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INDONESIA
Jurnal Kefarmasian Indonesia
Published by Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan
ISSN : 2085675X     EISSN : 23548770     DOI : -
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology
Pharmaceutical Technology, Pharmacology, Pharmaceutical Chemistry, Traditional Medicines, and Pharmaceutical Care.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 269 Documents
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Front Matter Volume 11 No 1 Tahun 2021 managerxot, jki
Jurnal Kefarmasian Indonesia VOLUME 11, NOMOR 1, FEBRUARI 2021
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Back Matter Volume 11 No 1 Tahun 2021 JKI, Editor
Jurnal Kefarmasian Indonesia VOLUME 11, NOMOR 1, FEBRUARI 2021
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Formulasi dan Uji Aktivitas Antioksidan Krim Biji dan Ekstrak Etanol Daun Jambu Biji (Psidium guajava L.) sebagai Body Scrub Putri, Noni Rahayu; Agustin, Diana; Nisa, Khairatun
Jurnal Kefarmasian Indonesia VOLUME 12, NOMOR 1, FEBRUARI 2022
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v0i0.4673

Abstract

Ethanol extract of guava leaf (Psidium guajava L.) contains flavonoids and tannins that are potentially as an antioxidant that may inhibit the activity of free radicals.The aim of this study is to formulate a body scrub cream from ethanol extract of guava leaf (Psidium guajava L.) and test their antioxidant activity.This study used three variations of concentration of ethanol extract 70% of guava leaf (Psidium guajava L.) i.e 1,5%, 2% and 2,5%.Body scrub creams are formulated into O/W type of creams by using guava seeds as a scrub.Evaluation of preparations included organoleptic examination, homogeneity, pH, cream type, stability test, particle size distribution, dispersion test and antioxidant activity test using DPPH method. The evaluation results showed that the physical properties of cream preparations provided good results and meet the requirements of cream preparations.The results of the antioxidant activity test found that the values of IC50 for each formula was F0 (without extract) 379,58 µg / mL, F1 (1,5%) 150,78 µg/mL, F2 (2%) 137,26 µg/mL and F3 (2,5%) 125,84 µg/mL.It can be concluded that body scrub creams of ethanol extract 70% of guava leaves (Psidium guajava L.) has the potential to be developed as a cosmetic preparation that can inhibit free radicals.
Aktivitas Ramuan Herbal sebagai Antagonis Reseptor H1, Relaksan Otot Polos dan Penghambat Degranulasi Sel Mast sebagai Antiasmatik Ratnawati, Galuh; Damayanti, Kiki; Nugroho, Agung Endro
Jurnal Kefarmasian Indonesia VOLUME 12, NOMOR 1, FEBRUARI 2022
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v0i0.4676

Abstract

Asthma is still become a major health problem worldwide, affected all ages from pediatrics to adults. The severity of the disease vary from mild to severe and leads to the risk of death. The uses of medicinal plants as antiasthmatic have often been conducted by the local community. The present study was conducted in vitro and in vivo to determine the activities of herbs containing of sembung leaves (Blumea balsamifera L.), kemukus seeds (Piper cubeba L.), teki rhizome (Cyperus rotundus L.), and patikan kebo herbs (Euphorbia hirta L.) with certain ratio as an antiasthmatic. The in vitro test was carried out on isolated smooth muscle cells of guinea pig. Histamine was used to stimulate the contraction of smooth muscle cells of guinea pig trachea. The in vivo test was carried out using guinea pigs which sensitized with ovalbumin and administered with the herbs formula. The trachea of guinea pigs were prepared for histopathological examination and stained on toluidine blue. The result revealed that the antiasthmatic herbs of 1, 2, and 3 showed activities as H1 receptor antagonists. The antiasthmatic herbs of 1, 2, and 3 were able to relax the smooth muscle of guinea pig’s trachea that was experiencing contraction, but in lower level compared to theophylline. The antiasthmatic herbs formula in this study did not have the activity to inhibit mast cell degranulation.
Pola Peresepan Anak dengan Infeksi Saluran Pernapasan Akut (ISPA) Non Pneumonia di Klinik Handayani, Rini Sasanti; Sari, Ida Diana; Prihartini, Nita; Yuniar, Yuyun; Gitawati, Retno
Jurnal Kefarmasian Indonesia VOLUME 11, NOMOR 2, AGUSTUS 2021
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v11i2.4734

