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Folia Medica Indonesiana The Unit of Journal Consortium and Folia Medica Indonesiana Faculty of Medicine, Universitas Airlangga Jl. Prof. Dr. Moestopo No.47, Pacar Kembang, Kec. Tambaksari, Surabaya, Jawa Timur 60132, Indonesia
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Folia Medica Indonesiana
Published by Universitas Airlangga
ISSN : 23558398     EISSN : 2599056X     DOI : https://doi.org/10.65346/2958-4515.2401
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience
Folia Medica Indonesiana, as indicated by its name, focuses on publishing good quality articles about research and education on health science and medicine in Indonesia. However, due to the fast growth of science and knowledge in these fields, we also welcome submitted articles from around the world, especially the ones that contain related matters from lower-middle income countries. Folia Medica Indonesiana is an open-access, peer-reviewed journal that is published online at least four times a year. The scope covers various aspects of basic medical sciences includes anatomy, physiology, pathology, microbiology, pharmacology, and molecular medicine) and clinical medicine (covers specialties like internal medicine, surgery, pediatrics, oncology, psychiatry, etc). We highlight the pathology and potential treatment of metabolic syndromes and infectious diseases. Folia Medica Indonesiana also encourages the publication of articles about health education. The scope includes, but is not limited to, articles that emphasize on preventive education on certain diseases in a community, also research report of various materials and/or methods to develop medical education. We recognize the importance of this type of articles to be published alongside the assigned topic in each of our yearly issues, to provide our readers with updated information in medical sciences’ research and education simultaneously.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 17 Documents
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Search results for , issue "Vol. 57, No. 1" : 17 Documents clear
Neuromuscular Taping Increases Muscle Strength, Flexibility, and Shortens The 100 Meter Sprinter Travel Time Endaryanto, Agung Hadi; Asnar, Elyana; Indrawati, Roostantia
Folia Medica Indonesiana Vol. 57, No. 1
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Abstract

Lari sprint atau lari jarak pendek adalah salah satu nomor dalam atletik yang paling bergengsi, pelarinya disebut Sprinter. NMT adalah tehnik aplikasi yang menggunakan elastic adhesif tape yang memberikan kemampuan peningkatan fungsional otot, dan stimulasi sistem saraf. Tujuan penelitian ini, untuk mengetahui pengaruh neuromuscular taping terhadap kekuatan otot, fleksibilitas otot dan waktu tempuh sprinter 100 meter. Penelitian ini menggunakan metode pre test-post test with control grup design dengan total sampel berjumlah 13 orang dengan rentang usia atlet 15-19 tahun, pada tanggal 4-5 Agustus 2016 di GOR Gresik. Metode 1 kelompok dengan 2 perlakuan yaitu perlakuan I sebelum pemberian NMT dilakukan pengukuran kekuatan otot, fleksibilitas otot, dan waktu tempuh berlari 100 meter dan sesudah pemberian NMT dilakukan pengukuran kembali, perlakuan 2 sebagai kelompok kontrol dilakukan tanpa pemberian NMT dilakukan pengukuran kekuatan otot, fleksibilitas otot, dan waktu tempuh berlari 100 meter. Hasil penelitian menunjukkan pada perlakuan 1 kekuatan otot gastrocnemius dengan peningkatan rerata 11,38±7,83kg, nilai p=0,000, fleksibilitas nilai p=0,003 (dorsofleksi), p=0,013 (plantarfleksi) dengan peningkatan rerata 3,46±4,27 derajat, dan pemendekan waktu tempuh dengan nilai p=0-001, pada perlakuan 2 kekuatan otot gastrocnemius dengan penurunan rerata 2,12±2,43kg, nilai p=0,009, fleksibilitas nilai p=1,000 (dorsofleksi), p=0,165 (plantarfleksi) dengan peningkatan rerata 0,77±1,88 derajat, dan waktu tempuh terjadi perpanjangan waktu dengan nilai p=0-001 . Pemberian NMT pada sprinter memberikan hasil yang lebih baik dalam peningkatan kekuatan otot, fleksibilitas otot dan memperpendek waktu tempuh.
Body Mass Index, Waist-Hip Ratio and Fasting Blood Glucose Levels amongst the University Students Oktariza, Rury Tiara; Kalanjati, Viskasari Pintoko; Tirthaningsih, Ni Wajan
Folia Medica Indonesiana Vol. 57, No. 1
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Abstract

