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Medula
Published by Universitas Lampung
ISSN : -     EISSN : 97726154     DOI : -
Core Subject : Health, Science, Education,
Education Medicine & Pharmacology Neuroscience Public Health
Medical Profession Journal of Lampung didirkan pada tahun 2013. Medula hadir memenuhi kebutuhan publikasi jurnal bagi mahasiswa Fakultas Kedokteran, Dosen ataupun klinisi dan profesi lain dibidang kedokteran. Medula diterbitkan dengan frekuensi 4 kali dalam setahun yang tiap nomornya mencakup 30 jenis artikel ilmiah seperti artikel penelitian, laporan kasus, tinjauan pustaka dan lain-lain. Medula sudah memiliki nomor ISSN media cetak sejak tahun 2013
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 906 Documents
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Pengaruh Asupan Asam Folat Maternal terhadap kejadian Neural Tube Defect Arina Muti Amaliah; Ratna Dewi PS
Medula Vol 10 No 4 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i4.150

Abstract

Neural tube defects (NTDs) are common complex congenital malformations resulting from failure of the neural tube closure during embryogenesis. Human NTDs are multifactorial, with contributions from both genetic and environmental factors. The genetic basis is not yet well understood, but several nongenetic risk factors have been identified as have possibilities for prevention by maternal folic acid supplementation. Congenital abnormalities included in NTD include anencephaly, encephalocele, cranial meningocele, myelomeningocele, spinal meningocele, lipomeningocele, spina bifida, and several other brain defects. Spina bifida and anencephaly are the two most common forms of NTD. The incidence of NTD can be caused by several risk factors such as nutritional status, prevalence of obesity and diabetes, use of folic acid supplements and / or fortification, presence of toxicity in the environment, and different genetic predispositions between ethnic groups. The genetic basis is not well understood, but several non-genetic risk factors have been identified as likely to be prevented by maternal folic acid supplementation. The incidence of NTD can be reduced if women consume a folic acid supplement before and during the early weeks of pregnancy.Folate is involved in the methylation process of homocysteine ​​and cytosine. It also contributes to the synthesis of purines and pyrimidines. As a result, a lack of folate causes an inability to properly build proteins and DNA and also changes the expression of some genes. Although the role of folate in reducing the risk of NTDs is unknown, women of reproductive age are encouraged to include folate supplements in their diets.
Penatalaksanaan Holistik Pasien Balita dengan Asma Persisten Ringan melalui Pendekatan Kedokteran Keluarga Arinda Stefani; Diana Mayasari
Medula Vol 10 No 3 (2020): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i3.151

Abstract

Asthma is a chronic respiratory disease based on chronic inflammation which results obstruction and hyperreaction of the respiratory tract as a result of the interaction between genetic, host, and environmental factors. Studies on the natural history of asthma show that nearly 80% of cases begin during the first 6 years of life. Asthma management must be continuous monitoring to achieve controlled asthma, doctors must manage patients holistically from various aspects to improve quality of life.  Implementation of family-based evidence based medicine by identifying risk factors, clinical problems, and patient management based on patient problem solving framework with patient centred and family approach. This study is a case report. Primary data were obtained through alloanamnesis, physical examination, home visits to complete family and psychosocial data, as well as the environment. Assessment based on holistic diagnostic from the beginning, process and in the end of thr study quantitatively and qualitatively. Patients under five with mild persistent asthma. Internal factors in cases such as genetic factors, age, and lack of awareness in avoiding trigger factors. External factors are lack of family knowledge about asthma and its complications and a dusty environment. Pharmacological and non-pharmacological interventions are carried out in the form of education in preventing asthma attacks in patients. The diagnosis and management of these patients has been carried out in a holistic, patient centered, family approach and based on several recent theories and studies. In the behavior change process, the patient and family have reached the adoption stage.
: Perbedaan Skor Clinical Reasoning Mahasiswa Tahap Pre-Klinik Dan Tahap Kepaniteraan Klinik Fakultas Kedokteran Universitas Lampung Aninda Nur Kumalasari; Oktafany; Merry Indah Sari; Dwita Oktaria
Medula Vol 11 No 1 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v11i1.152

Abstract

Clinical reasoning is a complex set ideas of diagnosis decision making process that involves those experiences, skill, and reflective thought. Medical faculty students undergoing pre-clinical and clinical students should improve their clinical reasoning as early as possible, so it can produce good quality of medical students. This study aims to determine the difference of clinical reasoning score between pre-clinical and clinical medical students of Lampung University. This was a descriptive analytic study using cross sectional study. Sampling using non-probability sampling method with the type of consecutive sampling and measuring instruments in the form of script concordance test. Data analysis was done by independent T test. The research conducted on 124 respondents with independent test result shows the score of preclinical student with mean 4,927 ± 1.3727 and score of clinical students with mean 5,416 ± 1,6020 with p = 0,041. There are a significant difference clinical reasoning score between pre-clinical and clinical medical students of Lampung University. This study has a significant difference of clinical reasoning score between pre-clinical and clinical medical students of Lampung University. Clinical reasoning in students can be improved by increasing cognition and metacognition through learning self-regulation.
Manajemen Preoperatif dan Anestesia Pasien Geriatri Dita Mauliana Prabiwi; Ari Wahyuni
Medula Vol 10 No 4 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i4.153

