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Waras Nurcholis
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INDONESIA
Indonesian Journal of Jamu
Published by Institut Pertanian Bogor
ISSN : 24077178     EISSN : 24077763     DOI : https://www.doi.org/10.29244/jji
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology
Jurnal Jamu Indonesia (JJI) is dedicated to the exchange of information and widespread scientific understanding regarding the development of the world of herbal medicine through the publication of scientific papers. The themes of scientific papers within the scope of JJI include the theme of herbal medicine research from upstream to downstream which is not limited to ethnobotanical research and local knowledge, exploration, conservation, domestication of biological resources related to herbal medicine, variety breeding, development of Good Agricultural and Collection Practices (GACP) for herbal medicine raw materials, development of standards for raw materials and herbal medicine products, development of herbal medicine products, identification of active compounds and their synthesis, working mechanisms for the bioactivity of herbal medicine formulas, social and economic aspects related to the development of herbal medicine.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 163 Documents
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Efektivitas Hipoglikemik Fraksi Etil Asetat Ampas Tahu menggunakan Model Hewan Ikan Zebra (Danio rerio) Herlina, Nina; Mulyati; Yulianita; Ananda, Putri
Jurnal Jamu Indonesia Vol. 5 No. 1 (2020): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v5i1.183

Abstract

Ampas tahu mengandung isoflavon genistein dan daidzein yang diduga memiliki efek hipoglikemik. Penelitian ini bertujuan untuk menguji efek hipoglikemik fraksi etil asetat ampas tahu (FEAAT). Ekstraksi isoflavon ampas tahu dilakukan dengan metode refluks menggunakan etanol dan HCl, kemudian fraksinasi menggunakan etil asetat. Efek hipoglikemik FEAAT dibuktikan menggunakan ikan zebra sebagai hewan uji. Kelompok perlakuan terdiri dari kontrol negatif (akuades), FEAAT1 dan FEAAT2 dengan konsentrasi 3,75% dan 5% serta kontrol positif (metformin). Hiperglikemia diinduksi dengan perendaman menggunakan aloksan 0,05% selama 30 menit, glukosa 1% selama 30 menit. Selanjutnya dilakukan pemberian sampel uji selama 120 menit secara berurutan untuk menguji efek hipoglikemik dari sampel uji. Cuplikan darah diambil pada menit ke-0, 30, 60, 90, dan 120 untuk diuji kadar glukosa darah. Hasil uji menunjukkan bahwa terdapat perbedaan yang nyata pada luas Area Under Curve (AUC0-120) kontrol negatif dengan FEAAT2 dan metformin (p < 0,01). Sementara hasil nilai AUC0-120 FEAAT1 tidak berbeda nyata dengan kontrol negatif. FEAAT2 efektif sebagai agen hipoglikemik pada model hewan ikan zebra yang diinduksi hiperglikemik.
Pengaruh Teknik Ekstraksi Daun Ubi Jalar Ungu (Ipomoea batatas) dan Daun Jambu Biji (Psidium guajava) terhadap Aktivitas Antioksidan Br Sembiring, Bagem; Bermawie, Nurliani; Rizal, Molide; Kartikawati, Andriana
Jurnal Jamu Indonesia Vol. 5 No. 1 (2020): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v5i1.184

Abstract

Daun ubi jalar ungu dan daun jambu biji dikenal sebagai tanaman obat dan telah banyak dimanfaatkan untuk membantu mengatasi berbagai masalah kesehatan. Kandungan senyawa bioaktif yang bermanfaat bagi kesehatan dipengaruhi oleh mutu bahan baku dan teknik ekstraksi. Penelitian ini bertujuan mendapatkan teknik ekstraksi terstandar daun ubi jalar ungu dan daun jambu biji Australia untuk menghasilkan aktivitas antioksidan yang tinggi. Tahap kegiatan meliputi penanganan bahan baku, analisis mutu simplisia, ekstraksi, dan pengujian aktivitas antioksidan. Kegiatan menggunakan Rancangan Acak Lengkap faktorial yang terdiri dari 2 faktor yaitu konsentrasi pelarut etanol (50, 70 dan 96%) dan lama ekstraksi (2, 3, 4 jam). Parameter yang diamati yaitu mutu simplisia, rendemen ekstrak dan aktivitas antioksidan. Hasil penelitian diperoleh kandungan flavonoid simplisia daun ubi jalar ungu sebesar 1,30% dan daun jambu biji Australia 2,72%. Rendemen ekstrak berkisar antara 8,4-68,2% dan 21,2-53,8%. Nilai IC50 untuk aktivitas antioksidan terkecil ekstrak daun ubi jalar ungu yaitu 33,34 bpj hasil ekstraksi dengan etanol 70% selama 2 jam dan daun jambu biji Australia nilainya 10,10 bpj hasil ekstraksi dengan pelarut etanol 96% selama 3 jam. Aktivitas antioksidan ekstrak daun jambu biji Australia lebih kuat dibandingkan ekstrak daun ubi jalar ungu. Konsentrasi pelarut berpengaruh terhadap rendemen ekstrak dan kekuatan aktivitas antioksidan.
Efek Antidiabetes Fraksi Etil Asetat Ampas Tahu Pada Model Hewan Resisten Insulin Herlina, Nina; Indriati, Dwi; Mulyati; Yulianita; Fitria, Elsa
Jurnal Jamu Indonesia Vol. 5 No. 1 (2020): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v5i1.185

