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Jurnal Sains dan Kesehatan
Published by Universitas Mulawarman
ISSN : 23030267     EISSN : 24076082     DOI : 10.25026/jsk
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology
Jurnal Sains dan Kesehatan menerima naskah karya asli (Artikel Penelitian, Artikel Review, dan Studi Kasus), baik eksperimental maupun teoretis, dalam bidang-bidang berikut: Sains dan Kesehatan (Kedokteran, Farmasi, Kesehatan Masyarakat, Keperawatan, Kebidanan, Gizi, dan lain-lain). Tujuan penerbitan Jurnal Sains dan Kesehatan adalah untuk menyediakan informasi ilmiah tentang perkembangan ilmu dan teknologi di bidang Ilmu Pengetahuan dan Kesehatan.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 764 Documents
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Total Bakteri Asam Laktat (BAL) dari Sauerkraut Kubis Singgalang (Brassica oleracea var. capitata L.) dengan Konsentrasi Garam yang Berbeda: Total Lactic Acid Bacteria (LAB) from Sauerkraut of Singgalang Cabbage (Brassica oleracea var. capitata L.) with Addition of Various Salt Concentration Niken Maharani Putri; Resti Fevria; Linda Advinda; Moralita Chatri
Jurnal Sains dan Kesehatan Vol. 5 No. SE-1 (2023): Spesial Edition J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5iSE-1.2062

Abstract

Lactic Acid Bacteria are a group of bacteria that produce lactic acid as their main product in the fermentation process and are probiotic agents that are good and safe for humans. LAB is found in many fermented processed food products, one of which is sauerkraut. Sauerkraut is a fermented product that only uses cabbage and salt in the manufacturing process. Sauerkraut can be made from various types of cabbage compatriots such as for example Singgalang Cabbage (Brassica oleracea var. capitata L.). Cabbage can be fermented into sauerkraut using a certain concentration of salt. The research was carried out with 3 treatment groups, namely Singgalang Cabbage Sauerkraut with salt concentrations of 2%, 2.5%, and 3%. The results showed that the highest total LAB was found in the addition of 2.5% salt, namely 186.67×106 cfu/ml. Meanwhile, the total LAB at concentration of 2% was 83.33×106 cfu/ml and at concentration of 3%, it was 51×106 cfu/ml. This amount has met the minimum standards of LAB in each product and meets the minimum standards to be beneficial for human body. Keywords: Lactic Acid Bacteria, Sauerkraut Abstrak Bakteri Asam Laktat merupakan kelompok bakteri penghasil asam laktat sebagai produk utamanya dalam proses fermentasi dan merupakan agen probiotik yang baik dan aman bagi manusia. BAL banyak ditemukan pada produk makanan olahan fermentasi salah satunya pada sauerkraut. Sauerkraut  merupakan produk fermentasi yang hanya menggunakan kol dan garam dalam proses pembuatannya. Sauerkraut dapat dibuat dari berbagai jenis sayuran sebangsa kol seperti contohnya Kubis Singgalang (Brassica oleracea var. capitata L.). Kol dapat difermentasi menjadi sauerkraut menggunakan garam dengan konsentrasi tertentu. Penelitan dilakukan dengan 3 kelompok perlakuan yaitu Sauerkraut Kubis Singgalang dengan pemberian konsentrasi garam 2%, 2,5%, dan 3%. Hasil penelitian didapatkan bahwa total BAL terbanyak terdapat pada penambahan garam 2,5% yaitu 186,67×106 cfu/ml. Sedangkan total BAL pada konsentrasi 2% yaitu 83,33×106 cfu/ml dan konsentrasi 3% yaitu 51×106 cfu/ml. Jumlah tersebut sudah memenuhi standar minimum BAL dalam tiap produk dan memenuhi standar minimum agar bermanfaat bagi tubuh manusia. Kata Kunci: Bakteri Asam Laktat, Sauerkraut
Formulasi dan Uji Stabilitas Fisik Krim Tabir Surya Nanoenkapsul Ekstrak Daun Ubi Jalar Ungu (Ipomoea batatas L.) Varietas Antin-3: Formulation and Physical Stability Test of Sunscreen Cream of Purple Sweet Potato Leaf Extract (Ipomoea batatas L.) Antin-3 Variety Nanocapsulated Siti Nur Hasbiah; Alycia Eka Putri Apriyana; Damaranie Dipahayu
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.2068

