cover
Contact Name
Assyifa Junitasari
Contact Email
assyifajunitasari@uinsgd.ac.id
Phone
+6281287749909
Journal Mail Official
alkimiya@uinsgd.ac.id
Editorial Address
Department of Chemistry, Faculty of Science and Technology Building, UIN Sunan Gunung Djati Bandung, A.H. Nasution Street No. 105 Bandung 40614
Location
Kota bandung,
Jawa barat
INDONESIA
al Kimiya : Jurnal Ilmu Kimia dan Terapan
ISSN : 24071897     EISSN : 24071927     DOI : http://doi.org/10.15575/ak
The scope of al Kimiya Jurnal Ilmu Kimia dan Terapan s publication included general studies and special studies The general studies are pure chemistry in general and in specific fields as follows Study of inorganic organic and biochemical substances materials that have traditionally been successively entered into studies of inorganic chemistry organic chemistry and biochemistry. Some examples of specific topics from the study of these substances are bioanorganic bioorganic organometallic heterogeneous catalysts transition metal chemistry and coordination chemistry (complex) metabolism enzymology natural material chemistry and solids. Study of the physical and chemical properties of matter and their changes that have traditionally entered into the study of physical chemistry. Some examples of specific topics from this study are reaction kinetics and mechanisms surface chemistry polymers dyes, thermo dynamics chemistry theoretical chemistry and computation membrane catalysis radiochemistry electrochemistry photochemistry and spectroscopy. Experimental studies and chemical instrumentation that have traditionally entered into analytic chemistry studies. Some examples of specific topics from this study are spectroscopy microscopy and chromatography. Specific studies that can be raised in the publication of al-Kimiya in general are as follows Study of applied chemistry in the field of food. Some examples of specific topics from this study are proteins lipids carbohydrates vitamins minerals enzymes additives food coloring agents and food chemical technologies related to these topics. Study of applied chemistry in the energy field. Some examples of specific topics from this study are photochemistry cell chemistry fuel biomass petroleum and natural gas fuels renewable chemical energy sources and chemical energy conversion Study of applied chemistry in the field of environment. Some examples of specific topics from this study are soil chemistry aquatic chemistry atmospheric chemistry green chemistry toxicology and water treatment. Pure chemistry studies as well as applied in the problem of local wisdom. This study was inspired by the lack of habits traditions in local tribe customs or culture related to the use of substances from nature. Back to Nature can be the ultimate term to describe the contribution of culture to modern traditions that are more prudent in managing nature. Pure and applied chemistry studies to understand the universality values of Islam rahmatan lil alamin.
Articles 163 Documents
Sintesis dan Karakterisasi Selulosa Termetilasi sebagai Biokomposit Hidrogel Neng Rita Nurjannah; Tety Sudiarti; Lena Rahmidar
al Kimiya: Jurnal Ilmu Kimia dan Terapan Vol 7, No 1 (2020): al Kimiya: Jurnal Ilmu Kimia dan Terapan
Publisher : Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ak.v7i1.6490

Abstract

Penggunaan biomaterial di bidang klinis semakin banyak dilakukan, karena biomaterial lebih aman digunakan (tidak toksik) serta ketersediaannya di alam sangat banyak. Salah satu pemanfaatan  biomaterial ini adalah yang berasal serat batang pisang. Serat batang pisang ini merupakan prekursor untuk disintesis menjadi Metil Selulosa (MS) yang bisa digunakan sebagai bahan hidrogel untuk proses penyembuhan luka dan iritasi kulit. Penelitian ini dimulai dari sintesis selulosa mikrobial dari batang pisang dengan menggunakan starter Acetobacter xylinum yang diinkubasi selama 9 hari. Nata yang diperoleh dimurnikan dan dihasilkan selulosa mikrobial. Selulosa mikrobial yang dihasilkan kemudian disintesis menjadi metil selulosa. Metil selulosa disintesis secara swelling, kemudian ditambahkan pelarut dan metilen klorida untuk proses metilasi. Selulosa dan metil selulosa dianalisis FTIR dan dilakukan pengujian pada metil selulosa meliputi warna, titik leleh serta kelarutan, sehingga dapat diperkirakan nilai DS-nya. Hasil karakterisasi FTIR pada selulosa mikrobial terdapat gugus –OH pada bilangan gelombang 3388,93 cm-1 dan gugus -CH pada bilangan gelombang 2931,80 cm-1. Karakterisasi metil selulosa dengan FTIR dapat diketahui dengan munculnya puncak daerah serapan gugus  –CH yang semakin tajam, yaitu pada MS-air dan MS-aseton terdapat gugus –CH masing-masing pada panjang gelombang 2918,30 cm-1 dan 2900,94 cm-1. Metil selulosa hasil sintesis dari batang pisang tidak dapat larut dalam pelarut air dingin (0-15°C), NaOH 4% dan asam asetat glasial. Nilai Derajat Substitusi (DS) MS-aseton 0,912 dan MS-air 0,834, sehingga pelarut aseton lebih baik untuk mengoptimalkan nilai DS pada metil selulosa.
Kajian Farmakoinformatika Senyawa Brazilin dan 3-O-Methyl Brazilin Caesalpinia sappan Sebagai Terapi Demam Berdarah Dengue Dewi Ratih Tirto Sari; Heny Yusuf; Laily Sifaiyah; Nur Dina Camelia; Yohanes Bare
al Kimiya: Jurnal Ilmu Kimia dan Terapan Vol 9, No 1 (2022): al Kimiya: Jurnal Ilmu Kimia dan Terapan
Publisher : Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ak.v9i1.17613

