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Contact Name
Assyifa Junitasari
Contact Email
assyifajunitasari@uinsgd.ac.id
Phone
+6281287749909
Journal Mail Official
alkimiya@uinsgd.ac.id
Editorial Address
Department of Chemistry, Faculty of Science and Technology Building, UIN Sunan Gunung Djati Bandung, A.H. Nasution Street No. 105 Bandung 40614
Location
Kota bandung,
Jawa barat
INDONESIA
al Kimiya : Jurnal Ilmu Kimia dan Terapan
ISSN : 24071897     EISSN : 24071927     DOI : http://doi.org/10.15575/ak
The scope of al Kimiya Jurnal Ilmu Kimia dan Terapan s publication included general studies and special studies The general studies are pure chemistry in general and in specific fields as follows Study of inorganic organic and biochemical substances materials that have traditionally been successively entered into studies of inorganic chemistry organic chemistry and biochemistry. Some examples of specific topics from the study of these substances are bioanorganic bioorganic organometallic heterogeneous catalysts transition metal chemistry and coordination chemistry (complex) metabolism enzymology natural material chemistry and solids. Study of the physical and chemical properties of matter and their changes that have traditionally entered into the study of physical chemistry. Some examples of specific topics from this study are reaction kinetics and mechanisms surface chemistry polymers dyes, thermo dynamics chemistry theoretical chemistry and computation membrane catalysis radiochemistry electrochemistry photochemistry and spectroscopy. Experimental studies and chemical instrumentation that have traditionally entered into analytic chemistry studies. Some examples of specific topics from this study are spectroscopy microscopy and chromatography. Specific studies that can be raised in the publication of al-Kimiya in general are as follows Study of applied chemistry in the field of food. Some examples of specific topics from this study are proteins lipids carbohydrates vitamins minerals enzymes additives food coloring agents and food chemical technologies related to these topics. Study of applied chemistry in the energy field. Some examples of specific topics from this study are photochemistry cell chemistry fuel biomass petroleum and natural gas fuels renewable chemical energy sources and chemical energy conversion Study of applied chemistry in the field of environment. Some examples of specific topics from this study are soil chemistry aquatic chemistry atmospheric chemistry green chemistry toxicology and water treatment. Pure chemistry studies as well as applied in the problem of local wisdom. This study was inspired by the lack of habits traditions in local tribe customs or culture related to the use of substances from nature. Back to Nature can be the ultimate term to describe the contribution of culture to modern traditions that are more prudent in managing nature. Pure and applied chemistry studies to understand the universality values of Islam rahmatan lil alamin.
Articles 163 Documents
THE ARTIFICIAL NOSE-BASED PMMA-rGO COMPOSITE COATED QCM SENSOR TO SNIFF COFFEE AROMA AT DIFFERENT ROASTING DEGREE Nalle, Ferry Chrismiadi; Sabarudin, Akhmad; Sakti, Setyawan Purnomo
al Kimiya: Jurnal Ilmu Kimia dan Terapan Vol 11, No 2 (2024): al Kimiya: Jurnal Ilmu Kimia dan Terapan
Publisher : Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ak.v11i2.40381

Abstract

The quality of a product, including coffee, can be determined by its aroma, which is influenced by various chemical compounds. Human olfactory-based assesment and other technologies have been developed to assess coffee aroma; however, these methods are often costly and require highly trained professionals. Gravimetric-based sensors, such as quartz crystal microbalance (QCM) sensors, offer high sensitivity, ease of use, and the capacity to modify their effective surface with nanomaterials. In this research, an artificial nose-based QCM sensor has been modified using a material-sensitive polymethyl methacrylate-reduced graphene oxide (PMMA-rGO) composite.The composite materials were synthesised using an in-situ polymerisation method in the presence of dual solvent. IR characterisation revealed PMMA and PMMA-rGO spectra to be highly similar, suggesting successful trapping of rGO within the PMMA matrix via physical interaction. Increasing the content of rGO resulted in a slight increase in the surface roughness of the QCM sensor.The composite-based QCM sensor demonstrated the capacity to detect coffee aroma at three distinct roasting temperatures (220℃, 225℃, and 230 ℃). The highest response was observed in sample PR1, with a value of -35.2 Hz (220℃), -44.3 Hz (225℃), and -83 Hz (230℃) for the variation in the amount of rGO in the polymer matrix. The presence of rGO with their surface area properties enhanced the QCM sensor to detect coffee aroma.
EFFECT OF ACIDITY, BASICITY, HETEROGENEOUS CaO/SILICA GEL CATALYST FROM BIOMASS WASTE ON BIODIESEL YIELD FROM CRUDE PALM OIL Mulyani, Yenni; Nurhayati, Nurhayati; Awaluddin, Amir
al Kimiya: Jurnal Ilmu Kimia dan Terapan Vol 11, No 2 (2024): al Kimiya: Jurnal Ilmu Kimia dan Terapan
Publisher : Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ak.v11i2.39301