Abstract

UVA and UVB sunlight can damage skin tissue. The flavonoids and polyphenols in purple sweet potato (Ipomoea batatas L.) leaf extract of the Antin-3 variety nanoencapsulated was able to absorb the intensity of UV light so that can be used as an active ingredient for sunscreen cream preparations. The aim of this research is to examine the effect of variations Antin-3 leaf extract nanoencapsulated were 0.3% : 0.6% : 0.9% [F1:F2:F3] on the physical stability using a mechanical and freeze thaw test (3 cycles,48 hours for each cycle). Mechanical test results show that all of the formula were not separated. The freeze and thaw test result show that the differences of variations nanoencapsulated Antin-3 leaf extract had not affect for the color, aroma and homogeneity, type of cream (water in oil type) and pH value but had an influence for the spreadability value. The best formula that can be chosen is F3 because it had the highest concentration of Antin-3 leaf extract nanoencapsulated. It is necessary to reformulate by increasing the concentration of consistency stabilizer agent. Keywords:          Sunscreen, nanoencapsulation, Antin-3, freeze thaw, mechanical test   Abstrak UVA dan UVB sinar matahari mampu merusak jaringan kulit. Flavonoid dan polifenol dalam nanoenkapsulasi ekstrak daun ubi jalar ungu (Ipomoea batatas L.) varietas Antin-3 mampu menyerap intensitas sinar UV sehingga dapat dijadikan bahan aktif untuk sediaan krim tabir surya. Tujuan penelitian ini adalah untuk mencari pengaruh variasi kandungan nanoenkapsulasi ekstrak daun Antin-3 yaitu 0,3% : 0,6% : 0,9% [F1:F2:F3] terhadap stabilitas fisik mekanik dan freeze thaw (3 siklus, per siklus 48 jam). Hasil uji mekanik menunjukkan bahwa ketiga formula tersebut tidak memisah. Hasil uji freeze and thaw menunjukkan bahwa perbedaan variasi nonoenkapsulasi ekstrak daun Antin-3 tidak mempengaruhi warna, aroma dan homogenitas, tipe krim minyak dalam air dan nilai pH namun memberikan pengaruh terhadap nilai daya sebar. Formula terbaik yang dapat dipilih adalah F3 karena memiliki konsentrasi nanoenkapsulasi ekstrak daun Antin-3 paling tinggi. Perlu dilakukan reformulasi dengan meningkatkan konsentrasi bahan penstabil konsistensi. Kata Kunci:         tabir surya, nanoenkapsulasi, Antin-3, freeze thaw, uji mekanik
Aktivitas Antibakteri Kokristal Sefiksim-Nikotinamida Menggunakan Agar Diffusion dan Broth Dilution Test: Antibacterial Activity of Cocrystals of Cefixime with Nicotinamide Using Agar Diffusion and Broth Dilution Test Abulkhair Abdullah; Muhammad Subhan A. Sibadu; Mutmainnah Mutmainnah
Jurnal Sains dan Kesehatan Vol. 5 No. 6 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i6.2069

