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INDONESIA
Jurnal Sains dan Teknologi Farmasi
Published by Universitas Andalas
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Core Subject : Science, Education,
Computer Science & IT Education
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Articles 94 Documents
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Pengaruh Pemberian Jus Jambu Biji Merah (Psidiumguajava L.) Terhadap Jumlah Sel Eritrosit, Hemoglobin, Trombosit dan Hematokrit pada Mencit Putih Arifin, Helmi; Agustina, Agustina; Rizal, Zet
Jurnal Sains dan Teknologi Farmasi Vol 18 No 1 (2013)
Publisher : Fakultas Farmasi Universitas Andalas

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Abstract

Evaluation of the effect of red guava juice (Psidiumguajava, L.) on hematology parameters (red blood cell, hemoglobin, thrombocyts, and hematocrit) to female white mice has been done. The juice was administered orally with variation of doses at 25, 50 and 100 % one times a day for 7, 14, and 21 days respectively. As a control group was female white mice administered aquadest.  Results showed that administration of guava juice with a variation of dose did not influence red blood cell counts, hemoglobin and hematocrit, but increased thrombocytes  levels.
Studi Sistem Dispersi Padat Gliklazid Menggunakan Polivinil Pirolidon K-30 (PVP K-30) dan Tween 80 Halim, Auzal; Shilvi, Aulia; Erizal, Erizal
Jurnal Sains dan Teknologi Farmasi Vol 16 No 2 (2011)
Publisher : Fakultas Farmasi Universitas Andalas

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Abstract

Solid dispersions of gliclazide were prepared by solvent evaporation method using PVP K-30 and Tween 80 as dispersion carriers. The  physicochemical characteristics of solid dispersions were evaluated using microscopic analysis, X-ray diffraction, differential thermal analysis, determination of recovery, and dissolution rate test. Difractogram X-rays showed the physical interaction between the drug (gliclazide) and carrier (PVP K-30 and Tween 80), and polymorphic transformation occured during the evaporation of solvent in the preparation of solid dispersion. Thermogram DTA showed that the components of PVP K-30 and Tween 80 used affected the position of endothermic peak and peak sharpness. Determination of gliclazide in the recovery of solid dispersion was done using derivative spectrophotometry. Solid dispersion of gliclazide-PVP K-30-Tween 80 prepared in this study were found to have higher dissolution rates than pure gliclazide.
Uji Efek Antipiretik Ekstrak Etanol, Fraksi N-Heksana dan Fraksi Etil Asetat Daun Beringin (Ficus Benjamina L.) pada Tikus Putih Jantan (Rattus Norvegicus) Hasti, Syilfia; Sandi, Nofri Hendri; Srianti, Teti
Jurnal Sains dan Teknologi Farmasi Vol 17 No 1 (2012)
Publisher : Fakultas Farmasi Universitas Andalas

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Abstract

Banyan plant has been used by communities as a traditional medicine in order to heal heat cramps in children but it has not been scientifically tested. A study has been conducted to observe an antipyretic effect of the ethanolic extract, the fraction of n-hexane and ethyl acetate fraction of the leaves of banyan (Ficus benjamina. L) in male white rats (Rattus norvegicus) with fever induction method using a solution of peptone 2% as much as 0.5 mL / 200 g body weigt intra peritonially, with the dose of ethanol extract, the fraction of n-hexane and ethyl acetate fractions 100, 200, and 400 mg / kg orally. Respectively as a positive control, asetosal was administered at a dose 117 mg / kg and the negative control was 1% CMC Na. Temperature observations of mice performed at 30, 60, 90, 120, 150, and 180 minutes, then percent protection was calculated. Data analysis was done using Two-way Analysis of Variance (ANOVA) and Tukey test. Results showed that the fraction of n-hexane at a dose of 400 mg/kg had an antipyretic effect as significantly (p<0.05).
Pengaruh Penggunaan Kombinasi Maltodekstrin De 5-10 dari Pati Beras (Oryza sativa) dengan Laktosa sebagai Pengisi Terhadap Kompresibilitas dan Komprimabilitas Tablet Ibuprofen Syofyan, Syofyan; Rosanih, Rosanih; Arsyadi, Arsyadi
Jurnal Sains dan Teknologi Farmasi Vol 16 No 2 (2011)
Publisher : Fakultas Farmasi Universitas Andalas

