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Malahayati International Journal of Nursing and Health Science
Published by Universitas Malahayati
ISSN : 26209152     EISSN : 26214083     DOI : https://doi.org/10.33024/minh.v7i10
Core Subject : Health,
Health Professions Nursing Public Health
Malahayati International Journal of Nursing and Health Science is a peer-reviewed journal and provides a platform to publish areas of nursing and health science. The journal also seeks to advance the quality of research by publishing papers introducing or elaborating on new methods in nursing and health science, subject areas for publication include nursing and health science core
Arjuna Subject : Keperawatan - Keperawatan (Lain-Lain)
Articles 346 Documents
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Physical activity and menstrual cycle regularity among young women: A cross-sectional study Dewi Susilowati; Siti Yulaikah; Helmi Nurlaili
Malahayati International Journal of Nursing and Health Science Vol. 9 No. 6 (2026): Volume 9 Number 6
Publisher : Program Studi Ilmu Keperawatan-fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/minh.v9i6.3897

Abstract

Background: Globally, around 14–25% of women have irregular menstrual cycles, characterized by heavier or lighter periods, or cycle lengths exceeding 35 days or shorter than 21 days. Irregular menstrual cycles have been linked to various diseases and medical conditions. Various factors can influence menstrual cycle, including age, body mass index, physical activity, diet, medical status, and overall lifestyle. WHO recommendation for adults aged 18-64 years should do at least 150 minutes of moderate-intensity physical activity per week. Excessive exercise can disrupt the balance of estrogen and progesterone and lead to irregular periods. Purpose: To assess the influence of physical activity and menstrual cycle among female adolescent. Method: A cross-sectional study was conducted to 111 students who met the criteria, such as had a record of the first day of her menstrual period since December 2024 until February 2025 and did not have reproductive system disorders. The physical activity measured by PAQ-A questionnaire, while menstruation cycle was collected by questionnaire. The data were analysed using Spearman test. Results: Most of respondents were 19 years old (54.1%), had light physical activity (66.7%), and got regular menstrual cycle (58.6%). Spearman's rank correlation showed a significant negative association (ρ = −0.558, p < 0.001). Conclusion: There was an association between physical activity with menstrual cycle.
Factors associated with carpal tunnel syndrome among bag craftsmen in Sidoarjo, Indonesia Farha Kamilatun Noha Fadilah; Nadila Octaria Milenia; Reny Indrayani; Noeroel WIdajati
Malahayati International Journal of Nursing and Health Science Vol. 9 No. 6 (2026): Volume 9 Number 6
Publisher : Program Studi Ilmu Keperawatan-fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/minh.v9i6.3914

Abstract

Background: Carpal Tunnel Syndrome (CTS) is a wrist disorder caused by compression of the median nerve within the carpal tunnel. It commonly manifests as tingling, numbness, and muscle weakness in the fingers or hand. If left untreated, CTS can lead to more severe physical impairment. Workers engaged in repetitive tasks with awkward postures, such as bag craftsmen at UD Sumber Rejeki, are particularly at risk. Purpose: To identify risk factors associated with CTS complaints among bag craftsmen in Sidoarjo Regency. Method: An observational analytic design with a cross-sectional approach was employed. The sample comprised all 43 bag craftsmen. Data were collected through interviews and direct observation using questionnaires, Phalen’s Test sheets, the Boston Carpal Tunnel Questionnaire (BCTQ), and wrist posture evaluations with the RULA method. Bivariate analysis was conducted using Chi-square or Fisher’s Exact tests, with associations expressed as Odds Ratios (OR) and 95% Confidence Intervals (CI). Results were considered significant at p<0.05. Results: CTS complaints were reported by 26 workers (60.5%). Significant associations were found between gender (p=0.045; OR=3.75), length of service (p=0.009; OR=6.81), repetitive movements (p<0.001; OR=19.60), and awkward hand posture (p=0.002; OR=7.11). In contrast, age (p=0.055), smoking history (p=0.206), and medical history (p=0.154) showed no statistically significant associations with CTS complaints. Conclusion: Gender, duration of employment, repetitive movements, and non-ergonomic postures were significantly associated with CTS complaints among bag craftsmen. The industry is encouraged to implement adequate rest breaks and improve workstation ergonomics to reduce the risk of CTS complaints.
Bladder KI-67 expression and IL-6 levels after Ipomoea Batatas extract administration Nyoman Pramudita; Kadek Budi Santosa; Ketut Putu Yasa
Malahayati International Journal of Nursing and Health Science Vol. 9 No. 6 (2026): Volume 9 Number 6
Publisher : Program Studi Ilmu Keperawatan-fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/minh.v9i6.3917