Abstract

Cefixime has been formulated in cocrystal form with nicotinamide (coformer). SEF-NIK cocrystals were prepared at a mole ratio of 1:1 using a liquid-assisted grinding method. The cocrystals were characterized using DSC, FTIR, SEM, and PXRD. The characterization results showed that cocrystals were formed between cefixime and nicotinamide. The results of the solubility test, dissolution rate and permeability of the SEF-NIK cocrystal showed a significant increase compared to pure cefixime. Based on these results, the SEF-NIK cocrystal was continued for pharmacodynamic studies with in vitro antibacterial activity studies. This study aims to determine the effect of cocrystallization techniques on the antibacterial activity of cefixime. The test was carried out using two methods, namely the Agar Diffusion Test and the Broth Dilution Test. The results showed that cocrystallization of cefixime with nicotinamide did not inhibit its effectiveness against Escherichia coli bacteria, but its effectiveness was better than pure cefixime. In the agar diffusion method, the inhibition zones of cefixime and SEF-NIK cocrystals against Escherichia coli bacteria were 6.2 mm and 8.6 mm, respectively. On the fifth day of the broth dilution test method, the OD values of Escherichia coli bacteria in the cefixime and SEF-NIK cocrystals were 1.330 and 1.064, respectively.   Keywords:          cefixime, liquid-assisted grinding, antibacterial activity   Abstrak Sefiksim telah berhasil dibuat dalam bentuk kokristal dengan nikotinamida (koformer). Kokristal SEF-NIK dibuat dengan perbandingan mol 1:1 menggunakan metode liquid-assisted grinding­. Kokristal dikarakterisasi menggunakan DSC, FTIR, SEM, dan PXRD. Hasil karakterisasi menunjukkan bahwa terbentuk kokristal antara sefiksim dan nikotinamida. Hasil uji kelarutan, laju disolusi, dan permeabilitas kokristal SEF-NIK menunjukkan peningkatan yang signifikan dibandingkan dengan sefiksim murni. Berdasarkan hasil penelitian tersebut, kokristal SEF-NIK dilanjutkan ke tahap uji farmakodinamik yakni uji aktivitas antibakteri secara in vitro. Penelitian ini bertujuan untuk mengetahui pengaruh dari teknik kokristalisasi terhadap aktvitas antibakteri sefiksim. Pengujian dilakukan menggunakan dua metode yakni Agar Diffusion Method (difusi agar) dan Broth Dilution Method (dilusi cair). Hasil penelitian menunjukkan bahwa kokristalisasi sefiksim dengan nikotinamida tidak menghambat efektivitasnya terhadap bakteri Escherichia coli, akan tetapi efektivitasnya lebih baik dibandingkan sefiksim murni. Pada metode difusi agar, zona hambat sefiksim terhadap bakteri Escherichia coli sebesar 6,2 mm sedangkan kokristal SEF-NIK lebih besar yakni 8,6 mm. Pada metode dilusi cair, hasil pengukuran OD bakteri Escherichia coli hari kelima pada sefiksim sebesar 1,330 sedangkan pada kokristal SEF-NIK sebesar 1,064. Kata Kunci:         sefiksim, liquid-assisted grinding, aktivitas antibakteri
Formulasi Masker Gel Peel-Off Ekstrak Etanol Daun Petai Cina (Leucaena leucocephala (Lam.) De Wit.) sebagai Antijerawat terhadap Pertumbuhan Bakteri Propionibacterium acnes: Formulation of Peel-Off Mask Gel with Ethanol Extract of Chinese Petai Leaves (Leucaena leucocephala (Lam.) De Wit.) as an Anti-acne Against the Growth of Propionibacterium acnes Bacteria Arifin, Arfiani; Djide, Natsir; Nurhidayah, Nurhidayah
Jurnal Sains dan Kesehatan Vol. 6 No. 1 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i1.2075

