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Jurnal Sains dan Kesehatan
Published by Universitas Mulawarman
ISSN : 23030267     EISSN : 24076082     DOI : 10.25026/jsk
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology
Jurnal Sains dan Kesehatan menerima naskah karya asli (Artikel Penelitian, Artikel Review, dan Studi Kasus), baik eksperimental maupun teoretis, dalam bidang-bidang berikut: Sains dan Kesehatan (Kedokteran, Farmasi, Kesehatan Masyarakat, Keperawatan, Kebidanan, Gizi, dan lain-lain). Tujuan penerbitan Jurnal Sains dan Kesehatan adalah untuk menyediakan informasi ilmiah tentang perkembangan ilmu dan teknologi di bidang Ilmu Pengetahuan dan Kesehatan.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 764 Documents
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Literatur Review: Plant Efficacy as Biolarvicide for Anopheles Mosquito Vector Control: Literatur Review: Efikasi Tanaman Sebagai Biolarvasida Untuk Pengendalian Vektor Nyamuk Anopheles Asrianto Asrianto; Suarna Samai; Muhamad Sahidin; Indra Taufik Sahli; Risda Hartati; Wiwiek Mulyani
Jurnal Sains dan Kesehatan Vol. 5 No. 2 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i2.1172

Abstract

Mosquito vectors are a severe threat to the prevalence and incidence of malaria, dengue fever, yellow fever, and filariasis. Malaria is a Plasmodium infection that is transmitted by the female Anopheles mosquito. Malaria cases in tropical and subtropical countries have social and economic impacts. Mosquito vector control has been using chemical and synthetic compounds. This method can reduce malaria cases, but it creates new problems that also slow down the elimination of malaria in the long run. Vector control in the larval phase using bioactive compounds of various plants is an alternative to eradicating vectors; besides that, utilizing these bioactive compounds is relatively safer, cheaper, and more accessible. Plants contain several compounds that are toxic to Anopheles mosquito larvae. This literature study summarizes research on extracts of various plants that function as larvicides of the Anopheles mosquito. The research method uses a literature study. The literature related to the research topic was obtained from the databases of Google Scholar, Semantic Sholar, Garuda, PubMed, and Science Direct. The primary literature is a publication of the last ten years. The literature study results showed that the plants Vitex negundo Linn., Lawsonia inermisLinn., Stachys byzantina K.Koch., Pithecellobium dulce Bth., Olax dissitiora Oliv., Ipomea cairica Linn., Ricinnus communis Linn., Carica papaya Linn., Paederia foetida Linn., Glycosmis pentaphylla Retz., Terminalia chebula Retz., Annona squamosa Linn., Tagetes erecta Linn. and Azadiracha indica Juss. against mosquito vectors. This study concludes that secondary plant metabolites can be used as candidates and alternatives for controlling Anopheles mosquito larvae.
Analisis Efek Samping Kanamisin dan Kapreomisin terhadap Fungsi Ginjal pada Pasien TB RO di RSUD Dr. Soetomo: Adverse Effect Analysis of Kanamicin and Capreomycin on Kidney Function in DR TB Patients at Dr. Soetomo Hospital Syefi Nuraeni Fitriana; Bambang Subakti Zulkarnain; Heri Yulimanida
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.1174

