cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Nanang Yunarto
Contact Email
jurnalkefarmasian@gmail.com
Phone
+628156867400
Journal Mail Official
jurnalkefarmasian@gmail.com
Editorial Address
Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan Kementerian Kesehatan RI Jl. Percetakan Negara No. 23 - Jakarta 10560
Location
Kota adm. jakarta pusat,
Dki jakarta
INDONESIA
Jurnal Kefarmasian Indonesia
Published by Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan
ISSN : 2085675X     EISSN : 23548770     DOI : -
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology
Pharmaceutical Technology, Pharmacology, Pharmaceutical Chemistry, Traditional Medicines, and Pharmaceutical Care.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 269 Documents
 11   12   13   14   15 
Uji Toksisitas Subkronik Kombinasi Ekstrak Daun Uncaria gambir dan Caesalpinia sappan Ningsih, Sri; Agustini, Kurnia; Nizar, Nizar; Damayanti, Rini
Jurnal Kefarmasian Indonesia VOLUME 7, NOMOR 1, FEBRUARI 2017
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v7i1.3483

Abstract

Hiperuresemia prevalence tends to increase in society. A combined extract of Uncaria gambir (gambir) and Caesalinia sappan (secang), had been proven to reduce blood uric acid level in vivo. This study aimed to evaluate the subchronic toxicity of this combination in male and female Sprague Dawley rat strain. Animals were randomly grouped into four groups, namely, DOSE-1 (75 mg/kg bw), DOSE-2 (300 mg/kg bw), DOSE-3 (1200 mg/kg bw) and control group gavaged with carrier. The tested sample was given for 7 weeks orally. The result of blood biochemical parameters were not different significantly compared to control (p> 0.05), as well as the results of hematology analysis. However, the NEUT level of female of DOSIS-2 showed lower and significantly different compared to control (p 0,05). Furthermore, this dose did not influence feed intake and body weight of animals in each sex. From this study, it could be concluded that the combination administrated at the dose of 75 mg/kg bw for 7 consecutive weeks did not affect blood biochemistry and hematology and also organ histopathology of kidney, liver, heart, small intestine, and stomach
Gambaran Cemaran dan Kadar Metil Galat pada Tiga Mutu Ekstrak Gambir (Uncaria gambir Roxb.) Alegantina, Sukmayati; Setyorini, Herni Asih
Jurnal Kefarmasian Indonesia VOLUME 7, NOMOR 1, FEBRUARI 2017
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v7i1.3484

Abstract

Gambir (Uncaria gambirRoxb) is a plant that has many benefits to health such as antioxidants, antihiperlipidemiaandantibacterial. Gambir extract derived from the leaves and twigs of Uncaria gambirRoxb through the process of removing the sap by being boiled, squeezed / compressed, liquid is deposited, molded and dried. During the plant grows, then harvest, process, stored and distributed, it is might contaminated with microbes or chemicals. Based on the requirement issued by BPOM No. 12, 2014 about Traditional Medicine Quality Requirements, it requires us to test the extract that we will use. To determine the contaminant of all three gambir extracts, we tested against yeast fungi figures, total plate count, aflatoxin and heavy metals. Besides that, we also determine content of active compound of methyl gallate which has benefits as an antioxidant with a densitometer. the result shows, there werecontaminants that exceeded the requirements. Contaminants that exceeds the requirement are number of fungi yeasts (7,5.10-6) and aflatoxin G2 (47,38.106ppb) in gambier extract quality 3. The highest content of active compound of methyl gallate was obtained from extracts of gambir quality 3 (2.30%) followed by gambir quality 2 (0.44%) and gambir quality1 (0.14%).
Pemanfaatan Minyak Kayu Putih (Melaleuca leucadendra Linn) sebagai Alternatif Pencegahan ISPA: Sebuah Studi Etnografi di Pulau Buru, Provinsi Maluku Agustina, Zulfa Auliyati; Suharmiati, Suharmiati
Jurnal Kefarmasian Indonesia VOLUME 7, NOMOR 2, AGUSTUS 2017
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v7i2.3486

Abstract

The Acute Respiratory Infections (ARIs) is a disease which commonly infects children. Based on Indonesian basic health research 2013, the national and Buru Island's period prevalence of ARIs were 25% and 24,8%. The other side, cajuput oil has been traditionally used to reduce respiratory tract disorders and infections. This research used the ethnographic approach with observation participation and direct communication to collected the data. The results showed a high number in ARIs cases in Buru Island area were affected by many factors, some of them are the lack of Clean and Healthy Behaviour (PHBS) and had a little faith in health services, especially for people who live in the mountain area. It was because of minimum intervention from public health services. This research showed the Cajuput oil was potentially used as an alternative prevention of ARIs in Buru Island by inhalation method. The main content of Melaleuca leucadendra Linn had a benefit to be the mucolytics, bronchodilator, anti-inflammation and antitussive.
Pengaruh Penghambatan Enzim Siklooksigenase-2 dan Aktivitas Antiinflamasi dari Ekstrak Daun Ketumbar (Coriandrum sativum L.) Ifora, Ifora; Sintia, Bella; Srangenge, Yoneta
Jurnal Kefarmasian Indonesia VOLUME 11, NOMOR 1, FEBRUARI 2021
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v11i1.3487

