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Medical Sains : Jurnal Ilmiah Kefarmasian
Published by Universitas Muhammadiyah Ahmad Dahlan Cirebon
ISSN : 25482114     EISSN : 25412027     DOI : https://doi.org/10.37874/ms
Core Subject : Health,
Medicine & Pharmacology
The Medical Sains journal is a scientific publication media published by the Muhammadiyah Cirebon College of Pharmacy which is published 4 (four) times in 1 (one) year, namely January-March, April-June, July-September and October-December. The journal contains research in the field of pharmacy covering the fields of formulation, pharmacology, communication pharmacy, A natural chemical chemistry, pharmacognomy and other health sciences which is a means for lecturers and researchers in the health sector to share knowledge and establish cooperation in implementing the Tri Dharma of Higher Education. Purpose and Scope The objective of the publication of the Medical Science journal is to publish articles in the field of pharmacy and other health as well as application of pharmaceutical . Based on this, the editorial board of Medical Sains invites lecturers and researchers to contribute to submit research articles related to the following themes: 1. Pharmaceutical formulation technology 2. Pharmacology 3. Community pharmacy 4. Clinical Pharmacy 5. Natural material chemistry 6. Pharmacognosy 7. Pharmaceutical Analysis and Medicinal Chemistry . All papers submitted to medical science journals will be examined by peer review partners who are tailored to their respective fields.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 26 Documents
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Search results for , issue "Vol 9 No 4 (2024)" : 26 Documents clear
EVALUATION AND ANTIOXIDANT TEST OF SAFFRON FACE MIST AS A SKIN MOISTURIZER Al-Bari, Akhmad; Pratiwi, Shoffi Ajeng; Ni'am, Musfirotun
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 4 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i4.486

Abstract

Saffron (Crocus sativus L.) is a medicinal plant used as a spice in food, but recent times have shown that has a role in cosmetics. The saffron stigma has antioxidant activity and is useful in cosmetics. Antioxidants can protect the skin from various types of cell damage due to free radicals from ultraviolet light, motor vehicle fumes, chemicals in food, chemicals, and drugs. The antioxidant content of saffron stigma makes it an ingredient in cosmetics such as face mist. Face mist is a cosmetic skin freshener that refreshes facial skin, removes residual oil from the skin, kills some skin microorganisms, and helps close the pores. The aim of this study was to evaluate the antioxidant properties of the saffron face mist. The evaluation of saffron face mist includes an organoleptic test based on odor, color, and shape/texture, a pH test using a universal pH indicator paper, a specific gravity test using a pycnometer, and a moisture test using a skin moisture meter. The saffron stigma antioxidant test was performed using the DPPH assay. The results showed that the face mist had a rose aroma, golden yellow color, and moist form, the specific gravity ranged from 1.0637 to 1.0689 g/mL, the pH was 6, the moisture value of the facial skin after the application of the face mist to the face ranged from 47.77 ± 3.81 – 56.52 ± 0.72 % ...
THE ANTIBACTERIAL ACTIVITY OF A COMBINATION OF YOGURT AND SAFFRON EXTRACT AGAINST Staphylococcus aureus Fitriany, Erna; Priyoherianto, Andri; Iswandi; Deny Budi L.; Didik Andito
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 4 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i4.996

Abstract

Background: Yogurt is a fermented milk product that has a positive influence on health because of its bioactive proteins, vitamins, minerals, improved bioavailability, and hydrolyzed carbohydrates. Yogurt contains lactic acid bacteria that can inhibit the growth of Staphylococcus aureus. Objectives: This study aimed to determine the addition of Saffron Extract to yogurt against Staphylococcus aureus and to test its antibacterial activity against Staphylococcus aureus. Material and Methods: The study was an experimental study with various concentrations of Saffron extract (25%; 50%; 75%; and 100%) that were added to the cow milk-based yogurt. The mixed saffron extract (MSE) was centrifuged to obtain the supernatant. The antibacterial activity was evaluated using the disc diffusion method. based on the strength of the zone of inhibition. The negative control was plain yogurt and the positive control was chloramphenicol. Results: Phytochemical screening was used to observe flavonoids, steroids, phenols, saponins, and tannins in the saffron extract. MSE showed antibacterial activity against S. aureus with inhibition zones of 5.19 ± 0.39 mm, 5,77± 0.78 mm, 7,98± 1.43 mm, 9,01± 1.48 mm for, concentration of  25%, 50%, 75%, and 100%, respectively. The positive control inhibition zone was 46.61 mm and the negative control was 4.98± 0.39 mm.  Conclusions: Saffron extract added to yogurt at concentrations of 75%  and 100% inhibited the growth of S. aureus. Keywords: Saffron extract, S. aureus, Yogurt
REAL WORLD DATA; EFFECTIVENESS OF COVID-19 TREATMENT IN SEVERE SYMPTOMS PATIENTS AT RS PKU MUHAMMADIYAH GAMPING IN AUGUST 2022-2023 Simamora, Patimah; Risdiana, Irma; Khuluq, Muh. Husnul; Perwitasari, Dyah A
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 4 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i4.1133