Abstract

The high of adverse effect of resistant TB treatment and the long duration of the treatment is the main obstacle in the success of resistant TB therapy. One of the serious and life-threatening adverse effect of the treatment is nephrotoxic. Kanamycin and capreomycin are MDR TB drugs that can induce nephrotoxic and kidney disorder. This study aims to determine the incidence of hypokalemia and nephrotoxic induced by kanamycin and capreomycin, the onset of the kidney disorder, and its management. Data were collected retrospectively from the medical records of patients in the MDR TB outpatient clinic at Dr. Soetomo Hospital Surabaya during the period January 2018-June 2020. There were 183 patient medical records and only 112 medical records that met the inclusion criteria. The adverse effects studied were hypokalemia and nephrotoxicity which were analyzed based on potassium and creatinine serum levels. The result showed that adverse effect on kidney disorders were more common in the group of patients taking capreomycin than in the group of patients taking kanamycin. Hypokalemia were found 70.45% and nephrotoxicity were found 30.23% in the capreomycin group, while in the kanamycin group, hypokalemia were found 38.24% and nephrotoxicity were found 20.29%. Keywords: kanamycin, capreomycin, MDR TB, nephrotoxicity Abstrak Tingginya efek samping dan lamanya terapi pengobatan TB resisten menjadi kendala utama dalam keberhasilan terapi TB resisten. Salah satu efek samping obat yang serius dan dapat mengancam jiwa adalah gangguan ginjal. Kanamisin dan kapreomisin merupakan obat TB MDR yang dapat menyebabkan efek samping gangguan ginjal. Penelitian ini bertujuan untuk mengetahui insidensi efek samping hipokalemia dan nefrotoksik pada pasien TB MDR, berapa lama onsetnya, dan bagaimana cara pengatasannya. Pengambilan data dilakukan secara retrospektif dari rekam medis pasien di poli rawat jalan TB MDR RSUD dr. Soetomo Surabaya selama periode Januari 2018-Juni 2020. Didapatkan 183 rekam medis pasien dan yang memenuhi kriteria inklusi sebanyak 112 rekam medis. Efek samping yang diteliti adalah hipokalemia dan nefrotoksik yang dianalisis berdasarkan kadar kalium dan serum kreatinin. Hasil penelitian menunjukkan efek samping terhadap gangguan ginjal lebih banyak ditemukan pada kelompok pasien yang menggunakan kapreomisin dibandingkan pada kelompok pasien yang menggunakan kanamisin, yaitu hipokalemia 70,45% dan nefrotoksik 30,23% pada kelompok kapreomisin, sedangkan pada kelompok kanamisin hipokalemia 38,24% dan nefrotoksik 20,29%. Kata Kunci: kanamisin, kapreomisin, TB MDR, gangguan ginjal 
Pengaruh Penambahan Ekstrak Aloe vera Terhadap Karakteristik Fisik Basis Polietilen Glikol Sediaan Suppositoria: The Effect of Aloe vera Extract Addition to Physical Characteristic of Polyethylene Glycol Suppository Base Mirhansyah Ardana; Wilujeng Cahya Arundina; Sabaniah Indjar Gamma
Jurnal Sains dan Kesehatan Vol. 4 No. 3 (2022): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v4i3.1177

Abstract

Ekstrak Aloe vera berpotensi untuk dikembangkan menjadi sediaan suppositoria karena terbukti memiliki aktivitas laksatif. Pada penelitian ini sejumlah ekstrak yang dosisnya telah dikonfersi dicampurkan dengan basis suppositoria polietilen glikol (PEG). Kemudian dilakukan evaluasi karakteristik fisik meliputi kekerasan, disolusi, dan titik leleh terhadap basis dan sediaan suppositoria yang mengandung ekstrak. Hal ini bertujuan untuk melihat pengaruh penambahan ekstrak terhadap karakteristik basis PEG suppositoria yang telah dioptimasi komposisinya, sehingga akan mempermudah formulator untuk melakukan penyesuaian komposisi basis terhadap persyaratan sediaan suppositoria yang baik. Hasil pengujian menunjukan bahwa ekstrak tidak mengubah kekerasan basis suppositoria, tetapi mempengaruhi disolusi dan titik leleh basis. Ekstrak Aloe vera mempercepat disolusi basis dari 37,163 menit menjadi 36,933 menit dan meningkatkan titik leleh basis dari 62,967 °C menjadi 80,467 °C. Dari data yang diperoleh dapat disimpulkan bahwa basis PEG yang ditambahkan ekstrak Aloe vera tidak memerlukan penyesuaikan komposisi karena perubahan yang terjadi masih sesuai dengan persyaratan dan tidak mempengaruhi performa sediaan dalam hal pelepasan zat aktif.
Profil Elektrolit dan Hematologi Pasien Balita Diare Akut dengan Dehidrasi Ringan-Sedang di RSUD Abdoel Wahab Sjahranie Samarinda: Electrolyte and Hematological Profiles of Children Under Five with Acute Diarrhea Complicated by Mild to Moderate Dehydration at RSUD Abdoel Wahab Sjahranie Samarinda Aegirine Rafilah Dahlan; Meiliati Aminyoto; Annisa Muhyi
Jurnal Sains dan Kesehatan Vol. 5 No. 4 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i4.1179

