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Nanang Yunarto
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Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan Kementerian Kesehatan RI Jl. Percetakan Negara No. 23 - Jakarta 10560
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INDONESIA
Jurnal Kefarmasian Indonesia
Published by Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan
ISSN : 2085675X     EISSN : 23548770     DOI : -
Core Subject : Health, Science,
Chemistry Medicine & Pharmacology
Pharmaceutical Technology, Pharmacology, Pharmaceutical Chemistry, Traditional Medicines, and Pharmaceutical Care.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 257 Documents
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Socioeconomic and Clinical Profile of Diabetic Foot Ulcer Patients with National Health Insurance during Pandemic COVID-19 in Indonesia Fitrianingsih, Fitrianingsih; Sauriasari, Rani; Yunir, Em; Banun Saptaningsih, Agusdini
Jurnal Kefarmasian Indonesia VOLUME 15, NUMBER 1, FEBRUARY 2025
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

During the COVID-19 pandemic, the mandatory lockdown and government policy in prioritizing COVID-19 patients affected patients with diabetic foot ulcers (DFU). Most DFU patients experienced difficulties visiting hospitals and covering the cost of treatment, which led to changes in patient characteristics, poor clinical outcomes, and higher total costs. This study aimed to determine the sociodemographic and clinical outcomes profile of DFU patients under National Health Insurance (NHI-DFU) during the COVID-19 pandemic and their effect on the total direct medical cost. This cross-sectional study enrolled all JKN-DFU hospitalized patients at the National Referral Hospital, Cipto Mangunkusumo Hospital (RSCM), Jakarta, Indonesia, during COVID-19 pandemic (March 2nd, 2020, to December 2022). We used electronic health records, electronic billing, and foot registry systems. Participants were over 18 years old in a single admission period. Statistical analysis used Mann-Whitney and Kruskal-Wallis; Post hoc used the Mann-Whitney test. There were 158 JKN-DFU patients with predominated criteria: female patients (55.1%), aged over 60 years old (55.1%) with a mean age of 59.3 ± 11.0 years, unemployed (63.9%), intermediate educated (41.8%), Jakarta residents (68.4%), and mostly severe infection (63.3%). The total cost was much higher than INA-CBG’s coverage. The occupation (p=0.048), length of stay (LOS) (p=0.001), and amputation status (p<0.001) significantly affected total cost. Civil servants, longer LOS, and major amputation status leading higher total costs.
Formulation of Komba-Komba Leaf Extract Ointment (Chromolaena odorata L) for Wound Healing Satria, Beny Maulana; Zulfahrin, LM Zulfahrin; Sopian, Ahmad
Jurnal Kefarmasian Indonesia VOLUME 15, NUMBER 1, FEBRUARY 2025
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Wounds are physical injuries that can cause damage to skin tissue. The extract of komba-komba leaves (Chromolaena odorata L) contains flavonoids, saponins, and tannins, which are wound healers formulated as ointment preparations. This study aims to determine how administering komba-komba leaf extract ointment affects wound healing. The maceration method obtained a thick extract of komba-komba leaves. Komba-komba leaf extract ointment was made in three formulas based on differences in extract concentration: FI = 5%, FII = 10% and FIII = 15%). The ointment preparations obtained were subjected to organoleptic tests (color, odor, and consistency) and physical tests, including homogeneity, pH, viscosity, spreadability, stability tests, and scratch wound healing activity tests. The results showed that the extract’s concentration affected the ointment preparation's color, consistency, and physical properties. The effectiveness test results for healing scratches showed that the ointment preparation with an extract concentration of 15% provided an effective healing speed.