Abstract

Propionibacterium acnes is one of the gram-positive bacteria that can lead to the development of acne. One of the plants with the potential to be an anti-acne agent is the Petai Cina leaf (Leucaena leucocephala (Lam.) De Wit.). This study aims to formulate a peel-off gel mask preparation of the ethanol extract of Petai Cina leaf (Leucaena leucocephala (Lam.) De Wit.) that meets the physical quality test requirements and to determine the antiacne activity of the formulation. The extraction method used was maceration with 96% ethanol solvent. From the obtained extract, peel-off gel mask preparations were made and tested for their minimum inhibitory concentration (MIC): FI (2.5%), FII (5%), and FIII (10%), Medi-klin® (positive control), and gel base (negative control). The antibacterial activity was tested using the well diffusion method. The results of this study showed that the peel-off gel mask preparations FI (2.5%), FII (5%), FIII (10%), and the gel base (negative control) met the physical quality test requirements. The results of the anti-acne activity testing against the growth of Propionibacterium acnes bacteria obtained concentrations of extract FI (2.5%) 18.53 mm, FII (5%) 18.85 mm, FIII (10%) 22.27 mm, Medi-klin® 26.43 mm, and the negative control of Petai Cina leaf 6 mm. This indicates that the ethanol extract of Petai Cinaleaf has inhibitory effects on the growth of Propionibacterium acnes bacteria as an anti-acne agent. Keywords:          Chinese petai leaves (Leucaena leucocephala (Lam.) De Wit.), Peel-off gel mask, Propionibacterium acnes, Anti-acne   Abstrak Propionibacterium acnes merupakan salah satu bakteri gram positif yang dapat mengakibatkan timbulnya jerawat. Salah satu tanaman yang berpotensi sebagai antijerawat adalah daun petai cina (Leucaena leucocephala (Lam.) De Wit.). Penelitian ini bertujuan untuk memformulasi sediaan masker gel peel-off ekstrak etanol daun petai cina (Leucaena leucocephala (Lam.) De Wit.) yang memenuhi syarat uji mutu fisik dan untuk mengetahui aktivitas antijerawat formulasi sediaan masker gel peel-off ekstrak etanol daun petai cina (Leucaena leucocephala (Lam.) De Wit.). Metode ekstraksi digunakan yaitu metode maserasi dengan pelarut etanol 96%. Ekstrak yang diperoleh dibuat sediaan masker gel peel-off yang telah di uji konsentrasi hambat minimumnya (KHM) dengan konsentrasi ekstrak FI (2,5%), FII (5%) dan FIII (10%), Medi-klin® (kontrol positif) dan basis gel (kontrol negatif). Pengujian aktivitas antibakteri menggunakan metode sumuran. Hasil penelitian sediaan masker gel peel-off FI (2,5%), FII (5%), FIII (10%) dan basis gel (kontrol negatif) memenuhi syarat uji mutu fisik. Hasil pengujian aktivitas antijerawat terhadap pertumbuhan bakteri Propionibacterium acnes diperoleh konsentrasi ekstrak FI (2,5%) 18,53 mm, FII (5%) 18,85 mm, FIII (10%) 22,27 mm, Medi-klin® 26,43 mm dan kontrol negatif daun petai cina 6 mm. Hal ini menunjukkan bahwa ekstrak etanol daun petai cina memiliki daya hambat terhadap pertumbuhan bakteri Propionibacterium acnes sebagai antijerawat. Kata Kunci:         Daun petai cina (Leucaena leucocephala (Lam.) De Wit.), Masker gel peel-off, Propionibacterium acnes, Antijerawat
Skrining Fitokimia dan Penentuan Nilai SPF (Sun Protection Factor) Ekstrak Etanol 95% Daun Rambusa (Passiflora foetida L) sebagai Tabir Surya: Phytochemical Screening and Determination of SPF (Sun Protection Factor) Value of 95% Ethanol Extract of Rambusa Leaves (Passiflora foetida L) as a Sunscreen Ghani Nurfiana Fadma Sari; Endang Sri Rejeki
Jurnal Sains dan Kesehatan Vol. 5 No. 6 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i6.2077

Abstract

According to several studies, the rambusa plant has great antioxidant, antidiabetic, antibacterial, antihyperuricemic and anti-inflammatory activity. Rambusa leaves have nutritive compounds such triterpenoids, flavonoids, tannins, and saponins. The Sun Protection Factor (SPF) number, which defines the length of time a person's skin can be exposed to sunlight without experiencing sunburn, determines the quantity of sunscreen's effectiveness. The purpose of this study is to examine the composition and in vitro sunscreen activity of a 95% ethanol extract of rambusa leaves. This research began with making rambusa leaf powder. The powder obtained is followed by determining the water content. This study used the maceration method of extraction with a 95% ethanol solvent. Sunscreen activity is measured using a spectrophotometer at a wavelength between 290 and 320 nm. The Mansur method is employed for determining the SPF value. The study's findings showed that the SPF value of rambusa leaf extract was 4.26 at a concentration of 41.28 g/ml has moderate protection, 3.74 at a dosage of 41.16 g/ml, and 3.18 at a concentration of 40.88 g/ml, which was categorized as providing only minimal protection. Furthermore, alkaloid, flavonoid, triterpenoid, tannin, and saponin chemicals are present in the 95% ethanol extract of rambusa leaves. Keywords:          Rambusa leaves, sunscreen, SPF   Abstrak Beberapa penelitian menunjukkan bahwa tanaman rambusa memiliki aktivitas antioksidan yang tinggi, antidiabetes, antibakteri, antihiperurisemia dan antiinflamasi. Daun rambusa mengandung zat berkhasiat yaitu triterpenoid, flavonoid, tanin dan saponin. Besarnya kemampuan tabir surya ditentukan melalui nilai Sun Protection Factor (SPF) yang menyatakan lamanya kulit seseorang berada dibawah sinar matahari tanpa mengalami sengatan surya. Penelitian ini bertujuan untuk mengetahui kandungan senyawa dan aktivitas tabir surya ekstrak etanol 95% daun rambusa secara invitro. Penelitian ini diawali dengan pembuatan serbuk daun rambusa. Serbuk yang diperoleh dilanjutkan dengan penetapan kadar air. Pembuatan ekstrak daun rambusa menggunakan metode maserasi dengan pelarut etanol 95%. Ekstrak yang diperoleh diidentifikasi skrining fitokimia dan penentuan aktivitas tabir surya. Penetapan aktivitas tabir surya menggunakan alat spektrofotometer pada panjang gelombang 290 hingga 320 nm. Penentuan nilai SPF menggunakan metode Mansur. Hasil yang diperoleh dari penelitian adalah nilai SPF ekstrak daun rambusa sebagai berikut: konsentrasi 41,28 µg/ml sebesar 4,26 memiliki proteksi sedang, konsentrasi 41,16 µg/ml sebesar 3,74 dan konsentrasi 40,88 µg/ml sebesar 3,18 tergolong memiliki proteksi minimal. Ekstrak etanol 95% daun rambusa mengandung golongan senyawa alkaloid, flavonoid, triterpenoid, tanin dan saponin. Kata Kunci:         Daun rambusa, tabir surya, SPF
Identifikasi Senyawa Flavonoid Ekstrak Kulit Buah Petai (Parkia Speciosa) Asal Bulukumba Secara Spektrofotometer Infra Merah: Identification of Flavonoid Compounds in Petai (Parkia Speciosa) Bark Extract from Bulukumba Regency by Infrared Spectrophotometer Samsidar Usman; Julia Sapitri; Sry Widyastuti
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.2078