Abstract

The global energy sector has been dominated by non-renewable fossil fuels, prompting many countries to invest in renewable energy sources such as biodiesel. Crude palm oil (CPO), as a biodiesel feedstock, has a high FFA content, which can cause saponification reactions. This can reduce the quality of biodiesel if only CaO catalyst is used. Therefore, acid catalysts such as silica gel are needed to overcome this problem. Silica gel can also improve the stability, reactivity, and effectiveness of CaO catalyst in biodiesel production. This study aims to synthesize and characterize the heterogeneous CaO/silica gel catalyst obtained from biomass waste, and evaluate its activity in the conversion of CPO into biodiesel. The CaO/silica gel hybrid catalyst was prepared by wet impregnation method with varying percentage of silica gel (5%, 10%, and 15%), which was synthesized from coconut husk using sol-gel method, and mixed with CaO from calcination of blood clam shells at 900°C for 5 hours. The basicity characterized using the acid-base titration method, while the acidity was analyzed using pyridine adsorption method with FTIR, and the surface area was analyzed by BET method. The results showed that the synthesis of CaO/silica gel was successful, with confirmation of FTIR data at specific wavelengths. The addition of silica gel increased the acidity and surface area and decreased the basicity of CaO catalyst, with 10% CaO/silica gel showing optimal acidity and surface area. Testing the catalyst activity in the reaction of biodiesel formation from CPO produced the highest biodiesel yield of 96.71% using CaO/silica gel 10%. The conclusion of this study is that biomass waste-based heterogeneous catalysts have high potential for biodiesel production, which is influenced by their acidity and surface basicity, and offer a low-cost and environmentally friendly solution.
CYTOTOXIC ANALYSIS OF CAPSAICINOID COMPOUND FROM ROTTEN AND FRESH Capsicum frutescens L. ON T47D CELLS Abrilia, Putri Riza; Hayati, Elok Kamilah; Kadarani, Deva Krisna
al Kimiya: Jurnal Ilmu Kimia dan Terapan Vol 11, No 2 (2024): al Kimiya: Jurnal Ilmu Kimia dan Terapan
Publisher : Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ak.v11i2.40821

Abstract

Cayenne pepper has a distinctive spicy and hot taste that indicates the presence of capsaicinoid compounds. The content of capsaicinoid compounds is thought to increase along with the level of maturity. This study aims to distinguish between the capsaicinoid content in Rotten Capsicum Frutescens (RCF) and fresh Capsicum Frutescens (FCF) samples and their use as anticancer agents. Capsaicinoid extraction was performed by using reflux extraction and the identification processes using Thin Layer Chromatography (TLC) with a chloroform:methanol eluent. Identification was conducted by using Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy (ATR-FTIR) while a cytotoxicity test on T47D breast cancer cells was conducted using the Methylthiazol Tetrazolium (MTT) assay. The results showed the presence of a capsaicinoid compound group, with Retardation Factor (Rf) values of 0.76 in RCF and 0.72 in FCF, as well as orange spots due to its reaction to Dragendorff's reagent. ATR-FTIR analysis was able to identify some of typical functional groups typical of capsaicinoid, including -OH, CH3, CH2 (stretching), C=O, C=C, -CH2- (bending), C-N, C-O, O-CH3, and -NH with the intensity value of RCF greater than FCF. The cytotoxicity test results showed that the Inhibition Concentration (IC50) value for RCF isolates was 512.37 µg/mL, while for FCF isolates was1386.82 µg/mL. These results indicate that capsaicinoid isolates from RCF have a higher cytotoxicity compared to isolates from FCF. A higher IC50 value corresponds to lower cytotoxic activity.
IDENTIFICATION OF ACTIVE COMPOUNDS AND FORMULATION AS AN ANTISEPTIC MOUTHWASH FROM THE PLANT Cassia fistula L. AS A PREVENTIVE MEASURE AGAINST DENTAL AND ORAL DISEASES CAUSED BY THE BACTERIA Enterococcus faecalis Romundza, Febbry; Harizon, Harizon
al Kimiya: Jurnal Ilmu Kimia dan Terapan Vol. 11 No. 2 (2024): al Kimiya: Jurnal Ilmu Kimia dan Terapan
Publisher : Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ak.v11i2.38474