Nutraceutical Drink as Immune Booster Made from Red Ginger Combined with Lime and Honey to Prevent Viral Infection Hasanah, Nur; Utami, Sheila Meitania; Ismaya, Nurwulan Adi; Imansari, Aulia Nadya Rizki
Jurnal Kefarmasian Indonesia VOLUME 15, NUMBER 1, FEBRUARY 2025
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Nutraceutical drinks are increasingly being chosen by the public as alternative medicine or as supportive therapy for disease prevention, offering minimal side effects with long-term use. This trend has gained momentum, mainly due to the rising incidence of COVID-19 and the emergence of highly transmissible variants. The combination of red ginger, lime juice, and honey will produce a healthy drink preparation containing antioxidants with vitamin C levels as an immune booster. This study aims to formulate a nutraceutical drink made from red ginger ((Zingiber officinale var. rubrum) combined with lime (Citrus aurantifolia) and honey also determine the antioxidant activity and the highest vitamin C levels. Physical stability tests include organoleptic, homogeneity, pH, specific gravity, viscosity, and accelerated stability tests using freeze-thaw cycling method. The antioxidant activity test using DPPH (1,1-diphenyl-2-picrylhydrazyl) method and analysis of vitamin C levels using the UV-Vis spectrophotometry method. The formulation was made with variations of lime juice FI (1%), FII (2%), and FIII (4%). The results of physical stability of the three formulations are not much different but based on organoleptic, FI has the best taste which is not too spicy and we are sure that most people will like it. Meanwhile, the highest antioxidant activity was possessed by FIII with an IC50 value of 11.21 ppm, which is classified as very strong and has the highest vitamin C content of 9103.88 µg/mL.
The Characterization of Instant Granule Melinjo Peel (Gnetum gnemon Linn.) as Alternative Treatment for Hyperuricemia Maelaningsih, Firdha Senja; Sari, Diah Permata; Fahriati, Andriyani Rahmah; Saputra, Teungku Raviola; Ansori, Andika Al
Jurnal Kefarmasian Indonesia VOLUME 15, NUMBER 1, FEBRUARY 2025
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Hyperuricemia is a non-communicable disease characterized by high levels of purine in the blood. One of the foods high in purine is melinjo chips. Instant granules from melinjo peel extract with a concentration of 450 mg have been proven to be effective as an anti-hyperuricemia treatment. To ensure the quality of the instant granule preparation, a quality evaluation was conducted to establish it as a new alternative in hyperuricemia therapy. The study aimed to assess the quality of the instant granule preparation of melinjo peel extract, including physical evaluation (particle size, loss on drying, and pH), characterization with Scanning Electron Microscope (SEM) and Fourier Transform Infrared Spectroscopy (FT-IR), and specific microbial tests. The test results revealed that the particle size of the instant granules was classified as coarse particles, the Loss on Drying results showed 1.29% granule loss, and the pH evaluation indicated that the granules had a pH of 7.78. Based on the SEM characterization, the granules exhibited non-clumping and heterogeneous morphology. FTIR analysis showed the presence of quercetin in the instant granules of melinjo peel. Specific microbial testing indicated the absence of E. Coli in the preparation. Therefore, it is concluded that the instant granule preparation of melinjo peel has characteristics that make it suitable for development as an instant nutraceutical granule preparation for anti-hyperuricemia treatment.
Formulation and Antioxidant Activity of Syrup Preparation Containing Saga Leaf Extract (Abrus precatorius L.) Dewi, Bheta Sari; Utami, Sheila Meitania; Sayyidah, Sayyidah; Alamsyah, Salwa Season; Rahmadani, Novita Tri
Jurnal Kefarmasian Indonesia VOLUME 15, NUMBER 1, FEBRUARY 2025
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Saga leaf (Abrus precatorius L.) have tannins, saponins, alkaloids, and flavonoids that have functions as antioxidants. The plant belongs to the Fabaceae family and is widespread in the tropics and subtropics. Syrup is one form of pharmaceutical preparation used in providing drugs in liquid form so that it is easily drunk by patients, especially children. The purpose of this study was to obtain the best syrup preparation formulation physically and its antioxidant activity. Saga leaf are extracted in ethanol and then syrup preparations by adding saga leaf extract with concentration variations of 0.5% (FI), 1% (FII), and 2% (FIII). Evaluation of syrup preparations includes organoleptic, pH, homogeneity, and antioxidant activity test using DPPH (1,1-diphenyl-2-picrylhydrazyl) measured by UV-Vis spectrophotometer at wavelength 516 nm. The results showed that Formula III had the best results, namely clear dark brown organoleptic, slightly viscous shape, distinctive smell and slightly bitter taste, pH 6.15, homogeneous, and the preparation was stable in storage for 12 days and showed the best IC50 value of 116.94 g/mL compared to FI (132.65 g/mL) and FII (118.03 g/mL). The antioxidant activity of saga leaf extract is categorized as moderate. In conclusion, saga leaf can be formulated as a syrup preparation with an extract concentration of 2% in formula III showing effectiveness as the best IC50 value of 116.94 g/mL and the best formulation.