Abstract

Ampas tahu telah menunjukkan efek antidiabetes pada model hewan yang diinduksi aloksan. Penelitian ini bertujuan untuk menguji efek antidiabetes fraksi etil asetat ampas tahu (FEAAT) pada model hewan resisten insulin. Ampas tahu diekstraksi dengan metode refluks menggunakan etanol dan HCl, kemudian difraksinasi menggunakan etil asetat. Mencit dibagi menjadi lima kelompok, yaitu kelompok normal, induksi, obat pembanding (Metformin), FEAAT1 (200 mg/kg bb) dan FEAAT2 (400 mg/kg bb). Mencit diinduksi resisten insulin dengan pemberian diet tinggi lemak dan glukosa selama 14 hari. kemudian diberikan bahan uji selama 14 hari. Pengujian efektivitas antidiabetes dilakukan dengan modifikasi Tes Toleransi Glukosa Oral (TTGO). Nilai Area Under Curve (AUC) diukur sebagai gambaran efek penurunan kadar glukosa darah. Data AUC yang diperoleh dianalisis secara statistik menggunakan uji Analisi of varians (ANOVA) dengan tingkat kepercayaan 95%. Hasil uji menunjukkan bahwa nilai AUC kelompok FEAAT1 tidak memberikan perbedaan yang nyata (p > 0,05) dibandingkan dengan kontrol negatif, sedangkan kelompok FEAAT2 dan Metformin memberikan perbedaan yang nyata (p < 0,05). Jika dibandingkan dengan kelompok normal, kelompok FEAAT2 dan Metformin tidak memiliki pengaruh yang berbeda nyata (p > 0,05) sementara nilai AUC FEAAT1 berbeda nyata (p < 0,05). Dengan demikian dapat disimpulkan bahwa FEAAT2 efektif sebagai antidiabetes pada model hewan resisten insulin.
Profile of Micro, Small, and Medium Industrial Herbal Medicine Products in Sukoharjo Regency Batubara, Irmanida; Purnaningsih, Ninuk; Mawasti, Titi
Jurnal Jamu Indonesia Vol. 5 No. 3 (2020): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v5i3.186

Abstract

Sukoharjo is one of the districts in Central Java that has a large number of herbal medicine entrepreneurs, including many small and medium industries. This small and medium industry needs to improve the quality of product safety. Therefore, this study aims to obtain the profile of small and medium industry herbal medicine products in Sukoharjo Regency. A total of 6 types of products (candy (1), mixture (3), extract (1), and tea (1)) were collected and the uniform weights, water content, organoleptic, hazardous metal content and microbiological safety were determined. The results showed that the product had fulfilled the water content, lead, cadmium, and arsenic content, and fulfilled the requirements of total plate count (TPC), coliform, and yeast mold. Product quality still needs to be improved in terms of uniformity of weight and packaging labels. The conclusion of this research is the profile of small and medium industry products in Sukoharjo Regency has met safety requirements but needs to be improved in quality.
Gelatin Extraction and Characterization from Femur Bones of Bovine and Porcine with Acid Process Purwantiningsih Sugita; Muhamad Rifai; Ambarsari, Laksmi; Rahayu, Dyah Utami Cahyaning; Dianhar, Hanhan
Jurnal Jamu Indonesia Vol. 6 No. 1 (2021): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v6i1.188

