cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
-
Contact Email
-
Phone
-
Journal Mail Official
-
Editorial Address
Fakultas Kedokteran Universitas Brawijaya Gedung Graha Medika Lt. 1, Ruang 104
Location
Kota malang,
Jawa timur
INDONESIA
Jurnal Kedokteran Brawijaya
Published by Universitas Brawijaya
ISSN : 02169347     EISSN : 23380772     DOI : http://dx.doi.org/10.21776/ub.jkb
Core Subject : Health,
Medicine & Pharmacology
JKB contains articles from research that focus on basic medicine, clinical medicine, epidemiology, and preventive medicine (social medicine).
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 835 Documents
 80   81   82   83   84 
Potential Vitamin D3 in Reducing Hyperglicemia on Wistar Diabetic Mellitus Maulidi, Ahmad; Parmasari, Wahyuni Dyah; Ari Tania, Putu Oky; Setiawan, Heru; Sunaryati, Titiek
Jurnal Kedokteran Brawijaya Vol. 34 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2026.034.01.8

Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by hyperglycemia due to impaired insulin secretion or insulin resistance. Potential alternative to DM management is vitamin D supplementation, which is known to play a role in glucose homeostasis by enhancing insulin sensitivity and protecting pancreatic beta cells. This study aimed to evaluate the effect of vitamin D3 administration on blood glucose levels in Wistar rats induced diabetes mellitus using alloxan. Alloxan causes diabetes by damaging pancreatic β-cells in the islets of Langerhans. This substance enters the cells via the glucose transporter (GLUT2), producing free radicals (ROS), promote oxidative stress and β-cell necrosis, resulting in decreased insulin secretion and increased blood glucose levels. This study uses an experimental design with pre-test and post-test control group. The results showed a significant difference in blood glucose levels between groups (p=0.002) with Kruskal-Wallis Test. The treatment groups (P1 and P2) demonstrated a reduction in blood glucose levels compared to the positive control, with a greater decrease observed in group with the high dose of Vitamin D3, although the difference of glucose level between P1 and P2 was not statistically significant. These findings suggest that vitamin D3 administration plays a beneficial role in lowering blood glucose levels in alloxan-induced diabetic Wistar rats. It may help improve glucose regulation by enhancing insulin sensitivity or protecting pancreatic β-cells from oxidative damage. This paper describes our experimental approach, from the methodology through to the results and discussion, to explore the impact of Vitamin D3 on diabetic Wistar rats.
Uric Acid as a Significant Risk Factor for Hypertension Severity, Unlike Lipid Profiles Basuki, Sri Wahyu; Triastuti, N Juni; Erna Herawati; Sintowati, Retno; Faizah , Ariyani; Anisa Putri, Dede; Amalia, Raisya; Embiysne , Viamell; Amalia, Regal; Kusuma Ningrum, Sukma
Jurnal Kedokteran Brawijaya Vol. 34 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2026.034.01.5

Abstract

Hypertension remains a global health problem experienced by the world's population, as evidenced by its high prevalence and mortality rate. For 90-95% of hypertension sufferers, the cause of hypertension was reported as unknown. However, there are several risk factors associated with hypertension, notably genetic factors, age, gender, diabetes mellitus, lifestyle and diet, as well as lipid and uric acid profiles. This study aims to analyze uric acid and propyl lipid levels with hypertension severity. The study employed a quantitative research design. Data were collected through purposive sampling, yielding a total sample of 110 participants. The dataset was subsequently analyzed using logistic regression test. Based on the logistic regression statistical test, the following results were obtained: uric acid levels (p-value <0.05; OR >1; CI did not exceed 1); triglyceride levels (p-value >0.05; OR >1; CI exceeded 1); total cholesterol levels (p-value >0.05; OR <1; CI exceeded 1); and low-density lipoprotein levels (p-value >0.05; OR >1; CI exceeded 1). Thus, it can be concluded that abnormal uric acid levels significantly affect the severity of hypertension. Abnormal triglyceride levels and low-density lipoprotein levels show a tendency to increase the risk of hypertension severity but are not yet statistically significant. There is a tendency for abnormal total cholesterol levels to be less risky for severe hypertension compared to normal total cholesterol levels, but this disparity is not significant. Nevertheless, the probability of all variables with abnormal levels possessed a 12% risk of hypertension severity remains.
Calloselasma rhodostoma Envenomation in An Indonesian Pregnant Woman: A Rare Case Report Mahrus, Mahrus; Zainayah, Munsifah; Abdullah, Taufiq; Haedar, Ali; Maharani, Tri; Azizah, Maghfira Rahma; Khairunnisa, Naila Nurhana; Octavandi, Rafliandy Achmad; Aryanto, Zaki Yuli
Jurnal Kedokteran Brawijaya Vol. 34 No. 2 (2026): Article in Press 2026
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Abstract