Formulation Optimization Peel-Off Gel Mask Base of Red Rice Ethanolic Extract in Combination of HPMC and PVA using Factorial Design Method Wulansari, Eka; Siswanto, Agus; Diniatik, Diniatik
Jurnal Kefarmasian Indonesia VOLUME 15, NUMBER 1, FEBRUARY 2025
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

In earlier research, red rice extract was shown to possess anti-oxidant, anti-inflammatory, anti-cancer, and anti-photoaging qualities. It was also shown to inhibit the degradation of collagen and hyaluronic acid (HA) in cutaneous fibroblast cells caused by sunlight. Red rice has been used for cosmetics for centuries, and its benefits have been applied to modern skin care products. It can be made as a peel-off gel mask to increase its practicality. The peel-off gel mask has the main ingredients of PVA as a film layer and HPMC as a gelling agent. This research is experimental research with extraction stages, DPPH assay, and gel formulations. Formula optimization was carried out through a Factorial Design method approach with a total of 12 formulas. The results of the evaluation of the physical properties of the red rice ethanol extract peel-off gel mask were processed using Design Expert software ver 13. The results of this study obtained an optimum formula with HPMC and PVA concentrate levels of 15.37% and 4.99%, respectively. The results of the physical evaluation of the red rice ethanol extract peel-off gel mask with the optimum formula obtained a pH of 5.89, a spread of 5.19 cm, and a drying time of 14.71 minutes. Keywords: Peel-Off Gel Mask; Factorial Design; HPMC; PVA  
Cytotoxic Activities of Bioactive Fraction of Uncaria gambir (Hunter) Roxb on MCF-7 Human Breast Cancer Cell Line Yunarto, Nanang; Fadhilah, Humaira; Purnamasari, Rini; Reswandaru, Uud Nourma
Jurnal Kefarmasian Indonesia VOLUME 15, NUMBER 1, FEBRUARY 2025
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Breast cancer is a disease with the highest mortality rate. The first line of breast cancer treatment uses chemotherapy, but it has serious side effects on patients. Gambir (Uncaria gambir (Hunter) Roxb.) contains catechin compounds that show cytotoxic activity. This study aims to evaluate the antioxidant activity and cytotoxic effects on MCF-7 human breast cancer cells from the bioactive fraction of gambir leaves. Gambir extract was fractionated with water, ethyl acetate, and n-hexane solvents. Determination of catechin levels in the fractions used high-performance thin-layer chromatography. Antioxidant activity was tested using 2,2'-diphenyl-1-picrylhydrazyl (DPPH) and cytotoxicity tests on MCF-7 cells were carried out using MTT assay with inhibition of protein expression anti-apoptosis was determined by immunocytochemistry assay. The ethyl acetate fraction had the highest catechin content, namely 93.05%. The results of the antioxidant activity test showed that the IC50 values were consecutively for the water fraction 42.48 µg/mL, ethyl acetate 14.86 µg/mL, and n-hexane 49.63 µg/mL. In the MTT test, the ethyl acetate fraction had more potent cytotoxic activity with an IC50 value of 87.52 µg/mL. This study shows that the ethyl acetate fraction of gambir leaves has potent antioxidant and cytotoxic activity. The higher catechin content relates to antioxidant and cytotoxic activity against MCF-7 cells.

Page 26 of 26 | Total Record : 257

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