Abstract

Gelatin has been widely used as an additive in food industry pharmaceutical, and cosmetic. The similar physical appearance between bovine and porcine gelatin causes an issue for some communities like a Muslim due to awareness of halal food. This study aims to produce gelatin from femur bones of bovines with acid hydrolysis and their characteristics compared to standard gelatin of bovine and porcine. Bovine and porcine bones were soaked in 5% HCl for 10 days and every 2 days a HCl solution was replaced to get ossein. Ossein is hydrolyzed by gradual heating at 65, 75, and 85oC. Gelatin confirmed by the physico-chemical characters, FT-IR and analysis amino acid with HPLC.The results showed that the yield of bovine gelatin was 4.33%. The physico-chemical characters of bovine gelatin resulting from isolation and bovine gelatin standards are in conformity with porcine gelatin standards and meet the requirements of SNI 06-3735-1995 and GMIA. Therefore, bovine gelatin is specifically capable of substituting porcine gelatin for application in the pharmaceutical field. The FTIR spectrum of bovine gelatin shows the presence of amide A, amide I, amide II and amide III groups. The amino acid characters of gelatin were identified as glycine (13.57%) and proline (1.62%) for bovine gelatin and glycine (0.51%) and proline (0.09%) for porcine gelatin.
Total Flavonoid Content in Hydro-ethanolic Extract of Sauropus androgynus (L.) Merr Leaves from Three Regions with Different Altitude Ni Putu Ermi Hikmawanti; Hayati; Yeni Andriyani
Jurnal Jamu Indonesia Vol. 6 No. 2 (2021): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v6i2.195

Abstract

Sauropus androgynus (L.) Merr (Phyllanthaceae), also known as katuk in Indonesia, is a plant that grows in tropical climates. The study aimed to determine the total flavonoid levels of hydroethanolic extract of katuk leaves from three regions with different altitudes. Dried katuk leaves were macerated using hydroethanolic (the mixture of ethanol:H2O (7:3, v/v)) as solvent extraction at room temperature. Determination of flavonoid levels was carried out by the colorimetry method using AlCl3 reagent. Quercetin was used as a reference. A UV-Visible spectrophotometer measured the absorbance at the maximum wavelength of 434.50 nm. The total flavonoids level of hydroethanolic extract of katuk leaves from a different region with low-altitude (Bogor), medium-altitude (Sleman), and high-altitude (Bandung) are 8.56±0.63 mgQE/g, 4.67±0.30 mgQE/g, and 9.72±0.24 mgQE/g, respectively. Thus, it can be concluded that there are differences in total flavonoid levels of hydroethanolic extract of katuk leaves from three regions with different altitudes.
Antidiabetic Activity of Manonjaya Snakefruit Skin Extract with Zebra Fish (Danio rerio) as Animal Model Eti Rohaeti; Dea Nurafifah; Irmanida Batubara
Jurnal Jamu Indonesia Vol. 7 No. 3 (2022): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v7i3.201

Abstract

This research aimed to determine the active fraction and profile of active compounds in Manonjaya sSnakefruit skin extract that can be used as antidiabetic and the antidiabetic activity using zebra fish. Manonjaya sSnakefruit skin was extracted by maceration using 70% ethanol and then fractionated using n-hexane, ethyl acetate and methanol. The ethyl acetate fraction showed the highest yield and total phenolic content as well as the strongest α-glucosidase inhibition with an inhibition percentage of 64.43%. The ethyl acetate fraction provided the most active spot as an α-glucosidase inhibitor. The profile of active compounds that act as antidiabetic compound is flavonoid from glycosylflavone and flavone groups. Antidiabetic activity using zebra fish was indicates that Manonjaya Snakefruit skin extract from ethanol extract and ethyl acetate fraction can decrease blood sugar level of zebra fish after induced with alloxan. The crude extract group had 54.51% lower sugar content than the induction group and 41.70% lower than the negative control. Meanwhile, the ethyl acetate fraction group had 65.10% lower sugar content than the induction group and 55.27% lower than the negative control.
Traditional Use of Medicinal Plants in Baturraden, Central Java Nofrianti, Nofrianti; Utaminingrum, Wahyu; Hartanti, Dwi
Jurnal Jamu Indonesia Vol. 6 No. 2 (2021): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v6i2.206