Abstract

Inflammation is a normal protective response to tissue damage that mediated by Cyclooxygenase-2 (COX-2) enzyme. The enhancement incidence and impact of inflammatory diseases have encouraged the search for new pharmacological strategies to overcome the problem. Ketumbar (Coriandrumsativum L.) has been traditionally used as an anti-inflammatory and antioxidant, thus giving chance for anti-inflammatory studies. This study aims to determine the ethanol extract of Ketumbar (Coriandrumsativum L.) leaves anti-inflammatory activity and inhibitory effect on COX-2 enzyme. This study uses male wistar rats with 180–220 g body weights. The rats is divided into six groups by the dose of 125 mg/kg BW, 250 mg/kg BW, and 500 mg/kg BW; positive control (Carrageenan 1%); negative control (Na. CMC 0,5%); and comparative group (Celecoxib 9 mg/kg BW). Determining the anti-inflammatory activity, the oedema formation is measured using a plethysmometer and the inhibition activity is determined by ELISA methods. The results showed that the ethanol extract of Ketumbar leaves by the dose of 125 mg/kg BW, 250 mg/kg BW, and 500 mg/kg BW was significantly inhibitted COX-2 valued 65,61%, 76,83%, and 62,93%. The anti-inflammatory activity was shown by inhibiting oedema valued of 62.26%, 70.59%, and 54.90% respectively. These findings suggested that the ethanol extract of Ketumbar leaves had anti-inflammatory activity, that was possibly mediated through inhibition of COX-2 enzymes
Pengetahuan, Sikap, dan Perilaku Masyarakat dalam Memilih Obat yang Aman di Tiga Provinsi di Indonesia Siahaan, Selma; Usia, Tepy; Pujiati, Sri; Tarigan, Ingan Ukur; Murhandini, Sri; Isfandari, Sitti; Tiurdinawati, Tiurdinawati
Jurnal Kefarmasian Indonesia VOLUME 7, NOMOR 2, AGUSTUS 2017
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v7i2.3492

Abstract

Medicine is an important component that cannot be replaced in health service. Indonesia National Agency of Drug and Food Control conducted survey to assess knowledge, attitude, and practice (KAP) of communities on selecting safe and quality medicines. The aim of the study is to get description KAP of community in choosing a safe medicine. Data were collected in West Java, DKI Jakarta, and South East Sulawesi. Sampling calculation use probability proportional to size sampling and census block. There were 1271 households as samples that analysed. Data results were analysed using descriptive and index analysis. Knowledge relates to criteria of quality medicines, rules for antibiotics use, and medicines logo. Attitude relates to how to select over the counter medicines, reasons of taking traditional medicines, and opinion about giving half dose of adults medicines to children. Practice relates to source of medicines information, the way to buy prescribe medicines, and reading label information. The results showed that KAP of communities on selecting safe and quality medicines close to 50%. According to score of index analysis are 4.65 (1 to 10 scale), it is recommended that information, education, and communication has to be delivered to communities intensively and continuously by the government.
Uji Aktivitas Antibakteri Ekstrak Etanol Tanaman Obat Suku Musi di Kabupaten Musi Banyuasin, Sumatera Selatan Muharni, Muharni; Fitrya, Fitrya; Farida, Sofa
Jurnal Kefarmasian Indonesia VOLUME 7, NOMOR 2, AGUSTUS 2017
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v7i2.3493