Abstract

Acute respiratory infection (ARI) is a common disease in the community. Riskesdas 2018 stated that ARI prevalence was 4.4% and the highest was in 1-4 years old children (8%). The capitation payment system in clinics collaborated with BPJS Kesehatan demands the physician to prescribe as effective and as efficient as possible. On the other hand, the capitation tariff obtained by clinics is considered as too low, thus constrains of the prescription leading to irrational prescribing is likely to occur. This study analyses further the prescribing pattern for ARI children in clinics and its rationality based on the difference in source of funding. A cross sectional research using retrospective method was conducted. Data were gathered from 409 medical records and or patients’ prescription of children between 1-12 years old and diagnosed as having non pneumonia ARI during 1st January to 30th November 2019. Result showed that non pneumonia ARI patients were mostly boys (54,3%) aged 1-5 years old (6.0%). The average number of items for BPJS patients was 3,45, the percentage of generic prescribing was twofold higher for BPJS group (63.94%), the percentage of essential medicine prescribing was 63.96% while the percentage of antibiotic use was lower (48.50%). Dosage propriety for BPJS patients was 70.80% which was slightly higher than non-BPJS group. Overall, the prescribing indicators and dosage properness for BPJS patients were better than non-BPJS patients.
Optimasi Penggunaan High Shear Mixer pada Pembuatan Fraksi Alkaloid dari Daun Awar-awar (Ficus septica) dengan Desain Faktorial Kusnanto, Chelvin Ari; Gani, Andayana Puspitasari; Wahyuono, Subagus; Fakhrudin, Nanang
Jurnal Kefarmasian Indonesia VOLUME 11, NOMOR 2, AGUSTUS 2021
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v11i2.4874

Abstract

Awar-awar (Ficus septica) is an Indonesian anticancer plant that contains alkaloids as the active compound. The n-hexane insoluble fraction (FTLH) is alkaloid-containing fraction obtained from the ethanolic extract of F. septica leaves (EEDFS) by fractionation using n-hexane. High shear mixer (HSM) can be used to optimize the separation processes, including fractionation. The application of HSM in the fractionation of EEDFS is affected by fractionation duration, amount of solvent per gram extract, and strirring strength. Thus, these parameters must be optimized to obtain the optimum condition for the production of FTLH with the highest alkaloid content. This study aimed to optimize the production of FTLH using HSM with factorial designs. The single factor experimental design was employed to determine the influence of the individual variable on the alkaloid content and to define the optimum range value of each variable. A full factorial design was used to determine the presence of interaction among the factors and to determine the optimal fractionation condition. The results showed that all investigated factors independently affected alkaloid contents. The solvent volume of 14-18 mL per gram extract, the fractionation duration of 2.5-5.0 minutes, and the stirring strength of 3000 rpm are the optimal range value of each factor. The optimal conditions were solvent volume of 14.0-14.4 mL/gram extract, fractionation duration of 2.5-2.7 minutes, and strirring strength at 3000 rpm. At the optimal condition, the total alkaloid content in the FTLH reached 0.1466% or 1.3 times higher than the extract (0.1128%).
Uji Aktivitas Sitotoksik Ekstrak Polar, Semipolar, dan Non-Polar Daun Sambiloto (Andrographis paniculata) terhadap Sel Kanker Hati (HepG2) Shofa, Andzar Fikranus; Alam, Tunas; Nuralih, Nuralih
Jurnal Kefarmasian Indonesia VOLUME 12, NOMOR 1, FEBRUARI 2022
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v0i0.4875

Abstract

Cancer is one of the causes of 6 major deaths in the world besides HIV, malaria, and tuberculosis. The incidence of liver cancer cases in 2018 reached 841 thousand, where there were 782 deaths. Modern medicine such as surgery, radiation, and chemotherapy has various drawbacks, high side effects, therapeutics failure, and high costs. Therefore, WHO recommends herbal medicine as a complementary therapy for various diseases, one of which is cancer. Sambiloto is one of the herbal plants that has been widely used by the people of Indonesia. The potential efficacy of sambiloto as a prospective herbal plant has been widely proven both through in vitro and in vivo studies. This study aims to determine the cytotoxic activity and IC50 value of polar, semipolar, and non-polar fractions of sambiloto leaves on HepG2 cells. Each fraction was tested for its cytotoxic activity against HepG2 cells with a concentration of 500; 250; 125; 62.5; 31.25; and 15,625 µg/mL using the MTT method. The results showed that the IC50 value for the polar, semipolar, and non-polar fractions was 82.585; 53,154; 614,349 µg / mL. Based on these results, the ethyl acetate and ethanol fractions of sambiloto leaves had strong cytotoxic activity against HepG2 cells.
Pola Pengadaan Obat di 4 Apotek Jaringan Wilayah Bumi Serpong Damai (BSD) Tangerang Selatan Ismaya, Nurwulan Adi; Pratiwi, Rita Dwi; Sari Indah, Fenita Purnama; Aulia, Gina; Sumarwati, Sumarwati
Jurnal Kefarmasian Indonesia VOLUME 12, NOMOR 1, FEBRUARI 2022
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v0i0.4937