Abstract

Demam berdarah Dengue (DBD) merupakan penyakit tropis yang diakibatkan oleh gigitan nyamuk yang terinfeksi oleh virus DENV. Beberapa tanaman herbal dapat digunakan untuk mengatasi demam berdarah baik upaya preventif maupun kuratif. Kayu secang merupakan salah satu tanaman herbal kayu yang memiliki berbagai aktivitas biologis, utamanya sebagai immunomodulator dan antivirus. Penelitian ini bertujuan untuk mengidentifikasi aktivitas brazilin dan 3-O-methyl brazilin sebagai obat terapi demam berdarah melalui kajian komputasi. Pendekatan molecular docking digunakan dalam studi penelitian ini. Senyawa brazilin dan 3-O-methyl brazilin diunduh dari database PubChem dan diinteraksikan dengan protein non- structural-5 (NS-5) yang didapatkan dari database PDB. Pemodelan docking dilakukan dengan Molegro virtual Docker versi 5.0 dan dianalisis dengan PyMol 2.2 dan Discovery studio versi 21.1.1. Hasil interaksi menunjukkan bahwa brazilin dan 3-O-methyl brazilin berikatan dengan protein NS-5 di sisi aktif guanosine triphosphate dan daerah RNA dependent RNA polymerase (RdRP). Pengikatan kedua senyawa aktif ini menyebabkan tidak terjadinya replikasi virus DENV pada sel inang dan berpotensi sebagai penghambat infeksi DENV. Berdasarkan analisis in silico, disimpulkan bahwa brazilin dan 3-O-methyl brazilin berpotensi sebagai agen terapi demam berdarah, studi in vitro perlu dilakukan untuk pembuktian lebih lanjut. 
Molecular Docking of Brazilin from Secang Wood Plant (Caesalpinia sappan L.) as an Anti-Breast Cancer Astriany, Dewi; Baroroh, Umi; Umam, Khotibul
al Kimiya: Jurnal Ilmu Kimia dan Terapan Vol 11, No 1 (2024): al Kimiya: Jurnal Ilmu Kimia dan Terapan
Publisher : Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ak.v11i1.35590

Abstract

Breast cancer is a disease characterized by abnormal cell growth, which can invade adjacent tissues or metastasize to other organs. Secang (Caesalpinia sappan L.) is a plant that has been used as an alternative medicine for a variety of health conditions, including some types of cancer. This study aims to determine whether the brazilin compound found in secang wood can interact with the target receptors estrogen alpha, 17-β-HSD-1, and NUDT5, potentially serving as an anticancer candidate. Molecular docking simulations were employed to identify the molecular interactions of brazilin against estrogen receptor alpha (ERα) (PDB ID: 3ERT), 17β-HSD-1 (PDB ID: 3HB5), and NUDT5 (PDB ID: 5NQR) using AutoDockTools software. The results showed that the best free-binding energy (ΔG) value obtained for brazilin against the 17-β-HSD-1 receptor was -9.16 kcal/mol, with an inhibition constant of 192.45 nM. The ΔG value of brazilin with estrogen alpha was -6.68 kcal/mol, and the ΔG value for brazilin against NUDT5 was -4.8 kcal/mol. Brazilin has a higher potency compared to innate ligands based on the docking result of estrogen alpha receptor and NUDT5. Some structural similarities and interactions occurred between the amino acids GLY186 and TYR155 in brazilin with the binding of amino acids formed in the innate ligand against the 17-β-HSD-1 receptor, thus showing similar affinity to the 17-β-HSD1 receptor. In silico approaches provided valuable insights into the potential of brazilin as an anti-breast cancer agent.
EVALUATION OF MICROSPHERE OF POLY(LACTIC ACID) AS CELECOXIB CARRIER nurhayati, lany; Achmadi, Suminar S.; Sudaryanto, Sudaryanto
al Kimiya: Jurnal Ilmu Kimia dan Terapan Vol 11, No 2 (2024): al Kimiya: Jurnal Ilmu Kimia dan Terapan
Publisher : Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ak.v11i2.39310

