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INDONESIA
Indonesian Journal of Pharmaceutical Science and Technology
Published by Universitas Padjadjaran
ISSN : 23561971     EISSN : 2406856X     DOI : -
Core Subject : Health, Science,
Computer Science & IT Medicine & Pharmacology
Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.
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Search results for , issue "Vol 11, No 1 (2024)" : 15 Documents clear
Studi In Vitro dan In Vivo Sediaan Topikal Salep Ekstrak Jahe, Serai dan Cengkeh (Jasekeh) terhadap Penyembuhan Luka Diabetes Melitus Tipe II Nurwahita, Nurwahita; Masriadi, Masriadi; Mahmud, Nur U.; Amelia, Rizki
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 1 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i1.47645

Abstract

Kombinasi Jahe, Serai dan cengkeh (JaSeKeh) yang mengandung  zat bioaktif seperti alkaloid, flavonoid, saponin, tanin, phenolic acid, dan terpenoid  dan senyawa eugenol berefek dalam menurunkan kadar glukosa dalam darah. Kandungan fenol memiliki sifat antioksidan, antibakteri dan antinflamasi yang akan mengurangi radikal bebas dan proses inflamasi sehingga dapat menurunkan kadar gula darah pada pasien diabetes mellitus. Penelitian ini bertujuan menganalisis pengaruh sediaan topikal salep ekstrak JaSeKeh terhadap penyembuhan luka Diabetes Mellitus tipe II. Desain penelitian adalah eksperimen laboratorium dengan Pre-Posttest Group Design. Penelitian dilakukan 2 tahap:  In Vitro dan In Vivo. In Vitro dilakukan untuk mengukur daya hambat kelompok ekstrak dalam menghambat Staphylococcus Aureus pada 20 ekor tikus putih Rattus Norvegicus yang di bagi dalam 4 kelompok yang terdiri dari 5 ekor dalam masing-masing kelompok 50mg, 75mg, 1000mg dan metcovazin sebagai kelompok kontrol. Hasil Penelitian menunjukkan perbedaan signifikan zona daya hambat pertumbuhan bakteri menggunakan ekstrak JaSeKeh konsentrasi 50%, 75 %, 95% dan kontrol positif ciprofloklaxin 5% terhadap pertumbuhan bakteri Staphylococcus Aureus. Terjadi peningkatan diameter zona daya hambat antibakteri seiring dengan bertambahnya ekstrak JaSeKeh. Pada uji In vivo terdapat perbedaan signifikan antara sediaan ekstrak JaSeKeh 750mg, 1000mg, dan kontrol positif metcovazin terhadap penyembuhan luka diabetes mellitus pada tikus putih rattus norvegicus.
PENGARUH EKSTRAK KENCUR (Kaempferia Galanga L) TERHADAP KELENJAR SUSU MENCIT Nurmala, Sara; Rahminiwati, Min; Sholehah, Akipah Nazla; Zaddana, Cantika
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 1 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i1.41247

Abstract

Rimpang kencur (Kaemferia galanga L) mengandung senyawa alkaloid, flavonoid, saponin dan steroid yang berpotensi dapat menstimulasi hormon oksitosin yang memiliki fungsi merangsang prolaktin agar terus dapat memproduksi ASI. Penelitian ini bertujuan untuk menentukan dan menetapkan gambaran histologi kelenjar mammae terbaik terhadap mencit yang diberikan ekstrak etanol kencur. ekstrak etanol kencur dibuat dengan metode suspensi. Pengujian dilakukan terhadap hewan mencit betina dengan lima ulangan yang diberikan ekstrak etanol kencur dengan dosis 10, 20, dan 40 mg/Kg BB, obat moloco® sebagai kontrol positif dan tanpa perlakuan sebagai kontrol negatif, Hasil statistiK menunjukkan untuk parameter bobot kelenjar mammae, jumlah lobus, dan luas alveoli menunjukkan ekstrak etanol kencur mempunyai efek yang signifikan terhadap peningkatan gambaran histologi kelenjar mammae mencit berkaitan dengan produktivitas kelenjar mammae sebagai penghasil air susu induk hewan mencit betina. Hasil statsitik menunjukkan dosis 40 mg/kg BB dosis terbaik efeknya setara dengan obat moloco®.
Analisis Flavonoid pada Fraksi Hasil Hidrolisat Ekstrak Daun Cordia sebestena L. Hikmawanti, Ni Putu Ermi; Hanani, Endang; Mardiyanti, Rini
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 1 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i1.38849

