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Medical Sains : Jurnal Ilmiah Kefarmasian
Published by Universitas Muhammadiyah Ahmad Dahlan Cirebon
ISSN : 25482114     EISSN : 25412027     DOI : https://doi.org/10.37874/ms
Core Subject : Health,
Medicine & Pharmacology
The Medical Sains journal is a scientific publication media published by the Muhammadiyah Cirebon College of Pharmacy which is published 4 (four) times in 1 (one) year, namely January-March, April-June, July-September and October-December. The journal contains research in the field of pharmacy covering the fields of formulation, pharmacology, communication pharmacy, A natural chemical chemistry, pharmacognomy and other health sciences which is a means for lecturers and researchers in the health sector to share knowledge and establish cooperation in implementing the Tri Dharma of Higher Education. Purpose and Scope The objective of the publication of the Medical Science journal is to publish articles in the field of pharmacy and other health as well as application of pharmaceutical . Based on this, the editorial board of Medical Sains invites lecturers and researchers to contribute to submit research articles related to the following themes: 1. Pharmaceutical formulation technology 2. Pharmacology 3. Community pharmacy 4. Clinical Pharmacy 5. Natural material chemistry 6. Pharmacognosy 7. Pharmaceutical Analysis and Medicinal Chemistry . All papers submitted to medical science journals will be examined by peer review partners who are tailored to their respective fields.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 39 Documents
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Search results for , issue "Vol 9 No 1 (2024)" : 39 Documents clear
ANTIOXIDANT ACTIVITY OF Homotrigona fimbriata PROPOLIS EXTRACT Rabiatul Demiati; Rendri Arista Avimaro; Paula Mariana Kustiawan
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.916

Abstract

Antioxidant compounds have a role in protecting the body from free radicals, Propolis from Homotrigona fimbriata species is widely used as an alternative to natural healing in East Kalimantan. The secondary metabolite compounds in propolis contain many flavonoids and phenolic compounds. These compounds can be utilized to fight free radicals. The purpose of this study was to determine the antioxidant content of stingless bee (Homotrigona fimbriata) propolis extract. This was a quantitative study of the antioxidant potential of propolis extract. The benchmark antioxidant activity was measured based on its ability to counteract free radicals using the DPPH method. The results of this study showed the presence of secondary metabolites of alkaloids, flavonoids, tannins, and saponins as well as antioxidant activity of Homotrigona fimbriata propolis extract with a value of   95,8 ppm as strong category. This can be caused by differences in geographical location, and various resins found in the trees around the beehive will affect antioxidant activity. Keywords: Homotrigona fimbriata, antioxidant, stingless bee
SYNTHESIS AND CHARACTERIZATION OF MOLECULAR IMPRINTED POLYMERS FOR PHENYLBUTAZONE EXTRACTION Dang Soni; Selvira Anandia Intan Maulida; Meilia Suherman; Aliqa Azqia Azzahra
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.920

Abstract

Phenylbutazone is a pharmaceutical substance often added to rheumatic herbs. However, because of the complexity of the matrix caused by the presence of compounds in herbal medicines, the determination of phenylbutazone requires a time-consuming sample preparation process prior to analysis. This study was conducted to develop a specific sorbent that can be used to prepare phenylbutazone in herbal medicine. The performance of phenylbutazone Molecularly Imprinted Polymer (MIP) was evaluated using three distinct porogens (ethanol, methanol, and methanol-chloroform (1:1)) and two polymerization procedures (bulk and precipitation). According to the results of the polymer optimization, the polymer generated by precipitation in methanol-chloroform (1:1) has good sorbent characteristics. FTIR physical characterization revealed complete polymerization. The bulk procedure produces a more physically stable sorbent than the precipitation method does.  Keywords: MIP Performance Evaluation, Phenylbutazone Molecular Imprinted Polymer, Polymer Imprinting Factor
FORMULATION AND ANTIBACTERIAL ACTIVITY OF HERBAL TOOTHPASTE BASED ON ACEH TRADITIONAL MEDICINE Rima Hayati; Amelia Sari; Rini Handayani
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.925

