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Fakultas Kedokteran Universitas Brawijaya Gedung Graha Medika Lt. 1, Ruang 104
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Jurnal Kedokteran Brawijaya
Published by Universitas Brawijaya
ISSN : 02169347     EISSN : 23380772     DOI : http://dx.doi.org/10.21776/ub.jkb
Core Subject : Health,
Medicine & Pharmacology
JKB contains articles from research that focus on basic medicine, clinical medicine, epidemiology, and preventive medicine (social medicine).
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 832 Documents
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Potential Vitamin D3 in Reducing Hyperglicemia on Wistar Diabetic Mellitus Maulidi, Ahmad; Parmasari, Wahyuni Dyah; Ari Tania, Putu Oky; Setiawan, Heru; Sunaryati, Titiek
Jurnal Kedokteran Brawijaya Vol. 34 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by hyperglycemia due to impaired insulin secretion or insulin resistance. Potential alternative to DM management is vitamin D supplementation, which is known to play a role in glucose homeostasis by enhancing insulin sensitivity and protecting pancreatic beta cells. This study aimed to evaluate the effect of vitamin D3 administration on blood glucose levels in Wistar rats induced diabetes mellitus using alloxan. Alloxan causes diabetes by damaging pancreatic β-cells in the islets of Langerhans. This substance enters the cells via the glucose transporter (GLUT2), producing free radicals (ROS), promote oxidative stress and β-cell necrosis, resulting in decreased insulin secretion and increased blood glucose levels. This study uses an experimental design with pre-test and post-test control group. The results showed a significant difference in blood glucose levels between groups (p=0.002) with Kruskal-Wallis Test. The treatment groups (P1 and P2) demonstrated a reduction in blood glucose levels compared to the positive control, with a greater decrease observed in group with the high dose of Vitamin D3, although the difference of glucose level between P1 and P2 was not statistically significant. These findings suggest that vitamin D3 administration plays a beneficial role in lowering blood glucose levels in alloxan-induced diabetic Wistar rats. It may help improve glucose regulation by enhancing insulin sensitivity or protecting pancreatic β-cells from oxidative damage. This paper describes our experimental approach, from the methodology through to the results and discussion, to explore the impact of Vitamin D3 on diabetic Wistar rats.
Uric Acid as a Significant Risk Factor for Hypertension Severity, Unlike Lipid Profiles Sri Wahyu Basuki; Triastuti, N Juni; Erna Herawati; Sintowati, Retno; Faizah , Ariyani; Anisa Putri, Dede; Amalia, Raisya; Amalia, Regal; Embiysne , Viamell; Kusuma Ningrum, Sukma
Jurnal Kedokteran Brawijaya Vol. 34 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Abstract

Hypertension remains a global health problem experienced by the world's population, as evidenced by its high prevalence and mortality rate. For 90-95% of hypertension sufferers, the cause of hypertension was reported as unknown. However, there are several risk factors associated with hypertension, notably genetic factors, age, gender, diabetes mellitus, lifestyle and diet, as well as lipid and uric acid profiles. This study aims to analyze uric acid and propyl lipid levels with hypertension severity. The study employed a quantitative research design. Data were collected through purposive sampling, yielding a total sample of 110 participants. The dataset was subsequently analyzed using logistic regression test. Based on the logistic regression statistical test, the following results were obtained: uric acid levels (p-value <0.05; OR >1; CI did not exceed 1); triglyceride levels (p-value >0.05; OR >1; CI exceeded 1); total cholesterol levels (p-value >0.05; OR <1; CI exceeded 1); and low-density lipoprotein levels (p-value >0.05; OR >1; CI exceeded 1). Thus, it can be concluded that abnormal uric acid levels significantly affect the severity of hypertension. Abnormal triglyceride levels and low-density lipoprotein levels show a tendency to increase the risk of hypertension severity but are not yet statistically significant. There is a tendency for abnormal total cholesterol levels to be less risky for severe hypertension compared to normal total cholesterol levels, but this disparity is not significant. Nevertheless, the probability of all variables with abnormal levels possessed a 12% risk of hypertension severity remains.

Page 84 of 84 | Total Record : 832

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