Abstract

Cordia sebestena L. (Boraginaceae) atau Cordia merupakan tanaman hias dengan kandungan flavonoid. Penelitian ini bertujuan menganalisis senyawa flavonoid pada fraksi hasil hidrolisat ekstrak etanol 70% daun Cordia. Penelitian terbagi menjadi 7 tahapan, yaitu (1) maserasi daun menggunakan etanol 70%, (2) hidrolisis asam pada ekstrak dengan HCl 2N pada 95 °C selama 2 jam, (3) fraksinasi hidrolisat dengan etil asetat, (4) penentuan kadar flavonoid total dengan kolorimetri, (5) pengujian aktivitas antiradikal terhadap 2,2’-difenil-1-pikrilhidrazil (DPPH), (6) pemisahan flavonoid menggunakan kromatografi lapis tipis (KLT), dan (7) identifikasi flavonoid menggunakan spektrofotometri UV-Vis dan infra merah. Hasil menunjukan kadar flavonoid total fraksi etil asetat sebesar 8,20 mgQE/g dengan nilai IC50 terhadap radikal DPPH sebesar 296,91 µg/mL. Kromatogram KLT menunjukkan keberadaan satu bercak senyawa pada fraksi etil asetat dengan nilai hRf adalah 85,5. Hasil spektrum UV-Vis pada bercak tersebut diperoleh serapan pada 340 nm (pita I) dan 240 nm (pita II). Sedangkan spektrum infra merah menunjukan adanya sinyal pada 3363 cm-1 (O-H ulur), 1727 cm-1 (C=O), 1459 cm-1 (cincin aromatik) dan 1060 cm-1 kuat (C-O). Dengan demikian, dapat disimpulkan bahwa fraksi etil asetat hidrolisat ekstrak etanol daun Cordia mengandung senyawa flavonoid yang mirip dengan kelompok kalkon.
Subchronic Toxicity Test of Cincalok Oil Towards Wistar Rats Haematology Nugraha, Fajar; Kurniawan, Hadi; Fajriaty, Inarah; Nurbaeti, Siti Nani; Goh, Sri Wahyuni
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 1 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i1.43023

Abstract

Cincalok is a fermented shrimp product which has the potential to be used as pharmaceutical preparations. Its LD50 showed non-toxic. However, subchronic toxicity tests have not been performed. Therefore, this study aims to determine its subchronic toxicity assay towards haematology in male and female white rats in the Wistar strain. The animals used were divided into six groups, the control group induced with virgin coconut oil (VCO), the dose group induced with Cincalok oil (100, 400, 1000 mg/kg BW), and two satellite groups (control group VCO and 1000 mg/kg BW). Haematological parameters evaluated include hemoglobin, Red Blood Cell Count (RBC), Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH), Mean Corpuscular Hemoglobin Concentration (MCHC), leukocytes, basophils, lymphocytes, eosinophils, platelets, and neutrophils. The average level of haematological profile in this study indicated that hemoglobin, MCH, MCHC, basophils, eosinophils, stem neutrophils, neutrophil segments, lymphocytes, and monocytes platelets in female and male rats were still in the normal range.While, there was a decrease in levels below the normal range in the parameters of RBC, leukocytes, MCV and hematocrit. It was concluded that the consumption of cincalok oil orally had no effect in hemoglobin, RBC, MCV, MCH, MCHC, leukocytes, basophils, lymphocytes, eosinophils, platelets, and neutrophil.
Anti-Inflammatory Activity of Ethanolic Extract Melophlus sp. and Callyspongia sp. from Southeast Sulawesi Fristiohady, Adryan; Sahidin, Idin; Sadarun, Baru; Purnama, La O. M. J.; Rahmatika, Nur S.; Tien, Tien; Haruna, Lidya A.; Yodha, Agung W. M.; Wahyuni, Wahyuni
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 1 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i1.28809

