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INDONESIA
Jurnal Sains dan Teknologi Farmasi
Published by Universitas Andalas
ISSN : -     EISSN : -     DOI : -
Core Subject : Science, Education,
Computer Science & IT Education
Arjuna Subject : -
Articles 94 Documents
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Uji Efek Sitotoksik Ekstrak Etanol Kulit Buah Asam Kandis (Garcinia cowa Roxb.) Terhadap Sel Kanker Payudara T47d dengan Metoda Mtt (Microtetrazolium) Assay Wahyuni, Fatma Sri; Sutma, Suci; Aldi, Yufri
Jurnal Sains dan Teknologi Farmasi Vol 16 No 2 (2011)
Publisher : Fakultas Farmasi Universitas Andalas

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The evaluation of cytotoxic effect on ethanolic extract from the fruit rinds of asam kandis (Garcinia cowa Roxb.) on T47D human breast cancer cells in vitro had been evaluated. The cytotoxic effect was carried out by using MTT assay. Extraction of dried fruit rinds of G. cowa Roxb. was macerated with ethanol 70%. The extract was prepared into 4 concentration groups, 100, 10, 1, and 0,1 μg/ml. Results showed that the IC50 of G. cowa Roxb. ethanolic extract was 19,33 μg/ml ± 1,15 on breast cancer T47D cells. The percentage of cells viability and concentration were analyzed analyzed by the two-way analysis of variance (ANOVA) followed by Duncan test. Result showed that the ethanolic extract of G. cowa Roxb gave a significant effect on T47D breast cancer cells viability (P<0.05).
Pembuatan Mikrokristalin Selulosa dari Ampas Tebu (Saccharum officinarum L.) Zulharmita, Zulharmita; Dewi, Siska Nola; Mahyuddin, Mahyuddin
Jurnal Sains dan Teknologi Farmasi Vol 17 No 2 (2012)
Publisher : Fakultas Farmasi Universitas Andalas

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A study on the preparation of microcrystalline cellulose from sugar cane bagasse (Saccharum officinarum L.) has been carried out. A total of 250 grams of dry sugar cane bagasse was made into alpha-cellulose by the method of multistage pulping and hydrolyzed with hydrochloric acid to produce microcrystalline cellulose which was further characterized. Microcrystalline cellulose were obtained as much as 71.5 grams with a yield of 28.6%. Characterization of microcrystalline cellulose from dry sugar cane bagasse, was done, including loss on drying, organoleptic, blue-violet coloured with of iodinated zinc chloride solution, soluble in the ammoniacal copper tetrammine solution, water-disoluble substances, not giving blue coloured with iodine 0.05 M, pH ± 6 and absorbance spectrum using FT-IR spectrophotometer as same as the standard. It was concluded that microcrystalline cellulose from sugar cane bagasse and Vivacel PH 102® has fulfilled the requirements of British Parmacopoeia 2002.
Pengaruh Kombinasi Surfaktan Natrium Lauryl Sulfat dan Benzalkonium Klorida Terhadap Kelarutan Ibuprofen Syofyan, Syofyan; Safari, Tuti Agustia; Azhar, Rieke
Jurnal Sains dan Teknologi Farmasi Vol 18 No 1 (2013)
Publisher : Fakultas Farmasi Universitas Andalas

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A study on the influence of sodium lauryl sulfate and benzalkonium chloride combination on the solubility of ibuprofen has been done. The solubility of ibuprofen with sodium lauryl sulfate, benzalkonium chloride and it’s combination was determined by surface tension method with Du Nouy Tensiometer and by refractive index method with Refractometer ABBE. The solubility was determined at surfactant concentration above the CMC value. Results showed that formula 4 gave the highest solubility of ibuprofen (96,25 %). Combination of the surfactants caused precipitation.
Pengaruh Air Perasan Bengkuang (Pachyrhizus Erosus (L.) Urb.) Terhadap Kadar Gula Darah Mencit Putih Jantan Diabetes Arifin, Helmi; Merry C, Ann; Ahmad, Asram
Jurnal Sains dan Teknologi Farmasi Vol 16 No 2 (2011)
Publisher : Fakultas Farmasi Universitas Andalas