Abstract

Background: Estrogen deficiency after menopause contributes to structural and functional alterations of the bladder, including impaired urothelial proliferation, increased oxidative stress, and chronic inflammation. Ki-67 reflects cellular proliferative activity, whereas interleukin-6 (IL-6) represents a key pro-inflammatory mediator involved in tissue injury. Ipomoea batatas L., a purple sweet potato rich in anthocyanins and phytoestrogenic compounds, may exert regenerative and anti-inflammatory effects on estrogen-sensitive tissues. Purpose: To evaluate the effect of Ipomoea batatas L. ethanol extract on bladder Ki-67 expression and IL-6 levels in a surgically induced estrogen deficiency (menopause-like) Wistar rat model. Method: This experimental study used a post-test-only control group design. Thirty-six female Wistar rats were randomly allocated into two groups: a control group receiving distilled water and a treatment group receiving Ipomoea batatas L. ethanol extract at 40 mg/kg body weight/day for one month. Menopause was induced through ovariectomy. Bladder tissue samples were collected for assessment of Ki-67 and IL-6 levels. Data normality and homogeneity were assessed using the Shapiro-Wilk and Levene tests, respectively. Between-group comparisons were performed using the independent samples t-test. Results: The treatment group showed significantly lower IL-6 levels than the control group (14.11 ± 2.45 vs. 28.28 ± 3.58; mean difference 14.17; 95% CI 12.09–16.24; p < 0.001). Conversely, Ki-67 expression was significantly higher in the treatment group than in the control group (24.94 ± 3.06 vs. 13.56 ± 2.31; mean difference 11.39; 95% CI 9.55–13.22; p < 0.001). Both differences corresponded to very large effect sizes (Cohen’s d = 4.62 for IL-6 and 4.20 for Ki-67). Conclusion: Ipomoea batatas L. ethanol extract significantly reduced bladder IL-6 levels and increased Ki-67 expression in menopause-induced Wistar rats. These findings suggest that Ipomoea batatas L. may have potential anti-inflammatory and pro-regenerative effects on bladder tissue under estrogen-deficient conditions.
Predictive performance of cardiovascular risk scores for ischemia detected by exercise stress testing: A systematic literature review Juins Remon Fanu Rakmeni; Baiduri Widanarko
Malahayati International Journal of Nursing and Health Science Vol. 9 No. 6 (2026): Volume 9 Number 6
Publisher : Program Studi Ilmu Keperawatan-fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/minh.v9i6.3922