Abstract

Marine sponges display significant potencies as an anti-inflammatory agent. Thus this study aims to investigate the effect of anti-inflammatory of Melophlus sp. and Callyspongia sp. by decreasing plasma IL-1β levels of rats. This study was conducted by detecting chemical constituents of extracts and their anti-inflammatory by measuring the plasma IL-1β level of animals.  Animals were acclimatized for seven days, followed at day-8 animals were induced by 1% carrageenan injection intraplantar. Animals were divided into ten groups (n=4) and treated orally according to groups which were C+ and K+ (diclofenac sodium 3598 ppm), C- and K- (Na CMC 0.5%), M50 (Melophlus sp 50 ppm), M100 (Melophlus sp 100 ppm), M200 ((Melophlus sp 200 ppm), C50 (Callyspongia sp. 50 ppm), C100 (Callyspongia sp. 100 ppm), and C200 (Callyspongia sp. 200 ppm). After being left out for 1 hour, blood was collected at the first, second, and third hour. Blood samples were then centrifugated and assayed with ELISA kit Rat IL-1β. Data collected were statistically analyzed. Both marine sponges contain flavonoid, saponin, alkaloid, and terpenoid. Tannin was only detected in Melophlus sp. Both marine sponges provided an effect in decreasing plasma IL-1β at the concentration of 100 ppm and 200 ppm. In conclusion, both extracts of Melophlus sp. and Callyspongia sp. have anti-inflammatory activity with effective concentration are 100 ppm. Keywords: Anti-Inflammatory; Plasma IL-1β; Melophlus sp.; Callyspongia sp.
Formulasi dan Karakterisasi Nanoemulsi dari Ekstrak Biji Buah Makasar (Brucea javanica (L) Merr) Hajrin, Wahida; Subaidah, Windah A.; Juliantoni, Yohanes
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 1 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i1.38691

Abstract

Potensi antiinflamasi B. javanica perlu dikembangkan menjadi sediaan topikal. Bioavailabilitas dan stabilitas zat aktif menjadi batasan dalam pengunaannya sehingga perlu pengembangan formula yang sesuai. Nanoemulsi merupakan salah satu alternatif sediaan yang dapat meningkatkan stabilitas maupun penetrasi obat ke dalam kulit. Penelitian ini bertujuan untuk menentukan formula sediaan nanoemulsi ekstrak etanol biji B. javanica serta mengetahui stabilitasnya. Metode formulasi sediaan nanoemulsi dilakukan dengan bantuan pseudoternary phase diagram dengan 3 variasi komponen, yaitu minyak zaitun (EVOO), Smix (tween-propilenglikol 5:1), dan air. Karakterisasi nanoemulsi yang dilakukan adalah ukuran globul, % transmitan, pH, viskositas, dan drug load. Nanoemulsi biji B. javanica kemudian diuji stabilitasnya menggunakan metode Freeze-thaw cycle. Karakteristik sediaan nanoemulsi yang dihasilkan adalah ukuran globul 14,4±0,3 nm, zeta potensial sebesar 7,7±0,2 mV, % transmittant sebesar 93,05±4,06%, pH 7,14±0,05, viskositas 35800±2700 cps, dan drug load 83,81±8,49%. Nanoemulsi B. javanica memiliki karakteristik yang baik, namun tidak stabil berdasarkan nilai transmitan dan zeta potensial.
Biomolecular Mechanism of Herbal Medicine on Muscle Atrophy in Type 2 Diabetes Mellitus Rats: Systematic Review Kuswandi, Asep; Ikram, NKK; Muchtaridi, Muchtaridi
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 1 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i1.50895

Abstract

Musculoskeletal atrophy causes an increase in advanced glycation end products, a proinflammatory phenotype, and oxidative stress, which can lead to micro- and macrovascular complications.This can cause loss of skeletal muscle mass, strength, and function, potentially leading to sarcopenia. Herbal medicines have been proven to be able to treat various diseases in humans, herbal medicines have the potential to increase skeletal muscle mass. There are various genes that have been induced by herbal medicines to prevent muscle atrophy in chronic diseases. It is necessary to explain the molecular mechanisms of the role of herbal medicines in preventing muscle atrophy due to chronic diseases. This study explores the biomolecular mechanisms of each herbal medicine based on the pathways of inflammation, protein synthesis, apoptosis, autophagy, and glucose uptake in T2DM mice. The research results show that herbal medicine can potentially activate 81 gene expressions that can prevent muscle atrophy in T2DM mouse models. Keywords: biomolecular, herbal medicine, musculoskeletal atrophy, type 2 diabetes 
Determination of Gamma Oryzanol from Ethanolic Extract of Indonesian Rice Bran (Oryza sativa) Vardhani, Afifah; Perdanastuti, Hidayah Sunar
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 1 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i1.46297

