ini menggunakan consecutive sampling yang melibatkan 40 penderita nefropati diabetik. data di analisis menggunakan korelasi spearman. Teknik pengumpulan data menggunakan kuesioner KDQOL SF 1.3. Hasil: berdasarkan hasil penelitian didapatkan 23 penderita 57.5% yang menjalani hemodialisis 1- 3 tahun  dan 6 di antara nya penderita yang memiliki kualitas hidup kurang sebanyak 2 orang, dan yang memiliki kualitas hidup cukup  sebanyak 2 orang serta sebanyak  15 orang lainya memiliki kualitas hidup baik. Simpulan: kesimpulan penelitian ini terdapat korelasi yang bermakna p=0,043 antara lama menjalani hemodialisis dengan kualitas hidup dengan nilai (r): 0.309 yang mana mengarah ke arah positif sehingga ketika penderita telah lama melakukan terapi hemodialisis maka semakin baik kualitas hidup dari penderita.
Acute Abdominal Case Report: Ruptured Ovarian Endometriotic Cyst Concurrent with Acute Appendicitis Nareswari, Gupita
Sanus Medical Journal Vol. 4 No. 2 (2022)
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v4i2.9939

Abstract

Acute pain of pelvic origin is a common symptom necessitating emergent medical evaluation. Acute pelvic pain in young women can present as a unique diagnostic dilemma. Differential diagnosis in acute pelvis pain can vary according to risk. Possible causes span a gamut from functional ovarian cysts that require routine follow-up to adnexal torsion and ectopic pregnancy requiring urgent surgical management. This case report illustrates how concomitant gynecologic disorders can occur in patients with acute appendicitis. The laparoscopic operation revealed a ruptured ovarian endometriotic cyst concurrent with acute appendicitis and was proven by histopathology. This serves as a reminder that even though a rare case is contemporary, two different entities can occur.
D-Dimer Sebagai Salah Satu Parameter Perbaikan Klinis pada Kasus Covid-19 Gejala Berat Trilaksmi, Antin; Martin
Sanus Medical Journal Vol. 4 No. 2 (2022)
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v4i2.10039

Abstract

Background. Coronavirus Disease 2019 (COVID-19) has been a global pandemic since March 2020. The number of patients is massive and clinical symptoms vary from mild to severe symptoms. Several laboratory results showed abnormal values in Covid-19 patients, including an increase in the value of D-dimer. Elevated levels of D-dimer in COVID-19 patients are strongly associated with severity and increased mortality. We report a case of a severe symptomatic COVID-19 patient with high D dimer levels at the start of treatment and showing clinical improvement according to a decrease in D dimer levels. Methods. We treat and follow the clinical and laboratory developments of COVID-19 patients with severe symptoms from the time they enter the Intensive Care Unit (ICU) until they move to a regular ward. Results. A 53-year-old male patient diagnosed with viral pneumonia et causa covid-19 was admitted to the ICU with severe symptoms and high initial d-dimer levels (1,413 ug/ml). The patient received ventilator assistance and standard therapy according to the Covid 19 management protocol of the Ministry of Health of the Republic of Indonesia. Anticoagulation using heparin intravenously with a dose adjusted to the level of d dimer, aPTT, and clinical condition of the patient who is monitored regularly. The trend of d dimers decreased parallel to the decrease in C reactive protein (CRP) levels, increased lung gas exchange function was evaluated from the PaO2/Fio2 ratio (PF ratio) and the clinical improvement of the patients. Conclusion. D-dimer is closely related to the severity of covid 19 patients. D dimer can be used as one of the parameters of patient clinical improvement.

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