Abstract

Diarrhea is the second leading cause of mortality in children under five years old worldwide. Diarrhea is also the highest cause of death in children under five in Indonesia and in East Kalimantan. Various complications can be caused by diarrhea, such as dehydration, electrolyte disturbances, and even death. Most of these complications are related to delay in diagnosis and inappropriate therapy. Some of the modalities that can help to diagnose acute diarrhea in children are electrolyte and hematology examination. This study aims to describe the electrolyte and hematological profiles of children under five with acute diarrhea complicated by mild to moderate dehydration at RSUD Abdoel Wahab Sjahranie Samarinda. This research design was descriptive observational with a retrospective approach. The research data were obtained from the medical records at RSUD Abdoel Wahab Sjahranie Samarinda over the course of 2019-2021. The results of this study showed that on hematological examination, the average values of leukocytes, hemoglobin, and hematocrit were 12500/µL, 12.04 g/dL, and 35.91%, respectively. On electrolyte examination, the average values of sodium, potassium, and chloride were 135.4 mmol/L, 4.31 mmol/L, and 106.39 mmol/L, respectively. The conclusion of this study were the electrolyte and hematological profiles in most children under five with acute diarrhea complicated by mild to moderate dehydration were normal and the most common electrolyte imbalances were hyponatremia, followed by hypokalemia and hyperchloremia. Keywords: children under five, acute diarrhea, electrolyte profile, hematological examination Abstrak Di seluruh dunia, diare berada pada urutan kedua teratas sebagai penyebab mortalitas pada anak di bawah lima tahun (balita). Diare juga menjadi penyebab kematian tertinggi pada balita di Indonesia maupun di Kalimantan Timur. Berbagai komplikasi dapat ditimbulkan oleh diare, seperti dehidrasi, gangguan elektrolit, hingga kematian. Sebagian besar komplikasi tersebut terkait dengan keterlambatan diagnosis serta pemberian terapi yang tidak tepat. Salah satu modalitas yang dapat membantu penegakan diagnosis diare akut pada anak adalah pemeriksaan elektrolit dan hematologi. Penelitian ini bertujuan untuk mendeskripsikan profil elektrolit dan hematologi pasien balita diare akut dengan dehidrasi ringan-sedang di RSUD Abdoel Wahab Sjahranie Samarinda. Penelitian ini menggunakan desain observasional deskriptif dengan pendekatan retrospektif. Data penelitian diperoleh dari rekam medis RSUD Abdoel Wahab Sjahranie Samarinda periode 2019-2021 menggunakan teknik purposive sampling dan diperoleh 102 sampel. Hasil penelitian ini menunjukkan pada pemeriksaan hematologi, nilai rata-rata leukosit, hemoglobin, dan hematokrit masing-masing 12500/µL, 12.04 g/dL, dan 35.91%. Pada pemeriksaan elektrolit, didapatkan nilai rata-rata natrium, kalium, dan klorida masing-masing 135.4 mmol/L, 4.31 mmol/L, dan 106.39 mmol/L. Kesimpulan penelitian ini adalah profil elektrolit dan hematologi pada sebagian besar balita diare akut dengan dehidrasi ringan-sedang berada pada nilai normal serta gangguan elektrolit yang paling sering terjadi adalah hiponatremi, diikuti oleh hipokalemi dan hiperkloremi. Kata Kunci: balita, diare akut, profil elektrolit, pemeriksaan hematologi
Detection of Flavonoid Compounds of Daruju Root Extract (Acanthus ilicifolius Linn) using Thin Layer Chromatography and UV-Vis Spectrophotometry Aden Dhana Rizkita; Ilham Maulana; Sintia Ayu Dewi
Jurnal Sains dan Kesehatan Vol. 5 No. 1 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i1.1185