Abstract

Tanaman petai (Parkia Speciosa) merupakan salah satu tanaman yang melimpah di Indonesia karena tanaman ini mudah tumbuh dimana saja. Diketahui kulit buah petai memiliki kandungan antioksidan yang cukup tinggi. Tujuan dari penelitian ini untuk mengetahui jenis senyawa flavonoid dalam ekstrak Kulit Buah Petai (Parkia Speciosa) asal Kota Bulukumba. Metode yang di gunakan adalah spektrofotometri infra merah. Hasil Identifkasi senyawa Flavonoid dilakukan dengan teknik pemisahan secara KLT menggunakan cairan pengelusi Klorofom : Metanol : Air (20 : 6 : 1) ekstrak n-Butanol kemudian diKromatografi Lapis Tipis dengan cairan pengelusi Klorofom : Metanol: Air (20 : 6 : 1) diperoleh 1 Fraksi yaitu Fraksi A. Fraksi tersebut menunjukkan masing-masing 1 noda dan diduga sebagai Noda Tunggal. Selanjutnya Fraksi A diukur dengan Spektrofotometri Infra Merah diperoleh gugus O-H, C-C, dan C-H yang merupakan bagian dari struktur senyawa Flavonoid. Dengan demikian kulit buah petai mengandung senyawa flavonoid Keywords:          Kulit Buah Petai (Parkia Speciosa), n-Butanol Spektrofotometri Inframerah   Abstrak Petai plants (Parkia Speciosa) are one of the most abundant plants in Indonesia because they are easy to grow anywhere,It is known that the skin of the petai fruit has a fairly high antioxidant content. The purpose of this study was to determine the types of flavonoid compounds in the extract of the peel of Petai (Parkia Speciosa) from Bulukumba Regency. The method used is infrared spectrophotometry. Results Identification of flavonoid compounds was carried out by separation technique using TLC using Chlorophome: Methanol: Water (20: 6: 1) extract of n-Butanol then Thin Layer Chromatography with Chlorophome: Methanol: Water (20: 6: 1) elution fluid obtained 1 The fraction is Faction A. The fractions showed 1 stain each and were suspected as a single stain. Furthermore, fraction A was measured by Infrared Spectrophotometry, obtained O-H, C-C, and C-H groups which are part of the structure of the Flavonoid compound. Thus, the skin of the petai fruit contains flavonoid compounds. Kata Kunci:         Petai Fruit Skin (Parkia Speciosa), n-Butanol Infrared Spectrophotometry
Uji Aktivitas Ekstrak Daun Belimbing Manis (Averrhoa Carambola L.) terhadap Penyembuhan Luka Sayat pada Kelinci New Zealand: Activity Test of Sweet Starfruit Leaf Extract (Averrhoa Carambola L.) on Wound Healing in New Zealand Rabbits Nafisatul Laili; Supriyanto Supriyanto; Maulita Saraswati
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.2080