Despite their relatively frequent occurrence, snakebite incidents in Indonesia are often underreported. Calloselasma rhodostoma, a hemotoxic snake, can cause coagulopathy and severe bleeding. Envenomation during pregnancy is rare but poses significant risks to both mother and fetus. We report a case of a 34-year-old woman in her second trimester who sustained a bite on her lower right leg. She presented within two hours with local pain, swelling, and gingival bleeding, indicating early systemic involvement. Laboratory findings confirmed severe thrombocytopenia (2,000/µL). Prompt management with immobilization and antivenom therapy was initiated. Following treatment, platelet counts improved significantly to 84,000/µL after the first dose and 176,000/µL after the second dose, without any obstetric complications. Early administration of antivenom effectively reversed coagulopathy and prevented maternal and fetal adverse outcomes. This case highlights the importance of timely intervention in hemotoxic snakebite during pregnancy and demonstrates favorable maternal and fetal outcomes with appropriate management. 
Relationship between Urinary Disorders and Body Mass Index in Women with Polycystic Ovary Syndrome Anggraeni, Asih; Budihastuti, Uki Retno; Darto, Darto; Laqif, Abdurrahman; Melinawati, Eriana; Insan Ksyatria, Yudhista Ngudi; Wijayanti, Agung Sari; Putrinadia, Aninditya Verinda
Jurnal Kedokteran Brawijaya Vol. 34 No. 2 (2026): Article in Press 2026
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Abstract

Early detection and management of obesity in women with polycystic ovary syndrome (PCOS) have been shown to reduce the risk of urinary problems and enhance their overall quality of life. The present study investigates the correlation between urinary disorders and body mass index (BMI) in women diagnosed with PCOS at Dr. Moewardi Regional General Hospital, Surakarta. A retrospective cohort approach was used over a 12-month time frame in both the outpatient clinic and the inpatient ward. The diagnosis of PCOS was made in accordance with the Rotterdam criteria (2003), whereby it is imperative that a woman fulfils two out of the three criteria, established after ruling out other hormonal disorders. Patients were stratified according to their BMI levels and the presence of urinary symptoms. Information on urinary issues, including urgency, frequency, nocturia, stress incontinence, and symptoms during and after urination, was extracted from the medical records. Statistical analysis was conducted to examine the correlation between urinary dysfunction and body mass index. In 54% of patients diagnosed with PCOS, urinary issues were identified. Of these, 63% were classified as obese. The study established that women diagnosed with PCOS who were obese were found to have more than twice the probability of developing urinary dysfunction in comparison to those with a normal weight. The most commonly reported symptoms included urgency and frequency, nocturia, stress incontinence, and post-voiding complaints. The present study demonstrates a significant correlation between urinary dysfunction and obesity in women diagnosed with PCOS.
Sagittal Knee Alignment Is Associated with Reduced Knee Flexion Range of Motion in Asymptomatic Elderly: A Cross-Sectional Study Mustamsir, Edi; Putra, Domy Pradana; Aji, Aulia Pandu; Firladi, Haidar Abror; Auzan, Asyrafly; Sasongko, Armabar Dwipantara; Tegar, Bintang Taqwa Nan
Jurnal Kedokteran Brawijaya Vol. 34 No. 2 (2026): Article in Press 2026
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Abstract