Abstract

Background: Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality worldwide. Identifying early risk stratification before fatal clinical manifestations occur represents a major challenge in modern diagnostic cardiology. Although conventional cardiovascular risk scores and exercise stress testing (EST) are frequently used independently, the accuracy of validated risk scores in predicting physical stress-induced ischemia requires systematic evaluation. Purpose: To evaluate the discriminative ability of validated cardiovascular risk scores in predicting positive ischemic events during an exercise stress test (EST). Method: A systematic literature review (SLR) was conducted in accordance with the PRISMA framework. Articles published between 2020 and 2025 were retrieved from Scopus, ScienceDirect, and Google Scholar. Two reviewers independently extracted data using a standardized form. Study quality and bias were assessed with JBI Critical Appraisal Tools, and eligibility criteria were defined by the PICOS framework. The initial search yielded 174 articles, and 8 relevant studies were selected for narrative synthesis. Results: Validated cardiovascular risk scores show strong predictive value for ischemic outcomes on EST. Traditional risk factors (diabetes, hypertension, age, smoking) correlate with ECG ST‑segment depression, abnormal hemodynamics, and perfusion defects. High‑risk profiles also predict future MACE, even in patients with non‑ischemic stress test results. Conclusion: Cardiovascular risk scores enable effective early screening for ischemia in EST, optimizing referrals, interpretation, and cost‑effectiveness. Future work should develop composite scores integrating clinical and stress test parameters, and conduct longitudinal studies to establish long‑term prognostic value.
Analysis of area-based specific and sensitive interventions for stunting prevention Herizal Herizal; Basri Aramico; Maidar Maidar; Asnawi Abdullah; Hermansyah Hermansyah
Malahayati International Journal of Nursing and Health Science Vol. 9 No. 6 (2026): Volume 9 Number 6
Publisher : Program Studi Ilmu Keperawatan-fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/minh.v9i6.3969

Abstract

Background: The World Health Assembly has set a global target of 40% reduction in the number of children under five years of age who are stunted. In Bireuen Regency, however, cases have risen sharply, with prevalence increasing from 23.4% in 2022 to 32.9% in 2023. Purpose: To analyze area-based specific and sensitive interventions for stunting prevention in Bireuen Regency. Method: A quantitative cross-sectional study was conducted using secondary data from the Bireuen Regency Health Office, obtained from the Electronic Community-Based Nutrition Recording and Reporting System (E-PPGBM) and the Healthy Indonesia Program with a Family Approach (PIS-PK). The analysis included all 609 villages in Bireuen Regency. Chi-square tests and logistic regression were used to assess the associations between interventions and stunting prevalence. Results: Significant associations were found for iron–folic acid supplementation among adolescent girls (OR=12.2; p=0.001) and pregnant women (OR=0.21; p=0.001), early initiation of breastfeeding (OR=2.02; p=0.008), child growth monitoring (OR=0.47; p=0.002), and complete immunization (OR=2.56; p=0.024). Antenatal care and exclusive breastfeeding were not significantly associated with stunting. Sensitive interventions, including access to clean water (OR=3.24; p=0.001), sanitation (OR=3.02; p=0.001), and social security (OR=0.50; p=0.008), were also significantly associated with stunting prevalence. Conclusion: Integrated, area-based implementation of both specific and sensitive interventions is essential for sustainable stunting reduction in Bireuen Regency.
Family support and iron supplementation adherence among pregnant women Ernika Wati Putri Situmorang; Lasria Yolivia Aruan; Ribur Sinaga; Lely Enjel Zhenita Manurung; Sayidina Br Ginting
Malahayati International Journal of Nursing and Health Science Vol. 9 No. 6 (2026): Volume 9 Number 6
Publisher : Program Studi Ilmu Keperawatan-fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/minh.v9i6.4025

Abstract

Background: Anemia is a condition where the hemoglobin level in the blood is below normal and can occur in various groups. Hemoglobin functions to transport oxygen to all body tissues while supporting the energy needs of each cell. Anemia in pregnancy remains a major health concern in Indonesia, as it threatens maternal and fetal well-being and increases risks of premature birth, low birth weight, and other complications. High coverage of iron supplementation among pregnant women does not reduce anemia prevalence if adherence remains low. Purpose: To analyze the family support on pregnant women's iron-tablet adherence. Method: A quantitative, cross-sectional analytical study design was employed. The study population comprised 36 pregnant women selected via purposive sampling based on predefined inclusion criteria. Family support was evaluated using an adapted 9-item questionnaire scored on a dichotomous Guttman scale, while adherence was evaluated using a single self-reported item. Data were analyzed using the chi-square test, with statistical significance established at p < 0.05. Results: Chi-Square test revealed a significant association between family support and iron-tablet adherence, with a p-value of 0.004 (p < 0.05). Conclusion: A statistically significant association was observed between family support and adherence to iron supplementation among pregnant women.
Neuroinflammation in psychosis: Immune pathways, biomarkers, and therapeutic implications: A literature review Nur Muhamad Jati Kusuma; Muh Alim Jaya; Ilma Khaerina Amaliyah Bakhtiar
Malahayati International Journal of Nursing and Health Science Vol. 9 No. 6 (2026): Volume 9 Number 6
Publisher : Program Studi Ilmu Keperawatan-fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/minh.v9i6.4030