Abstract

Severe COVID-19 has created significant real-world clinical challenges, particularly in the management of critically ill patients in intensive care units. The disease is often accompanied by serious complications, such as acute respiratory distress syndrome (ARDS), multiple organ damage, and increased risk of mortality, particularly in individuals with risk factors such as advanced age and comorbidities. Real World data provide evidence related to effectiveness as patients are observed from admission to discharge. This study aimed to obtain an overview of the effectiveness of COVID-19 treatment with severe symptoms at RS PKU Muhammadiyah Gamping in August 2022-2023. This observational study used a descriptive research design. Data collection was retrospective and was obtained from medical records. Descriptive analyses were conducted including patient characteristics, drug usage, and therapy effectiveness. This study obtained data from 45 patients who met the inclusion criteria for severe COVID-19 ...
REVIEW: PLANTS WITH REPELLENT ACTIVITY Purnama, Uwan; Faramayuda, Fahrauk
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 4 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i4.1174

Abstract

Mosquitoes are vectors of illnesses, such as encephalitis, dengue, filariasis, intestinal sickness, and encephalitis. These diseases have become epidemics in Indonesia and around the world. Natural repellents are alternatives for preventing mosquito-borne diseases that are safe, easily degradable, and eco-friendly. This review aimed to identify compounds in plants with mosquito repellent activity. Data were obtained from national and international journals using search platforms, including PubMed, Scholar, SciDirect, and Hindawi. This review focuses on plants with repellent activity, their resulting repellent activity, the content of bioactive compounds, and the mosquito species used. Many plants contain naturally occurring compounds that can repel mosquitoes. Following scientific research, 14 bioactive compounds have been shown to have repellent activity in plants. Keywords: repellent, volatile oil, mosquitos, bioactive compounds, narrative literature review
FORMULATION AND CHARACTERIZATION OF INSTANT POWDER COMBINATION OF MILK, YOLK AND TEMULAWAK (Curcuma xanthorriza Roxb) TO PREVENT STUNTING Sutiswa, Shandra Isasi; Aji, Nur
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 4 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i4.1234

Abstract

Through its health transformation program, the Ministry of Health has replaced giving biscuits as additional food to toddlers and pregnant women to prevent stunting with animal protein made from local food. Milk and eggs are local food sources of animal proteins that can be processed into nutraceuticals. Another cause of stunting is lack of appetite, nausea, and vomiting in children during pregnancy. Temulawak is a traditional medicine that can improve appetite. A combination of milk, yolk, and temulawak can be formulated for nutraceutical preparation. This study aimed to develop and test the characteristics of instant powder combinations of milk, yolk, and temulawak to prevent stunted growth. The laboratory experimental method was used in this study. The formula was prepared by mixing temulawak extract granules with powder obtained from the freeze-drying process of milk and yolk. There were 3 variations of the combination concentration with a ratio of milk : yolk : temulawak, F1 (40:2:3), F2 (50:3:2), and F3 (60:4:1). The results of the research showed that all formulas had physical characteristics in the form of light yellow powder with a typical ginger aroma, particle size between 119.66–120.39µm, angle of repose between 36.40–44.46°, flow rate between 1.32–1 .34g/sec, specific gravity between 0.44-0.47g/mL, tap density between 0.62–0.68g/mL, compressibility between 13.00-13.33%, pH between 6.45–6, 48, dispersibility time between 02.14 – 02.17 minutes and water content between 3.48 – 4.93% according to SNI-01-2970-2006 instant milk powder ...
REVIEW: POTENTIAL PHARMACOLOGICAL ACTIVITY OF KALANGKALA PLANT (Litsea angulata) Enti Rikomah, Setya; Mahfudh, Nurkhasanah; Yuliani, Sapto
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 4 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i4.1245