Abstract

An ethnopharmacological study is an initial step for the development of jamu, which has been simultaneously conducted throughout Indonesia. This study aimed to explore the utilization of medicinal plants in Baturraden, a region with relatively rich plant biodiversity in Java. Our research is a quantitative ethnobotanical study reporting the utilization of medicinal plants as a single plant botanical preparation in the studied area. The data were collected through semi-structured interviews with 36 informants on the local names, indications, parts used, method of preparation, and application of the plants. The species use-value (SUV), relative frequency citation (RFC), and the fidelity level (FL) of each species were calculated accordingly. The study recorded the utilization of 47 species of medicinal plants, which were employed to treat 32 ailments. Leaves, decoctions, and oral were recorded as the most commonly used plant part, herbal preparation, and application. There were 24 botanical preparations with the FL value of 100%, which were indicated for the treatment of fourteen diseases/symptoms. Curcuma longa, Zingiber officinale, Piper betle, Cymbopogon citratus, Andrographis paniculata, Syzygium polyanthum, Citrus aurantiaca, and Zingiber montanum were considered as the most important and valuable plants by the local community. Hence, those plants should be evaluated further for their pharmacological activity and developed into standardized botanical preparations.
Antibacterial Activity of Ethanolic Extract, n-Hexane Fraction, and Chloroform Fraction of Binahong Leaves (Anredera Cordifolia) on Escherichia Coli and its Phytochemical Screening Pramita Yuli Pratiwi; Ana Mardiyaningsih; Nur Ismiyati; Hery Setiyawan
Jurnal Jamu Indonesia Vol. 6 No. 2 (2021): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v6i2.207

Abstract

Binahong leaves (Anredera cordifolia (Ten.) Steenis) are known to contain antibacterial activity compounds. The compounds contained in binahong leaves include flavonoids, alkaloids, saponins, and tannins. Escherichia coli is a gram-negative bacteria that often causes infections such as diarrhea. The purpose of this study was to determine the effect of ethanolic extract, n-hexane fraction, and chloroform fraction of binahong leaves on the growth of Escherichia coli bacteria and its phytochemical screening This research used ethanolic extract, hexane fraction and chloroform fraction of binahong leaves against Escherichia coli bacteria with concentrations of 12.5, 25 and 50% The positive control was chloramphenicol and the negative control was DMSO The method used disk diffusion technique, marked the presence of clear areas around the paper disc that showed an obstacle to bacterial growth phytochemical screening of alkaloids, flavonoids, saponins and tannins using a test tube. The result showed antibacterial activity against the growth of Escherichia coli with the diameter of the inhibition zone at concentrations of 12.5, 25, and 50%, namely the hexane fraction of 8.16; 9.73 and 12.93 mm. At the chloroform fraction 7.67; 8.47 and 9.87 mm. and the ethanolic extract of 7.33; 9.95 and 13.32 mm. The result of the largest inhibition zone was the ethanolic extract of binahong leaves with a concentration of 50%. The results of phytochemical screening using a test tube showed that the compounds contained in the ethanolic extract were flavonoids, alkaloids, saponins, and tannins.
Phytochemical analysis and Antibacterial Activity of Acetone Extract of Secang (Caesalpinia sappan L) Juwitaningsih, Tita; Sri Adelia Sari; Iis Siti Jahro; Neneng Windayani
Jurnal Jamu Indonesia Vol. 6 No. 2 (2021): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v6i2.209

Abstract

In North Sumatra, the stem of the secang (Caesalpinia Sappan L) has been used in traditional medicine. This study aimed to conduct phytochemical analysis of the acetone extract of C. sappan and determine its antibacterial potency. Phytochemical test using 1H-NMR spectroscopy method andantibacterial activity were carried out on six pathogenic bacteria, including paper disc diffusion tests, determination of the minimum inhibitory concentration (MIC) using the microdilution method, and minimum bactericidal concentration (MBC). Based on 1H-NMR spectroscopic data, the acetone stem extract of C. Sappan L contains flavonoids and terpenoids and has activity against all tested bacteria with an inhibition zone in the range of 6.20 ± 0.53 - 10.93 ± 2.55 mm, MIC 312 - 5000 µg / mL and MBC 625-> 5000 µg / mL. The acetone extract of C. sappan showed the best activity against S. aureus ATCC 25923 with a MIC of 312 µg / mL. C. sappan L is a potential source of new antibacterial compounds.

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