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Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Published by SEKOLAH TINGGI ILMU KESEHATAN SAMARINDA
ISSN : 2443115X     EISSN : 24771821     DOI : https://doi.org/10.51352/jim
Core Subject : Health, Science,
Chemistry Immunology & microbiology Medicine & Pharmacology Nursing Public Health
Jurnal Ilmiah Manuntung is a journal on pharmaceutical and health sciences published by Sekolah Tinggi Ilmu Kesehatan Samarinda which includes the study of pharmaceutical sciences, medicine, synthetic organic chemistry, organic chemistry of natural materials, biochemistry, analytical chemistry, physical chemistry, biology, microbiology, tissue culture, botany and animals related to pharmaceutical products, nursing, midwifery, health analysts, nutrition and public health.
Arjuna Subject : Profesi Kesehatan - Farmasi
Articles 326 Documents
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AKTIVITAS ANTIKOLESTEROL EKSTRAK ETANOL BUAH KIWI HIJAU (Actinidia deliciosa) Novena Yety Lindawati; Desi Widya Ningsih
Jurnal Ilmiah Manuntung Vol 6 No 2 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i2.344

Abstract

Disease in the liver caused by hypercholesterolemia is fatty liver. Fatty liver is one of the damages to the liver, a condition in which the liver experiences fat accumulation. Green kiwifruit (Actinidia deliciosa) is a plant that contains a lot of flavonoid compounds can be used as cholesterol-lowering. Flavonoids are able to release cholesterol found in the walls of blood vessels and organs in the body. The purpose of this study was to determine the presence or absence of anticholesterol activity and EC50 values in ethanol extracts of green kiwifruit (Actinidia deliciosa) with a concentration series of 2.5; 5.0; 7.5; 10.0; 12.5 ppm. Ethanol extract of green kiwifruit was tested for active substance content and quantitative analysis using UV-Vis spectrophotometry method at a wavelength of 668 nm and operating time of 15 minutes. The results showed ethanol extract of green kiwifruit contains phenols, flavonoids, saponins, vitamin C which can reduce cholesterol levels with an average EC50 value of 7.3 ppm with a coefficient of variation value of 1.12%. Keywords : Cholesterol, Lieberman-burchard, Extract, Green kiwifruit (Actinidia deliciosa), UV-VIS spectrophotometry.
PENETAPAN KADAR FLAVONOID TOTAL JUS BUAH DELIMA (Punica granatum L.) YANG BERPOTENSI SEBAGAI HEPATOPROTEKTOR DENGAN METODE SPEKTOFOTOMETRI UV-VIS Suharyanto Suharyanto; Anisa Dinda Ramadhani
Jurnal Ilmiah Manuntung Vol 6 No 2 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i2.345

Abstract

Pomegranate is one of the plants of the Lythraceae family. Pomegranate plants are spread from the subtropics to the tropics, from the lowlands to altitudes below 1000 masl. Pomegranate contains flavonoid compounds that can be used as traditional medicine for hepatoprotectors. The aim of the researcher was to determine the total flavonoid levels in pomegranate juice (Punica granatum L) by UV-Vis Spectrophotometry. The method used in the study is the Chang method. Identification of flavonoids with concentrated HCl reagents and magnesium metal causes a change in color to red which indicates a positive sample containing flavonoids. The results of the study showed total flavonoid levels contained in pomegranate juice 0.0075766% QE. Results Variation Coefficient Value (% KV) of the sample is 0.7475%, Variation Coefficient (% KV) is the percentage ratio between the standard deviation and the average. % KV is used in grading to express precision.
ANALISIS KINERJA PELAYANAN APOTEK DAN KINERJA KEUANGAN PADA APOTEK PROGRAM RUJUK BALIK (PRB)-KRONIS BPJS DAN APOTEK TIDAK BEKERJA SAMA BPJS DI KOTA BOGOR, JAWABARAT M. Kenli Kendi Tampoliu; MGS. Aritonang; Yusi Anggriani
Jurnal Ilmiah Manuntung Vol 6 No 2 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i2.346