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Abstract

Telah dilakukan penelitian tentang air perasan umbi bengkuang (Pachyrhizus erosus (L.) Urb.) terhadap kadar gula darah mencit putih jantan diabetes yang diinduksi dengan aloksan dosis 200 mg/kg BB. Air perasan umbi bengkuang diberikan secara oral dengan dosis 10, 20 dan 30 ml/kg BB selama 21 hari. Parameter yang diukur adalah kadar glukosa darah, berat badan, volume air minum, dan volume urin. Hasil penelitian menunjukkan bahwa air perasan umbi bengkuang dengan dosis 30 ml/kg BB mampu menurunkan kadar glukosa darah mencit diabetes secara bermakna (P<0.05). Air perasan umbi bengkuang juga dapat memperbaiki konsumsi air minum, tetapi tidak dapat memperbaiki berat badan dan volume urin mencit diabetes.
EFEK EKSTRAK ETANOL BIJI PINANG MUDA (Areca catechu L.) TERHADAP AKTIFITAS SISTEM SARAF PUSAT MENCIT PUTIH Arifin, Helmi; Riyono, Heppy; Elka, Elka
Jurnal Sains dan Teknologi Farmasi Vol 15, No 1 (2010)
Publisher : Universitas Andalas

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The central nervous system stimulant activity of the ethanol extract of young areca nut (Areca catechu L.) has been studied on mice. The observation was done by assessing the indurance, motor activity, curiousity, sleeping induced time and sleeping time in many variable of doses. Results showed that the ethanolic extract of 500 mg/ Kg bodyweight dose showed significant effect (P<0,05).
Optimasi Proses Produksi Bioplastik Poli (3-Hidroksibutirat) dengan Bakteri Bacillus Sp Faac 20801 Menggunakan Bahan Dasar Jerami Padi Secara Fermentasi Krisyanella, Krisyanella; Djamaan, Akmal; Aulia, Witra
Jurnal Sains dan Teknologi Farmasi Vol 17 No 1 (2012)
Publisher : Fakultas Farmasi Universitas Andalas

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Optimization of a production of a bioplastic poly (3 - hidroxybutirat) (P(3HB) by fermentation using Bacillus sp FAAC 20801 bacteria and rice straw as carbon source has been carried out. Detection of P(3HB) was done using gas chromatography. The highest glucose level obtain by using H2SO4 5% for hydrolisis. 46,800 mg straw (glucose concentration 200 mg/ml) were obtained 5,379 mg biomass and 0.058 mg P(3HB) ; from 83,400 mg rice straw (glucose concentration 400 mg/ml) were obtained 5,011 mg biomass and 0.124 mg P(3HB) ; from 142,800 mg rice straw (glucose concentration 600 mg/ml) were obtained 3,992 mg biomass and 2.309 mg P(3HB). 
Uji Fetotoksisitas Ekstrak Daun Kemangi (Ocimum Sanctum L.) pada Mencit Putih A, Almahdy; Yandri, Marina
Jurnal Sains dan Teknologi Farmasi Vol 15 No 1 (2010)
Publisher : Fakultas Farmasi Universitas Andalas

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The fetotoxicity effect of  methanolic extract  of the leaf of  kemangi (Ocimum Sanctum L.) on mice had been studied. The extract was given orally at various doses of 50, 100, and 200 mg/kg BW at 6th ­ until 15th day of pregnancy. On the 18th day of  pregnancy laparactomy was perpormed on half number of fetuses from each litter. Mice on  doses of 500 mg/kg BW showed abortion. Macroscopic observation on the fetuses showed some anomalis of body weight compared to control but there was no malformation occured at all doses.
Kajian Biodegradasi Filem Plastik Campuran Polimer Sintetik dengan Biopolimer dalam Larutan Air Octaviani, Melzi; Dewi, Asiska Permata; Boestari, Agusri; Zaini, Erizal; Djamaan, Akmal
Jurnal Sains dan Teknologi Farmasi Vol 17 No 1 (2012)
Publisher : Fakultas Farmasi Universitas Andalas