Abstract

This research is based on Acehnese traditional medicine containing betel leaf, areca nut, kencur rhizome, gambier sap, and clove buds. Traditionally, all parts of the plant are wrapped in betel leaf folds and chewed to maintain oral health. This study aimed to incorporate these ingredients into an herbal toothpaste and test its efficacy against bacteria that cause tooth decay, such as S. mutans and E. faecalis. Extracts from betel leaf, areca nut, aromatic ginger, gambier sap, and clove buds were used in this study. Based on variations in extract concentrations, three formulations were developed: F1, F2, and F3. In addition, F0 was the toothpaste base. The herbal toothpaste was light brown in color, homogeneous, semisolid, and had a characteristic betel leaf aroma, according to the evaluation results. The final product had a pH of 7.52–8.59, viscosity of 238.9–242.3 cP, and a foam height of 20 mm (F0), 11 mm (F1), 9 mm (F2), and 6 mm (F3). These values meet the toothpaste quality standard (SNI 112-3524-1995). While F1 showed moderate inhibition against S. mutans and E. faecalis in the antibacterial test, F2 and F3, showed high inhibition against S. mutans and moderate inhibition against E. faecalis. Based on these results, the optimal formula is F3 which has a larger inhibition diameter of 12.23 mm for S. mutans and 9.10 mm for E. faecalis. This herbal toothpaste can be developed to prevent oral candidiasis and gingivitis.  Keywords: herbal toothpaste, antibacterial activity, Streptococcus mutans, Enterococcus faecalis
FORMULATION AND IMMUNOMODULATORY BIOACTIVITY TEST OF NANOPARTICLE SYRUP OF ETHANOL EXTRACT OF SUNGKAI LEAVES (Peronema canescens Jack) Haflin; Agusriani; Kartika Mustofa; Ruri Putri Mariska; Rizky Yulion; Pitriani; Shafira Al Fadhilah; Barmi Hartesi
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.936

Abstract

Sungkai plants are beneficial immunomodulators because of the presence of flavanoid compounds that increase oxygen radicals and antibody production. Pharmaceutical preparations function as immunomodulators, typically in the form of syrups, tablets, capsules, suspensions, and emulsions. Until now, there has been no nanoparticle syrup on the market, even though nanoparticle preparations have the advantage of modifying particle size, controlling the release of active ingredients to reach the active side, protecting drugs from degradation, reducing toxicity, and minimizing side effects. The purpose of this study was to determine whether the syrup of nanoparticles in the ethanol extract of Sungkai leaves acts as an immunomodulator and the stability of the preparation during storage. The methods used were experimental in the laboratory with extraction using the maceration method. The extract obtained was formulated into a nanoparticle solution using the ionic gelation method, then formulated into FO syrup (Base syrup) and F1 syrup (Nanoparticles of ethanol extract of sungkai leaves) and then carried out transmittance tests, particle size analyzer tests, immunomodulatory tests and stability tests. The yield of the extract was 17.5%. The raw material examination of all the materials was in accordance with the literature. The particle size of the nanoparticle solution was 40 nm, that of F0 syrup was 670 nm, and that of F1 syrup was 964 nm. All syrup preparations fell into the nanoparticle size category of 10–1,000 nm. The leukocyte count of the negative control treatment (syrup base) was 5,011 cells/mm³, ...
EFFECT OF TOTAL PHENOLIC AND TOTAL FLAVONOID LEVELS ON THE ANTIOXIDANT POWER OF WATER EXTRACT, ETHANOL AND CHLOROFORM OF GREEN TEA LEAVES (Camellia sinensis L) Ahwan Ahwan; Anik Suwarni; Reni Ariastuti; Rosyadah Hafidz; Sinta Mei Enjelina
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.940