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Abstract

Has conducted research on the effect of the combined use of maltodextrin DE 5-10 of starch rice (Oryza sativa) with lactose as a filler to the compressibility and comprimability ibuprofen tablets. Mass properties of compressibility and comprimability examined and evaluated according to the quality of the tablet Indonesian pharmacopoeia. The results showed that the analysis using one-way ANOVA F calculation obtained 1,130 less than the value of 3.48 which means the F table did not show any difference between the formulas. It can be concluded that the difference in the levels of the combination of lactose-maltodextrin DE 5-10 of rice starch did not affect the value of compressibility and tablet dosage ibuprofen komprimabilitas.
Penggunaan Kombinasi Pati Bengkuang Avicel Ph101 sebagai Bahan Pengisi Co-Process Tablet Isoniazid Cetak Langsung Syofyan, Syofyan; Yelni, Ezi Afri; Azhar, Rieke
Jurnal Sains dan Teknologi Farmasi Vol 17 No 2 (2012)
Publisher : Fakultas Farmasi Universitas Andalas

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Starch yam bean (Pachyrrhizus erosus Urban) is tablet excipient with poor of both flowability and compressibility which can not be used as diluents of direct tablet compression. The purpose of this research is to know the influence of the combination avicel PH101 – starch as a filler material co-process. Tablet made with direct compression method with isoniazid as a model drug. Results of the study show that the formula 4 (Avicel PH101 concentration with 4%) can produce co-process with mechanical and physical properties of compresibilitas-the most good, as for the evaluation of isoniazid tablets do not meet the requirements of violence and friabilytas on all formula. In summary, use of Co-Process yam bean starch – Avicel PH101 with 0-4% Avicel PH101 concentration was not produced a tablet that meet the requirements.
Mikroenkapsulasi Metformin Hidroklorida dengan Penyalut Etilsellulosa Menggunakan Metoda Penguapan Pelarut Noviza, Deni; Harliana, Tita; Rasyad, Ade Arinia
Jurnal Sains dan Teknologi Farmasi Vol 18 No 1 (2013)
Publisher : Fakultas Farmasi Universitas Andalas

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Abstract

Metformin hydrochloride is a biguanide class of oral antidiabetic drugs that have a half-life 1.5 to 3 hours, and it administration was repeated. In order to support the treatment of diabetic disease, metformin hydrochloride was made into microcapsules as a maintenance dose using solvent evaporation method using ethyl cellulose as a coated. The comparison between metformin hydrochloride and ethyl cellulose were 1: 0.75; 1: 1 and 1: 1.25. Microencapsulation evaluated by microscopic photograph, assay and dissolution test. At the microscopic picture shows metformin hydrochloride veiled by a layer of ethyl cellulose. The amount of metformin hydrochloride in F1 is 20.73%, 15.40% at FII and FIII is 10.11%. The biggest drug release inhibiton was achieved in formula 3 (1; 1.25) with dissolution efficiency was 0.170.
Analisis Aspek Farmakokinetika Klinik Pasien Gagal Ginjal pada Irna Penyakit dalam RSUP Dr. M. Djamil Padang Lucida, Henny; Trisnawati, Riah; Suardi, Muslim
Jurnal Sains dan Teknologi Farmasi Vol 16 No 2 (2011)
Publisher : Fakultas Farmasi Universitas Andalas