Abstract

The isolation and detection of flavonoids in the extract of Daruju root has been carried out. extract obtained from maceration modification using 96% ethanol, ethanol extract The extraction result is concentrated with a rotary evaporator and then evaporated above water bath until a thick extract is obtained. The resulting extract was further separated using a separating funnel and diethyl ether and n-butanol as solvents. Then the thick extract was tested for plavonoid preliminaries by reacting the thick extract with H2SO4 and Mg the results obtained were a change in color to yellow, it proved that the extract was positive for plavonoid. After that, TLC was carried out to purify the extract which would later detect plavonoid using a UV-Vis spectrophotometer. TLC results show an Rf value of 0.6-0.8. UV-Vis spectrophotometer results at a wavelength of 200-800 nm give results in fraction A with a maximum wavelength at 291 nm which is suspected to have detected flavonoids.
Penggunaan Aplikasi Edukasi Seksual dalam Mendukung Sustainable Development Goals 2030: Usage of Sexual Education Applications for Sustainable Development Goals, 2030 Dhani Wijaya; Humaira Ramzi; Azian Firman Saputra; Ilmiyatul Muhimmah
Jurnal Sains dan Kesehatan Vol. 5 No. 2 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i2.1186

Abstract

Increasing sexual reproductive health information and knowledge about Human Immunodeficiency Virus/ Acquired Immune Deficiency Syndrome in adolescents is one of the targets of the Sustainable Development Goals, 2030. The use of sexual education applications helps educate adolescents that supports the achievement of these targets. This study describes the effect of sexual health education applications on adolescent knowledge and decreases the prevalence of Human Immunodeficiency Virus/ Acquired Immune Deficiency Syndrome to support the 2030 Sustainable Development Goals. This research is a literature study of articles published in NCBI, Google Scholar, and PubMed. The keywords used in the article search were: sex education, android application, Human Immunodeficiency Virus/ Acquired Immune Deficiency Syndrome, and reproduction health. Inclusion criteria were articles published in 2016-2020, using English or Indonesian, original article, can be accessed in full text, free of charge and the manuscript content’s were relevant to the study. Review articles and duplicate journals were excluded. In this study, only ten of the 1250 articles met the inclusion criteria. Study shows that sexual education applications can increase adolescents' understanding of reproductive health, good and healthy sexuality, improve sexual attitudes and behavior, and also reduce the prevalence of Human Immunodeficiency Virus/ Acquired Immune Deficiency Syndrome that supports the 2030 Sustainable Development Goals. Keywords: Sexual Education Applications, Reproductive Health, HIV/AIDS Abstrak Peningkatan informasi kesehatan reproduksi dan seksual serta pengetahuan mengenai Human Immunodeficiency Virus dan Acquired Immune Deficiency Syndrome pada remaja merupakan salah satu target Sustainable Development Goals 2030. Penggunaan aplikasi edukasi seksual membantu edukasi terkait kesehatan seksual dan reproduksi yang mendukung pencapaian target tersebut. Tujuan penelitian ini untuk mendeskripsikan pengaruh aplikasi edukasi kesehatan seksual terhadap pengetahuan remaja dan penurunan prevalensi Human Immunodeficiency Virus/ Acquired Immune Deficiency Syndrome dalam kaitannya untuk mendukung Sustainable Development Goals 2030. Penelitian ini merupakan studi literatur atas artikel yang terbit NCBI, Google Scholar dan PubMed. Kata kunci yang digunakan dalam pencarian artikel adalah: sex education, application android, Human Immunodeficiency Virus/ Acquired Immune Deficiency Syndrome dan reproduction health. Kriteria inklusi meliputi artikel terbitan 2016-2020, berbahasa Inggris atau Indonesia, original article, dapat diakses secara lengkap, gratis dan isi naskah relevan dengan topik penelitian. Review article dan duplikasi jurnal dikeluarkan dari penelitian. Dalam penelitian ini, sepuluh dari 1250 artikel yang memenuhi kriteria inklusi. Berdasarkan tinjauan artikel diketahui bahwa aplikasi edukasi seksual dapat meningkatkan pemahaman remaja terkait kesehatan reproduksi, seksualitas yang sehat, memperbaiki sikap dan perilaku seksual serta menurunkan prevalensi Human Immunodeficiency Virus/ Acquired Immune Deficiency Syndrome. Hal ini mendukung tercapainya Sustainable Development Goals 2030. Kata Kunci: Aplikasi Edukasi Seksual, Kesehatan Reproduksi, HIV/AIDS
High Calcium Boba from Egg Shells to Prevent Stunting and Boost the Immune System Laillatul Mas’udah; Dhani Wijaya; Nabila Asha Rahmita; Ulva Nur Rahmawati
Jurnal Sains dan Kesehatan Vol. 5 No. 2 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i2.1187