Abstract

Sweet starfruit leaf extract (Averrhoa carambola L.) contains alkaloids and flavonoids which can be useful as anti-bacterials, saponins and tannins which can stimulate collagen formation, namely in the healing process of cut wounds. The aim of this research was to determine the effect of sweet starfruit leaf extract on healing cut wounds. Sweet starfruit leaves were extracted using 70% ethanol solvent and using the maceration method. Making variations of star fruit leaf extract was applied to 3 test animals. Each rabbit was given 5 treatments, namely manais starfruit leaf extract 25%, 50%, 75%, negative control, positive control. All rabbits were injured 2 cm long and 0.2 cm deep. Data was tested statistically using ANOVA (Analysis of Variance). The research results showed that all variations in extract concentration experienced narrowing of the wound, forming scabs and closing the wound. The statistical test results had a significant effect on wound healing in New Zealand rabbits, namely (p<0.05). These results show that making variations of star fruit leaf extract of 25%, 50% and 75% can heal cuts in New Zealand rabbits. Keywords:          Sweet Carambola Leaf Extract, New Zealand Rabbit, Cuts   Abstrak Ekstrak  daun belimbing manis (Averrhoa carambola L.) memiliki kandungan alkaloid dan flavanoid yang dapat berguna sebagai anti bakteri, saponin dan tanin yang dapat memacu pembentukan kolagen yaitu dalam proses penyembuhan luka sayat. Tujuan dari penelitian ini  untuk mengetahui pengaruh ekstrak daun belimbing manis terhadap penyembuhan luka sayat. Daun belimbing manis di ekstrak menggunakan pelarut etanol 70% dan menggunakan metode  maserasi. Pembuatan variasi ekstrak daun belimbing manis di oleskan pada hewan uji sebanyak 3 ekor. Masing-masing kelinci di beri 5 perlakuan, yaitu ekstrak daun belimbing manais 25%,50 %, 75 %, kontrol negatif, kontrol positif. Semua kelinci dilukai sepanjang 2 cm dengan kedalaman 0,2 cm. Data diuji secara statistik menggunakan ANOVA (Analisys Of Varian). Hasil penelitian menunjukan semua varisi konsentrasi ekstrak mengalami penyempitan luka, membentuk keropeng dan menutup luka. Hasil uji statistik memberikan efek signifikan terhadap penyembuhan luka pada kelinci new zealand, yaitu (p<0,05). Hasil ini menunjukan pembuatan variasi ekstrak daun belimbing manis 25%, 50% dan 75% dapat menyembuhkan luka sayat pada kelinci new zealand. Kata Kunci:         Ekstrak Daun Belimbing Manis, Kelinci New Zealand, Luka Sayat
Aktivitas Antibakteri Nanoemulsi Kombinasi Minyak Sereh (Cymbopogon citratus (DC.) Stapf) dan Minyak Kemangi (Ocimum basilicum L.) terhadap Staphylococcus aureus: Antibacterial Activity of Nanoemulsion of Lemongrass Oil (Cymbopogon citratus (DC.) Stapf) and Basil Oil (Ocimum basilicum L.) Combination against Staphylococcus aureus Hasan, Nuradnin; Mulyaningsih, Sri; Setianto, Arif Budi
Jurnal Sains dan Kesehatan Vol. 6 No. 1 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i1.2082