Abstract

Geriatric patients are elderly patients over 60 years of age and have multi-pathological characteristics whose symptoms are atypical with decreased physiological reserve and are usually accompanied by functional disorders. Up to 60 years of age, both basal organ function and physiological reserve are well preserved. Furthermore, the physiological reserve function will decrease. In addition to the pharmacokinetic changes in drug metabolism associated with aging, pharmacodynamic changes can also alter drug response in geriatric patients. The preoperative evaluation and assessment in elderly patients is usually more complex than in younger patients because of the heterogeneity and the increased frequency and severity of comorbidities associated with aging. In addition, perioperative functional status may be difficult to evaluate. Aging produces changes in physiology that are linked to reduced functional reserves and the ability to compensate for physiological stress. As a result, the consumption of several drugs typical of elderly patients can alter the homeostatic mechanism. Elderly patients are at greater risk of long-term functional impairment after the stress of surgery than younger patients. In general, elderly patients with complex medical histories should be given more attention before surgery to ensure that they are properly prepared. All elderly patients should undergo preoperative evaluation and preparation of anesthesia as well as relevant consultations.
Hububgan Hubungan Riwayat Merokok, Konsumsi Alkohol dan Diabetes dengan Derajat Histopatologi Karsinoma Kolorektal di RSUD Dr. H. Abdul Moeloek Bandar Lampung Periode 2017-2018 Gede Ardi Saputra; Rizki Hanriko; Hendri Busman; Muhartono
Medula Vol 10 No 4 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i4.154

Abstract

Colorectal carcinoma is a malignant neoplasm which originating or growing in the colon or rectum. Colorectal carcinoma is one of the 10 most common cancers suffered by Indonesians. Carcinomas develop much less in the duodenum, jejunum, and ileum than in the colon and rectum. The duodenum, jejunum, and ileum join the colon in the lower right abdomen. In the early stages most cancers do not show any particular clinical symptoms, however, early testing can minimize a poor prognosis. Screening or screening for colorectal carcinoma can be performed in groups of men and women over 50 years of age or patients who are at risk of developing colorectal carcinoma. Screening should also be done by people with polyps or individuals at risk of other carcinomas. The purpose of this study was to determine the frequen distribution and the relationship between smoking history, alcohol consumption history and diabetes history to the histopathological degree of colorectal carcinoma in RSUD Dr. H. Abdul Moeloek. This research was conducted in October-November 2019 at Dr. H. Abdul Moeloek Bandar Lampung using the observational method. The sample of this study consisted of 94 people with medical record data determined using total sampling techniques. Data were processed using statistical tests with a confidence level of 0.05. Chi-square test results showed that there is a  correlation between smoking history (p = 0.0008), alcohol consumption (p = 0.006) and diabetes mellitus (p = 0.015) with the histopathological degree of colorectal carcinoma. So, it can be concluded there is a correlation between smoking history, alcohol consumption and diabetes.
Pengaruh Pemberian Ekstrak Teh Hijau (Cammelia Sinensis) Terhadap Gambaran Histopatologi Silia Pada Trakea Tikus Putih Jantan Galur Sprague Dawley yang Dipapar Uap Rokok Elektronik Ahmad Syah Putra; Susianti; Rizki Hanriko
Medula Vol 10 No 4 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i4.156

Abstract

At present, there is a shift in the use of cigarettes, from conventional cigarettes to e-cigarettes. Exposure to particulate e-cigarettes can cause damage to the airway, one of which is ciliary tracheal. Green tea (Camellia sinensis) has a source of antioxidants in the form of polyphenols which can reduce the number of organ damage through a mechanism as an anti-oxidant. The study used an experimental design using 30 Sprague Dawley strain white rats which were divided into 6 groups, namely 3 control groups and 3 treatment groups. In the control group, given regular treatment, exposure to electric cigarettes and exposure to conventional cigarettes. In the treatment group, mice were given peritoneal injection of green tea extract each of 50 mg/kg body weight, 100 mg/kg body weight, and 200 mg/kg body weight. After 14 days of treatment, the 15th day of mice was euthanized and preparations were taken. There was a change in histopathological damage in all samples where there were significant differences in the control group, but not significantly in the treatment group with a value of K1 to K2 with p = 0.005, and K1 to K3 with p = 0.007. Whereas in vape control group (K2) between treatment groups P1, P2, and P3 were p = 0.521.There is not difference between the administration of green tea extract to histological ch es in cilia’s tracheal structure of rats exposed to steam electronic cigarettes with p=0,521.
Laporan Kasus : Bayi 3 Bulan dengan Ulkus Kornea Ocular Dextra et causa Koloboma Palpebra Superior Ocular Dextra Rani Himayani; Farhandika Muhammad
Medula Vol 10 No 4 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i4.157