Overweight and obesity have been correlated to the higher risk for developing metabolic diseases in later life, i.e. DM type 2. We study the body mass index (BMI), the waist to hip ratio (WHR) and the fasting blood glucose levels (FBG) in the seemingly healthy male and female university students to comprehend these variables amongst the youth in Indonesia in 2019. The BMI and WHR of 150 male and female students aged 18-22 years old of the IIKBW, Kediri were measured by standardised anthropometry. The FBG was measured after 8 hours-minimum of fasting from the capillary blood drop using glucometer. Data was then analysed using SPSS 17 with level of significance of p<0.05. According to Asia-Pacific BMI classification, students were 30.7% obese with males significantly higher than females (p=0.016), 18% overweight (significantly higher in females, p=0.04), 36% normal and 15.3% underweight.When compared between genders, the WHR is significantly higher in males (p<0.001); whilst no significant differences in FBG (p=0.6). Four males and 5 females with FBG ≥ 100 mg/dl, whereas others were within normal limits. There are positive significant correlations between BMI and WHR in males and females (r=0.777, p<0.001; r=0.54, p<0.001, respectively). There is a significant positive correlation between the BMI and FBG with r=0.217, p=0.008; and between the WHR and FBG with r=0.21, p=0.01 amongst all students. In this study, male students have significantly higher BMI and WHR than females. Higher FBG was well observed in students with either higher BMI or WHR.
Radiology Perspective One-Year Study of Hirschsprung Disease Tjan, Anastasia
Folia Medica Indonesiana Vol. 57, No. 1
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Abstract

Hirschsprung disease is a rare developmental disorder of the enteric nervous system. This researched purpose to give an epidemiological database and current trend analysis from radiological perspective of Hirschsprung disease at our center. A prospective descriptive study was conducted for a year in 2017 at Sanglah Public General Hospital Bali. Colon in loop examination using either water-soluble or barium was conducted. All baseline characteristics, contras media used, and HD type were the parameter being evaluated in this study. Hirschsprung accounted for 2.16% from all 1018 newborn. Male is 3.4 times more prone to Hirschsprung disease. Age distribution predominant during 0 – 4 weeks after birth (36.4%). Ultrashort, short, long segments were 45.5%, 45.5%, and 9% respectively. Contras media used was mainly barium rather than water soluble 8:3, due to standard operating procedure adapted by some pediatric surgeon. Ultrashort and short segment HD has the same contribution. Barium is dominated at our center although water soluble is chosen in most literature for infant, due to its ability as diagnostic as well as therapeutic. Hence further research should be done to support and change the perspective in making the diagnosis.
Early Stunting Detection Education as an Effort to Increase Mother's Knowledge about Stunting Prevention Sari, Gadis Meinar
Folia Medica Indonesiana Vol. 57, No. 1
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Abstract

Stunting is one of the main nutritional problems that is still common in children under five and has serious health impacts. The results of National Health Research (Riskesdas) in 2018 showed the prevalence of stunting at 30.8%, indicating that 1 out of 3 Indonesian children are still stunted. Probolinggo Regency is a priority area for stunting handling in 2019 with a prevalence of 50.2% according to a report from the National Team for the Acceleration of Poverty Reduction (TNP2K). One of the factors that directly affect the incidence of stunting is low birth weight (LBW), while the mothers' knowledge level of health is an indirect factor that affects the growth conditions of children under five. The purpose of this study was to analyze the effect of providing stunting early detection education on maternal knowledge regarding stunting prevention. This is a pre experimental research study with one group pre-post test design, children aged 0-24 months as the research subjects. The case group consisted of stunted children (BL/A <-2 SD Z-score), while the control group consisted of normal children according to the BL/U indicator. The number of research subjects for the case and control groups was 40 with mothers of the toddlers as research respondents. The samples were selected using total sampling technique. Data were analyzed using dependent T test and linear regression. The results suggested that at the beginning of the session before provided education about early detection of stunting, mothers with stunting toddlers had lower level of knowledge (73.3%) than those with normal toddlers (77%). After provided with education, the knowledge level of mothers with stunted toddlers appreared to be higher (89%) than those with normal children (87.6%), with significant increase in each group (P <0.05). It can be concluded that education on stunting detection can significantly improve mothers' knowledge regarding the prevention of stunting in children aged 0-24 months. Providing regular education, both by nutrition workers at the health center and integrated service post (posyandu) cadres, is necessary as an effort to prevent stunting to the maximum.
Analysis of Quality of Antibiotic Usage on Patient with Internal and Surgical Service Ma'rifah, Nurul; Hasmono, Didik; Hadi, Usman; Kuntaman, Kuntaman
Folia Medica Indonesiana Vol. 57, No. 1
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Abstract