Abstract

The number of JKN participants increase continuously everyday. Therefore, health facilities should be grow and developed well to serve them. One of the facility is pharmacy. In Bogor, there are three districts that do not have BRP pharmacy, they are East Bogor, North Bogor and Tanah Sareal. The less and uneven of pharmacy on those districts will affect the eviciency and accesibility of the participants. We could say that the accesibility is not good on those districts. And if it does, it will affect the satisfaction of patients against the BRP. This research was conducted in Bogor City. The purpose of this research is to find out the comparison of service performance and financial performance between BRP-Chronic pharmacy cooperating to BPJS and pharmacy non cooperating to BPJS. This research was conducted by using descriptive comparative method with qualitative and quantitative approach. It was build with survey, questionaire, observation and interview. Using purposing sampling, there was 2 BRP-Chronic pharmacies and 10 non BRP-Chronic pharmacies that become the sample of this research. The instruments were developed based on Permenkes number 73 on 2016. The qualitative data analysis method was made descriptively. The qualitative data was presented descriptively to explain the qualitative data. The result of this research showed that the BPR-Chronic pharmacies were more prime on pharmaceutical preparations, clinical pharmaceutical service, pharmaceutical service quality evaluation, and ensuring the availability. On the other hand, non cooperating to BPJS pharmacies were more excellent on pharmaceutical resources and service report. The result of financial performance research showed that pharmacy non cooperating to BPJS was better than BRP-Chronic. The BRP-Chronic has problem on claiming, not being collected and late claim payment. Pharmacy non cooperating to BPJS was rely on clients’ prescriptions and suplement salling and also it use the new technology such as media social and e-commerce.
UJI DAYA HAMBAT EKSTRAK ETANOL DAUN MAHKOTA DEWA (Phaleria macrocarpa Boerl.,) TERHADAP Klebsiella pneumonia. Aulia Nur Rahmawati; Putri Afiana Solicah
Jurnal Ilmiah Manuntung Vol 6 No 2 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i2.349

Abstract

Mahkota Dewa (Phaleria macrocarpa Boerl) is a medical plant of the Thymelaeaceae family originating from Indonesia, precisely from Papua. Phaleria macrocarpa Boerl the deity has been known in various treatments such as diabetes, cancer, liver, dysentery, allergic diabetes, eczema, or gout and others (Ratna & Wiwi, 2014). The purpose of this study is to find out whether extract ethanolic 96% of Phaleria macrocarpa Boerl can inhibit the growth of K. pneumoniae, and to know what concentration of extract ethanolic 96% of Phaleria macrocarpa goodnes to inhibit K. pneumoniae. The method used is the Kirby Bauer Method. With the average inhibition zone concentrations is 100%, 80%, 60%, 40%, 20% respectively 17.41mm, 15.37mm, 12.60mm, 11.10mm, 6.43mm.
EFEKTIVITAS GEL EKSTRAK AIR UMBI BAWANG PUTIH TERHADAP PENYEMBUHAN LUKA BAKAR DAN LUKA SAYAT Irene Puspa Dewi; Verawaty Verawaty; Tuty Taslim
Jurnal Ilmiah Manuntung Vol 6 No 2 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i2.356

Abstract

This study was conducted to determine the effectiveness of garlic (Allium sativum L.) extract gel for healing burns and cuts. Garlics are often used in healing wound because they contained sulfur in garlic, namely Diallyl thiosulfinate (allicin) and Diallyl disulfide (ajoene). Allicin in garlic will reduce inflammatory reactions and antibacterial, which will accelerate in healing wound. Garlics extract made in gel preparations with a concentration of 15% and 20%, then given to burns and cuts mice that have been divided into several groups. In testing, mice that had been made burns were divided into 4 groups and each group contain of 3 mice, namely the 15%, 20% concentration gel group. The Bioplacenton group as a comparison and also the control group. In the examination of cuts, the division of the group of mice that have been made the cuts is the same as the burn test, the comparison is Povidone iodine. From the burn test, the results are the 20% concentration gel group experienced the best healing after 18 days of gel administration and its healing power was better than Bioplacenton. The results of cuts testing is the 15% concentration gel group experienced the best healing and slightly better than Povidone Iodine.
FORMULASI DAN EVALUASI SEDIAAN MASKER SHEET EKSTRAK ETANOL DAUN SIRIH MERAH (Piper crocatum Ruiz & Pav) Verawaty Verawaty; Novita Sulimar; Irene Puspa Dewi
Jurnal Ilmiah Manuntung Vol 6 No 2 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i2.357