Abstract

Coloboma is a condition of congenital malformation in which the ocular structures are not fully formed due to failed fusion of the optic fissure during the embryonic development. The resulting defects can affect different structures, such as the eyelids, iris, lens, ciliary body, choroid, optic nerve, and retina.Eyelid coloboma is a congenital disorder that can occur unilateral or bilateral, partially or completely. This is due to the failure of mesodermal fusion during eyelid embryogenesis. There is no fusion between contigous tissue, the failure of the mesenchyme to fill the embryogenic process, and the result of necrosis due to the suppression effect of the amniotic band syndrome. This case reports a 3 month old baby with a chief complaint of white part  on right eye since 15 days. The complaint was initiated with the patient being born without a complete right eyelid. The ophthalmology examination of the right eye found that the sharp vision of the baby began to be able to follow the moving object that was seen, but the baby did not follow the instructions to see from one object to another without having to move his head, the pupil diameter was the same in both eyes, with normal pupillary reflex. Eyelid inspection found a coloboma on the right upper eyelid. In the sclera and limbus, there was minimal ciliary injection, the cornea was cloudy, the front chamber was shallow and it looked positive.Based on the history, physical examination, and investigations, the patient was diagnosed as right ocular corneal ulcer et causa coloboma of the superior ocular palpebrae. Medical management by administering antibiotic therapy and artificial tears, and in the patient planned operative action in the form of reconstruction of the superior palpebra on the oculi dextra.
Rabdomiosarkoma Helmi Ismunandar; Rani Himayani; Diki Prawira Adifa
Medula Vol 10 No 4 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i4.158

Abstract

Rhabdomyosarcoma is a soft tissue malignancy with prevalences about 5% of all malignancies in children and 20% of soft tissue malignancies that occur in children. The most common primary tumor sites include the head and neck area followed by the genitourinary and extremities. Meanwhile, the most common subtypes are embryonic in children and alveolar in adolescents. Although the specific etiology for RMS is largely unknown, there are increased risk factors for environmental factors such as radiation and drugs, syndromes, and chromosomal abnormalities. The clinical symptoms vary and are related to the location of the mass and the blockage it caused. Histopathological and immunohistochemical examinations are gold standard tests for diagnosing RMS and determining subtypes that serve as prognosis and therapy. Various therapeutic approaches can be surgery, chemotherapy, radiotherapy, or in a combination.
KORELASI PANJANG TULANG FEMUR TERHADAP TINGGI BADAN DAN USIA PADA PRIA DEWASA SUKU BUGIS DI KOTA KARANG KECAMATAN TELUK BETUNG TIMUR KOTA BANDAR LAMPUNG Anggraeni Janar Wulan; Hendro Sihaloho
Medula Vol 10 No 4 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i4.159

Abstract

Estimates of height based on bone length is the femur bone are the most widely used methods, because they have good correlation coefficient values. This study was conducted using a descriptive analytical method with a cross sectional approach to 38 subjects who were over 21 years old and there were no bone abnormalities. The averages of height Bughis is 162,758 ± 6,09, length of femur bone Bughis right is 33,2 ± 3,09 and left is 32,158 ± 2,86. By using Pearson correlation analysis, the value of r = 0.855 for the right femur bone with height and r = 0.862 for the left femur bone with height very strongthWhich means a very strong relationship between the length of the femur bone with height. And the Bughis regression formula to estimate of height is Y = 106,767 + 1,683X (right) and Y = 102,026 + 1,835X (left), meanwhile Y = estimated height (cm) and X = Femur Bone Length. And for the correlation of femur length with age, r = -0.206 for the right femur bone and r = -0.223 for the left femur bone is weak. There is correlation of femur bone length to height and age in Bughis adult men at Karang City East Teluk Betung Subdistrict Bandar Lampung City.
Rakhitis: Tinjauan Pustaka Helmi Ismunandar; Rani Himayani; Maula Al Farisi
Medula Vol 10 No 4 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v10i4.163

Abstract

Vitamin D and calcium are important nutrients in bones. Bone growth and mineralization are dependent on the availability of adequate calcium and phosphate. Due to the lack of mineralization in the bone plates it causes rickets. Rickets is the most common bone disease worldwide and became known in 1650’s when it first appeared in Europe. Rickets can have a profound impact on the health, growth and development of infant’s, children’s and adolescent’s which can result in death or persistence to adult. Rickets is a metabolic disease of the bones, that is often associated with vitamin D deficiency and decreased circulating calcium storage, mainly due to a lack of bone capacity to absorb the calcium. Usually people with rickets have a short stature and have joint disorders. There are several types of rickets, such as rickets type-1 and type-2 that depend on vitamin D (but in type-2 rickets involves a genetic disorder related to the FGF23 gene), renal rickets due to decreased of kidney function, rickets hypocalcemia caused by deficiency of calcium, and hypophosphatemic rickets caused by deficiency of phosphate. Rickets can be diagnosed based on history, physical examination, radiological examination and biochemical tests.

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