Abstract

Lemongrass oil (Cymbopogon citratus (DC.) Stapf) and basil oil (Ocimum basilicum L.) are secondary metabolites that can be utilized as antibacterials. This study aims to determine the antibacterial activity of nanoemulsion preparation formulations of a combination of lemongrass oil and basil oil against S. aureus bacteria and determine the effective concentration of the mixture of the two. Both oils used were verified including GC-MS analysis, specific gravity, refractive index, solubility in alcohol and acid number. The nanoemulsion preparation formulation contained 4% (v/v) combination of lemongrass oil and basil oil, each fraction consisting of F1 (1:3), F2 (2:2) and F3 (3:1). The resulting preparation was tested for physical properties including organoleptic, homogeneity, viscosity, particle size, pH, irritation test, hedonic test and antibacterial activity test using the pitting diffusion method. The results of GC-MS analysis, lemongrass oil has the main compound components, namely E-citral (38.49%) and Z-citral (25.26%) while basil oil has the main compounds, namely Methyl chavicol (58.14%) and linalool (31.72%). Evaluation of the physical properties of lemongrass oil and basil oil roll-on deodorant preparations met the parameters in accordance with the standard. From the results of the antibacterial activity test for S. aureus, F1 had an inhibition zone of 11.44 ± 2.51 mm, F2 18.89 ± 1.05 mm both included in the strong category and F3 23.78 ± 1.72 mm included in the very strong category. The positive control had a zone of inhibition of 10.56 ± 0.53 mm and the negative control had a zone of inhibition of 0 mm. In conclusion, F3 formulation of roll on deodorant preparation with a combination of lemongrass oil and basil oil (3:1) at 4% has effective antibacterial activity against S. aureus bacteria. Keywords:          Lemongrass oil and basil oil, nanoemulsion preparation, S. aureus   Abstrak Minyak sereh (Cymbopogon citratus (DC.) Stapf) dan minyak kemangi (Ocimum basilicum L.) adalah minyak esensial yang dapat dimanfaatkan sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri formulasi sediaan nanoemulsi kombinasi minyak sereh dan minyak kemangi terhadap bakteri S. aureus dan mengetahui konsentrasi yang efektif dari campuran keduanya. Kedua minyak yang digunakan diverivikasi meliputi analisis GC-MS, bobot jenis, indeks bias, kelarutan dalam alkohol serta bilangan asam. Formulasi sediaan nanoemulsi mengandung 4% (v/v) kombinasi minyak sereh dan minyak kemangi yang masing-masing fraksinya terdiri dari F1 (1:3), F2 (2:2) dan F3 (3:1). Sediaan yang dihasilkan diuji sifat fisik antara lain organoleptik, homogenitas, pH dan aktivitas antibakteri dengan menggunakan metode difusi sumuran. Hasil analisis GC-MS, minyak sereh memiliki komponen senyawa utama yaitu E-sitral (38,49%) dan Z-sitral (26,25%) sedangkan minyak kemangi senyawa utamanya yaitu Methyl chavicol (58,14%) dan linalool (31,72%). Evaluasi uji sifat fisik sediaan nanoemulsi minyak sereh dan minyak kemangi memenuhi parameter yang sesuai dengan standar. Dari hasil uji aktivitas antibakteri S. aureus F1 memiliki zona hambat sebesar 11,44 ± 2,51 mm, F2 18,89 ± 1,05 mm keduanya termasuk kategori kuat dan F3 23,78 ± 1,72 mm termasuk kategori sangat kuat. Kontrol positif mempunyai zona hambat 10,56 ± 0,53 mm dan kontrol negatif memiliki zona hambat 0 mm. Kesimpulannya, formulasi F3 sediaan deodoran roll on kombinasi minyak sereh dan minyak kemangi (3:1) sebanyak 4% memiliki aktivitas antibakteri terhadap bakteri S. aureus yang efektif. Kata Kunci:         Minyak sereh dan minyak kemangi, sediaan nanoemulsi, S. aureus
Pengaruh Jenis dan Pola Konsumsi Makanan yang Mengandung Vitamin D Terkait Gangguan Fungsi Paru pada Tukang Bangunan: Effect of Types and Food Consumption Patterns that Contain Vitamin D Related to Pulmonary Disorders in Builders Erlin Oktavia; Amelia Lorensia; Rivan Virlando Suryadinata
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.2085