Abstract

The research was conducted on ethanol extract formulation of red betel leaves (Piper crocatum Ruiz & Prav.). This research aims to formulate the ethanol extract of red betel leaves (Piper crocatum Ruiz & Prav.) to be a dosage of good, effective, and safe sheet mask to use. This research was experimental, in which 12 women aged 18-25 years old were selected to test for irritation that was observed on the skin behind the ear. To test the effectiveness, the observed dosage was facial skin moisture in the T. The results obtained are in the form of an essence that is slightly thick, brown in color, having a distinctive smell of red betel leaf extract, homogeneous, and safe for the skin. For the effectiveness, the test showed that the sheet mask of red betel leaf extract in formula 1 (1%), formula 2 (3%) and formula 3 (5%) were able to increase facial skin moisture. The analysis results showed that there was a significant difference in the average measurement of water content on the volunteers' facial skin of 0.01 (α <0.05).
UJI AKTIVITAS ANTIOKSIDAN DAN TABIR SURYA KOMBINASI EKSTRAK KULIT BUAH PISANG KEPOK (Musa Paradisiaca Linn) DAN EKSTRAK KULIT BUAH ALPUKAT (Persea Americana Mill) Wimpy Wimpy; Tri Harningsih; Whella Thalitha Larassati
Jurnal Ilmiah Manuntung Vol 6 No 2 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i2.365

Abstract

The kepok banana peel extract (Musa paradisiaca Linn) and avocado peel extract (Persea americana Mill) contain alkaloids, flavonoids, saponins and steroids. There is a linear relationship between antioxidant activity and sunscreen capability. The stronger antioxidant activity,the better sunscreen capability will be. This study aims to determine antioxidant activity and sunscreen capability from the combination of kepok banana peel extract and avocado peel extract compared to it’s single form. This study was conducted with quota sampling. The preparation of ethanol extract from kepok banana peel and avocado peel were using maceration method with 96 % of ethanol. The study was started by collecting samples, making the extract with 96% ethanol solvent, then continue with phytochemical testing, antioxidant activity testing of kepok banana peel extract and avocado peel extract with variation ratio (1:0), (1:1), (1:2), (2:1), (0:​​1). Further tests including cream formulation, cream stability test and in vitro SPF value determination was also conducted. The result of IC50 determination from : kepok banana peel extract is 122,77, belongs to medium category; avocado peel extract is 11,50, belongs to very strong category; (kepok banana peel extract : avocado peel extract) (1:1) is 39,88, belongs to very strong category; (kepok banana peel extract : avocado peel extract) (1:2) : 25,31, belongs to very strong category; (kepok banana peel extract : avocado peel extract) (2:1) : 76,77, belongs to the strong category. The result of SPF measurement from the single form kepok banana is 16,21, belongs to ultra category; single form avocado peel is 21,21, belongs to ultra category; (kepok banana peel extract : avocado peel extract) (1:1) is 21,32, belongs to ultra category; (kepok banana peel extract : avocado peel extract) (1:2) is 21,52 belongs to ultra category; (kepok banana peel extract : avocado peel extract) (2:1) is 21,51, belongs to ultra category. The antioxidant activity from the variation ratio of banana peel extract and avocado peel extract (1:2) is stronger than the single form of banana peel extract, but it is weaker than the single form of avocado peel extract. The combination of kepok banana peel extract and avocado peel extract (1:2) has better sunscreen capability than it’s single form.
SKRINING ANTIOKSIDAN DAN ANTIKANKER EKSTRAK ETANOL DAUN KARAMUNTING (RHONOMYRTUS TOMENTOSA L.) SEBAGAI OBAT ALTERNATIF Marwati Marwati; Mirnawati Salampe; Asril Burhan; Megawati Megawati; Khairuddin Khairuddin; A.Adi Al Ma’aridj Naneng; Nova Oktaviani
Jurnal Ilmiah Manuntung Vol 6 No 2 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i2.367