Knee alignment affects lower limb biomechanics and functional knee movement. However, the relationship between knee alignment and knee flexion range of motion (ROM) in healthy populations, particularly across different age groups, remains unclear. To compare coronal and sagittal knee alignment and knee flexion ROM between healthy young adults and elderly individuals, and to examine the association between knee alignment and knee flexion ROM using clinical goniometric assessment. This cross-sectional study included 64 healthy participants (32 young adults aged 20–24 years and 32 elderly individuals aged ≥60 years). Coronal and sagittal knee alignment and active knee flexion ROM were measured using a goniometer. Group differences were analyzed using independent t-tests and Chi-square tests, and associations between alignment categories and knee flexion ROM were assessed using the Kruskal-Wallis test. Elderly participants showed a higher prevalence of coronal varus alignment and sagittal flexion contracture compared with young adults. Mean knee flexion range of motion was significantly lower in elderly participants than in young adults (127.4±4.7° vs 137.6±4.4°, p<0.001). Coronal knee alignment was not significantly associated with knee flexion ROM in either young adults (p=0.056) or elderly participants (p=0.476). In contrast, sagittal knee alignment demonstrated a significant association with knee flexion ROM in elderly participants (p=0.017), whereas no significant association was observed in the young adult group (p=0.922). Sagittal knee alignment, rather than coronal alignment, correlates with reduced knee flexion range of motion in healthy elderly individuals. A straightforward clinical evaluation of sagittal alignment may assist in detecting early functional deterioration in ageing populations.

Page 84 of 84 | Total Record : 835

 80   81   82   83   84 

Filter by Year

2002 2026


Reset
Filter By Issues
All Issue Vol. 34 No. 2 (2026): Article in Press 2026 Vol. 34 No. 1 (2026) Vol. 33 No. 4 (2025) Vol. 33 No. 3 (2025) Vol. 33 No. 2 (2024) Vol. 33 Supplement 1 (2024) Vol. 33 No. 1 (2024) Vol. 32 No. 4 (2023) Vol. 32 No. 3 (2023) Vol. 32 No. 2 (2022) Vol. 32 No. 1 (2022) Vol. 32 Supplement 1 (2022) Vol. 32 Supplement 1 (2021) Vol 31, No 4 (2021) Vol. 31 No. 4 (2021) Vol. 31 No. 3 (2021) Vol 31, No 3 (2021) Vol. 31 Supplement 2 (2021) Vol 31, No 2 (2020) Vol 31, No 1 (2020) Vol 30, No 4 (2019) Vol 30, No 3 (2019) Vol 30, No 2 (2018) Vol 30, No. 1 (2018) Vol 29, No. 4 (2017) Vol 29, No. 3 (2017) Vol 29, No 3 (2016) Vol 29, No. 2 (2016) Vol 29, No 1 (2016) Vol 28, No 4 (2015) Vol 28, No 3 (2015) Vol 28, No 2 (2015) Vol 28, No 2 (2014) Vol 28, No 1 (2014) Vol 27, No 4 (2013) Vol 27, No 3 (2013) Vol 27, No 2 (2012) Vol 27, No 1 (2012) Vol 26, No 4 (2011) Vol 26, No 3 (2011) Vol 26, No 2 (2010) Vol 26, No 1 (2010) Vol 25, No 3 (2009) Vol 25, No 2 (2009) Vol 25, No 1 (2009) Vol 24, No 3 (2008) Vol 24, No 2 (2008) Vol 24, No 1 (2008) Vol 23, No 3 (2007) Vol 23, No 2 (2007) Vol 23, No 1 (2007) Vol 22, No 3 (2006) Vol 22, No 2 (2006) Vol 22, No 1 (2006) Vol 21, No 3 (2005) Vol 21, No 2 (2005) Vol 21, No 1 (2005) Vol 20, No 3 (2004) Vol 20, No 2 (2004) Vol 20, No 1 (2004) Vol 19, No 3 (2003) Vol 19, No 2 (2003) Vol 19, No 1 (2003) Vol 18, No 3 (2002) Vol 18, No 2 (2002) Vol 18, No 1 (2002) Article in Press 2 Article in Press More Issue