Abstract

Celecoxib, cyclooxygenase-2 inhibitor approved for the management of rheumatism and osteoarthritis. Celecoxib is a Biopharmaceutics Classification System (BCS) class II compound whose oral bioavailability is highly limited owing to its poor aqueous solubility. Microencapsulation is very helpful to increase the solubility and slow the release of drugs. For the drugs of BCS Class-II, we use this technique which enables us to get more solubility and increase dissolution profile. The present study aims to reduce the drug’s negative effect and boost its bioavailability. Poly(lactic acid) (PLA) a biodegradable polymer microsphere that can be synthesized to encapsulate celecoxib, was prepared by solvent evaporation with chloroform were used. The characterized surface morphology, drug entrapment efficiency (DDE), and in vitro drug release. Morphology was studied by scanning electron microscopy (SEM), crystallinity was studied using an X-ray diffractometer (XRD), and drug release was spectrophotometer UV-Vis. The results were observed to indicate there were microspheres homogeneous in the distribution of celecoxib in the polymer matrix. Formulations indicated that DEE was between 55.80 and 70.70% with prolonged length microspheres in the 10-30 µm range. Study in vitro drug release, when placed in phosphate buffer (pH 7.4) containing 2% w/w Tween 80 solvent, there was an initial burst of drug release within the first two hours followed by constant drug release. The PLA microsphere can release the confined celecoxib gradually but does not follow a controlled diffusion mechanism, but rather a mechanism of expansion and erosion of the microsphere matrix.
PREPARATION OF ACTIVATED CARBON FROM PALM SHELL BY CHEMICAL ACTIVATION WITH KOH AS AN ADSORBENT DYE Lestari, Intan -; Apriansyah, Rendi; Gusti, Diah Riski; Naswir, M.; Permana, Edwin
al Kimiya: Jurnal Ilmu Kimia dan Terapan Vol 11, No 2 (2024): al Kimiya: Jurnal Ilmu Kimia dan Terapan
Publisher : Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ak.v11i2.40978

Abstract

Activated carbon is a well known as porous material, with large specific surface area, which is useful in adsorption of both gases and solutes from aqueous solution. In this research, prepraration of activated carbon was through chemical activation of palm shells using KOH as an activator. Preparation of carbon from palm shell were the first carbonized in a furnace at temperature of 400 - 500 °C. Carbon is soaked in KOH activator solution for 8 hours and then carbonized at a temperature of 600 - 800 °C. The activated carbon obtained was characterized by XRD, SEM and FTIR. Characterization using SEM shows that activated carbon has pores and using FTIR shows the presence of several functional groups such as hydroxyl (-OH), carboxyl (-COOH), carbonyl (-C=O) that can be used for adsorption. Adsorption studies were carried out using batch experiments with synthetic naphthol and remazole dye solutions. The adsorption study was carried out in batch, based on isotherm assumptions and following Langmuir isotherm model. These results indicate that palm shell activated carbon has the potential used as an adsorbent for removing naphthol and remazole dyes from the solution.
EVALUATION OF MINERAL-BASED HYDROXYAPATITE/ZnO COMPOSITES AS PHOTOCATALISTS FOR METHYLEN BLUE DEGRADATION Hardian, Arie; Nafisah, Aulia Zakiyatun; Karya, Teguh; Halim, Riyan; Murniati, Anceu; Syarif, Dani Gustaman; Noviyanti, Atiek Rostika; Nurhayati, Mita; Jasmansyah, Jasmansyah; Reza, Muhammad
al Kimiya: Jurnal Ilmu Kimia dan Terapan Vol 11, No 2 (2024): al Kimiya: Jurnal Ilmu Kimia dan Terapan
Publisher : Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ak.v11i2.37886