Abstract

Background: Psychosis is increasingly understood as a heterogeneous neuropsychiatric syndrome in which immune dysregulation may interact with dopaminergic, glutamatergic, and neurodevelopmental mechanisms. Purpose: To synthesize evidence on neuroinflammatory pathways implicated in psychosis and evaluate their potential clinical relevance. Method: A narrative literature review was conducted through PubMed-based searching between January and June 2026. English- or Indonesian-language full-text publications issued from 2016 to 2026 were considered when they addressed psychosis or schizophrenia in relation to cytokines, chemokines, immune-cell profiles, microglial activation, blood–brain barrier dysfunction, oxidative stress, or the gut–brain axis. Ten highly relevant review-level articles were selected and narratively synthesized using a PICOS-informed extraction framework. Results: Across the included literature, psychosis was associated with increased pro-inflammatory mediators, particularly interleukin-6, interleukin-1β, tumor necrosis factor-α, interferon-γ, C-reactive protein, and selected chemokines. Peripheral immune-cell alterations, microglial activation, oxidative stress, impaired blood–brain barrier integrity, and microbiome-related immune signaling were repeatedly reported. These processes may disrupt synaptic pruning, N-methyl-D-aspartate receptor signaling, inhibitory interneuron function, and dopamine–glutamate balance. However, heterogeneity across disease stage, medication exposure, comorbidity, biospecimen, and assay method limits diagnostic specificity. Conclusion: Neuroinflammation is a plausible contributor to the pathophysiology and progression of psychosis, but current biomarkers are better viewed as stratification or prognostic candidates than stand-alone diagnostic tests. Longitudinal, multimodal, and phenotype-stratified studies are required before immune-targeted interventions can be incorporated into routine care.
Child, maternal, and environmental factors in stunting among children aged 12–59 months Rifda Haya Tsamaroh; Dian Indahwati Hapsari; Agus Samsudrajat S; Gandha Sunaryo Putra
Malahayati International Journal of Nursing and Health Science Vol. 9 No. 6 (2026): Volume 9 Number 6
Publisher : Program Studi Ilmu Keperawatan-fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/minh.v9i6.4042

Abstract

Background: Stunting is an irreversible condition resulting from inadequate nutritional intake, recurrent infections, or chronic illness during the first 1,000 days of life. It can adversely affect children’s cognitive and social development, physical health, and long-term economic productivity. Purpose: To identify factors associated with stunting among children aged 12–59 months in Indonesian border regions. Method: This cross-sectional study analyzed secondary data from the 2023 Indonesian Health Survey (SKI) among children aged 12–59 months living in Indonesian border regions. The analysis was conducted from March to May 2026. A total of 3,914 eligible children were included. The dependent variable was stunting, while the independent variables were diarrhea, tuberculosis (TB), acute respiratory infection (ARI), low birth weight (LBW), handwashing practices, sanitation facilities, maternal educational level, and parity. Data were analyzed using univariate and bivariate analyses. Results: The prevalence of stunting was 27.5%. Bivariate analysis showed significant associations between ARI, LBW, sanitation facilities, maternal educational level, parity, and stunting (p < 0.001). No significant associations were found between diarrhea (p = 0.999), TB (p = 0.669), handwashing practices (p = 0.130), and stunting. Conclusion: ARI, LBW, sanitation facilities, maternal educational level, and parity were significantly associated with stunting among children aged 12–59 months in Indonesian border regions. In contrast, diarrhea, TB, and handwashing practices were not significantly associated with stunting. These findings suggest that stunting in border regions is associated with a combination of child health, birth-related, environmental, and socio-demographic factors.
Implementation of worker health monitoring through a health, safety, and environment system Arien Abelia; Nurul Aziza; Febria Listina
Malahayati International Journal of Nursing and Health Science Vol. 9 No. 6 (2026): Volume 9 Number 6
Publisher : Program Studi Ilmu Keperawatan-fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/minh.v9i6.4079