It is well-known that hospitals are health facility with the widely use of antibiotics. It is about 13-37% from the total hospitalized patients in developed countries use antibiotic, even in developing countries can reach 30-80%. There is identified correlation between antibiotic use and the development of bacterial resistance. Even though the resistance cannot be eliminated, but its development can be suppressed by the increasing of prudent use of antibiotics. The aim of this study was to determine the quality of antibiotic use on internal medicine and surgical patients in Aisiyah Hospital Bojonegoro. The study was a prospective cross sectional observational analytical study of among patients of internal and surgical who received antibiotic therapy in the period of August - September 2017. The total 50 samples were collected in this study which consists of 33 internal medicine and 17 surgical patients. From 50 samples, there were 16 types of antibiotics with the total use of 81 of antibiotic use. As the result, in internal medicine patients there were 22 (40%) of appropriate use of antibiotics, 4 (7.27%) of inappropriate use and 29 (52.73%) use of antibiotics without indication. In surgical patients, there were 12 (46.15%) of appropriate use of antibiotics, 2 (7.69%) of inappropriate use and 12 (46.15%) use of antibiotics without indication. This study showed that more than 50% of antibiotic use were inappropriate, and mainly antibiotic with no indication, among patients hospitalized in Aisyiyah Hospital Bojonegoro.
Determinant Factors of Depression in Beta Major Thalassemia Children Suryawan, Ahmad; Ningtiar, Hapsari Widya; Irwanto, Irwanto; Ugrasena, I Dewa Gede
Folia Medica Indonesiana Vol. 57, No. 1
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Abstract

Thalassemia is a chronic disease with long-term treatment that increases the potential for impact on physical, cognitive, and psychological conditions. About 80% of patients with major thalassemia have at least one psychiatric disorder, depression is one of the most frequently reported, especially in prepubertal and puberty periods. The aim of this study is to evaluate determinant factors of depression in beta mayor thalassemia children. This was a cross-sectional study on patients aged 9 to 17 years at hematology outpatient clinic in Dr. Soetomo General Hospital from September to Desember 2018. Level of depression determinded by Children Depression Inventory (CDI) questionnaire. The data were collected and analyzed using using the IBM SPSS Statistics version 21. It is statistically significant with p<0.05. Forty-five participants were included in this study, 15 participants with mild depression and 30 participants without depression. Gender (p=0.462), age of diagnosis (p=0.385), frequency of tranfussion (p=0.065), family history of depression (p=0,350), physical change (p=0.711), duration of illness (p=0.674) have no significant value as a determinant factor while complication (p=0.049) and serum cortisol level (p=0.037) had significant value as determinant factors of depression in Beta Major Thalassemia children. Mild depression is more common in thalassemia patients who experience complications and had high serum cortisol levels
Mechanism of Physical Exercise on Lowering Levels of C-Reactive Protein (CRP) in Overweight and Obese As'ad, Muchammad Rif'at Fawaid; Liben, Paulus; Herawati, Lilik
Folia Medica Indonesiana Vol. 57, No. 1
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Abstract