Abstract

Musi tribe community used medicinal plants generally based on cultural heritage. Unproper use of medicinal plants unproperly cause the drug does not work effectively. Ten medicinal plants were selected for antibacterial activity tested using disc diffusion method against two testb bacteria i.e Escherichia coli (E. coli) and Staphylococcus aureus(S. aureus) at concentrations of 125, 250, 500, and 1000 μg/mL. Minimum inhibitory concentration (MIC) were determined for the active extract which still gives antibacterial activity using well method. The result showed only three test extracts, i.e Coleus scutellarioides, Blumea balsamifera and Lantana camara gave inhibition zone diameter of 11-20 mm against E. coli. Meanwhile, four extracts i.e Coleus scutellarioides, Blumea balsamifera, Dillenia alata and Dimocarpus melayensis gave inhibition zone diameter of 11-20 mm against S. aureus. Determination of MIC values for Coleus scutellarioides and Blumea balsamifera extracts gave the same MIC value of 125 μg/mL for both test bacteria. Meanwhile, Lantana camara gave MIC value of 250 ug/mL for E. coli. Dillenia alata and Dimocarpus melayensis also provide MIC value of 125 ug/mL againts E. Coli. It was found that there were five active extracts among ten extracts tested. Two extracts which active against both test bacteria were Coleus scutellarioides and Blumea balsamifera. One extract, Lantana camara only active against E. coli and the two others Dillenia alata and Dimocarpus melayensis were active against S. auerus.
Efek Kapsul Ekstrak Etanol Kulit Buah Delima (Punica granatum L.) terhadap Penanda Pembentukan dan Kualitas Tulang pada Wanita Pascamenopause Handayani, Nur Hayati Dwi; Bahtiar, Anton; Louisa, Melva
Jurnal Kefarmasian Indonesia VOLUME 7, NOMOR 2, AGUSTUS 2017
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v7i2.3494

Abstract

Studies of pomegranate peel (Punica granatum L.), which contain ellagic acid, suggest its ability to increase osteoblast, calcium, and phosphorus in ovariectomized rats. The effects of the pomegranate peel extracts on postmenopausal women was not known. This study was aimed to evaluate the effect of pomegranate peel ethanol extract capsules in the modulation of bone formation and bone quality markers in postmenopausal women. This study is a pilot study of 1st phase of clinical trial using parallel, randomized, double-blind, and placebo controlled design, with 30 subjects. Subjects were randomized to receive commercial capsules of pomegranate peel ethanol extract 2 × 1100 mg/ day or placebo, for 8 weeks. Levels of osteocalcin, calcium, and phosphorus were examined before and after treatment. This study showed that administration of the capsules in postmenopausal women tends to reduce blood osteocalcin level (4,129±5,66 ng/mL on placebo group versus 1,79±5,04 ng/mL on punica group, p=0,245), has not significant on blood calcium level (9,13±0,36 mg/dL placebo group versus 9,21±0,39 mg/dL punica group, p=0,379), has not significant on blood phosphorus level (3,93±0,38 mg/dL placebo group versus 4,12±0,41 mg/dL on punica group, p=0,138), does not affect the function of liver and kidney, and was well tolerated. In conclusion, the commercial capsules is safe, potentially reduce marker of bone formation serum level,and increase bone quality on postmenopausal women.
Identifikasi Senyawa Aktif dari Tumbuhan Hutan Berkhasiat Obat sebagai Inhibitor HMG-CoA Reductase Rahmania, Shelly; Sulistiyani, Sulistiyani; Lelono, Arthur A
Jurnal Kefarmasian Indonesia VOLUME 7, NOMOR 2, AGUSTUS 2017
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v7i2.3495

Abstract

Cardiovascular disease is a leading cause of death worldwide, hypercholesterolemia is one of the causes. Three medicinal forest plants are potential natural resources to be developed as cholesterol-reducing herbal product, but scientific informations on their mechanism is still limited. The objective of this research is to explore the potency of the leaf of Jati Belanda (Guazuma ulmifolia), Jabon (Antocephalus macrophyllus), and Mindi (Melia azedarach) as inhibitor of HMG-CoA reductase (HMGR), a key enzyme in the regulation of cholesterol biosynthesis. Samples were macerated in ethanol 96% and the filtrate was partitioned using n-hexane and chloroform to obtain the ethanolic flavonoid extract. The effect of each extracts on the HMG-CoA reductase activity were analyzed using HMGR assay kit. At concentration of 10 ppm the G.ulmifolia ethanolic extract showed the highest inhibitory activity as well as pravastatin control inhibitor. The phenolic content of the ethanolic extracts of G.ulmifolia, A.macrophyllus, and M.azedarach were: 11.00, 34.83, and 13.67 mg gallic acid AE/g dried leaves, respectively. The flavonoid content of the ethanolic extracts of G.ulmifolia, A.macrophyllus, and M.azedarach were: 0.22, 0.64, and 0.78 mg QE/g dried leaves, respectively. Interestingly, G.ulmifolia extract the lowest concentration of phenolic and flavonoid content. HPLC analysis showed that all samples contain quercetin at similiar small concentrations (6.7%, 6.6%, and 7.0% for G.ulmifolia, A.macrophyllus, and M.azedarach, respectively). This indicating other active compounds may play some roles in this inhibitory action on HMG-CoA reductase activity. Further identification using LC-MS/MS showed that G.ulmifolia flavonoid extract contained an unidetified coumpound with molecural weight of 380.0723 Da.
Aktivitas Ramuan Daun Salam, Herba Pegagan, Akar Alang-Alang dan Biji Pala pada Tikus Hipertensi yang Diinduksi Prednison dan Garam Nisa, Ulfatun; Fitriani, Ulfa; Wijayanti, Enggar
Jurnal Kefarmasian Indonesia VOLUME 7, NOMOR 2, AGUSTUS 2017
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v7i2.3496