Abstract

Pharmacies are an inseparable part of the drug distribution chain until it reaches the patient. However, patients often hear complaints about the availability of drugs in pharmacies because sometimes there are drug shortage. The aim of this study was to identify the drug procurement pattern in four network pharmacies in the Bumi Serpong Damai (BSD) area in 2019. A retrospective study of four network pharmacies in the Bumi Serpong Peace (BSD) area of South Tangerang was carried out. A total of 8,959 samples were obtained by census from procurement documents of all drugs sold beginning in 2019. (A, B, C, and D pharmacies). The ABC and VEN methods were used in this study. The information gathered includes the name of the drug, the unit, the manufacturer's name, the creditor's name, and the amount and selling price. During 2019, four pharmacies had a total of 2,876 medicinal items of pharmacy A, 1,918 medicinal items of pharmacy B, 1,939 medicinal items of pharmacy C, and 2,226 medicinal items of pharmacy D, with a total drug expenditure of pharmacy A Rp.2,649,438;pharmacy B Rp.683,389,661; pharmacy C Rp. 881,540,329; and pharmacy D Rp. 1,245,520,143. Based on the findings of the study, it is possible to conclude that the four pharmacies have the most drugs in the essential category based on the VEN analysis. However, based on the Pareto ABC analysis, there are still many drugs in four network pharmacies in the BSD Region that fall into the Pareto C category, necessitating further investigation of the procurement.
Pengaruh Variasi Konsentrasi Surfaktan Iselux Ultra Mild pada Formulasi Hydrating Facial Wash Potassium Azeloyl Diglycinate Rohmani, Sholichah; Ningrum, Sonia Karunia; Wardhani, Wening Dyah; Kundarto, Wisnu
Jurnal Kefarmasian Indonesia VOLUME 12, NOMOR 1, FEBRUARI 2022
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v0i0.4969

Abstract

Potassium Azeloyl Diglycinate is an innovative molecule that active as a skin hydrating, brightening agent, and treating skin hyperpigmentation. Facial Wash with foam stabilizing agents called surfactants is a facial cleansing soap that used daily to clean dirt and oil on the face. Iselux ultra mild surfactant as a mild surfactant has a low irritation profile, stable to pH and has a soft and abundant foam. This research is an experimental study. Formulating a good Hydrating Facial Wash Potassium azeloyl diglycinate with the addition of of Iselux ultra mild surfactants in various concentration, according to physical and chemical characteristics as well as a facial wash hydration test. Researchers used various concentration of 28: 30: 32% Iselux Ultra Mild for 3 types of formulas. The test results were analyzed by one way ANOVA. The results of testing the characteristics of physical and chemical properties including organoleptic tests, homogeneity, spreadability, foam height, viscosity, and pH as well as hydration evaluation showed that the facial wash was not change during storage for 12 days using the cycling test method. Formula 3 with the highest surfactant concentration met the best qualification on the parameters compared to Formula 1 and Formula 2. The hydration activity test based on the results of the pre and post test showed that the Facial Wash Potassium azeloyl diglycinate had moisturizing activity on the face.
Uji In Vitro Beberapa Kombinasi Antibiotik Antipseudomonas terhadap Pseudomonas aeruginosa yang Resisten terhadap Karbapenem Prasetyo, Dimas Seto; Herna, Herna; Mursinah, Mursinah; Ibrahim, Fera; Bela, Budiman
Jurnal Kefarmasian Indonesia VOLUME 12, NOMOR 1, FEBRUARI 2022
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v0i0.5008

Abstract

Lower respiratory tract, sepsis, or urinary tract infection caused by the multidrug resistance Pseudomonas aeruginosa is common in the hospital, especially in the ICU wards. The treatment against this bacteria requires combination of antibiotics with different mechanism of actions. In this study, several combinations of antibiotics were evaluated in vitro against carbapenem-resistant P. aeruginosa isolated from the ICU of Cipto Mangunkusumo Hospital. The combination of antibiotics tested were ceftazidime-amikacin, ceftazidime-ciprofloxacin, and ciprofloxacin-amikacin. Checkerboard assay to the combination of antibiotics was conducted to assess the in vitro synergistic activity. A total of 22 P. aeruginosa isolates were collected, 16 of them were resistant to ceftazidime, ciprofloxacin, amikacin, as well as carbapenem. The result revealed that the combination of ceftazidime and amikacin showed promising synergistic activity. Conversely, no synergitic activities were shown by the combination of ceftazidime-ciprofloxacin and ciprofloxacin-amikacin. The combination of ceftazidime-amikacin may has potential effect againsts carbapenem-resistant P. aeruginosa in vitro.

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