Abstract

A compound with the molecular formula C15H24O has been identified as Caryophyllenol-II through analysis using HR-TOF-MS, IR, and NMR spectroscopy. The ¹³C-NMR spectrum indicates that this compound is a bicyclic sesquiterpenoid, characterized mainly by the presence of a hydroxyl group replacing an epoxide ring and the addition of an olefinic bond. The relationship between the compounds analyzed from Cassia fistula L. and their antibacterial activity against Enterococcus faecalis can be explained through the identification of bioactive compounds with specific mechanisms to inhibit or kill the bacteria. Compounds from Cassia fistula L. have significant potential as an antibacterial agent against Enterococcus faecalis, particularly through membrane disruption and bacterial enzyme inhibition mechanisms. Further research on their role, either individually or in combination with other compounds, could support the development of C. fistula-based antiseptic products, such as mouthwash, for the prevention and treatment of oral and dental diseases. Additionally, this research explores the antibacterial potential of Cassia fistula L. in developing an antiseptic mouthwash. Extracts from Cassia fistula L. are known to contain active compounds such as flavonoids, alkaloids, and tannins, which demonstrate effectiveness against Enterococcus faecalis, as a primary cause of dental and oral infections. The mouthwash formulation based on this extract was tested in vitro and proposed as a natural and safer alternative compared to synthetic chemical-based products for the prevention of dental and oral infections. This study indicates the significant potential of Cassia fistula L. in supporting oral health through effective antiseptic products. These findings support the use of traditional medicinal plants like Cassia fistula L. as a source of active compounds for the development of effective natural antiseptics and have the potential to reduce dependence on synthetic antiseptics while also promoting economic empowerment through simple industries.
ANTIBACTERIAL POTENTIAL OF Nicotiana tabacum LEAVES EXTRACTS AND THEIR ANTIOXIDANT ACTIVITIES Putri, Devi Anggraini; Fahmi, Norma Farizah; Mawli, Rizka Efi; Fatmawati, Sri
al Kimiya: Jurnal Ilmu Kimia dan Terapan Vol. 11 No. 2 (2024): al Kimiya: Jurnal Ilmu Kimia dan Terapan
Publisher : Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ak.v11i2.39227

Abstract

Nicotiana tabacum, recognized as tobacco, has been reported its secondary metabolites and biological activities in the past decade. Madura is one of the islands in Indonesia that produces N. tabacum rapidly. In Madura, N. tabacum is called as bhekoh. Previously, antioxidant activity of N. tabacum leaves extracts has been reported. However, the extracts showed very low antioxidant activity due to low of the stock concentration. Accordingly, this research was aimed at the antibacterial and antioxidant evaluation of N. tabacum leaves from Madura with improvement of the concentration. Furthermore, N. tabacum leaves were extracted by using different solvents including n-hexane, dichloromethane, ethyl acetate, acetone, and methanol. The extracts have been evaluated their antibacterial activities by using colorimetric resazurin microtiter assay (REMA) method. The extracts have been assayed their antibacterial activities against both gram-positive and negative bacteria. While, the antioxidant evaluation has been determined by using 2,2-diphenyl-1-picryl-hydrazyl (DPPH) method. The result showed that the extracts have fine antibacterial and antioxidant activities. The methanol extract presented antioxidant activity with IC50 of 12.12 ppm compared to gallic acid as a standard. Furthermore, the acetone extract showed the highest antibacterial activity against Bacillus subtilis, Propionibacterium acnes, and Salmonella typhi with MIC of 0.31, 0.63, and 0.63 mg/mL, respectively, compared to ampicillin as a standard. In conclusion, the acetone and methanol extracts have the highest antibacterial and antioxidant activities. Therefore, our result suggested acetone and methanol extracts of N. tabacum leaves as antibacterial and antioxidant agents.
EFFECT OF ACIDITY, BASICITY, HETEROGENEOUS CaO/SILICA GEL CATALYST FROM BIOMASS WASTE ON BIODIESEL YIELD FROM CRUDE PALM OIL Mulyani, Yenni; Nurhayati, Nurhayati; Awaluddin, Amir
al Kimiya: Jurnal Ilmu Kimia dan Terapan Vol. 11 No. 2 (2024): al Kimiya: Jurnal Ilmu Kimia dan Terapan
Publisher : Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ak.v11i2.39301