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A study on degradation of plastic film of the mixture of polystyrene sintetic polymers (PS) with poli(3-hidroxyibutirat) [P(3HB)] dan poli(3-hidroksibutirat-ko-3-hidroxyvalerat) [P(3HB-ko-3HV)] biopolymers in-vitro and in-vivo has been done. The assay was done by immersion test method in aquadest, river water at various pH of 4,6,8, and 10 respectively. Degradation rate was determined by linear regression with parameters including : t 50%, t 95% and rate constant (k). Degradation rate of plastic film of 1 PS/P(3HB) 95:5 at pH 6 was the fastest with k = 0,79 % week, t 50 % = 63,06 week and t 95 % = 119,84 week, followed by PS/P(3HB) 90 : 10 with k = 1,22 % / week, t 50 % = 41,25 week and t 95 % = 78,21 week and PS/P(3HB) 80 : 20 with k = 3,16 % week, t 50 % = 15,81 week and t 95 % = 30,05 week while pure PS plastic film (100 : 0 ) did not degraded at all. The degradation rate of a mixture of plastic film in river water, PS/P(3HB-ko-3HV) 95:5 showed k= 0,64 % week, t 50 % = 82,63 week and t 95 % = 157,17 week, PS/P(3HB-ko-3HV) 90:10 with k = 0,69 % week, t 50 % = 72,16 week and t 95 % = 137,4 week ; PS/P(3HB-ko-3HV) 85:15 with k = 0,74 %/week, t 50% = 66,79 week and t 95% = 127,32 week, while the pure PS plastic film (100:0) did not degrade.
Uji Efek Sitotoksik Ekstrak Etanol Akar Asam Kandis (Garcinia Cowa Roxb.) pada Mencit Putih Betina dengan Metode Micronucleus Assay Wahyuni, Fatma Sri; Siregar, Fitriyani; Dharma, Surya
Jurnal Sains dan Teknologi Farmasi Vol 17 No 2 (2012)
Publisher : Fakultas Farmasi Universitas Andalas

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The cytotoxic effect of ethanolic extract of Garcinia cowa Roxb. roots had been investigated on female mice using Micronucleus Assay method. Sixty mice were grouped into five: negative control, positive control, dosage I (extract 30 mg/kgBW), dosage II (extract 100 mg/kgBW), and dosage III (300 mg/kgBW) and then each group were grouped into three groups based on the duration of treatment. The group of mice were induced by cyclophosphamide 50 mg/kgBW intraperitoneally. After 30 hours, the treatment groups were administered the extract orally during 3, 7, and 15 days. After that, mice were sacrificed and the femur bone marrow was taken. Some of cytotoxic parameters were observed i.e micronuclei cells and hematocrit level. The percentage of micronuclei (MN) cells was calculated from the quantity of micronuclei cells of the slides of femur bone marrow by using microscope. Results confirmed that ethanolic extract of Garcinia cowa Roxb. roots decreased percentage of micronuclei cells not significantly (P > 0.05). The most lowering of micronuclei cells was showed by the extract in the dosage of 100 mg/KgBW for 15 days. 
Preparasi dan Karakterisasi Mikrokristalin Selulosa dari Limbah Serbuk Kayu Penggergajian Gusrianto, Putra; Zulharmita, Zulharmita; Rivai, Harrizul
Jurnal Sains dan Teknologi Farmasi Vol 16 No 2 (2011)
Publisher : Fakultas Farmasi Universitas Andalas

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A study on the preparation and characterization of microcrystalline cellulose from waste of sawdust has been carried out. A total of 300 grams of sawdust made into alpha-cellulose by multistage pulping method and hydrolyzed by using hydrochloric acid to produce microcrystalline cellulose, which was characterized further. Microcrystalline cellulose obtained as much as 99 grams with a yield of 33%. The organoleptic characteristics were fine powder, white, odorless, and tasteless. Identification with a solution of iodinated zinc chloride produced a blue violet and the infrared spectrum produced nearly the same wavenumber with Vivacel PH 102®. Solubility in water was 0.117% and the pH was 5.08, dissolved in a solution of ammonia-copper tetramin. The loss on drying was 5.85 %, the bulk density was 0.329 g/ml and tapped density was 0.542 g/ml. Carrs index value was 39.60%, Hausner ratio was 1.656 and Hydration capacity was 3.191. There was no starch on this microcrystalline cellulose. Microcrystalline cellulose from waste of sawdust generally met the pharmacopoeia requirements and the characteristics were not significantly different from Vivacel PH 102®.

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