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A study on the evaluation of clinical pharmacokinetic aspect to in-patient with renal failure at internal Ward Dr. M. Djamil hospital Padang has been conducted. The aspect studied was dosage individualization bades on patient’s patophysiological condition. The study aimed at comparing the dosage regimen given to the renal failure patient with that calculated using pharmacokinetic equations. This study was observasionaly prospective by using cross-sectional method. In the period of June – September 2010, 48 renal failure patients includes in inclusion criterion. Results showed that medications which mainly renal excreted or potentially nephrotoxic given to patients are ciprofloxacin, digoxin, ranitidin, metformin, captopril, furosemide and hydrochlortiazide. Patients treated with those medications were evaluated in terms of dosage regimens and clinical response. There were 4 cases of higher dose than recommended included 1 of 8 cases of captopril use, 2 of 9 cases of ciprofloxacin use and 1 of case of metformin use. It uses also found that hydrochlortiazide which should be avoided to patients with Clcr < 30 ml/min (4 cases)
Kajian Penggunaan Obat Intravena di SMF Penyakit dalam RSUD Dr. Achmad Mochtar Bukittinggi Nasif, Hansen; Yuned, Monalisa; Muchtar, Husni
Jurnal Sains dan Teknologi Farmasi Vol 18 No 1 (2013)
Publisher : Fakultas Farmasi Universitas Andalas

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Abstract

Injeksi merupakan salah satu cara pemberian obat yang biasa digunakan dalam mengobati penyakit. Injeksi saat ini telah menjadi prosedur pengobatan yang paling umum ditemukan di dunia dengan 16 milyar injeksi diberikan setiap tahunnya. Pasien sebaiknya tidak diberikan injeksi intravena bila terapi per oral dapat dilakukan.Penelitian ini bertujuan untuk mempelajari ketepatan pilihan penggunaan obat secara intravena mengacu pada sembilan kriteria penggunaan obat secara intravena (Scot, 2003; Mycek, 2001; Ansel, 1989). Penelitian dilakukan dengan metode observasi prospektif melalui pengamatan langsung pada kondisi pasien yang mendapatkan obat dalam bentuk sediaan intravena dengan memperhatikan juga data rekam medik nya. Teknik pengambilan sampel menggunakan metoda purposive sampling di SMF Ilmu Penyakit dalam RSUD Dr. Achmad Mochtar Bukittinggi dari Mei sampai Agustus 2009.Setelah dilakukan penelitian di dapatkan penggunaan sediaan intravena untuk 81 orang pasien dengan 134 kali pemberian injeksi. Dalam penelitian ini masih ditemukan pemilihan penggunaan sediaan intravena yang tidak tepat yaitu pada 21 kali pemberian (15,7%) pada penggunaan furosemid, metoklopramide dan ranitidin.Farmasis sangat di butuhkan di ward/bangsal untuk memberikan rekomendasi farmasis supaya tidak terdapat keraguan dalam pemilihan penggunaan sediaan intravena sehingga peran farmasis sebagai drugs therapy advisor dapat dijalankan.
Potensi Senyawa Bioaktiv Spon Laut Axinella Carteri Asal Sumatera Barat Handayani, Dian
Jurnal Sains dan Teknologi Farmasi Vol 17 No 1 (2012)
Publisher : Fakultas Farmasi Universitas Andalas

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This paper reports the bioactivity potency of the marine sponge Axinella carteri, which has been investigated for its anticancer, antibacterial, antifungal and antiviral activities. This sponge is one of the most abudance organism in the coastline of West Sumatera. 
Formulasi Mikroenkapsulasi Protein dalam Poli(D,L-Laktida) dengan Teknik Penguapan Pelarut Fitriani, Lili; Rachmawati, Heni; Suciati, Tri
Jurnal Sains dan Teknologi Farmasi Vol 15 No 1 (2010)
Publisher : Fakultas Farmasi Universitas Andalas

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Abstract

Poly (D,L-lactide acid) has been used as scaffold and controlled release device for protein such as growth factor in tissue engineering. In this study, PDLLA microparticles were made and papain was used as model protein. Protein was encapsulated in microparticles using water-oil-water (W1/O/W2) and solid-oil-water (S/O/W) emulsification-solvent evaporation. Types of encapsulation methods and ratios of papain-PEG 20000 were observed in this study to provide the highest encapsulation efficiency. The entrapment efficiency made by W1/O/W2 method was 6,38%±0,025,  whilst S/O/W using ratios of papain-PEG 20000 1:1 ; 1:4 ; and 1:5 were 6,24%±0,91 ; 30,15%±1,66 and 60,67%±4,93, respectively. To conclude, S/O/W is the best method to encapsulate protein with highest entrapment efficiency.

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