Abstract

The use of dyes in the textile industry has increased significantly, raising concerns about their potential to pollute the environment and harm human health. Methylene blue is a widely used synthetic dye, necessitating effective methods for its degradation. Photodegradation is a promising approach to decompose dyes into simpler, less harmful compounds. In this study, hydroxyapatite combined with ZnO was employed as a photocatalyst material to enhance photocatalytic performance. The research aims to degrade methylene blue using a Hydroxyapatite/ZnO (HAp/ZnO) nanocomposite through photodegradation. The optimization of the photodegradation process was investigated by varying irradiation time, methylene blue concentration, and pH. The optimum degradation of methylene blue was achieved using 20 mg of HAp/ZnO nanocomposite at an irradiation time of 120 minutes, an initial methylene blue concentration of 5 ppm, and pH 7. Adsorption isotherm modeling revealed that the process followed the Langmuir isotherm model, with a maximum adsorption capacity (qmax) of 0.3353 mg/g. The degradation followed pseudo-second-order kinetics with a reaction rate constant of 4.0026×105 L/mol·s.
RAW STARCH-DEGRADING AMYLASE FROM BACTERIA IN KARANG MUMUS RIVER, SAMARINDA Astuti, Winni; Adawiyah, Rabiatul; Putri, Amanda Aulia; Pratiwi, Djihan Ryn
al Kimiya: Jurnal Ilmu Kimia dan Terapan Vol 11, No 2 (2024): al Kimiya: Jurnal Ilmu Kimia dan Terapan
Publisher : Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ak.v11i2.39438

Abstract

Raw starch-degrading amylase (RSDA) is an enzyme that has the ability to degrade starch granules into glucose without undergoing gelatinization. This research was conducted to explore and characterize extracellular RSDA-producing bacteria from body water of the Karang Mumus River, Samarinda. RSDA activity was analyzed qualitatively in nutrient agar containing 1% starch granules, bacterial colonies with RSDA activity are clear halos around bacterial colonies after the plates were flooded with iodine solution. Five of the 14 bacterial colonies secreted an RSDA extracellularly. The RSDA enzyme from the 5 bacteria was tested for amylase activity using the Dinitrosalicylic Acid (DNS) method. Bacteria with colony code KM 5 had the highest RSDA activity of 0.332 U/mL.The optimum working conditions for RSDA are at pH 5 and a temperature of 40°C. Identification of bacterial genotypes using the 16S rRNA gene showed that KM5 was Klebsiella sp, referred to as Klebsiella KM5.
IDENTIFICATION OF ACTIVE COMPOUNDS AND FORMULATION AS AN ANTISEPTIC MOUTHWASH FROM THE PLANT Cassia fistula L. AS A PREVENTIVE MEASURE AGAINST DENTAL AND ORAL DISEASES CAUSED BY THE BACTERIA Enterococcus faecalis Romundza, Febbry; Harizon, Harizon
al Kimiya: Jurnal Ilmu Kimia dan Terapan Vol 11, No 2 (2024): al Kimiya: Jurnal Ilmu Kimia dan Terapan
Publisher : Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ak.v11i2.38474

Abstract

A compound with the molecular formula C15H24O has been identified as Caryophyllenol-II through analysis using HR-TOF-MS, IR, and NMR spectroscopy. The ¹³C-NMR spectrum indicates that this compound is a bicyclic sesquiterpenoid, characterized mainly by the presence of a hydroxyl group replacing an epoxide ring and the addition of an olefinic bond. The relationship between the compounds analyzed from Cassia fistula L. and their antibacterial activity against Enterococcus faecalis can be explained through the identification of bioactive compounds with specific mechanisms to inhibit or kill the bacteria. Compounds from Cassia fistula L. have significant potential as an antibacterial agent against Enterococcus faecalis, particularly through membrane disruption and bacterial enzyme inhibition mechanisms. Further research on their role, either individually or in combination with other compounds, could support the development of C. fistula-based antiseptic products, such as mouthwash, for the prevention and treatment of oral and dental diseases. Additionally, this research explores the antibacterial potential of Cassia fistula L. in developing an antiseptic mouthwash. Extracts from Cassia fistula L. are known to contain active compounds such as flavonoids, alkaloids, and tannins, which demonstrate effectiveness against Enterococcus faecalis, as a primary cause of dental and oral infections. The mouthwash formulation based on this extract was tested in vitro and proposed as a natural and safer alternative compared to synthetic chemical-based products for the prevention of dental and oral infections. This study indicates the significant potential of Cassia fistula L. in supporting oral health through effective antiseptic products. These findings support the use of traditional medicinal plants like Cassia fistula L. as a source of active compounds for the development of effective natural antiseptics and have the potential to reduce dependence on synthetic antiseptics while also promoting economic empowerment through simple industries.
SYNTHESIS AND CHARACTERIZATION OF ALPHA TERPINEOL FROM TURPENTINE-DERIVED PINUS MERKUSII WASTE USING p-TOLUENE SULFONIC ACID CATALYST Berghuis, Nila Tanyela; Sari, Nurul Puspita
al Kimiya: Jurnal Ilmu Kimia dan Terapan Vol 11, No 2 (2024): al Kimiya: Jurnal Ilmu Kimia dan Terapan
Publisher : Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ak.v11i2.39786