Abstract

Kalangkala plants are native to Kalimantan and belong to the genus Litsea, family Lauraceae. Traditionally, it is used to treat diarrhea, boils, dyspepsia, diabetes, pain, asthma, fever, arthritis, traumatic injuries, gastroenteritis, edema, and stomachaches. This review article aims to explain the phytochemical components and pharmacological activities of the kalangkala plant. Databases from Google Scholar, ScienceDirect, and PubMed were searched for articles published from 2016 to 2024. The keywords used were Kalangkala, Litsea, and Litsea angulata. The results showed that Litsea angulata contains phytochemical compounds including saponins, alkaloids, flavonoids, tannins, steroids, triterpenoids, terpenoids, carotenoids, coumarin, ?-pinene, (S)-cis-verbenol and ?-sitosterol. The pharmacological activity of Litsea angulata includes antioxidant, antibacterial, antidiabetic, and spermacidal activities and is toxic. Antioxidant activity of kalangkala plant from various parts of the plant, namely branches, bark, leaves, seeds, fruits, leaves, and fruit seeds. Antibacterial activity in plant parts, namely branches, bark, leaves, seeds, and essential oils from leaves, and antidiabetic activity in the fruit seeds of the kalangkala plant. Litsea angulata is the most widely reported phytochemical component for its pharmacological activity, namely flavonoids. Flavonoids are found in various parts of plants, including the seeds, bark, and leaves. Pharmacological activity as an antioxidant, antibacterial, and antidiabetic. Further research is needed to identify the phytochemical components responsible for the pharmacological activity in the discovery of new drugs. Keywords: Kalangkala, Litsea, Litsea angulata
ANTIOXIDANT ACTIVITY OF 96% ETANOL EXTRACT OF KROKOT PLANT (Portulaca oleraceae L.) IN FACE SPRAY PREPARATION BY DPPH METHOD Dina Pratiwi; Abdul Aziz Setiawan; Dede Anggraeni
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 4 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i4.1247

Abstract

Krokot plants (Portulaca oleracea L.) are weeds that are commonly found in rice fields, plantations, and home yards. Krokot plants have many benefits, including their use as antirheumatic, antibacterial, and antioxidant drugs. The secondary metabolites contained in krokot plants, namely flavonoids, act as the main bioactive compounds. This study aimed to determine the physical properties of face spray preparations and the antioxidant activity of extracts and face spray preparations of 96% ethanol extract of krokot plant (Portulaca oleracea L.) to prevent free radicals. The research method used was Descriptive and inferential analyses were conducted in this study. Krokot plant extract was prepared by maceration using 96% ethanol solvent at a ratio of 1:10 and then used as the active ingredient of formulation (F) at various concentrations of face spray formulations. F1 as negative control, F2 at 0.7%, F3 at 1.4%, and F4 at 2.8%. The results of the physical evaluation of face spray preparations for all formulas met the requirements (organoleptic, pH, homogeneity, dry time test, viscosity, and spray spreadability test). The antioxidant activities of face spray preparations in F1, F2, F3, and F4 had IC50  values of 110.914, 106.581, 85.261, and 64.936 ppm, respectively. The conclusion of this study is that the extract and face spray preparation formula of 96% ethanol extract of krokot plant (Portulaca oleracea L.) have antioxidant activity. Formula 4 showed the best physical properties of face spray preparation. Keywords: Formulation, krokot plant extract, face spray, antioxidant.
REVIEW: PHYTOCHEMICAL CONSTITUENTS AND PHARMACOLOGICAL ACTIVITY OF Strobilanthes crispus Amin, Azizah
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 4 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i4.1252