Abstract

Tea (Camellia sinensis L.) was originally used as a refresh drink. Tea has many benefits, especially for health and beauty. The most widely used tea in the market is green tea, because its properties can be used as a daily drink to improve the quality of life in carrying out daily activities. The aim of this study was to determine the effect of the relationship between total phenolic and total flavonoid levels in water extract (EA), ethanol (EE), and chlorophorom (EK) of green tea leaves on antioxidant power. This experimental study used the extraction method, qualitative analysis, quantitative analysis using the colorimetric method, and antioxidant power using the DPPH method. The data obtained were statistically analyzed using SPPS and Microsoft Excel. The results obtained in The extraction process yielded extracts: EA (21.44%), EE (11.20 %), and EK (3.58 %). Qualitative analysis of flavonoid and phenolic compounds in all the extracts revealed the presence of these compounds. In the total phenolic test, the levels were: 229.07 ± 0.99 (EA); 573.70 ± 3.93 (EE); 45.27 ± 0.73 mg/g (EK) GAE (Galic Acid Equivalent). Meanwhile, the flavonoid content was 13.10 ± 0.31 (EA); 40.49 ± 0.67 (EE); 20.94 ± 0.50 mg/g (EK) QE (Quercetin Equivalent). The antioxidant results have an IC50 (Inhibitory Concentration) value of 34.64 ± 0.74 (EA); 7.02 ± 0.15 (EE); 99.11 ± 1.23; positive control 5.94 ± 0.07 µg/mL (vitamin C) ...
THE EFFECT OF PANDEMIC IN WILLINGNESS TO PAY (WTP) FOR NATIONAL HEALTH INSURANCE MONTHLY FEE AS INDEPENDENT PARTICIPANTS: A SURVEY IN SEMARANG Ragil Setia Dianingati; Eva Annisaa; Widyaningrum Utami; MG Isworo Rukmi
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.949

Abstract

Jaminan Kesehatan Nasional (JKN) is mandatory for every Indonesian. Some of them have to be independent participantswho need to pay the monthly fee by themselves. The monthly fee has fluctuated since 2014, and right before the COVID-19 pandemic. This research aimed to determine the willingness to pay for the independent participants before and during the pandemic using an online survey. Results showed that of 34 participants from Semarang, most of them have 2 members of the family (31%), 3 (26%), 5 (14%) 4 (9%) and need to pay for themselves only (17%). Most of them become second-class members (40%), first-class (31%), and third-class (26%). The willingness to pay during the pandemic was lower for all type of memberships significantly (p <0,05) and if the membership fee was raised by 10%, 20%, and 30 %, the rejection was increased (74%, 89%, and 94%). Most of the participants agreed that the pandemic has impacted their economic situation so they considered choosing a lower class because they did not only choose the type of membership based on the benefits but also the amount of the monthly fee. Keywords: willingness to pay, COVID-19, national health insurance
ANTIBACTERIAL ACTIVITY OF ETHANOL EXTRACT OF KERSEN LEAF (Muntingia calabura L.) TOWARDS Escherichia coli BACTERIA Sri Marfuati; Mustika Weni; Emilia Putri Agustin
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.953

Abstract

Escherichia coli is a bacteria that causes infection. In Indonesia, it has been reported that Escherichia coli is resistant to several types of antibiotics; therefore, other alternatives are needed to inhibit the growth of this Escherichia coli. One alternative method is to use medicinal plants, such as cherry leaves, which contain flavonoids, saponins, and tannins as antibacterials. Aim to determine the antibacterial activity of an ethanol extract of cherry leaves (Muntingia calabura L.) against Escherichia coli bacteria. The research used a post-test-only control group design. This study contained 7 groups: 1 positive control group, 1 negative control group, and 5 treatment groups. The treatment group consisted of an ethanol extract of cherry leaves with concentrations of 1%, 2%, 4%, 8%, and 10%. The control group was a positive control (K(+) with co-trimoxazole and a negative control (K(-) namely dimethyl sulfoxide (DMSO) at 10%. The data used was One-way ANOVA. The results of this study were the average zone of inhibition. The largest is at a concentration of 10%, namely 6 mm, while the smallest average inhibition zone is at a concentration of 4%, namely 4.37 mm. Concentrations of 2% and 1% do not indicate the presence of an inhibition zone. From these results it is concluded that there are significant differences between The concentration of cherry leaf ethanol extract against Escherichia coli bacteria and the minimum inhibitory level of cherry leaf ethanol extract against Escherichia coli bacteria is at a concentration of 4% with an average inhibition zone of 4.37mm.
ANALYSIS OF NON-SPECIFIC STANDARDIZED PARAMETERS ON KUMIS KUCING LEAVES (Orthosiphon aristatus (Blume) Miq.) PURPLE VARIETY Fahrauk Faramayuda; Soraya Riyanti; Totik Sri Mariani; Rizka Khoirunnisa Guntina; Winda Nur Halimah
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.977