Abstract

Respiratory disorders are a major cause of morbidity and mortality. In addition to pollution from vehicles, pollution from work such as building work, demolition, excavation can also cause respiratory problems. Vitamin D deficiency is the opposite of respiratory disease, with effects on respiratory infections and lung function. This study discusses the consumption patterns of foods containing vitamin D against lung function disorders in construction workers. This research is a retrospective study by collecting respondents using purposive sampling. Variables to be added: food intake containing vitamin D with the Food Frequency Questionnaire (FFQ) method, pulmonary function using the spirometry. In this study there were 118 respondents consisting of 58 respondents with pulmonary function disorders and 60 respondents without pulmonary function disorders. Of the 58 respondents who had a malfunctioning, there were 14 respondents (24.14%) who experienced a deficit in food intake containing vitamin D and 44 respondents (75.86%) enough food intake containing vitamin D. Of the 60 respondents who did not have functional problems pulmonary, 16 respondents (26.67%) needed to increase the food intake deficit that contained vitamin D and 44 respondents (73.33%) provided enough food containing vitamin D. The most commonly consumed foods were the second group containing eggs and catfish. The results of the different tests showed the results of a P value of 0.752 which means there was no difference between the intake of foods containing vitamin D between the two groups. The pattern of consumption of foods containing vitamin D does not affect the occurrence of lung function disorders in builders. Keywords:          Food intake, vitamin D, lung function   Abstrak Gangguan pernafasan merupakan penyebab utama morbiditas dan mortalitas. Selain pencemaran dari kendaraan, pencemaran dari pekerjaan seperti pekerjaan gedung, pembongkaran, penggalian juga dapat menyebabkan gangguan pernafasan. Kekurangan vitamin D adalah kebalikan dari penyakit pernafasan, dengan efek pada infeksi pernafasan dan fungsi paru-paru. Penelitian ini membahas tentang pola konsumsi makanan yang mengandung vitamin D terhadap gangguan fungsi paru pada pekerja bangunan. Penelitian ini merupakan penelitian retrospektif dengan pengambilan responden menggunakan purposive sampling. Variabel yang ditambahkan: asupan makanan yang mengandung vitamin D dengan metode Food Frequency Questionnaire (FFQ), fungsi paru menggunakan spirometri. Dalam penelitian ini terdapat 118 responden yang terdiri dari 58 responden dengan gangguan fungsi paru dan 60 responden tanpa gangguan fungsi paru. Dari 58 responden yang mengalami malfungsi terdapat 14 responden (24,14%) yang mengalami defisit asupan makanan yang mengandung vitamin D dan 44 responden (75,86%) yang cukup asupan makanan yang mengandung vitamin D. Dari 60 responden yang tidak berfungsi Masalah paru, 16 responden (26,67%) perlu meningkatkan defisit asupan makanan yang mengandung vitamin D dan 44 responden (73,33%) menyediakan makanan yang cukup mengandung vitamin D. Makanan yang paling banyak dikonsumsi adalah kelompok kedua yang mengandung telur dan ikan lele. Hasil uji beda menunjukkan hasil nilai P sebesar 0,752 yang berarti tidak ada perbedaan asupan makanan yang mengandung vitamin D antara kedua kelompok. Pola konsumsi makanan yang mengandung vitamin D tidak mempengaruhi terjadinya gangguan fungsi paru pada tukang bangunan. Kata Kunci:         Asupan makanan, vitamin D, fungsi paru-paru
An in Vitro Approach: Antibacterial Activity of Sansevieria trifasciata Prain. Leaves with Chemometric Analysis Kasmawati, Henny; Sida, Nurramadhani A.; Arfan, Arfan; Indrayanti, Wa Ode Dian; Rusman, Arman
Jurnal Sains dan Kesehatan Vol. 6 No. 1 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i1.2087

Abstract

Exploration the antibacterial activity of S.trifasciata Prain. is still limited, therefore this study aims to assess the antibacterial activity of extracts and ethyl acetate fractions of Sansevieria trifasciata Prain. The S.trifasciata leaves was macerated with ethanol 96%, then fractionated using the trituration method with ethyl acetate. The treatment group was divided into positive control group (PC) using ciprofloxacin, negative control (NC) using DMSO, extract, ethyl acetate fraction 5% (ET5%), 10% (ET10%), 20% (ET20%), 40% (ET40 %). Data were analyzed statistically by ANOVA and chemometrically with PCA. The inhibition zone for S.aureus bacteria in each sample is 26.69; 1.40; 23.32;2.82; 6.23; 11.11; 20.15 mm, respectively, E.coli is 26.65;0.63;22.65;3.61;7.11;11.44;21.15 mm respectively, P. aeruginosa is 27.40; 0.00; 23.23; 2.74;7.03;11.69;21.36 mm respectively. Percent inhibition of extract, ET5%, ET10%, ET20%, ET40% on S. aureus bacteria is 82.16; 5.31; 18.12; 36.39; 70.38% respectively, E.coli is 82.67; 11.13; 24.31; 40.56; 76.99% respectively, P. aeruginosa 84.85; 10.01; 25.65; 42.68; 77.98% respectively. Extract and ethyl acetate fraction have significant potential as antibacterial (p<0.05). The results of PCA chemometric analysis showed that the extract and ET40% had similar inhibition zone area to the positive control ciprofloxacin. The extract and the ethyl acetate fraction 40% are promising for development as antibacterials. Keywords:          Sansevieria trifasciata Prain., chemometric, bacterial

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