Abstract

Nutritional status and stunting are problems in several countries, including Indonesia. Calcium is one of the important micronutrients to prevent stunting, and the immune system can act as a second messenger of lymphocytes to maintain the body's immune response. Calcium in eggshells can be processed into boba which is popular in the community. This study aims to examine eggshells as a high-calcium food source to prevent stunting and help increase immunity. This research is a Literature Review of open access articles published in 2016 - 2021 on Google Scholar, PubMed, and Science Direct. Duplicate reports were excluded from the study. The keywords used in searching the journal in the database are eggshells, calcium, stunting, immune system, and popular foods. Research shows that every gram of eggshell contains 381 mg of calcium. Adequate calcium intake supports increasing height, maintaining bone health, and preventing stunting. Increased intracellular calcium is essential for the steps of intracellular signaling that induce proliferation, cytokine production, and regulation of several transcription factors. Eggshells can be safely consumed if they are kept for 20 minutes and finely ground with the high calcium content. High calcium boba from eggshell flour can prevent stunting and boost the immune system.
Aktivitas Antiinflamasi In Vitro dan In Vivo Ekstrak Etanol Daun Mangga Arumanis (Mangifera indica L.): In Vitro and In Vivo Anti-Inflamatory Activities of Ethanol Extract Mangifera indica L. Leaves Sholihatil Hidayati; Firda Oktavianti; Dhina Ayu Susanti; Qurrotul Aini
Jurnal Sains dan Kesehatan Vol. 4 No. 5 (2022): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v4i5.1195

Abstract

Inflammation is a normal process designed to protect oneself and promote healing of body tissues. The mechanism of action of flavonoids as antiinflammatory is through the inhibition of arachidonic acid and the secretion of lysosomal enzymes. The ethanol extract of Mangifera indica L. leaves (EEML) contains flavonoids and is widely used as a medicine empirically. This study was conducted to evaluate the antiinflammatory effect of EEML in vitro and in vivo. In vitro study of the antiinflammatory activity of EEML based on its effect on the stability of blood membranes using UV-Vis spectrophotometry method. While the in vivo activity was tested using the carrageenan induction method on white rats of the Wistar strain. In vitro activity was expressed as EC50 and in vivo activity was expressed as % edema reduction. The results showed that ethanol extract was able to increase membrane stability with an EC50 value of 8.56 ?g/ml better than positive control aspirin with EC50 21.57 ?g/ml. In vivo test results showed that the administration of EEML doses of 200 mg/kg.bw, 400 mg/kg.bw, and 800 mg/kg.bw was not significantly different from the positive control in reducing edema. EEML has shown antiinflammatory effects in vitro and in vivo, so it has the potential to be developed as an antiinflammatory agent.
Pengaruh Manipulasi Tangan secara Mandiri terhadap Nyeri Ulu Hati pada Mahasiswa Fakultas Kedokteran Universitas Mulawarman: Effect of In-Hand Manipulation on Heartburn Among Students at Medicine Faculty, Mulawarman University Azizah Salsa Billa; Sjarif Ismail; Yenny Abdullah
Jurnal Sains dan Kesehatan Vol. 5 No. 3 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i3.1196