Cases of overweight and obesity in the world increased continuously. In 2016, obesity increased by 3% in men and 6% in women compared to 1975. Overweight cases also increased by 20% in men and 23% in women compared to 1975. Overweight and obesity have been linked to an increase in adipose tissue in the body. Increased adipose tissue associated with inflammation, which one of its characteristics is an increase levels of C - Reactive Protein (CRP). This article aim is to describe the mechanism of physical exercise to diminish CRP level in overweight and obesity. Adipose tissue produces and releases various pro-inflammatory and anti-inflammatory factors such as leptin, adiponectin, resistin, TNF-α, IL-6, MCP-1 and CRP. One of the prevention and treatment of inflammatory for overweight and obesity cases is to do physical exercise. In cases of overweight and obesity, the physical exercise aims to increase energy expenditure. Physical exercise decreases the volume and amount of adipose and pre-adipose tissue as well as the number of endothelial cells and macrophages in adipose that contain pro-inflammation such as IL-1, TNF-α, CRP, serum amyloid protein (SAA), and cytokines. Physical exercise rises anti-inflammatory properties such as IL-10, IL-1ra which play a role in inhibiting the transduction of IL-1β signals and inhibiting TNF-α synthesis. Physical exercise also amplifies antioxidant enzymes such as SOD and GPX. The antioxidants play a role in fighting free radicals to reduce inflammation.
Effect of Atorvastatin in Lipid Profile Changes and Inflammation Marker TNF-alpha on Diabetes Patient with Dyslipidemia Melasari, Wulan Panduwi; Suharjono, Suharjono; Samsulhadi, Wiwid
Folia Medica Indonesiana Vol. 57, No. 1
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Diabetes is one of the risk factors for cardiovascular disease (CVD). Diabetics patients have 2 to 4 times increased risk of cardiovascular disease compared with non-diabetics. TNF-alpha is a proinflammatory cytokine that can be used to determine the risk of atherosclerosis complications triggered by inflammation in diabetes. Statins are a class of HMG CoA reductase inhibitors that inhibit cholesterol biosynthesis and have pleioropic effects that inhibit the release of inflammatory cytokines like TNF-alpha and stabilize atherosclerotic plaques. This study aims to determine the effect of atorvastatin 20 mg/day for 30 days in reducing the lipid profile and TNF-alpha inflammatory markers in patients with diabetes dyslipidemia. Diabetes patient with dyslipidemia who included the inclusion criteria in this observational prospective cohorts studies treated with atorvastatin for 30 days (n = 19). The efficacy of statin therapy was measured by lipid profiles (LDL, TG, HDL, and total cholesterol) and TNF-alpha. The results of the study showed that atorvastatin decreased 40.55% of LDL levels, 15.34% of TG levels, and 30.70% oftotal cholesterol levels which statistically significant (P <0.05). As for HDL, there is an increase of 6.06% but statistically non-significant (P >0.05). TNF-alpha levels increased by 11.30% which statistically non-significant (P >0.05). The use of atorvastatin 20 mg for 30 days gave reduction in LDL, TG, and total cholesterol and increased in HDL. Atorvastatin does not have a reducing effect on TNF-alpha. There was no correlation between lipid profile changes with TNF-alpha changes.
Hyperbaric Oxygen Effects on Contrast and Macular Light Sensitivity in Dry Type Age-Related Macular Degeneration Patients Dewi, Indriani Kartika; Moestidjab, Moestidjab; Harnanik, Titut
Folia Medica Indonesiana Vol. 57, No. 1
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This study was to compare the effectiveness of hyperbaric oxygen therapy (HBOT) on contrast and macular light sensitivity improvement in dry type age-related macular degeneration (AMD) patients. The subjects were eyes that had been diagnosed with dry type AMD which met inclusion criteria. The subjects were divided into two groups. The first group was given antioxidants and HBOT. The second group was given only antioxidants. Contrast and macular light sensitivity test were done using MARS contrast sensitivity chart and Humphrey Field Analyzer-3 for three times, pre-therapy, day-1 and 14 post- therapy. This study found that 25 eyes were included for analysis, 14 subjects in first group, and 11 subjects in second group. Statistical analysis results showed that there were significant increase on contrast sensitivity in intervention group between one-day post-therapy with pre-therapy, P = 0.003 (P <0.05), and between 14-days post-therapy with pre-therapy, P = 0,015 (P <0.05). From pre- and post-analysis, there were no significant difference found on contrast sensitivity in control group and macular light sensitivity in intervention group. In control group, there were significant increase on superotemporal, superonasal, and inferonasal area between one-day post-therapy and pra-therapy with P = 0.004, P = 0.013 and P = 0.008 (P <0.05), respectively, and there was significant decrease on inferonasal area between 14-days post-therapy and one-day post-therapy, P = 0.003 (P <0.05). In conclusion, patients with AMD who were subjected to HBOT achieved improvement in contrast sensitivity in cases considered as having low prognosis. HBOT should be considered as promising intervention for AMD management adjuvant and further research are needed to find optimal dosage.
Correlation between Cell Proliferation with Cervical Lymphoid Node Status in Nasopharyngeal Carcinoma Patients Nugroho, Puguh Setyo; Yusuf, Muhtarum; Hidayati, Titiek Ahadiyah
Folia Medica Indonesiana Vol. 57, No. 1
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Several studies showed that the index of nasopharyngeal carcinoma (NPC) cell growth could be used to assess the carcinogenesis interaction factor, development and prognosis of NPC. Cell proliferation index could always be assessed with Ki-67 protein expression test. This research was conducted to study the correlation between cell proliferation index with cervical lymphoid node status in NPC in clinical manifestation to asses the progressivity and prognosis on NPC patients. This study used cross sectional design. Biopsy tissue specimen were acquired from 35 NPC patients clinically divided into four criteria of cervical lymphoid node status (N0, N1, N2 and N3). Expression of Ki-67 protein was acquired by immunohistochemistry test using monoclonal rabbit antibody anti-human Ki-67 clone 901-325-091911 (Biocare Medical, LCC. 4040 Pike Line, CA 94520 USA). The measurement of Ki-67 protein was conducted by pathology consultant. Spearman statistic test was performed to asses the correlation between Ki-67 protein expression and cervical lymphoid node status. The statistical significance was defined as p<0.05. Positive expression of Ki-67 protein was found in 33 patients; 4 patients with N0 (11.43%), 5 patients with N1 (14.29%), 9 patients with N2 (25.71%), and 15 patients with N3. Negative expression of Ki-67 protein was found in 2 patients with N0 (5.71%). The Spearman test resulted at p=0.0001 with correlation coefficient of 0.758. The correlation between Ki-67 protein expression with cervical lymphoid node resulted in a significant correlation (p<0.05). In conclusion, cell proliferation index has correlation with cervical lymphoid node status in NPC patients.

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