Abstract

Rice bran contains gamma oryzanol, a chemical compound mostly consisted of complex ester trans-ferulate with phytosterols1. Gamma oryzanol has a strong antioxidant activity, explained by the free radical scavenging activity. This study was aimed to determine gamma oryzanol from ethanolic extract of rice bran. Quantitative analysis was conducted using HPLC analysis with mixture of methanol:acetonitrile:isopropanol (50%:40%:10%) as mobile phase and Inertsil ODS-3 5 μm as stationary phase. The UV detector wavelength was set to 327 nm, and the flow rate was set to 1 mL/min2. Gamma oryzanol standard and rice bran ethanolic extract 96% was injected into HPLC system. Ethanolic extract of rice bran (Oryza sativa) sample showed four major peaks as those of gamma oryzanol standard and contained 105,981 ppm of gamma oryzanol. As the conclusion, ethanolic extract of rice bran (Oryza sativa) contains gamma oryzanol
AKTIVITAS ANTIOKSIDAN EKSTRAK ETIL ASETAT BERBAGAI BAGIAN TANAMAN KESAMBI (Schleichera oleosa L.) DENGAN METODE DPPH Nursamsiar, Nursamsiar; Khairuddin, Khairuddin; Marwati, Marwati; Nur, Syamsu
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 1 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i1.38871

Abstract

Kesambi (Schleichera oleosa) merupakan salah tanaman asli Indonesia yang berpotensi sebagai obat dan memiliki senyawa aktif yang berpotensi sebagai antioksidan. Penelitian ini bertujuan untuk mengetahui potensi berbagai bagian tanaman sebagai antioksidan dengan metode DPPH. Simplisia diekstraksi dengan metode maserasi menggunakan pelarut etil astetat. Identifikasi golongan senyawa dilakukan dengan skrining fitokimia menggunakan reagen kimia sedangkan pengujian aktivitas antioksidan dilakukan dengan metode peredaman radikal DPPH menggunakan spektrofotometer pada panjang gelombang 515 nm. Hasil skrining fitokimia menunjukkan bahwa semua ekstrak etil asetat dari berbagai bagian tanaman mengandung senyawa flavonoid, fenolik dan tannin. Pengujian aktivitas menunjukkan ekstrak etil asetat daun kesambi memiliki aktivitas antioksidan paling baik dengan nilai IC50 5,4952 μg/mL, dibandingkan dengan kulit batang (14,3621 μg/mL), akar (43,4159 μg/mL), kulit buah (159,8782 μg/mL) dan daging buah (167,2912 μg/mL). Ekstrak etil asetat berbagai bagian tanaman kesambi memiliki aktivitas antioksidan dengan urutan paling baik yaitu daun, kulit batang, akar, kulit buah, dan daging buah. Adanya profil bioaktivitas tersebut dapat memberikan informasi tambahan terhadap kekuatan atioksidan pada berbagai bagian tanaman kesambi yang belum dilaporkan pada penelitian sebelumnya sehingga dapat dikembangkan untuk penelitian lebih lanjut.
Tea Fermentation of A. malacencis with Lactobacillus plantarum as a starter : Total Phenol Content, Total Flavonoids Content And Antioxidant Activity, In vitro study as a functional drink Apridamayanti, Pratiwi; Sari, Rafika
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 1 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i1.38426

Abstract

Some herbal teas contain antioxidant compounds that neutralize the free radicals involved in ageing processes and various diseases. Fermentation can increase the antioxidant activity in herbal teas due to the metabolic outputs of the microorganisms involved in the fermentation process. Aquilaria malaccencis is used to make teas in Indonesia and other countries and has been identified as demonstrating antioxidant properties. This study aimed to determine the characteristics of tea made from A. malaccencis leaves and fermented with Lactobacillus plantarum for 48 hours, 96 hours and 192 hours. The features investigated were antioxidant activity measured via DPPH assay and total phenol and flavonoid content measured spectrophotometrically. The fermentation results at 48, 96 and 192 hours were a pale yellow, sour aroma and sour taste and total lactic acid bacteria (LAB) content of 8.49 x 106 CFU/mL, 7.42 x 106 CFU/mL and 2.6 x 1010 CFU/mL, respectively. Antioxidant activity (IC50) at 48 hours was 439.444 µg/ml, at 96 hours was 235.309 µg/ml, and at 192 hours was 190.33 µg/ml. Total phenolic content (mg/g GAE) at 48 hours was 22.561, at 96 hours was 18.173, and at 192 hours was 21.14. Total flavonoid content (mg/g QE) at 48 hours was 1.901, at 96 hours was 1.938, and at 192 hours was 3.76. This research concluded that Lactobacillus plantarum as a starter for fermented tea made from Aquilaria malaccensis Lam. (A. malaccensis) leaves could produce appropriate characteristics for its functional food consumption. The best fermentation time was 192 hours, delivering an IC50 value of 190.33 ± 1.64 µg/ml, total phenol content of 36.346 mg/g GAE, and total flavonoid content of 3.876 ± 0.317 mg/g QE.Keywords: Tea fermentation, antioxidant activity, total phenolic content, total flavonoid content.

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