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INDONESIA
Jurnal Kefarmasian Indonesia
Published by Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan
ISSN : 2085675X     EISSN : 23548770     DOI : -
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology
Pharmaceutical Technology, Pharmacology, Pharmaceutical Chemistry, Traditional Medicines, and Pharmaceutical Care.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 269 Documents
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Optimasi Formula Mikroenkapsulasi Ekstrak Rimpang Temulawak (Curcuma xanthorrhiza Roxb.) dengan Penyalut Berbasis Air Nugraheni, Ade; Yunarto, Nanang; Sulistyaningrum, Novi
Jurnal Kefarmasian Indonesia VOLUME 5, NOMOR 2, AGUSTUS 2015
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v5i2.3692

Abstract

Java turmeric (Curcuma xanthorrhiza Roxb.) is a native plant of Indonesia which has been proved as anti-inflamation, antioxidant, antimicrobial, antitumor, hepatoprotective and antihyperlipidemic agent. The bitter taste with pungent aroma of java turmeric, improper storage that decreasing essential oil and curcuminoid level can be prevented by coating java turmeric as microcapsule. Recently, many microcapsule formulation is made based on organic solvent which have high risk on toxicity and also flammable. The study aimed to produce microcapsule using water based coating material from mixture of tapioca starch and carboxymethylceIlulose (CMC). There are 3 formulas of coating material that were used in this study, with proportion (w/v) of tapioca starch and CMC in formula I (3% : 1 %), formula II (2% : 2 %), and formula III (1% : 3%). The results showed that microcapsule with coating material made from formula III was the best, regarding to the measurements of physical parameter (recovery, water content, absorption efficiency, flow rate and particle size) and chemical parameter (curcumin content) compared to formula I and II. The higher CMC concentration on coating material compotition, the better microcapsule will be produced.
Deskripsi Hasil Uji Angka Lempeng Total (ALT) Pada Beberapa Susu Formula Bayi Puspandari, Nelly; Isnawati, Ani
Jurnal Kefarmasian Indonesia VOLUME 5, NOMOR 2, AGUSTUS 2015
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v5i2.3693

Abstract

Infant formula is the nutrient source for some babies who were not breastfed. Risk factors for infection in infants less than 6 months old who consume formula are greater than those who were breastfed. This is due to the baby's immune system is not well formed. Therefore, it is important to supervise formula safety more strict than adult’s food. Total plate count (TPC) is one of the factors considered in the infant formula. The aim of this study is to define safety of infant formula based on total plate count within infant formula distributed in Indonesia in 2011. The study was a cross sectional study. The samples were representative of infant formula distributed in 23 province. Total plate count method and interpretation were conducted based on ISO/TS 22964. The TPC of each samples were examined three times. The TPC of all infant formulas were below of SNI breakpoint, which is less than 104cfu/gram. TPC ranged from
Risiko Penggunaan ACEi Terhadap Kejadian Batuk Kering pada Pasien Hipertensi di RSUD Cengkareng dan RSUD Tarakan DKI Jakarta Halim, Margareth Christina; Andrajati, Retnosari; Supardi, Sudibyo
Jurnal Kefarmasian Indonesia VOLUME 5, NOMOR 2, AGUSTUS 2015
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v5i2.3694

Abstract

The use of angiotensin converting enzyme inhibitors (ACEi) as an antihypertensive agent can cause side effects such as dry cough. The aim of this study is to evaluate risk of ACEi administration on dry cough incidence with captopril as the standard against lisinopril and ramipril in hypertensive patients at RSUD Cengkareng and RSUD Tarakan Jakarta. The design of this study is prospective cohort. The inclusion criteria were patients who received ACEi as hypertension therapy for ≤ 3 months gathered from outpatient and willing to participate as sample in this study at RSUD Cengkareng and RSUD Tarakan. Subject of this study consist of 54 patients who received captopril and 54 patients received non captopril ACEi, taken by consecutive sampling from January-July 2014. Data was collected using structured interviews and medical record. Dry cough incidence due to ACEi was evaluated using Naranjo Algorithm and analyzed using Chi Square test. Dry cough incidence was found in 19,44% of sample. No significant relationship of age, gender, ethnic, comorbidity, body mass index (BMI), dosage, and duration of use with the dry cough incidence due to the use of ACEi. There is no difference on dry cough incidence between the use of captopril, lisinopril and ramipril.
Tradisi Masyarakat dalam Penanaman dan Pemanfaatan Tumbuhan Obat Lekat di Pekarangan Sari, Ida Diana; Yuniar, Yuyun; Siahaan, Selma; Riswati, Riswati; Syaripuddin, Muhamad
Jurnal Kefarmasian Indonesia VOLUME 5, NOMOR 2, AGUSTUS 2015
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v5i2.3695