Abstract

Background: Work health monitoring is an important component in the management of occupational safety and health (OSH), especially in the electrical sector. The implementation of an effective health monitoring program contributes to the prevention of workplace accidents, enhances worker welfare, and increases productivity. Purpose: To analyze the implementation of the worker health monitoring program through the health, safety, and environment (HSE) system. Method: This study uses a descriptive qualitative design. Data were collected through in-depth interviews, focus group discussions (FGD), and observations involving five informants who were purposively selected. Data is analyzed based on four components, namely planning, implementation, reporting, and monitoring, evaluation, and follow-up. Results: The planning component of the health monitoring program has generally been well implemented, supported by hazard identification procedures, HIRAC documentation, and the Wellness application. At the implementation stage, workers regularly undergo scheduled health check-ups, but special health examinations, health promotion, and on-site health services are still limited. The reporting system has not been implemented comprehensively because periodic health reporting, medical audits, and integrated health documentation are not yet available. Additionally, monitoring and evaluation activities have not been carried out systematically, with limitations in management reviews, follow-up mechanisms, and occupational health personnel, which reduce the program's effectiveness. Conclusion: The implementation of the worker health monitoring program through the HSE system has been partially carried out, but it is not yet fully optimal. Improvements are needed in specialized occupational health services, integrated health reporting systems, monitoring and evaluation mechanisms, as well as a commitment to strengthening occupational health management and enhancing worker safety and well-being.
Nutritional composition and safety of catfish (Clarias spp.) extract-based shredded fish for stunting prevention: Implications for community nursing Ferdinan Sihombing; Ellen Stephanie Rumaseuw; Maria Alfa Raniadita
Malahayati International Journal of Nursing and Health Science Vol. 9 No. 6 (2026): Volume 9 Number 6
Publisher : Program Studi Ilmu Keperawatan-fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/minh.v9i6.4080

Abstract

Background: Childhood stunting remains one of Indonesia's major public health challenges. Inadequate dietary protein intake during the first 1,000 days of life is a significant contributor to chronic undernutrition. Locally available, high-protein functional foods with proven nutritional quality and food safety are needed to strengthen community-based stunting prevention programs. Purpose: To compare the nutritional composition and food safety characteristics of catfish (Clarias sp.) extract-based shredded fish (E-Lele) with commercially available shredded catfish products and evaluate its potential as a complementary food supporting childhood stunting prevention. Method: A comparative laboratory study was conducted using one E-Lele product and three commercially available shredded catfish products. Proximate analysis included protein, fat, carbohydrate, moisture, ash, and total energy. Lead, cadmium, and Escherichia coli were also evaluated using standardized laboratory methods. Results: E-Lele demonstrated the highest protein content (38.33%), lowest moisture content (3.32%), and lowest carbohydrate level (21.36%). Lead and cadmium concentrations remained below national maximum allowable limits and were lower than those found in commercial products. No Escherichia coli contamination was detected. Conclusion: Catfish extract-based shredded fish demonstrates superior nutritional composition and satisfactory food safety compared with commercially available products, indicating potential as a locally produced functional complementary food supporting childhood stunting prevention. Further clinical and community intervention studies are required.

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