Abstract

The prevalence of hypertension in Indonesia was 25,8%. As much as 70% types of hypertensive patients were mild hypertension. There were some medicinal plants contain single formulation could be used for lowering blood pressure but not in a herbal formulation. This study determined the efficacy of antihypertension herbal formulation that consists of Indonesian bay leaves, Centella herbs, blady grass roots and nutmeg seeds. This study was an experimental laboratory research with pre and post-test controlled design, used thirty Sprague-Dawley rats that were classified randomly into five groups (negative control group which didn't have treatment, positive control group which consumed captopril 0,25 mg, and three groups which consumed antihypertension herbal formulation with doses of 0,08 g; 0,16 g; and 0,32 g. The rats were induced by prednisone and NaCl 2,5 % for 21 days. The data were analysed using ANOVA test with CI 95%. After two weeks observation, the results showed that the blood pressure in the negative control group increased, but in the positive control and treatment groups decreased significantly (p=0,001). In conclusion, the herbal formulation could decrease rat's blood pressure
Isolasi, Identifikasi, Karakterisasi, dan Uji antibiofilm Derivat Asam Galat dari Kulit Batang Sterculia quadrifida R.Br Rollando, Rollando
Jurnal Kefarmasian Indonesia VOLUME 7, NOMOR 2, AGUSTUS 2017
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Faloak (Sterculia quadrifida R.Br) is used empirically by residents of Timor island to treat hepatitis, typhoid, ulcers, and to restore stamina. Information of active compound contained in the bark of faloak specifically unpublished. This study aims to determine the active compound contained in faloak bark that can be used as antibiofilm. The extraction was performed by soxletation method, the isolation was performed by gradien isolation method, the elusidation was performed by merging information from NMR and LC-MS spectra analysis. The biofilm inhibition activity test was performed by microdilution method formed on flat bottom flexible microplate U-bottom PVC 96 wells with staining using 1% crystal violet. The isolation process obtained 3 gallic acid derivatives, named isolate 1, isolate 2, and isolate 3. Test of inhibition of biofilm formation showed isolate 1 has IC50 of 46,87 µg/mL, isolate 2 has IC50 of 45,87 µg/mL, and isolate 3 has IC50 42,65 µg/mL.The biofilm test results showed that isolates 1-3 had high biofilm inhibition potency.

Page 13 of 27 | Total Record : 269

 11   12   13   14   15 

Filter by Year

2009 2025


Reset
Filter By Issues
All Issue VOLUME 15, NUMBER 2, JULY-DECEMBER 2025 VOLUME 15, NUMBER 1, FEBRUARY 2025 VOLUME 14, NUMBER 2, AUGUST 2024 VOLUME 14, NUMBER 1, FEBRUARY 2024 VOLUME 13, NUMBER 2, AUGUST 2023 VOLUME 13, NOMOR 1, FEBRUARI 2023 VOLUME 12, NOMOR 2, AGUSTUS 2022 VOLUME 12, NOMOR 1, FEBRUARI 2022 VOLUME 11, NOMOR 2, AGUSTUS 2021 VOLUME 11, NOMOR 1, FEBRUARI 2021 VOLUME 10, NOMOR 2, AGUSTUS 2020 VOLUME 10, NOMOR 1, FEBRUARI 2020 VOLUME 9, NOMOR 2, AGUSTUS 2019 VOLUME 9, NOMOR 1, FEBRUARI 2019 VOLUME 8, NOMOR 2, AGUSTUS 2018 VOLUME 8, NOMOR 1, FEBRUARI 2018 VOLUME 7, NOMOR 2, AGUSTUS 2017 VOLUME 7, NOMOR 1, FEBRUARI 2017 VOLUME 6, NOMOR 2, AGUSTUS 2016 VOLUME 6, NOMOR 1, FEBRUARI 2016 VOLUME 5, NOMOR 2, AGUSTUS 2015 VOLUME 5, NOMOR 1, FEBRUARI 2015 VOLUME 4, NOMOR 2, AGUSTUS 2014 VOLUME 4. NOMOR 1 FEBRUARI 2014 VOLUME 3, NOMOR 2, AGUSTUS 2013 VOLUME 3, NOMOR 1, FEBRUARI 2013 VOLUME 2 NOMOR 2, AGUSTUS 2012 VOLUME 2, NOMOR 1, FEBRUARI 2012 VOLUME 1, NOMOR 3, 2009 VOLUME 1, NOMOR 2, 2009 VOLUME 1, NOMOR 1, 2009 More Issue