Abstract

The global energy sector has been dominated by non-renewable fossil fuels, prompting many countries to invest in renewable energy sources such as biodiesel. Crude palm oil (CPO), as a biodiesel feedstock, has a high FFA content, which can cause saponification reactions. This can reduce the quality of biodiesel if only CaO catalyst is used. Therefore, acid catalysts such as silica gel are needed to overcome this problem. Silica gel can also improve the stability, reactivity, and effectiveness of CaO catalyst in biodiesel production. This study aims to synthesize and characterize the heterogeneous CaO/silica gel catalyst obtained from biomass waste, and evaluate its activity in the conversion of CPO into biodiesel. The CaO/silica gel hybrid catalyst was prepared by wet impregnation method with varying percentage of silica gel (5%, 10%, and 15%), which was synthesized from coconut husk using sol-gel method, and mixed with CaO from calcination of blood clam shells at 900°C for 5 hours. The basicity characterized using the acid-base titration method, while the acidity was analyzed using pyridine adsorption method with FTIR, and the surface area was analyzed by BET method. The results showed that the synthesis of CaO/silica gel was successful, with confirmation of FTIR data at specific wavelengths. The addition of silica gel increased the acidity and surface area and decreased the basicity of CaO catalyst, with 10% CaO/silica gel showing optimal acidity and surface area. Testing the catalyst activity in the reaction of biodiesel formation from CPO produced the highest biodiesel yield of 96.71% using CaO/silica gel 10%. The conclusion of this study is that biomass waste-based heterogeneous catalysts have high potential for biodiesel production, which is influenced by their acidity and surface basicity, and offer a low-cost and environmentally friendly solution.
EVALUATION OF MICROSPHERE OF POLY(LACTIC ACID) AS CELECOXIB CARRIER nurhayati, lany; Achmadi, Suminar S.; Sudaryanto, Sudaryanto
al Kimiya: Jurnal Ilmu Kimia dan Terapan Vol. 11 No. 2 (2024): al Kimiya: Jurnal Ilmu Kimia dan Terapan
Publisher : Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ak.v11i2.39310

Abstract

Celecoxib, cyclooxygenase-2 inhibitor approved for the management of rheumatism and osteoarthritis. Celecoxib is a Biopharmaceutics Classification System (BCS) class II compound whose oral bioavailability is highly limited owing to its poor aqueous solubility. Microencapsulation is very helpful to increase the solubility and slow the release of drugs. For the drugs of BCS Class-II, we use this technique which enables us to get more solubility and increase dissolution profile. The present study aims to reduce the drug’s negative effect and boost its bioavailability. Poly(lactic acid) (PLA) a biodegradable polymer microsphere that can be synthesized to encapsulate celecoxib, was prepared by solvent evaporation with chloroform were used. The characterized surface morphology, drug entrapment efficiency (DDE), and in vitro drug release. Morphology was studied by scanning electron microscopy (SEM), crystallinity was studied using an X-ray diffractometer (XRD), and drug release was spectrophotometer UV-Vis. The results were observed to indicate there were microspheres homogeneous in the distribution of celecoxib in the polymer matrix. Formulations indicated that DEE was between 55.80 and 70.70% with prolonged length microspheres in the 10-30 µm range. Study in vitro drug release, when placed in phosphate buffer (pH 7.4) containing 2% w/w Tween 80 solvent, there was an initial burst of drug release within the first two hours followed by constant drug release. The PLA microsphere can release the confined celecoxib gradually but does not follow a controlled diffusion mechanism, but rather a mechanism of expansion and erosion of the microsphere matrix.
RAW STARCH-DEGRADING AMYLASE FROM BACTERIA IN KARANG MUMUS RIVER, SAMARINDA Astuti, Winni; Adawiyah, Rabiatul; Putri, Amanda Aulia; Pratiwi, Djihan Ryn
al Kimiya: Jurnal Ilmu Kimia dan Terapan Vol. 11 No. 2 (2024): al Kimiya: Jurnal Ilmu Kimia dan Terapan
Publisher : Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ak.v11i2.39438