Abstract

Home yard has been used to plant certain medicinal plants, also as known as TOGA program. This research was aimed to study the implementation of TOGA program and community tradition in planting and using medicinal plants. A qualitative research was conducted in West Java, Central Java, East Java and Bali which based on National Basic Health Research 2010 data had the highest percentage of jamu usage. Data was collected in 2011 through in depth interview and focus group discussion with related stakeholder and observation in research location. Result in Bogor district showed TOGA program has been included in Family Welfare Development Program and similar program was also developed in some villages. There was no certain TOGA program in Karanganyar, Sumenep and Gianyar districts. TOGA program in Karanganyar was inserted in other program due to economic needs while in Gianyar the program was originated from ornamental plants. The community usually used medicinal plants for the prime medication before going to health facility. Planting medicinal plants is an inherited tradition where parents become the main source of planting and usage information. The Agriculture Office and village officials had more significant roles to guide the community while the Health office only suggested or monitored them.
Formulation and Evaluation of Mangosteen (Garcinia mangostana L.) Fruit Pericarp Extract Gel Kuswahyuning, Rina; Lesmana, Indra
Jurnal Kefarmasian Indonesia VOLUME 11, NOMOR 2, AGUSTUS 2021
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v11i2.3701

Abstract

The topical antioxidant product may be useful for the treatment of oxidative stress-related skin disorder. This research aimed to evaluate a topical gel formulation of Garcinia mangostana L. fruit pericarp (GMP) extract. GMP extract was formulated into a gel and characterized for its physical properties. The antioxidant activity was evaluated based on the radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity. The ability of gel formulation to release GMP extract and promote skin delivery was estimated based on DPPH scavenging method and also compared to that of suspension form. The results showed that the GMP extract gel showed characteristics for topical application. The radical DPPH scavenging activity was confirmed both in GMP extract and GMP extract gel. In vitro study release showed that the GMP extract was released from gel. Some degree of GMP extract was also delivered into the shed snakeskin in vitro. When compared with the suspension form, GMP extract gel provided a more profoundly lower release.
Efek Pemberian Ekstrak Etanol Akar Kolesom (Talinum triangulare Willd) terhadap Spermatogenesis Tikus Putih Nugroho, Yun Astuti; Rahayu, Lestari; Susanti, Ratna Indah
Jurnal Kefarmasian Indonesia VOLUME 2, NOMOR 1, FEBRUARI 2012
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v2i1.3713

Abstract

In Indonesia infertility is still a problem for married couples, because 10-15% of married couples suffer from infertility. Infertility can be caused by the husband and wife, but in reality 40-60% are caused by the husband. Data infertility based on analysis of cement, which is one important way to determine the level of male fertility. Cement circumstances that can cause infertility, among others, the less the number of spermatozoa, sperm motility is low, the velocity of spermatozoa and so on. Kolesom (Talinum triangulare Willd) can increase the number and motility of spermatozoa and to increase testosterone levels. The study aims to determine the effect of kolesom root extract on spermatogenesis of male Wistar rats. The effect of kolesom root extract on spermatogenesis using the WHO (2000) with animal white mouse. 225 doses of ethanol extract; 675 and 2025 mg / kg. administered orally for 45 days. Distilled water as a control and comparative dosage Korean Ginseng 225 mg / kg. The results of the study, kolesom extract doses 225; 675 and 2025 mg / kg BB given for 45 days did not lose reproductive organ testis and epididymis can still increase the number of A spermatogonia, pachytene stage primary spermatocytes and the diameter of seminiferous.
Kajian Potensi Penggunaan Bioreaktor terhadap Senyawa Ajmalisin Suatu Contoh Produksi Metabolit Sekunder Tanaman Obat Saraswati, Ratih Dian
Jurnal Kefarmasian Indonesia VOLUME 2, NOMOR 1, FEBRUARI 2012
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v2i1.3714