Abstract

Pine tree sap can be distilled to produce gondorukem and turpentine with alpha-pinene as the primary compound (65-85%). The alpha-pinene contained in turpentine can be reacted with alcohol to produce alpha terpineol which has a higher selling value. The study aimed was to synthesize alpha terpineol from turpentine derived from processing pine tree sap with varying percentages of p- toluenesulfonic acid (p-TSA) catalyst (5, 10, 15%), reaction time (2, 4, 6 hours), and by comparing extracted and commercial turpentine as starting materials. The alpha-terpineol yields for a 10% catalyst were 53,515%; 54.28%; 62.08% and 15% catalyst amounting to 89.24%; 89.68%; 91.95%, as well as 15% catalyst with turpentine extraction of 92.96%. The densities for 10% alpha terpineol catalyst were 0.969 g/mL, 0.971 g/mL, and 0.969g/mL and with 15% catalyst were 0.969 g/mL, 0.972 g/mL, and 0.971 g/mL. The results of FTIR analysis for alpha terpineol samples with 10 and 15% catalyst for 2, 4 and 6 hours showed the presence of O-H and C-O functional groups. GC-MS analysis for alpha terpineol levels was obtained at 25.88% (10% catalyst) and 24.52% (15% catalyst). Several component compounds were obtained, namely 1-Cyclopentene-1-methanol, alpha, 4,5-tetramethyl-, trans.
ANTIBACTERIAL POTENTIAL OF Nicotiana tabacum LEAVES EXTRACTS AND THEIR ANTIOXIDANT ACTIVITIES Putri, Devi Anggraini; Fahmi, Norma Farizah; Mawli, Rizka Efi; Fatmawati, Sri
al Kimiya: Jurnal Ilmu Kimia dan Terapan Vol 11, No 2 (2024): al Kimiya: Jurnal Ilmu Kimia dan Terapan
Publisher : Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ak.v11i2.39227

Abstract

Nicotiana tabacum, recognized as tobacco, has been reported its secondary metabolites and biological activities in the past decade. Madura is one of the islands in Indonesia that produces N. tabacum rapidly. In Madura, N. tabacum is called as bhekoh. Previously, antioxidant activity of N. tabacum leaves extracts has been reported. However, the extracts showed very low antioxidant activity due to low of the stock concentration. Accordingly, this research was aimed at the antibacterial and antioxidant evaluation of N. tabacum leaves from Madura with improvement of the concentration. Furthermore, N. tabacum leaves were extracted by using different solvents including n-hexane, dichloromethane, ethyl acetate, acetone, and methanol. The extracts have been evaluated their antibacterial activities by using colorimetric resazurin microtiter assay (REMA) method. The extracts have been assayed their antibacterial activities against both gram-positive and negative bacteria. While, the antioxidant evaluation has been determined by using 2,2-diphenyl-1-picryl-hydrazyl (DPPH) method. The result showed that the extracts have fine antibacterial and antioxidant activities. The methanol extract presented antioxidant activity with IC50 of 12.12 ppm compared to gallic acid as a standard. Furthermore, the acetone extract showed the highest antibacterial activity against Bacillus subtilis, Propionibacterium acnes, and Salmonella typhi with MIC of 0.31, 0.63, and 0.63 mg/mL, respectively, compared to ampicillin as a standard. In conclusion, the acetone and methanol extracts have the highest antibacterial and antioxidant activities. Therefore, our result suggested acetone and methanol extracts of N. tabacum leaves as antibacterial and antioxidant agents.