Abstract

Raw starch-degrading amylase (RSDA) is an enzyme that has the ability to degrade starch granules into glucose without undergoing gelatinization. This research was conducted to explore and characterize extracellular RSDA-producing bacteria from body water of the Karang Mumus River, Samarinda. RSDA activity was analyzed qualitatively in nutrient agar containing 1% starch granules, bacterial colonies with RSDA activity are clear halos around bacterial colonies after the plates were flooded with iodine solution. Five of the 14 bacterial colonies secreted an RSDA extracellularly. The RSDA enzyme from the 5 bacteria was tested for amylase activity using the Dinitrosalicylic Acid (DNS) method. Bacteria with colony code KM 5 had the highest RSDA activity of 0.332 U/mL.The optimum working conditions for RSDA are at pH 5 and a temperature of 40°C. Identification of bacterial genotypes using the 16S rRNA gene showed that KM5 was Klebsiella sp, referred to as Klebsiella KM5.
SYNTHESIS AND CHARACTERIZATION OF ALPHA TERPINEOL FROM TURPENTINE-DERIVED PINUS MERKUSII WASTE USING p-TOLUENE SULFONIC ACID CATALYST Berghuis, Nila Tanyela; Sari, Nurul Puspita
al Kimiya: Jurnal Ilmu Kimia dan Terapan Vol. 11 No. 2 (2024): al Kimiya: Jurnal Ilmu Kimia dan Terapan
Publisher : Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ak.v11i2.39786

Abstract

Pine tree sap can be distilled to produce gondorukem and turpentine with alpha-pinene as the primary compound (65-85%). The alpha-pinene contained in turpentine can be reacted with alcohol to produce alpha terpineol which has a higher selling value. The study aimed was to synthesize alpha terpineol from turpentine derived from processing pine tree sap with varying percentages of p- toluenesulfonic acid (p-TSA) catalyst (5, 10, 15%), reaction time (2, 4, 6 hours), and by comparing extracted and commercial turpentine as starting materials. The alpha-terpineol yields for a 10% catalyst were 53,515%; 54.28%; 62.08% and 15% catalyst amounting to 89.24%; 89.68%; 91.95%, as well as 15% catalyst with turpentine extraction of 92.96%. The densities for 10% alpha terpineol catalyst were 0.969 g/mL, 0.971 g/mL, and 0.969g/mL and with 15% catalyst were 0.969 g/mL, 0.972 g/mL, and 0.971 g/mL. The results of FTIR analysis for alpha terpineol samples with 10 and 15% catalyst for 2, 4 and 6 hours showed the presence of O-H and C-O functional groups. GC-MS analysis for alpha terpineol levels was obtained at 25.88% (10% catalyst) and 24.52% (15% catalyst). Several component compounds were obtained, namely 1-Cyclopentene-1-methanol, alpha, 4,5-tetramethyl-, trans.
THE ARTIFICIAL NOSE-BASED PMMA-rGO COMPOSITE COATED QCM SENSOR TO SNIFF COFFEE AROMA AT DIFFERENT ROASTING DEGREE Nalle, Ferry Chrismiadi; Sabarudin, Akhmad; Sakti, Setyawan Purnomo
al Kimiya: Jurnal Ilmu Kimia dan Terapan Vol. 11 No. 2 (2024): al Kimiya: Jurnal Ilmu Kimia dan Terapan
Publisher : Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ak.v11i2.40381

Abstract

The quality of a product, including coffee, can be determined by its aroma, which is influenced by various chemical compounds. Human olfactory-based assesment and other technologies have been developed to assess coffee aroma; however, these methods are often costly and require highly trained professionals. Gravimetric-based sensors, such as quartz crystal microbalance (QCM) sensors, offer high sensitivity, ease of use, and the capacity to modify their effective surface with nanomaterials. In this research, an artificial nose-based QCM sensor has been modified using a material-sensitive polymethyl methacrylate-reduced graphene oxide (PMMA-rGO) composite.The composite materials were synthesised using an in-situ polymerisation method in the presence of dual solvent. IR characterisation revealed PMMA and PMMA-rGO spectra to be highly similar, suggesting successful trapping of rGO within the PMMA matrix via physical interaction. Increasing the content of rGO resulted in a slight increase in the surface roughness of the QCM sensor.The composite-based QCM sensor demonstrated the capacity to detect coffee aroma at three distinct roasting temperatures (220℃, 225℃, and 230 ℃). The highest response was observed in sample PR1, with a value of -35.2 Hz (220℃), -44.3 Hz (225℃), and -83 Hz (230℃) for the variation in the amount of rGO in the polymer matrix. The presence of rGO with their surface area properties enhanced the QCM sensor to detect coffee aroma.