Abstract

The limited availability of medicinal plants as well as their limitations in cultivation as a source of medicinal compounds can lead to excessive harvesting, habitat destruction and destructive exploration. This led to the extinction of rare plants and caused the condition of natural resources worse. The purpose of this study is to elucidate the potential of bioreactor in terms of its ability to increase the active compounds of plant obtained from C. roseus ajmalicine. The data was obtained from various references. The main references discuss about ajmalicine and bioreactor.In general, the concentration of compounds produced by cell suspension is higher than its original concentration in the plants. In study cases of ajmalicine, the compounds were produced as much as seven times more than these compounds in native plants. Other studies show that the use of different plant organs, the addition of elicitor, the weight ofinitial cells as well as aeration rate can affect the concentration of ajmalicine obtained from medium in the bioreactor. Tissue cultured plants in bioreactor can produce secondary metabolites in a short time with high yields. However, previous optimazation should be carried out in terms of adding elicitor, aeration rate and pH condition of the bioreactor
Tingkat Aktivitas Sel Endokrin Penghasil Folikel Stimulating Hormon (FSH) Terkait Pemberian Pasak Bumi (Eurycoma Longifolia JACK) Pratomo, Hurip; Supriatna, Iman; Winarto, Adi; Manalu, Wasmen
Jurnal Kefarmasian Indonesia VOLUME 2, NOMOR 1, FEBRUARI 2012
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v2i1.3715

Abstract

Pasak bumi is popular as an aphrodisiac. Traditionally, pasak bumi infusion is used to increase libido and duration of erection. The research was focused on: Activity level of FSH cells after three days of pasak bumi treatment. The research was carried out by evaluation using immunohistochemistry method via antibody anti FSH staining. The result of the research showed that a dosage of 18 mg/200 g body weight (bw) orally of pasak bumi maintained certain endoceine positive cells e.g. FSH production cells and were found stabile in the third days. Pasak bumi serves a stabilizer for intracellular levels of FSH in the anterior hipophysis/pituatary.
Isolasi Biflavonoid Baru dari Garcinia tetranda Pierre Berdasarkan Jalur Biogenesis dan Aktivitas terhadap Antibakteri Sulistyaningrum, Novi; Ersam, Taslim
Jurnal Kefarmasian Indonesia VOLUME 2, NOMOR 1, FEBRUARI 2012
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v2i1.3716

Abstract

Garcinia tetranda Pierre (Clusiaceae) is a plant that is widely used to treat various diseases and its chemical compounds has not been much studied. Compound isolation using the three methods of chromatography (Vacuum Liquid Chromatography Column (VLCC), preparative Thin Layer Chromatography (pTLC) and TLC) generate novel compound 5,7,4 ', 5'', 7'', 3''', 4 '''-heptahidroksi-2'''-methoxy-flavanon [ 3,8 ]-flavone'' which is different from the compounds that had been found previously in Garcinia tetranda Pierre. Structure identification was conducted using UV, IR and NMR spectroscopic data and by comparing the 13C and 1H-NMR data of the isolate compound and known biflavonoid compounds. Biogenesis pathway analysis of the new compound showing relationship with molecular compounds which have previously been found in Garcinia. Antibacterial test of the novel compound using Kirby-Bauer agar diffusion methode against Gram-negative bacteria Salmonella typhi showed that the compound is not potentially used as antibacterial agent compared to chloramphenicol.
Analisis Biaya Tuberkulosis Paru Kategori Satu Pasien Dewasa di Rumah Sakit di DKI Jakarta Sari, Ida Diana; Herman, Max Joseph; Susyanty, Andi Leny; Su'udi, Amir
Jurnal Kefarmasian Indonesia VOLUME 8, NOMOR 1, FEBRUARI 2018
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v8i1.3718

Abstract

In 2014, new TB sufferers in Indonesia reached 324,579. An analysis of the cost aims to calculate the cost of treatment of adult category I pulmonary TB patient and the results obtained. The study was conducted in 5 District General Hospitals in Jakarta in 2014 with new adult TB patients treated as samples. Patients’ and attendants’ characteristics, the costs incurred, and treatment outcome were collected through in-depth interviews at every visit for 6 months. The results showed that 64,5% of patients are men aged between 18-70 years and 80,6% of patients using the BPJS. The number of visits for 6 months is 10 times in average (ideally 16 times). With a utilization of hospital by 10 times, then the total direct costs amount to Rp1.228.867, the total indirect costs are Rp614.670, and the total costs of the overall TB treatment are Rp1.843.537 with an average of Rp307.256 per month. The largest components of direct costs are the cost of the drug and the largest component of indirect costs are the cost of TB patient’s attendants. Drug compliance (68,9%) and being cured (41,9%) of TB patients treated for 6 months are far from expectations.

Page 15 of 27 | Total Record : 269

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