Abstract

Strobilanthes crispus (S. crispus), called keji beling leaves, is a plant belonging to the genus Strobilanthes and family Acanthaceae. Keji beling (S.crispus) has been applied by Indonesians to cure some diseases like diabetes and dissolve kidney stones. The aim of this review article is to compile an update on the phytochemical studies and pharmacological activity of S. crispus. A literature review was carried out by searching for articles in the Scopus, PubMed, and Google Scholar data bases between 2014-2024. Studies have shown that the leaves of S. crispus contain flavonoids, phenolics, alkaloids, tannins, terpenoids, phytosterols, and fatty acids. Current pharmacological studies have revealed that the extracts, fractions, or secondary metabolites of S. crispus possess antimicrobial, antioxidant, antidiabetic, anti-urothelial, immunomodulatory, wound healing, cytotoxic, and anti-cancer activities. Although previous studies have provided information about S. crispus, pharmacological and phytochemical data are still limited. Further studies are still necessary to explore the bioactive compounds, toxicity, safety and future development of S.crispus as herbal medicine Keywords: keji beling, Strobilanthes crispus, phytochemical constituent, pharmacological activity
NARRATIVE REVIEW: DRUG AVAILABILITY IN HEALTHCARE SERVICES IN INDONESIA Sagitasari, Yanna; Widayanti, Anna Wahyuni; Yuniarti, Endang
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 4 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i4.1255

Abstract

This narrative review delves into the availability of drugs within Indonesia’s healthcare services, analyzing 11 articles to uncover prevalent issues such as drug shortages, inadequate planning, and various factors influencing drug availability. This review underscores the critical need to ensure sufficient drug availability to enhance patient safety across healthcare settings. By examining journal articles, this review sheds light on the multifaceted aspects of drug availability, including planning management and the methods employed to evaluate their ability. The findings provide valuable insights into improving strategies for drug availability in hospitals and primary health care centers in Indonesia. This study found that out of the 11 articles reviewed, six reported insufficient drug availability, highlighting significant challenges in ensuring consistent access to necessary medications across different healthcare settings, including both primary healthcare centers and hospitals. Furthermore, the study identified geographical disparities in drug availability, with studies conducted outside Java Island reporting more severe drug shortages than those within Java Island. In summary, this study highlights the complex interplay between factors affecting drug availability in Indonesia, including geographical location, supply chain management, and procurement practices. This underscores the need for targeted interventions to address these challenges and improve drug availability across the healthcare system. Keywords: drug availability in Indonesia, patient safety, drug procurement in Indonesia, drug shortage.
REVIEW ON PHOTOSENSITIZER POTENTIAL OF NATURAL DYES FOR ANTIMICROBIALS USING PHOTODYNAMIC INACTIVATION Ayu Mulyani; Ika Yuni Astuti; Djalil, Asmiyenti Djaliasrin
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 4 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i4.1291

Abstract

Infectious diseases still threaten human life, with incidents continuing to increase every year. The increase in antibiotic resistance in recent years has been one of the causes. This incident triggered research to find alternative antibacterial therapies. One such alternative therapy is Photodynamic Inactivation (PDI). This paper reviews the application of PDI for treating diseases caused by microorganisms, especially dermatitis,  periodontitis, blood transfusions, and foodborne diseases, emphasizing the use of natural dyes as photosensitizers. The source for this article was obtained from several indexed databases, such as the National Center for Biotechnology Information (NCBI), Elsevier, and Google Scholar, from 2002 to 2024. The keywords used included “photodynamic therapy", “photodynamic inactivation (PDI)”, "antimicrobial photodynamic therapy (aPDT)", “laser-activated disinfection”, “photoactive disinfection”, “LED”, “natural photosensitizer”, “curcumin”, “riboflavin”, “hypericin”, “chlorophyll and chlorophyllin. Original (clinical and experimental) studies, case series, case reports, and reviews were also included. Letters to the editor and commentaries are excluded. After reviewing 148 relevant articles, 57 were selected. Full texts were read, and data were extracted and entered into tables. The review demonstrated that natural photosensitizers, such as curcumin, hypericin, riboflavin, and chlorophyll derivatives, have the potential to reduce the number of microorganisms in PDI therapy. Photosensitizers can be obtained from several natural sources. Using the PDI procedure, the ROS produced have been proven to effectively inhibit pathogenic microorganisms and can be widely used to treat diseases caused by microorganisms. Keywords: curcumin, hypericin, riboflavin, chlorophyllin derivatives, PDI, natural dye, antimicrobial.

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