Abstract

Heartburn is a physical pain that is experienced and felt in the epigastrium area. It can be managed with non-pharmacological therapy. Massage therapy with in-hand manipulation can be used as non-pharmacological therapy to treat heartburn. This study is aimed at finding the effect of in-hand manipulation therapy on heartburn among students at the Medicine Faculty, Mulawarman University. A quasi-experimental method with a nonequivalent pretest-posttest control group design was applied in this study. The primary data were obtained from a questionnaire, pre-test, and post-test at Medicine Faculty, Mulawarman University. Using a purposive sampling technique, 15 research subjects were assigned to the intervention and control groups. Based on Mann-Whitney statistical analysis, it was found that a p-value of 0.01 (p < 0,05) indicated a significant difference in the intensity scale of heartburn between the intervention group with treatment and the control group without treatment. Therefore, it can be concluded that in-hand manipulation helps to reduce the intensity scale of heartburn. Keywords: Heartburn, Non-Pharmacological Therapy, Massage, Hand Manipulation Abstrak Nyeri ulu hati adalah keluhan fisik yang dialami dan dirasakan di daerah epigastrium pada abdomen. Pada penatalaksanaan nyeri ulu hati dapat dilakukan tindakan terapi secara non-farmakologi. Terapi pijat dengan manipulasi tangan dapat digunakan sebagai terapi non-farmakologi pada penderita nyeri ulu hati. Tujuan dari penelitian ini untuk melihat pengaruh terapi dengan manipulasi tangan secara mandiri terhadap nyeri ulu hati pada mahasiswa Fakultas Kedokteran Universitas Mulawarman. Penelitian ini menggunakan desain eksperimen semu dengan metode nonequivalent pretest-posttest control group design. Data yang didapatkan berasal dari data primer berupa kuesioner, pre-test, dan pos-test di Fakultas Kedokteran Universitas Mulawarman. Teknik sampling dengan metode purposive sampling diperoleh sebanyak 15 subjek tiap kelompok terdiri dari kelompok intervensi dan kelompok kontrol. Hasil uji statistik Mann Whitney didapatkan p sebesar 0,01 (p < 0,05) yang berarti adanya perbedaan bermakna antara persentase perubahan skala nyeri ulu hati pada kelompok intervensi yang diberikan perlakuan dan kelompok kontrol yang tidak diberikan perlakuan. Oleh karena itu, dapat disimpulkan bahwa manipulasi (Su Jok) pada tangan berpengaruh dalam menurunkan skala intensitas nyeri ulu hati. Kata Kunci: Nyeri ulu hati, Terapi Non-Famakologi, Pijat, Manipulasi Tangan
Perbandingan Uji Aktivitas Mukolitik Ekstrak Etanol, Infusa, dan Minyak Atsiri Batang Serai Wangi (Cymbopogon Nardus): Comparison Mucolytic Activity Test of Ethanol Extract, Infusion, and Essential Oil of Citronella stem (Cymbopogon Nardus) Costansia Clara; M. Arifuddin; Rolan Rusli
Jurnal Sains dan Kesehatan Vol. 4 No. 5 (2022): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v4i5.1201

Abstract

Batuk merupakan gejala klinis dari gangguan pada saluran pernapasan, sebagai perlindungan untuk menghilangkan lendir yang berlebihan, zat abnormal seperti cairan atau nanah, maupun benda asing yang dihirup dari saluran udara bagian atas. Serai Wangi (Cymbopogon nardus) merupakan salah satu tanaman yang dapat dijadikan tanaman obat yang berkhasiat mengobati batuk. Tanaman Serai memiliki kandungan kimia berupa alkaloid, saponin, tannin, flavanoid, antraquinon, dan minyak atsiri. Kandungan metabolit sekunder berupa saponin dan tannin memiliki aktivitas mukolitik.  Penelitian ini bertujuan untuk mengetahui perbandingan aktivitas mukolitik terbaik dari ekstrak etanol, infusa dan minyak atsiri batang Serai Wangi (Cymbopogon nardus). Pada penelitian ini digunakan metode ekstraksi dengan maserasi, infusa, dan destilasi uap. Pengujian mukolitik dilakukan dengan alat viskometer Rheosys dan diukur viskositas tiap sampel uji. Hasil penelitian menunjukkan bahwa ekstrak etanol 5% memiliki aktivitas mukolitik terbaik ditandai dengan penurunan viskositas yang signifikan dibandingkan dengan infusa 6% dan minyak atsiri. Penurunan viskositas ekstrak etanol pada menit ke 30 adalah sebesar 144,09 cps dan pada menit ke 60 adalah sebesar 187,1 cps.

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