Abstract

 One of the plants in Indonesia that can be used as a medicine is the purple variety of cat's whiskers (Orthosiphon aristatus (Blume) Miq.). This study aims to examine the quality and safety of the purple variety of Cat’s Whiskers as a raw material for traditional medicine so that it meets the requirements of being free from heavy metal, microbial, and aflatoxin contamination. The results of setting the standardization parameters on the dry material of cat’s whiskers leaves obtained drying losses, water content, total ash content, and acid insoluble ash content, respectively 8.45 ± 0.68%; 6.67 ± 1.15 %; 8.70 ± 0.09 %; 1.31 ± 0.16 %. The results of testing for the heavy metals lead (Pb) and mercury (Hg) on ??dry material and extracts were £ 0.0001 mg/kg. The results of testing the levels of microbial contamination in dry material and extracts obtained total bacteria 1.45x101 and 2.35x101 Cfu/gr, respectively. Test results for aflatoxin contamination on the dry material of Cat’s Whiskers leaves B1, B2, G1, G2 and total aflatoxin £ 0.50 ?g/kg and total aflatoxin £ 2 ?g/kg, respectively. The dried material and leaf extract of the purple variety of cat’s whiskers that were tested met the requirements stated in the regulation of the Food and Drug Supervisory Agency number 32 of 2019 about traditional medicines' safety and quality requirements.
EFFECT OF EXTRACTION METHOD ON ANTIOXIDANT ACTIVITY OF PALM PALM LEAVES (Elaeis guineensis Jacq.) Fahrauk Faramayuda; Ari Sri Windyaswari; Yeni Karlina; Muhamad Raihan Maulana; Rizka Khoirunnisa Guntina
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.994

Abstract

Oil palm (Elaeis guineensis Jacq.) is a plant that is native to Africa and South America. This plant can grow well in tropical areas, such as Indonesia. Indonesia is currently one of the largest producers of palm oil worldwide. As the area of palm oil plantations increases, the potential for waste from this plant continues to increase. The potential for palm oil leaf waste production in Indonesia is 658 kg dry matter/hectare/year. Palm oil leaf waste has been widely processed into organic fertilizers and animal feeds. This plant has the potential to be developed into a source of traditional medicinal ingredients. Based on the abundant sources of palm oil leaves and their pharmacological potential, palm oil leaves can be used as a source of raw materials for traditional medicine. This study aimed to compare the antioxidant activities of oil palm leaf extracts obtained by maceration and reflux to determine which extraction method produces the best antioxidant activity. Extraction was carried out using 70% ethanol solvent by maceration and reflux. The results of the phytochemical screening showed that oil palm leaves contain flavonoids, polyphenols, saponins, quinones, steroid-triterpenoids, and monoterpene-sesquiterpenes. Antioxidant activity using a UV-Visible spectrophotometer with DPPH free radicals showed that the extract obtained by maceration and reflux methods had IC50 values of 46.61 ± 1.76 ug/mL and 55.21 ± 2.91 ug/mL respectively. Therefore, extraction by maceration produces a better antioxidant activity.  Keywords: Palm leaves; Traditional medicine; Extraction; Active compound stability; Antioxidant
FORMULATION AND CHARACTERIZATION OF ANTI-INFLAMMATORY TRANSDERMAL PATCH PREPARATIONS FROM THE EXTRACT OF PATAH TULANG (Euphorbia tirucalli) Shandra Isasi Sutiswa; Syipa Siti Saripah; Nooryza Martihandini
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.998

Abstract

Transdermal patches are pharmaceutical preparations that aim to provide a drug delivery system across the surface of the skin and tissue, which is then delivered to the blood. is a plant that contains secondary metabolites with anti-inflammatory activity, such as alkaloids, flavonoids, polyphenols, tannins, steroids, and saponins. This study aimed to determine the characteristics of anti-inflammatory transdermal patch preparations prepared from Euphorbia tirucalli extract. The research method was laboratory experimental by preparing patches using varying concentrations of Euphorbia tirucalli extract, namely F1 (5%), F2 (10%), and F3 (15%). Next, an evaluation of patch preparation was carried out, including organoleptic tests, weight uniformity tests, thickness tests, fold durability tests, pH tests, and moisture tests. From the research results, it can be concluded that Euphorbia tirucalli extract at concentrations of 5%, 10%, and 15% can be made into patch preparations. The best characteristics of the patch preparation were F2 with an extract concentration of 10%, which had a smooth, flexible texture, folding durability >300 folds, pH 4.5, and moisture value of 7.30%.  Keywords: Anti-inflammatory, Euphorbia tirucalli, Transdermal patch

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