Abstract

Karamunting (Rhodomyrtus tomentosa (Aiton) merupakan salah satu tanaman yang digunakan sebagai obat tradisional yang banyak tersebar diseluruh Indonesia khususnya berasal Toraja, yang berpotensi sebagai antioksidan dan antikanker dengan adanya kandungan senyawa fenolik dan flavanoid. Penelitian ini bertujuan untuk melihat flavonoid total serta aktivitas antioksidan dan toksisitas ekstrak daun karamunting. Simplisia daun karamunting diekstraksi dengan metode maserasi menggunakan etanol 70%, pengujian aktivitas antioksidan diukur menggunakan microplet reader dan diuji toksisitasnya dengan metode BSLT. Hasi penelitian fenolik total 3,496% , Perolehan aktivitas antioksidan nilai IC50 ekstrak etanol daun karamunting sebesar 24,451 bpj dan Perolehan uji toksisitas nilai IC50 ekstrak etanol daun karamunting sebesar 31,80 bpj terhadap larva udang. Berdasarkan hasil tersebut, ekstrak etanol daun karamunting masuk dalam kategori antivitas sangat kuat dengan range <50 % dan dinilai memiliki sifat toksisitas katogori sangant kuat.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN MEKAI (Pycnarrhena cauliflora DIELS.) TERHADAP Staphylococcus aureus Yayuk Bulam Sarifati; Sjarif Ismail; Khemasili Kosala
Jurnal Ilmiah Manuntung Vol 6 No 2 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i2.369

Abstract

Mekai leaves (Pycnarrhena cauliflora Diels.) (P. cauliflora). Are known to contain flavonoid compounds, tannins and phenolics that act as antibacterial agents and are used in the treatment of eye pain. Staphylococcus aureus (S. aureus) is one of the examples of bacterial diseases of eye pain and also a major cause of many infections in communities and health facilities with cases of resistance to various antimicrobial agents. The purpose of this study was to prove the antibacterial activity of mekai leaves ethanol extract against S. aureus bacteria. This research is an experimental research. The stages of this research began by extracting mekai leaves using maceration method with 96% ethanol solvent. Antibacterial activity was tested by the disc method (Kirby-Bauer) using ethanol extract concentrations of mekai leaves (EPC) 20%, 30%, 40%, 50%, 60%, 70%, and 80%, positive control using 25 μg amoxicillin and negative control using DMSO 10%. The measurement results of inhibition zones of mekai leaf ethanol extract 20%, 30%, 40%, 50%, 60%, 70% and 80% respectively were 8.32 mm, 8.32 mm, 8.32 mm, 8.67 mm, 9.00 mm, 8.67 mm, and 8.33 mm. While the positive control measurement of 25 μg amoxicillin against S. aureus is 28.67 mm and the measurement of 10% negative DMSO control does not produce inhibitory zones, so it can be concluded that the ethanol extract of mekai leaves has antibacterial activity, but the area of ​​inhibition zone produced is smaller than amoxicillin 25 µg. The results of statistical tests using Mann Whitney between negative controls with all EPC concentrations obtained significant differences with p values ​​<0.05, it can be concluded that there is antibacterial activity produced at all EPC concentrations.
PENGARUH PROSES MASERASI DENGAN VARIASI KONSENTRASI PELARUT ETANOL TERHADAP KANDUNGAN SENYAWA EKSTRAK DAUN PEPAYA (Carica papaya L.) DAN DAUN UBI JALAR UNGU (Ipomoea batatas L. Lam) Herman Irawan; Sevty Syera; Nurlaili Ekawati; Djadjat Tisnadjaja
Jurnal Ilmiah Manuntung Vol 6 No 2 (2020): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v6i2.372

Abstract

Papaya (Carica papaya L.) and purple sweet potato (Ipomoea batatas L. Lam) are commonly used empirically as traditional medicines, including for malaria, malnutrition, fever and hemorrhagic fever. The purpose of this study was to determine the effect of differences in the concentration of ethanol solvents on the chromatogram profile and compound content. The research method began with maceration using 50%, 70%, and 96% ethanol, then thin layer chromatography test, and determination of total phenol and flavonoid levels with Elisa at λ of 750 nm and 415 nm, where the comparator used were gallic acid and quercetin . The results of total phenol levels obtained in papaya leaf extract were 3,493 mg GAE/gram and in sweet potato leaves the results were 4,786 mgGAE/mg. While the total flavonoid yield obtained from papaya leaf extract was obtained as much as 4,630 mg QE/gram and on sweetpotato which was 4,269 mgQE/mg. Characterisation of extract compound content was carried ouy by using Gas Chromatography- Mass Spectroscopy (GC-MS), where comparison of extracts used in extract combination samples are 50:50, 75:25, and 25:75. The results showed that ethanol extract contained alkaloids, flavonoids, saponins, tannins, and triterpenoids. Characterization by using GC-MS for single extract and combination extract of papaya leaves and purple sweet potato leaves obtained the main active compounds are Phytol, Neoheptadine, and n-Hexadecanoic acid.

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